chlorthalidone has been researched along with Hypokalemia in 83 studies
Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "One hundred seventy-one patients, 60 years of age or older with isolated systolic hypertension, were randomly assigned to receive chlorthalidone 12." | 9.06 | Isolated systolic hypertension in the elderly. A placebo-controlled, dose-response evaluation of chlorthalidone. ( Aranda, J; Barra, P; Davidov, M; Ettinger, B; Gorwit, J; McBarron, F; Morledge, JH, 1986) |
| "A double-blind crossover study was designed to compare the antihypertensive and hypokalaemic effects of chlorthalidone administered at 10h00 and 22h00 to sixteen patients with primary hypertension." | 9.05 | Influence of the administration time on the antihypertensive and hypokalaemic effects of chlorthalidone in patients with primary hypertension. ( Carpentiere, G; Castello, F; Marino, S, 1985) |
| "Some evidence suggests that chlorthalidone may be superior to hydrochlorothiazide for the treatment of hypertension." | 7.79 | Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study. ( Dhalla, IA; Gomes, T; Hellings, C; Juurlink, DN; Mamdani, MM; Nagge, J; Persaud, N; Yao, Z, 2013) |
| "Prazosin was better tolerated, with side effects tending to diminish with time." | 6.64 | Prazosin and clonidine for moderately severe hypertension. ( Hammond, JJ; Kirkendall, WM; Overturf, ML; Thomas, JC; Zama, A, 1978) |
| "Chlorthalidone (50 mg daily) was given for 14 days." | 5.26 | Initial potassium loss and hypokalaemia during chlorthalidone administration in patients with essential hypertension: the influence of dietary sodium restriction. ( Landmann-Suter, R; Struyvenberg, A, 1978) |
| " To determine whether thiazide-induced diabetes is mediated by changes in potassium, we analyzed data from 3790 nondiabetic participants in the Systolic Hypertension in Elderly Program, a randomized clinical trial of isolated systolic hypertension in individuals aged >or=60 years treated with chlorthalidone or placebo." | 5.13 | Changes in serum potassium mediate thiazide-induced diabetes. ( Appel, LJ; Klag, MJ; Miller, ER; Parekh, RS; Shafi, T, 2008) |
| "One hundred seventy-one patients, 60 years of age or older with isolated systolic hypertension, were randomly assigned to receive chlorthalidone 12." | 5.06 | Isolated systolic hypertension in the elderly. A placebo-controlled, dose-response evaluation of chlorthalidone. ( Aranda, J; Barra, P; Davidov, M; Ettinger, B; Gorwit, J; McBarron, F; Morledge, JH, 1986) |
| "Men and women with isolated systolic hypertension who were at least 60 years of age were treated for 1 year with chlorthalidone (25-50 mg daily) or matching placebo as the step I drug." | 5.06 | Use of diuretics in treatment of hypertension in the elderly. ( Feigal, DW; Furberg, CD; Greenlick, M; Kuller, L; Perry, HM; Schnaper, HW; Schoenberger, JA; Smith, WM, 1986) |
| "A single-blind trial was carried out in 36 people with mild to moderate hypertension to compare the efficacy and tolerance of long-term treatment with furosemide and chlorthalidone." | 5.05 | Long-acting and short-acting diuretics in the treatment of hypertension. ( Ansuini, R; Belogi, M; Campolucci, G; Pupita, F, 1983) |
| "In an open two-period crossover study hydrochlorothiazide/amiloride and chlorthalidone were compared with regard to their anti-hypertensive and biochemical properties in ambulatory patients with mild to moderate hypertension." | 5.05 | The antihypertensive and biochemical effects of hydrochlorothiazide/amiloride (Moduretic) versus chlorthalidone. ( van Soeren, F, 1980) |
| "A double-blind crossover study was designed to compare the antihypertensive and hypokalaemic effects of chlorthalidone administered at 10h00 and 22h00 to sixteen patients with primary hypertension." | 5.05 | Influence of the administration time on the antihypertensive and hypokalaemic effects of chlorthalidone in patients with primary hypertension. ( Carpentiere, G; Castello, F; Marino, S, 1985) |
| "In essential hypertension, 25 mg and 100 mg of chlorthalidone per day reduced blood pressure to a similar extent." | 5.04 | Optimal dose of a thiazide diuretic. ( Carney, S; Gillies, AI; Morgan, T, 1976) |
| "This cohort study found that among older adults, chlorthalidone use was associated with a higher risk of eGFR decline, cardiovascular events, and hypokalemia compared with hydrochlorothiazide use." | 4.02 | Comparison of Clinical Outcomes and Safety Associated With Chlorthalidone vs Hydrochlorothiazide in Older Adults With Varying Levels of Kidney Function. ( Bugeja, A; Burns, K; Canney, M; Edwards, C; Hundemer, GL; Knoll, G; Petrcich, W; Sood, MM, 2021) |
| "Some evidence suggests that chlorthalidone may be superior to hydrochlorothiazide for the treatment of hypertension." | 3.79 | Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study. ( Dhalla, IA; Gomes, T; Hellings, C; Juurlink, DN; Mamdani, MM; Nagge, J; Persaud, N; Yao, Z, 2013) |
| "The effect of a maximal dose of a commonly used diuretic, chlorthalidone, on renal function was assessed in 6 patients with untreated essential hypertension." | 3.67 | Diuretic-induced hypokalemia and altered renal function. ( Carney, SL; Morgan, TO, 1986) |
| " In six patients with Bartter's syndrome, four with pseudo-Bartter's syndrome, and twenty with essential hypertension (EH) chronically treated with chlorthalidone, serum potassium (serum K+) and extracellular fluid volume (ECFV) were decreased, while plasma volume (PV) and blood volume (BV) were normal (see Table 1 for means, standard deviations, and levels of significance)." | 3.67 | Blood to interstitial fluid volume ratio in chronic hypokalaemic states. ( Boer, P; Dorhout Mees, EJ; Geyskes, GG; Hené, RJ; Koomans, HA; Roos, JC; Van Shaik, BA, 1985) |
| "A retrospective survey using chart review was conducted to determine the incidence of clinically significant hypokalemia resulting from therapy with chlorthalidone (CTLD) or hydrochlorothiazide (HCTZ)." | 3.66 | Potassium loss associated with hydrochlorothiazide versus chlorthalidone. ( Frisof, KB; Podany, EC; Sumiye, L; Vivian, AS, 1981) |
| "Hyperkalemia was associated with increased risk of combined cardiovascular disease (hazard ratio, 1." | 2.77 | Clinical significance of incident hypokalemia and hyperkalemia in treated hypertensive patients in the antihypertensive and lipid-lowering treatment to prevent heart attack trial. ( Alderman, MH; Calhoun, DA; Cushman, WC; Davis, BR; Eckfeldt, JH; Einhorn, PT; Ford, CE; Franklin, SS; Furberg, CD; Ong, ST; Oparil, S; Papademetriou, V; Piller, LB; Probstfield, JL, 2012) |
| "Prazosin was better tolerated, with side effects tending to diminish with time." | 2.64 | Prazosin and clonidine for moderately severe hypertension. ( Hammond, JJ; Kirkendall, WM; Overturf, ML; Thomas, JC; Zama, A, 1978) |
| "Hydrochlorothiazide (HCTZ) has often been contrasted with chlorthalidone, but relatively little is known about HCTZ versus indapamide (INDAP)." | 2.52 | Head-to-head comparisons of hydrochlorothiazide with indapamide and chlorthalidone: antihypertensive and metabolic effects. ( Ernst, ME; Kostis, JB; Roush, GC; Sica, DA; Tandon, S, 2015) |
| "She satisfied the clinical criteria for Bartter's syndrome and more precisely for Gitelman's syndrome: hypokalemia in the presence of inappropriately high potassium excretion, metabolic alkalosis, hyperreninemic hyperaldosteronism, hypomagnesemia with inappropriately high magnesium excretion, normocalcemia, hypocalciuria and normal blood pressure." | 1.29 | [Surreptitious intake of diuretics as the cause of pseudo-Bartter's syndrome: apropos of a case and differential diagnosis]. ( C-Soriaguer Escofet, F; Esteva de Antonio, I; Mancha Doblas, I; Olveira Fuster, G; Vázquez San Miguel, F, 1996) |
| "An episode of torsade de pointes was registered on electrocardiographic monitoring." | 1.28 | [Torsade de pointes and use of phenothiazine and diuretic]. ( Jarchovsky, J; Plavnik, L; Zamir, D, 1991) |
| "She was comatose for more than a month, apparently from extrapontine myelinolysis." | 1.27 | Thiazide-induced hyponatremia: an unusual neurologic course. ( Frankl, O; Lieberman, P; Mozes, B; Olchovsky, D; Pines, A; Werner, D, 1986) |
| "Chlorthalidone (50 mg daily) was given for 14 days." | 1.26 | Initial potassium loss and hypokalaemia during chlorthalidone administration in patients with essential hypertension: the influence of dietary sodium restriction. ( Landmann-Suter, R; Struyvenberg, A, 1978) |
| "A case of hypokalaemia due to chronic administration of Clortalydone is reported." | 1.26 | [Clinical and muscle istochemical observations in secondary hypokalaemia (author's transl)]. ( Borghetti, A; Cavatorta, A; Franchini, I; Marbini, A; Mazzucchi, A; Parma, M, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 63 (75.90) | 18.7374 |
| 1990's | 5 (6.02) | 18.2507 |
| 2000's | 4 (4.82) | 29.6817 |
| 2010's | 6 (7.23) | 24.3611 |
| 2020's | 5 (6.02) | 2.80 |
| Authors | Studies |
|---|---|
| Edwards, C | 1 |
| Hundemer, GL | 1 |
| Petrcich, W | 1 |
| Canney, M | 1 |
| Knoll, G | 1 |
| Burns, K | 1 |
| Bugeja, A | 1 |
| Sood, MM | 1 |
| Rosenberg, K | 1 |
| Bashir, K | 1 |
| Burns, T | 1 |
| Pirruccello, SJ | 1 |
| Aurit, SJ | 1 |
| Hilleman, DE | 1 |
| Chekka, LMS | 1 |
| Cooper-DeHoff, RM | 1 |
| Gums, JG | 1 |
| Chapman, AB | 1 |
| Johnson, JA | 1 |
| Ravioli, S | 1 |
| Bahmad, S | 1 |
| Funk, GC | 1 |
| Schwarz, C | 1 |
| Exadaktylos, A | 1 |
| Lindner, G | 1 |
| Liang, W | 1 |
| Ma, H | 1 |
| Cao, L | 1 |
| Yan, W | 1 |
| Yang, J | 1 |
| Dhalla, IA | 1 |
| Gomes, T | 1 |
| Yao, Z | 1 |
| Nagge, J | 1 |
| Persaud, N | 1 |
| Hellings, C | 1 |
| Mamdani, MM | 1 |
| Juurlink, DN | 1 |
| Agarwal, R | 1 |
| Sinha, AD | 1 |
| Pappas, MK | 1 |
| Ammous, F | 1 |
| Roush, GC | 1 |
| Ernst, ME | 1 |
| Kostis, JB | 1 |
| Tandon, S | 1 |
| Sica, DA | 1 |
| Springer, K | 1 |
| Shafi, T | 1 |
| Appel, LJ | 1 |
| Miller, ER | 1 |
| Klag, MJ | 1 |
| Parekh, RS | 1 |
| Parra, D | 1 |
| Rosenstein, R | 1 |
| Nicolás Sánchez, FJ | 1 |
| Sarrat Nuevo, RM | 1 |
| Soler Rosell, T | 1 |
| Gort Oromí, AM | 1 |
| Alderman, MH | 1 |
| Piller, LB | 1 |
| Ford, CE | 1 |
| Probstfield, JL | 1 |
| Oparil, S | 1 |
| Cushman, WC | 2 |
| Einhorn, PT | 1 |
| Franklin, SS | 1 |
| Papademetriou, V | 2 |
| Ong, ST | 1 |
| Eckfeldt, JH | 1 |
| Furberg, CD | 2 |
| Calhoun, DA | 1 |
| Davis, BR | 1 |
| LABADIE, P | 1 |
| BAGROS, P | 1 |
| CHRISTENSSON, B | 1 |
| GUSTAFSON, A | 1 |
| WESTLING, H | 1 |
| EDLEN, A | 1 |
| STOKES, W | 1 |
| ROOTH, G | 1 |
| FUERST, C | 1 |
| OECHSLIN, RJ | 1 |
| SCHMID, JR | 1 |
| SPERBER, RJ | 1 |
| FISCH, S | 1 |
| DEGRAFF, AC | 1 |
| FREUDENTHAL, RR | 1 |
| Fletcher, R | 1 |
| Khatri, IM | 1 |
| Freis, ED | 1 |
| Pupita, F | 1 |
| Belogi, M | 1 |
| Ansuini, R | 1 |
| Campolucci, G | 1 |
| Licht, JH | 1 |
| Haley, RJ | 1 |
| Pugh, B | 1 |
| Lewis, SB | 1 |
| Lovaste, MG | 1 |
| Aldovini, D | 1 |
| Dal Ri, E | 1 |
| Ferrari, G | 1 |
| Caralis, PV | 1 |
| Materson, BJ | 1 |
| Perez-Stable, E | 1 |
| Perry, HM | 2 |
| van Soeren, F | 1 |
| Baronchelli, A | 1 |
| Agosta, R | 1 |
| Verdecchia, P | 1 |
| Bichisao, E | 1 |
| Fischer, RG | 1 |
| Navarro, RP | 1 |
| O'Brien, DK | 1 |
| Nuffort, P | 1 |
| Spencer, DL | 1 |
| Pines, A | 2 |
| Goldhammer, E | 1 |
| Frankl, O | 2 |
| Haalboom, JR | 2 |
| Struyvenberg, A | 4 |
| Collart, F | 1 |
| Laurent, M | 1 |
| Ducobu, J | 1 |
| Cembrowski, GS | 1 |
| Huntington, RW | 1 |
| Sumiye, L | 1 |
| Vivian, AS | 1 |
| Frisof, KB | 1 |
| Podany, EC | 1 |
| Morgan, DB | 1 |
| Davidson, C | 1 |
| Olveira Fuster, G | 1 |
| Mancha Doblas, I | 1 |
| Vázquez San Miguel, F | 1 |
| Esteva de Antonio, I | 1 |
| C-Soriaguer Escofet, F | 1 |
| Zanella, MT | 1 |
| Baptista, M | 1 |
| Costa, CH | 1 |
| Kohlmann, NE | 1 |
| Kohlmann Júnior, O | 2 |
| Ribeiro, AB | 2 |
| Bagatin, J | 1 |
| Sardelić, S | 1 |
| Pivac, N | 1 |
| Polić, S | 1 |
| Ljutic, D | 1 |
| Rakic, D | 1 |
| Naranca, M | 1 |
| Bojić, L | 1 |
| Kovacić, Z | 1 |
| Rumboldt, Z | 1 |
| Franse, LV | 1 |
| Pahor, M | 1 |
| Di Bari, M | 1 |
| Somes, GW | 1 |
| Applegate, WB | 1 |
| Leemhuis, MP | 1 |
| van Damme, KJ | 1 |
| Landmann-Suter, R | 1 |
| Kirkendall, WM | 1 |
| Hammond, JJ | 1 |
| Thomas, JC | 1 |
| Overturf, ML | 1 |
| Zama, A | 1 |
| Patzschke, U | 1 |
| Manegold, C | 1 |
| Carney, S | 1 |
| Gillies, AI | 1 |
| Morgan, T | 1 |
| Jensen, OB | 1 |
| Mosdal, C | 1 |
| Reske-Nielsen, E | 1 |
| Cavatorta, A | 1 |
| Borghetti, A | 1 |
| Marbini, A | 1 |
| Franchini, I | 1 |
| Parma, M | 1 |
| Mazzucchi, A | 1 |
| Hatt, PY | 1 |
| Leblond, JB | 1 |
| Jarchovsky, J | 1 |
| Zamir, D | 1 |
| Plavnik, L | 1 |
| Fitzovich, DE | 1 |
| Hamaguchi, M | 1 |
| Tull, WB | 1 |
| Young, DB | 1 |
| Kuller, LH | 1 |
| Hulley, SB | 1 |
| Cohen, JD | 1 |
| Neaton, J | 1 |
| Odugbesan, O | 1 |
| Chesner, IM | 1 |
| Bailey, G | 1 |
| Barnett, AH | 1 |
| Severin, E | 1 |
| Mladovan, G | 1 |
| Plavnik, FL | 1 |
| Maranhão, MF | 1 |
| Nusbaum, IM | 1 |
| Morledge, JH | 1 |
| Ettinger, B | 1 |
| Aranda, J | 1 |
| McBarron, F | 1 |
| Barra, P | 1 |
| Gorwit, J | 1 |
| Davidov, M | 2 |
| Carney, SL | 1 |
| Morgan, TO | 1 |
| Acquarone, N | 1 |
| Vinciguerra, G | 1 |
| Crisalli, MP | 1 |
| de Graeff, A | 1 |
| Erkelens, DW | 1 |
| Mozes, B | 1 |
| Werner, D | 1 |
| Olchovsky, D | 1 |
| Lieberman, P | 1 |
| Smith, WM | 1 |
| Feigal, DW | 1 |
| Greenlick, M | 1 |
| Kuller, L | 1 |
| Schnaper, HW | 1 |
| Schoenberger, JA | 1 |
| Carpentiere, G | 1 |
| Marino, S | 1 |
| Castello, F | 1 |
| Skerrett, FD | 1 |
| Boer, P | 1 |
| Koomans, HA | 1 |
| Hené, RJ | 1 |
| Geyskes, GG | 1 |
| Van Shaik, BA | 1 |
| Roos, JC | 1 |
| Dorhout Mees, EJ | 1 |
| Stewart, DE | 1 |
| Ikram, H | 1 |
| Espiner, EA | 1 |
| Nicholls, MG | 1 |
| Louis, WJ | 1 |
| Doyle, AE | 1 |
| Dawborn, JK | 1 |
| Johnston, CI | 1 |
| Dustan, HR | 1 |
| Tarazi, RC | 1 |
| Bravo, EL | 1 |
| Fotiu, S | 1 |
| Mroczek, WJ | 1 |
| Finnerty, FA | 1 |
| Imler, M | 1 |
| Bockel, R | 1 |
| Peter, B | 1 |
| Kieny, R | 1 |
| Stahl, J | 1 |
| Ikeda, T | 1 |
| Leiter, L | 1 |
| Fichman, MP | 1 |
| Vorherr, H | 1 |
| Kleeman, CR | 1 |
| Telfer, N | 1 |
| Katz, FH | 1 |
| Eckert, RC | 1 |
| Gebott, MD | 1 |
| Oh, SJ | 1 |
| Douglas, JE | 1 |
| Brown, RA | 1 |
| Schmidt, P | 1 |
| Holzgreve, H | 1 |
| Loeschke, K | 1 |
| Chowdhury, FR | 1 |
| Bleicher, SJ | 1 |
| Holtmeier, HJ | 1 |
| Steim, H | 1 |
| Danner, H | 1 |
| Marongiu, F | 1 |
| Johansson, BW | 1 |
| Sievers, J | 1 |
| Remenchik, AP | 2 |
| Johnston, LC | 1 |
| Talso, PJ | 1 |
| Cutilletta, AF | 1 |
| Hueber, EF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Platelet Effects of Chlorthalidone and Hydrochlorothiazide[NCT02100462] | Phase 4 | 30 participants (Anticipated) | Interventional | 2014-03-31 | Recruiting | ||
| DD-study: Diet or Diuretics for Salt-sensitivity in Chronic Kidney Disease[NCT02875886] | Phase 4 | 28 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial[NCT03923933] | Phase 2 | 34 participants (Actual) | Interventional | 2019-06-18 | Completed | ||
| [NCT00000542] | Phase 3 | 0 participants | Interventional | 1993-08-31 | Completed | ||
| [NCT00005122] | 0 participants | Observational | 1958-07-31 | Completed | |||
| [NCT00000487] | Phase 3 | 0 participants | Interventional | 1972-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | mmHg (Mean) |
|---|---|
| Placebo | -3.4 |
| Treatment Grup | -13.5 |
Decrease in extracellular water measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | litres (Mean) |
|---|---|
| Placebo | -0.15 |
| Treatment Grup | 2.55 |
Decrease in extracellular water / total body water ratio measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | percentage of ECW/TBW (Mean) |
|---|---|
| Placebo | -0.24 |
| Treatment Grup | -2.92 |
decrease in blood pressure compared wit baseline measure (mmhg) (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | mmHg (Mean) |
|---|---|
| Placebo | -5.4 |
| Treatment Grup | -18.1 |
(NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | mmHg (Mean) |
|---|---|
| Placebo | -10 |
| Treatment Grup | -26.1 |
Increase in the fractional excretion of sodium compared with the baseline measure (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | percentage of sodium excreted (Mean) |
|---|---|
| Placebo | -0.348 |
| Treatment Grup | 0.598 |
Measured by bioelectrical impedance analysis, compared to the initial measurement (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | litres (Mean) |
|---|---|
| Placebo | -0.075 |
| Treatment Grup | -4.36 |
5 reviews available for chlorthalidone and Hypokalemia
| Article | Year |
|---|---|
Comparison of thiazide-like diuretics versus thiazide-type diuretics: a meta-analysis.
Topics: Antihypertensive Agents; Blood Glucose; Blood Pressure; Chlorthalidone; Cholesterol; Diuretics; Huma | 2017 |
Head-to-head comparisons of hydrochlorothiazide with indapamide and chlorthalidone: antihypertensive and metabolic effects.
Topics: Blood Pressure; Chlorthalidone; Diuretics; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; I | 2015 |
Managing diuretic-induced hypokalemia in ambulatory hypertensive patients.
Topics: Aged; Ambulatory Care; Chlorthalidone; Diuretics; Food; Humans; Hydrochlorothiazide; Hypertension; H | 1982 |
[Hypertension--diuretics as antihypertensive agents].
Topics: Aged; Antihypertensive Agents; Arthritis; Benzothiadiazines; Blood Pressure; Chlorothiazide; Chlorth | 1970 |
Combinations of diuretics in the treatment of edema.
Topics: Acetazolamide; Benzothiadiazines; Chlorthalidone; Diuretics; Edema; Ethacrynic Acid; Furosemide; Glu | 1970 |
18 trials available for chlorthalidone and Hypokalemia
| Article | Year |
|---|---|
Comparative antiplatelet effects of chlorthalidone and hydrochlorothiazide.
Topics: Antihypertensive Agents; Aspirin; Blood Pressure; Chlorthalidone; Diuretics; Double-Blind Method; Dr | 2022 |
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo | 2014 |
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo | 2014 |
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo | 2014 |
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo | 2014 |
Changes in serum potassium mediate thiazide-induced diabetes.
Topics: Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Chlorthalidone; Diabetes Mellitus, Type 2; | 2008 |
Clinical significance of incident hypokalemia and hyperkalemia in treated hypertensive patients in the antihypertensive and lipid-lowering treatment to prevent heart attack trial.
Topics: Aged; Amlodipine; Antihypertensive Agents; Blood Chemical Analysis; Cardiovascular Diseases; Chlorth | 2012 |
Long-acting and short-acting diuretics in the treatment of hypertension.
Topics: Adult; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Female; Furosemide; Humans; Hyperte | 1983 |
The antihypertensive and biochemical effects of hydrochlorothiazide/amiloride (Moduretic) versus chlorthalidone.
Topics: Adult; Aged; Amiloride; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Drug Combinations; | 1980 |
[Advantages of a fixed association of oxprenolol-chlorthalidone, as opposed to chlorthalidone alone, in the treatment of chronic essential arterial hypertension].
Topics: Adult; Aged; Chlorthalidone; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Drug Co | 1981 |
[Comparative effects of captopril and chlorthalidone on glucose tolerance and insulin levels essential hypertensives].
Topics: Adolescent; Adult; Aged; Analysis of Variance; Blood Glucose; Captopril; Chlorthalidone; Female; Glu | 1996 |
Comparison of chlorthalidone, propranolol and bopindolol in six-month treatment of arterial hypertension.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Chlorthalidone; Double-Blind Method; Female; Humans; Hyp | 1998 |
Hypokalemia associated with diuretic use and cardiovascular events in the Systolic Hypertension in the Elderly Program.
Topics: Aged; Aged, 80 and over; Blood Pressure; Chlorthalidone; Diuretics; Female; Humans; Hypertension; Hy | 2000 |
Prazosin and clonidine for moderately severe hypertension.
Topics: Adult; Aged; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Clonidine; Drug Therapy, Comb | 1978 |
Optimal dose of a thiazide diuretic.
Topics: Chlorthalidone; Clinical Trials as Topic; Humans; Hypertension; Hypokalemia | 1976 |
A comparative study of the activity of a new agent, indapamide, in essential arterial hypertension.
Topics: Aged; Chlorthalidone; Clinical Trials as Topic; Diuretics; Drug Evaluation; Drug Tolerance; Female; | 1975 |
[Chlorthalidone at low doses in the treatment of mild and moderate hypertension: analysis of efficacy, hypokalemia frequency and cardiac rhythm disorders].
Topics: Adult; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Female; Heart Rate; Humans; Hyperte | 1988 |
Isolated systolic hypertension in the elderly. A placebo-controlled, dose-response evaluation of chlorthalidone.
Topics: Age Factors; Aged; Blood Glucose; Body Weight; Chlorthalidone; Cholesterol; Clinical Trials as Topic | 1986 |
Use of diuretics in treatment of hypertension in the elderly.
Topics: Aged; Chlorthalidone; Creatinine; Double-Blind Method; Female; Humans; Hypertension; Hypokalemia; Ma | 1986 |
Influence of the administration time on the antihypertensive and hypokalaemic effects of chlorthalidone in patients with primary hypertension.
Topics: Adult; Antihypertensive Agents; Chlorthalidone; Clinical Trials as Topic; Double-Blind Method; Femal | 1985 |
Antihypertensive efficacy of metolazone.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Chlorthalidone; Diuretics; Edema; | 1974 |
60 other studies available for chlorthalidone and Hypokalemia
| Article | Year |
|---|---|
Comparison of Clinical Outcomes and Safety Associated With Chlorthalidone vs Hydrochlorothiazide in Older Adults With Varying Levels of Kidney Function.
Topics: Aged; Chlorthalidone; Drug-Related Side Effects and Adverse Reactions; Female; Glomerular Filtration | 2021 |
Electrolyte Disorders Common in Thiazide Diuretic Users.
Topics: Chlorthalidone; Cross-Sectional Studies; Humans; Hypokalemia; Hyponatremia; Sodium Chloride Symporte | 2022 |
Pairwise comparison of hydrochlorothiazide and chlorthalidone responses among hypertensive patients.
Topics: Antihypertensive Agents; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Humans; Hydrochl | 2022 |
Risk of Electrolyte Disorders, Syncope, and Falls in Patients Taking Thiazide Diuretics: Results of a Cross-Sectional Study.
Topics: Accidental Falls; Aged; Antihypertensive Agents; Chlorthalidone; Cross-Sectional Studies; Female; Hu | 2021 |
Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study.
Topics: Aged; Antihypertensive Agents; Chlorthalidone; Follow-Up Studies; Hospitalization; Humans; Hydrochlo | 2013 |
Chlorthalidone vs. Hydrochlorothiazide for Treatment of Hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Chlorthalidone; Evidence-Base | 2015 |
Benazepril plus amlodipine or hydrochlorothiazide for hypertension.
Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzazepines; Calcium | 2009 |
[Long term hypopotassaemia associated with chlorthalidone].
Topics: Aged; Chlorthalidone; Diuretics; Female; Humans; Hypokalemia; Time Factors | 2009 |
[RENAL CARBONIC ANHYDRASE: ITS PHYSIOLOGICAL ACTION; ITS INHIBITORS].
Topics: Acetazolamide; Acidosis; Ammonia; Carbonic Anhydrases; Chlorothiazide; Chlorthalidone; Dichlorphenam | 1963 |
[THE TREATMENT OF EDEMA WITH SULFONAMIDE DIURETICS].
Topics: Acetazolamide; Acidosis; Benzothiadiazines; Chlorothiazide; Chlorthalidone; Dehydration; Diuretics; | 1964 |
THE EFFECT OF SALURETICS ON PULSE RATE, BLOOD PRESSURE AND ELECTROCARDIOGRAM DURING EXERCISE IN NORMAL SUBJECTS.
Topics: Aspirin; Biomedical Research; Blood; Blood Pressure; Blood Pressure Determination; Chlorides; Chlort | 1964 |
[IATROGENIC KALIPENIA].
Topics: Chlorthalidone; Diuretics; Electrocardiography; Humans; Hypokalemia; Iatrogenic Disease; Potassium; | 1964 |
A NEW EFFECTIVE DIURETIC--LASIX.
Topics: Chlorthalidone; Diuretics; Drug Therapy; Furosemide; Heart Failure; Hydrochlorothiazide; Hypokalemia | 1964 |
THE RELATION BETWEEN HYPOPOTASSAEMIA AND ALKALOSIS DURING ADMINISTRATION OF POLYTHIAZIDE AND CHLORTHALIDONE.
Topics: Alkalosis; Biomedical Research; Chlorides; Chlorthalidone; Drug Therapy; Hypertension; Hypokalemia; | 1964 |
[EXTREMELY SEVERE HYPOELECTROLYTEMIA DUE TO SALIDIURETIC ADDICTION].
Topics: Alkalosis; Chlorthalidone; Diet, Sodium-Restricted; Electrocardiography; Hypokalemia; Kidney Disease | 1964 |
CORRECTION OF DIURETIC-INDUCED HYPOKALEMIA AND HYPERURICEMIA.
Topics: Bicarbonates; Blood Chemical Analysis; Chlorthalidone; Diuretics; Drug Therapy; Geriatrics; Hydrochl | 1965 |
Diuretic-induced hypokalemia in uncomplicated systemic hypertension: effect of plasma potassium correction on cardiac arrhythmias.
Topics: Adult; Aged; Ambulatory Care; Antihypertensive Agents; Arrhythmias, Cardiac; Cardiac Complexes, Prem | 1983 |
Diuretic regimens in essential hypertension. A comparison of hypokalemic effects, BP control, and cost.
Topics: Blood Pressure; Chlorthalidone; Cost-Benefit Analysis; Diuretics; Female; Furosemide; Humans; Hydroc | 1983 |
Acute hypokalaemic myopathy with lipid storage during chlortalidone therapy.
Topics: Acute Disease; Chlorthalidone; Humans; Hypokalemia; Lipidoses; Male; Middle Aged; Muscular Diseases | 1984 |
Potassium and diuretic-induced ventricular arrhythmias in ambulatory hypertensive patients.
Topics: Adult; Aged; Ambulatory Care; Arrhythmias, Cardiac; Benzothiadiazines; Chlorthalidone; Diuretics; El | 1984 |
Some wrong-way chemical changes during antihypertensive treatment: comparison of indapamide and related agents.
Topics: Adult; Antihypertensive Agents; Chemical Phenomena; Chemistry; Chlorthalidone; Diuretics; Humans; Hy | 1983 |
Diuretic induced hypokalemia in the elderly.
Topics: Aged; Chlorthalidone; Diet; Diuretics; Female; Furosemide; Humans; Hydrochlorothiazide; Hypokalemia; | 1982 |
[Hiccup as a presenting symptom of hypokalemia].
Topics: Aged; Chlorthalidone; Hiccup; Humans; Hypokalemia; Male | 1982 |
The mechanism underlying chlorthalidone-induced hypokalaemia: effects of sodium restriction, potassium suppletion, spironolactone, and triamterene.
Topics: Adult; Chlorthalidone; Diet, Sodium-Restricted; Humans; Hypokalemia; Male; Potassium; Spironolactone | 1982 |
Lack of arrythmia during severe chlorthalidone induced hypokalaemia.
Topics: Chlorthalidone; Female; Humans; Hypokalemia; Middle Aged | 1982 |
Probable fatal cardiac dysrhythmia secondary to diuretic-induced hypokalemia.
Topics: Adult; Arrhythmias, Cardiac; Chlorthalidone; Death, Sudden; Female; Humans; Hypokalemia | 1981 |
Potassium loss associated with hydrochlorothiazide versus chlorthalidone.
Topics: Adult; Aged; Chlorothiazide; Chlorthalidone; Dose-Response Relationship, Drug; Female; Humans; Hyper | 1981 |
Hypokalaemia and diuretics: an analysis of publications.
Topics: Chlorothiazide; Chlorthalidone; Coronary Disease; Diuretics; Dose-Response Relationship, Drug; Furos | 1980 |
[Surreptitious intake of diuretics as the cause of pseudo-Bartter's syndrome: apropos of a case and differential diagnosis].
Topics: Adult; Bartter Syndrome; Chlorthalidone; Chromatography, High Pressure Liquid; Diagnosis, Differenti | 1996 |
Effects of chlorthalidone on serum and total body potassium in hypertensive patients.
Topics: Adult; Antihypertensive Agents; Body Weight; Chlorthalidone; Drug Therapy, Combination; Electrolytes | 1976 |
Initial potassium loss and hypokalaemia during chlorthalidone administration in patients with essential hypertension: the influence of dietary sodium restriction.
Topics: Adult; Bicarbonates; Chlorides; Chlorthalidone; Diet, Sodium-Restricted; Female; Humans; Hydrogen-Io | 1978 |
[Electrocardiographic signs of hypokalemia under antihypertensive treatment (author's transl)].
Topics: Antihypertensive Agents; Chlorthalidone; Electrocardiography; Female; Humans; Hypokalemia; Middle Ag | 1979 |
Hypokalemic myopathy during treatment with diuretics.
Topics: Chlorthalidone; Clopamide; Humans; Hypokalemia; Male; Middle Aged; Muscles; Muscular Diseases; Myofi | 1977 |
[Clinical and muscle istochemical observations in secondary hypokalaemia (author's transl)].
Topics: Aged; Chlorthalidone; Histocytochemistry; Humans; Hypokalemia; Lipid Metabolism; Muscles; Paralyses, | 1977 |
[Torsade de pointes and use of phenothiazine and diuretic].
Topics: Antipsychotic Agents; Chlorthalidone; Female; Humans; Hypokalemia; Middle Aged; Phenothiazines; Tors | 1991 |
Chronic hypokalemia and the left ventricular responses to epinephrine and preload.
Topics: Animals; Chlorthalidone; Dogs; Epinephrine; Hypokalemia; Isotonic Solutions; Myocardial Contraction; | 1991 |
Unexpected effects of treating hypertension in men with electrocardiographic abnormalities: a critical analysis.
Topics: Adult; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiomegaly; Catecholamines; Chlorthalid | 1986 |
Hazards of combined beta-blocker/diuretic tablets.
Topics: Antihypertensive Agents; Atenolol; Chlorthalidone; Drug Combinations; Female; Humans; Hypokalemia; M | 1985 |
[A beta blockader-diuretic combination in long-term anti-hypertensive therapy. Undesirable effects on blood potassium].
Topics: Adrenergic beta-Antagonists; Adult; Chlorthalidone; Drug Therapy, Combination; Female; Follow-Up Stu | 1985 |
Diuretic-induced hypokalemia and altered renal function.
Topics: Aged; Chlorthalidone; Glomerular Filtration Rate; Humans; Hypertension; Hypokalemia; Kidney; Kidney | 1986 |
[Hypokalemic rhabdomyolysis associated with diuretic and beta blockader therapy].
Topics: Chlorthalidone; Drug Therapy, Combination; Female; Humans; Hypertension; Hypokalemia; Metoprolol; Mi | 1987 |
Frusemide and chlorthalidone once daily in normal subjects: differences in diuresis, natriuresis, kaliuresis, and the incidence of hypokalaemia.
Topics: Adult; Chlorthalidone; Diuresis; Furosemide; Humans; Hypokalemia; Male; Natriuresis; Potassium | 1987 |
Thiazide-induced hyponatremia: an unusual neurologic course.
Topics: Acute Disease; Brain Edema; Chlorthalidone; Coma; Demyelinating Diseases; Female; Humans; Hypokalemi | 1986 |
Chlorthalidone treatment in patients with hypertension associated with hypokalaemia.
Topics: Chlorthalidone; Humans; Hypertension; Hypokalemia | 1985 |
Blood to interstitial fluid volume ratio in chronic hypokalaemic states.
Topics: Bartter Syndrome; Blood Volume; Chlorthalidone; Chronic Disease; Extracellular Space; Female; Humans | 1985 |
Arrhythmogenic potential of diuretic induced hypokalaemia in patients with mild hypertension and ischaemic heart disease.
Topics: Amiloride; Arrhythmias, Cardiac; Chlorthalidone; Coronary Disease; Cyclopenthiazide; Diuretics; Fema | 1985 |
A comparison of chlorothiazide, chlorthalidone and cyclopenthiazide in the treatment of hypertension.
Topics: Benzothiadiazines; Chlorothiazide; Chlorthalidone; Diuretics; Humans; Hypertension; Hypokalemia | 1973 |
Diuretic and diet treatment of hypertension.
Topics: Benzothiadiazines; Blood Volume; Chlorthalidone; Creatinine; Diet, Sodium-Restricted; Diuretics; Eth | 1974 |
[Importance of hyperammoniemia of the renal origin in the pathogenesis of hepatic coma released in cirrhotic patients by diuretics generating hypokaliemia].
Topics: Acetazolamide; Acid-Base Equilibrium; Alkalosis; Ammonia; Ascites; Chlorides; Chlorthalidone; Edema; | 1969 |
Diuretic-induced hyponatremia.
Topics: Adult; Aged; Alkalosis; Bendroflumethiazide; Biological Assay; Blood Urea Nitrogen; Bromine; Carbon | 1971 |
Hypokalemia caused by surreptitious self-administration of diuretics.
Topics: Adjustment Disorders; Adult; Bicarbonates; Body Weight; Chlorides; Chlorthalidone; Chromatography, T | 1972 |
Hypokalemic vacuolar myopathy associated with chlorthalidone treatment.
Topics: Acute Disease; Biopsy; Cathartics; Chlorthalidone; Female; Humans; Hypokalemia; Middle Aged; Muscles | 1971 |
[Diuresis and diuretics].
Topics: Acetazolamide; Acute Disease; Agranulocytosis; Anuria; Biological Transport; Blood Platelet Disorder | 1971 |
Renal effects and side effects of diuretics.
Topics: Absorption; Acetazolamide; Acidosis; Animals; Antihypertensive Agents; Bicarbonates; Chlorides; Chlo | 1970 |
Chlorthalidone--induced hypokalemia and abnormal carbohydrate metabolism.
Topics: Administration, Oral; Adult; Blood Glucose; Carbohydrate Metabolism; Chlorthalidone; Depression, Che | 1970 |
[On the effects and side effects of a diuretic].
Topics: Chlorthalidone; Diet, Sodium-Restricted; Edema; Humans; Hypertension; Hypokalemia | 1967 |
The effect on serum concentration of sodium, potassium and chloride during long term treatment with some diuretics.
Topics: Alkalosis; Blood; Chlorides; Chlorthalidone; Electrolytes; Humans; Hypokalemia; Potassium; Sodium; T | 1966 |
Potassium depletion produced by administration of chlorthalidone to nonedematous patients with arterial hypertensin.
Topics: Adult; Alkalosis; Blood Urea Nitrogen; Carbon Dioxide; Chlorine; Chlorthalidone; Creatine; Female; H | 1966 |
Effects of diuretic agents on serum and tissue electrolytes in rats.
Topics: Animals; Blood; Chlorthalidone; Diuretics; Hydrochlorothiazide; Hypokalemia; Polythiazide; Potassium | 1966 |
[On combined therapy of hypertension and heart insufficiency. Advantages and disadvantages].
Topics: Arrhythmias, Cardiac; Chlorthalidone; Digitoxin; Drug Synergism; Heart Function Tests; Humans; Hyper | 1966 |