chlorthalidone has been researched along with Hypertension, Renal in 15 studies
Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
Hypertension, Renal: Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A prospective study of propranolol versus chlorthalidone has been performed in eleven patients with renal hypertension and one with essential hypertension." | 9.05 | Propranolol versus chlorthalidone--a prospective therapeutic trial in children with chronic hypertension. ( Bachmann, H, 1984) |
| " Group A: In 14 patients with essential hypertension on chlorthalidone treatment, an additional daily dose of 640 mg propranolol for two months led to a significant reduction of the MAP (from 124 to 105 mm Hg) and PRA (from 5." | 9.04 | Effect of salt depletion and propranolol on blood pressure and plasma renin activity in various forms of hypertension. ( Boer, P; Geyskes, GG; Leenen, FH; Mees, EJ; Vos, J, 1975) |
| "A prospective study of propranolol versus chlorthalidone has been performed in eleven patients with renal hypertension and one with essential hypertension." | 5.05 | Propranolol versus chlorthalidone--a prospective therapeutic trial in children with chronic hypertension. ( Bachmann, H, 1984) |
| " Group A: In 14 patients with essential hypertension on chlorthalidone treatment, an additional daily dose of 640 mg propranolol for two months led to a significant reduction of the MAP (from 124 to 105 mm Hg) and PRA (from 5." | 5.04 | Effect of salt depletion and propranolol on blood pressure and plasma renin activity in various forms of hypertension. ( Boer, P; Geyskes, GG; Leenen, FH; Mees, EJ; Vos, J, 1975) |
| "Indapamide has a prolonged saluretic action which in combination with the direct vascular effects may well account for its antihypertensive activity." | 1.25 | Antihypertensive action of indapamide. Comparative studies in several experimental models. ( Kyncl, J; Oheim, K; Seki, T; Solles, A, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (93.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Agarwal, R | 1 |
| Sinha, AD | 1 |
| Pappas, MK | 1 |
| Ammous, F | 1 |
| TEUSCHER, A | 1 |
| LUGINBUEHL, H | 1 |
| OBROWSKY, L | 1 |
| JENNINGS, RC | 1 |
| SHAIKH, VA | 1 |
| ALLEN, WM | 1 |
| Chiaverini, P | 1 |
| Dalli, G | 1 |
| Bachmann, H | 1 |
| Schiffl, H | 1 |
| Weidmann, P | 1 |
| Meier, A | 1 |
| Ziegler, WH | 1 |
| Sullivan, JM | 1 |
| Gless, KH | 1 |
| Bönner, G | 1 |
| Gram, N | 1 |
| Mann, JF | 1 |
| Helber, A | 1 |
| Ganten, D | 1 |
| Geyskes, GG | 2 |
| Boer, P | 2 |
| Vos, J | 2 |
| Leenen, FH | 1 |
| Mees, EJ | 1 |
| Dorhout Mees, EJ | 1 |
| Kyncl, J | 1 |
| Oheim, K | 1 |
| Seki, T | 1 |
| Solles, A | 1 |
| Modai, D | 1 |
| Cohen, N | 1 |
| Weissgarten, J | 1 |
| Segal, B | 1 |
| Pik, A | 1 |
| D'Amelio, G | 1 |
| Dalla Volta, S | 1 |
| De Longhi, B | 1 |
| Razzolini, R | 1 |
| Enger, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| DD-study: Diet or Diuretics for Salt-sensitivity in Chronic Kidney Disease[NCT02875886] | Phase 4 | 28 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial[NCT03923933] | Phase 2 | 34 participants (Actual) | Interventional | 2019-06-18 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | mmHg (Mean) |
|---|---|
| Placebo | -3.4 |
| Treatment Grup | -13.5 |
Decrease in extracellular water measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | litres (Mean) |
|---|---|
| Placebo | -0.15 |
| Treatment Grup | 2.55 |
Decrease in extracellular water / total body water ratio measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | percentage of ECW/TBW (Mean) |
|---|---|
| Placebo | -0.24 |
| Treatment Grup | -2.92 |
decrease in blood pressure compared wit baseline measure (mmhg) (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | mmHg (Mean) |
|---|---|
| Placebo | -5.4 |
| Treatment Grup | -18.1 |
(NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | mmHg (Mean) |
|---|---|
| Placebo | -10 |
| Treatment Grup | -26.1 |
Increase in the fractional excretion of sodium compared with the baseline measure (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | percentage of sodium excreted (Mean) |
|---|---|
| Placebo | -0.348 |
| Treatment Grup | 0.598 |
Measured by bioelectrical impedance analysis, compared to the initial measurement (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | litres (Mean) |
|---|---|
| Placebo | -0.075 |
| Treatment Grup | -4.36 |
1 review available for chlorthalidone and Hypertension, Renal
| Article | Year |
|---|---|
Physiologic and biochemical profile of hypertension for rational clinical management.
Topics: Adrenal Gland Diseases; Angiotensins; Body Fluid Compartments; Chlorthalidone; Diuretics; Guanethidi | 1978 |
4 trials available for chlorthalidone and Hypertension, Renal
| Article | Year |
|---|---|
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo | 2014 |
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo | 2014 |
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo | 2014 |
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo | 2014 |
Propranolol versus chlorthalidone--a prospective therapeutic trial in children with chronic hypertension.
Topics: Adolescent; Blood Pressure; Child; Child, Preschool; Chlorthalidone; Chronic Disease; Clinical Trial | 1984 |
Effect of salt depletion and propranolol on blood pressure and plasma renin activity in various forms of hypertension.
Topics: Adult; Aged; Blood Pressure; Body Weight; Bromine; Chlorthalidone; Clinical Trials as Topic; Diet, S | 1975 |
[Antihypertensive effects of clonidine and of the clonidine-chlorthalidone combination].
Topics: Adult; Aged; Arteriosclerosis; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Clonidine; | 1974 |
10 other studies available for chlorthalidone and Hypertension, Renal
| Article | Year |
|---|---|
[ANTIHYPERTENSIVE PROPERTIES OF A MONOAMINE OXIDASE INHIBITOR (DL-SERINE-N2-ISOPROPYLHYDRAZIDE: RO 4-1038). CLINICAL RESULTS AND EFFECT ON RENAL FUNCTION].
Topics: Antihypertensive Agents; Blood Pressure Determination; Chemical and Drug Induced Liver Injury; Chlor | 1964 |
[CLINICAL EXPERIENCES WITH THE ANTIHYPERTENSIVE AGENT HYGROTON-RESERPINE].
Topics: Antihypertensive Agents; Arteriosclerosis; Biomedical Research; Chlorthalidone; Drug Therapy; Hypert | 1964 |
RENAL ISCHAEMIA DUE TO THROMBOSIS OF RENAL ARTERY RESULTING FROM METASTASES FROM PRIMARY CARCINOMA OF THE BRONCHUS.
Topics: Adrenal Gland Neoplasms; Angiography; Bronchi; Bronchial Neoplasms; Chlorthalidone; Diagnosis, Diffe | 1964 |
[Clinical observations on the hypotensive action of the association of chlorthalidone and reserpine].
Topics: Adult; Aged; Chlorthalidone; Female; Humans; Hypertension; Hypertension, Renal; Male; Middle Aged; R | 1967 |
Relationship between plasma catecholamines and urinary catecholamine excretion rates in normal subjects and certain diseased states.
Topics: Adult; Blood Pressure; Chlorthalidone; Creatinine; Diabetes Mellitus; Electrolytes; Epinephrine; Fem | 1981 |
Pharmacokinetic and pharmacodynamic studies of infusions with [Sar 1, Val5, Ala8] angiotensin II (saralasin).
Topics: Angiotensin I; Angiotensin II; Animals; Blood Pressure; Chlorthalidone; Diet, Sodium-Restricted; Fem | 1978 |
Observations of the role of body fluid volumes and plasma renin activity in the management of hypertension.
Topics: Adult; Blood Volume; Body Fluids; Chlorthalidone; Female; Heart Rate; Humans; Hypertension, Renal; M | 1975 |
Antihypertensive action of indapamide. Comparative studies in several experimental models.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Chlorthalidone; Diuretics; Dogs; | 1975 |
Symptomatic renal artery stenosis superimposed on chronic glomerulonephritis.
Topics: Antihypertensive Agents; Cardiomegaly; Chlorthalidone; Chronic Disease; Creatinine; Furosemide; Glom | 1985 |
[Self-control of the blood pressure in hypertension therapy].
Topics: Adolescent; Adult; Blood Pressure Determination; Chlorthalidone; Female; Humans; Hypertension; Hyper | 1972 |