chlorthalidone has been researched along with Hyperglycemia in 19 studies
Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
Hyperglycemia: Abnormally high BLOOD GLUCOSE level.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The authors studied the effects of these two classes of hypertension medications (doxazosin, an a blocker, and chlorthalidone, a diuretic) on cardiovascular disease outcomes in adults aged >55 years with hypertension and glucose disorders who were participants in the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (8749 had known diabetes mellitus and 1690 had a newly diagnosed glucose disorder [fasting glucose >/=110 mg/dL])." | 9.11 | Cardiovascular outcomes using doxazosin vs. chlorthalidone for the treatment of hypertension in older adults with and without glucose disorders: a report from the ALLHAT study. ( Barzilay, JI; Basile, JN; Bettencourt, J; Black, H; Ciocon, JO; Davis, BR; Ellsworth, A; Force, RW; Goff, DC; Habib, G; Margolis, KL; Wiegmann, T, 2004) |
| " The authors studied the effects of these two classes of hypertension medications (doxazosin, an a blocker, and chlorthalidone, a diuretic) on cardiovascular disease outcomes in adults aged >55 years with hypertension and glucose disorders who were participants in the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (8749 had known diabetes mellitus and 1690 had a newly diagnosed glucose disorder [fasting glucose >/=110 mg/dL])." | 5.11 | Cardiovascular outcomes using doxazosin vs. chlorthalidone for the treatment of hypertension in older adults with and without glucose disorders: a report from the ALLHAT study. ( Barzilay, JI; Basile, JN; Bettencourt, J; Black, H; Ciocon, JO; Davis, BR; Ellsworth, A; Force, RW; Goff, DC; Habib, G; Margolis, KL; Wiegmann, T, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (84.21) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, S | 1 |
| McDonough, CW | 1 |
| Gong, Y | 1 |
| Alghamdi, WA | 1 |
| Arwood, MJ | 1 |
| Bargal, SA | 1 |
| Dumeny, L | 1 |
| Li, WY | 1 |
| Mehanna, M | 1 |
| Stockard, B | 1 |
| Yang, G | 1 |
| de Oliveira, FA | 1 |
| Fredette, NC | 1 |
| Shahin, MH | 1 |
| Bailey, KR | 1 |
| Beitelshees, AL | 1 |
| Boerwinkle, E | 1 |
| Chapman, AB | 1 |
| Gums, JG | 1 |
| Turner, ST | 1 |
| Cooper-DeHoff, RM | 1 |
| Johnson, JA | 1 |
| NICOLE, JC | 1 |
| PULVER, W | 1 |
| GROSSI, F | 1 |
| CARLINER, NH | 1 |
| SCHELLING, JL | 1 |
| RUSSELL, RP | 1 |
| OKUN, R | 1 |
| DAVIS, M | 1 |
| Barzilay, JI | 1 |
| Davis, BR | 1 |
| Bettencourt, J | 1 |
| Margolis, KL | 1 |
| Goff, DC | 1 |
| Black, H | 1 |
| Habib, G | 1 |
| Ellsworth, A | 1 |
| Force, RW | 1 |
| Wiegmann, T | 1 |
| Ciocon, JO | 1 |
| Basile, JN | 1 |
| Silver, A | 1 |
| Foy, JM | 1 |
| Perry, HM | 1 |
| Meng, K | 1 |
| Kroneberg, G | 1 |
| Furman, BL | 1 |
| Curtis, J | 1 |
| Horrigan, F | 1 |
| Ahearn, D | 1 |
| Varney, R | 1 |
| Sandler, SG | 1 |
| Leiter, L | 1 |
| Grant, AM | 1 |
| Krees, S | 1 |
| Viktora, JK | 1 |
| Wales, JK | 2 |
| Wolff, FW | 2 |
| Coppi, G | 1 |
| Bonardi, G | 1 |
| Wahlberg, P | 1 |
| Ott, H | 1 |
| Zahnd, G | 1 |
| Königstein, RP | 1 |
| Bradley, P | 1 |
| Viktora, J | 1 |
| Tabachnick, II | 1 |
| Gulbenkian, A | 1 |
| Yannell, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacogenomic Evaluation of Antihypertensive Responses 2[NCT01203852] | Phase 4 | 839 participants (Actual) | Interventional | 2010-08-31 | Completed | ||
| Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR)[NCT00246519] | Phase 4 | 1,701 participants (Actual) | Interventional | 2005-10-31 | Completed | ||
| [NCT00000542] | Phase 3 | 0 participants | Interventional | 1993-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in glucose after treatment with study medication (NCT01203852)
Timeframe: after 6-8 weeks treatment
| Intervention | mg/dL (Mean) | |
|---|---|---|
| glucose response to metoprolol (n=365) | glucose response to chlorthalidone (n=318) | |
| Adverse Metabolic Effects | 1.02 | 5.12 |
Response to blood pressure medication will be assessed by measuring blood pressure before and after treatment (NCT01203852)
Timeframe: after 6-8 weeks of treatment
| Intervention | mmHg (Mean) | |
|---|---|---|
| diastolic blood pressure response | systolic blood pressure response | |
| Chlorthalidone Only | -7.68 | -13.65 |
| Metoprolol + Chlorthalidone | -7.56 | -11.70 |
| Metorprolol Only | -7.97 | -7.45 |
(NCT00246519)
Timeframe: baseline to 18 weeks of treatment
| Intervention | mmHg (Mean) |
|---|---|
| Atenolol +HCTZ Arm | -12.06 |
| HCTZ + Atenolol | -13.33 |
3 reviews available for chlorthalidone and Hyperglycemia
| Article | Year |
|---|---|
Genome Wide Association Study Identifies the
Topics: Adult; Antihypertensive Agents; Biomarkers; Black or African American; Blood Glucose; Blood Pressure | 2018 |
Genome Wide Association Study Identifies the
Topics: Adult; Antihypertensive Agents; Biomarkers; Black or African American; Blood Glucose; Blood Pressure | 2018 |
Genome Wide Association Study Identifies the
Topics: Adult; Antihypertensive Agents; Biomarkers; Black or African American; Blood Glucose; Blood Pressure | 2018 |
Genome Wide Association Study Identifies the
Topics: Adult; Antihypertensive Agents; Biomarkers; Black or African American; Blood Glucose; Blood Pressure | 2018 |
[2 IMPORTANT SIDE-EFFECTS OF SALURETIC DRUGS: HYPERURICEMIC AND HYPERGLYCEMIC SYNDROMES].
Topics: Acetazolamide; Blood Chemical Analysis; Chlorothiazide; Chlorthalidone; Diuretics; Humans; Hydrochlo | 1963 |
Combinations of diuretics in the treatment of edema.
Topics: Acetazolamide; Benzothiadiazines; Chlorthalidone; Diuretics; Edema; Ethacrynic Acid; Furosemide; Glu | 1970 |
1 trial available for chlorthalidone and Hyperglycemia
| Article | Year |
|---|---|
Cardiovascular outcomes using doxazosin vs. chlorthalidone for the treatment of hypertension in older adults with and without glucose disorders: a report from the ALLHAT study.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Cardiovascular Diseases; Chlorthalidone; Cohort Studi | 2004 |
15 other studies available for chlorthalidone and Hyperglycemia
| Article | Year |
|---|---|
[Hyperglycemic effect by means of salidiuretics in diabetes mellitus].
Topics: Chlorthalidone; Diabetes Mellitus; Humans; Hydrochlorothiazide; Hyperglycemia | 1962 |
THIAZIDE- AND PHTHALIMIDINE-INDUCED HYPERGLYCEMIA IN HYPERTENSIVE PATIENTS.
Topics: Amylases; Blood Chemical Analysis; Chlorthalidone; Creatine; Creatinine; Diabetes Mellitus; Drug The | 1965 |
What if chlorthalidone-associated hyperglycemia develops?
Topics: Antihypertensive Agents; Chlorthalidone; Diabetes Mellitus; Diuretics; Humans; Hyperglycemia | 2007 |
Acute diuretic induced hyperglycaemia in rats.
Topics: Acetazolamide; Adrenalectomy; Animals; Bendroflumethiazide; Chlorthalidone; Ergotamine; Ethacrynic A | 1967 |
Some wrong-way chemical changes during antihypertensive treatment: comparison of indapamide and related agents.
Topics: Adult; Antihypertensive Agents; Chemical Phenomena; Chemistry; Chlorthalidone; Diuretics; Humans; Hy | 1983 |
[Studies in the rat on the problem of the diabetogenic effect of saluretics].
Topics: Acetazolamide; Animals; Benzothiadiazines; Blood Glucose; Chlorthalidone; Diazoxide; Glucose Toleran | 1965 |
The hyperglycaemic effect of the diuretic chlorthalidone.
Topics: Animals; Blood Glucose; Chlorthalidone; Hyperglycemia; Injections, Intraperitoneal; Rats | 1971 |
Chlorthalidone-induced hyperosmolar hyperglycemic nonketotic coma.
Topics: Adult; Chlorthalidone; Dehydration; Diabetes Mellitus; Diabetic Coma; Diabetic Ketoacidosis; Humans; | 1972 |
Structure activity of diuretics as hyperglycaemic agents.
Topics: Animals; Chlorthalidone; Diuretics; Drug Antagonism; Haplorhini; Hyperglycemia | 1968 |
[Action of tolbutamide, chlorpropamide and insulin on hyperglycemia induced by non-thiazide diuretics in rats].
Topics: Animals; Chlorpropamide; Chlorthalidone; Diuretics; Ethacrynic Acid; Female; Furosemide; Hyperglycem | 1969 |
[Drugs and laboratory tests].
Topics: Alkalosis; Chlorthalidone; Drug Synergism; Drug-Related Side Effects and Adverse Reactions; Humans; | 1969 |
[Gout and diabetes induced by a salidiuretic treatment].
Topics: Aged; Chlorthalidone; Diabetes Mellitus; Diuretics; Female; Gout; Humans; Hyperglycemia; Uremia | 1967 |
[Hypertension, saluretics, and glucose tolerance].
Topics: Chlorthalidone; Diabetes Complications; Furosemide; Glucose Tolerance Test; Humans; Hyperglycemia; H | 1968 |
The hyperglycemic and antidiuretic activity of a phthalimidine analogue: 1-oxo-3-(4'-chlorophenyl)-3-hydroxyisoindoline (C3-176).
Topics: Animals; Blood Glucose; Blood Pressure; Catecholamines; Chlorthalidone; Diazoxide; Diuresis; Dogs; F | 1968 |
The hyperglycemic activity of benzothiadiazine and other diuretics.
Topics: Animals; Bendroflumethiazide; Benzothiadiazines; Chlorothiazide; Chlorthalidone; Diazoxide; Diuretic | 1965 |