chlorthalidone has been researched along with Diabetes Mellitus in 33 studies
Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The authors studied the effects of these two classes of hypertension medications (doxazosin, an a blocker, and chlorthalidone, a diuretic) on cardiovascular disease outcomes in adults aged >55 years with hypertension and glucose disorders who were participants in the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (8749 had known diabetes mellitus and 1690 had a newly diagnosed glucose disorder [fasting glucose >/=110 mg/dL])." | 9.11 | Cardiovascular outcomes using doxazosin vs. chlorthalidone for the treatment of hypertension in older adults with and without glucose disorders: a report from the ALLHAT study. ( Barzilay, JI; Basile, JN; Bettencourt, J; Black, H; Ciocon, JO; Davis, BR; Ellsworth, A; Force, RW; Goff, DC; Habib, G; Margolis, KL; Wiegmann, T, 2004) |
| " The authors studied the effects of these two classes of hypertension medications (doxazosin, an a blocker, and chlorthalidone, a diuretic) on cardiovascular disease outcomes in adults aged >55 years with hypertension and glucose disorders who were participants in the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (8749 had known diabetes mellitus and 1690 had a newly diagnosed glucose disorder [fasting glucose >/=110 mg/dL])." | 5.11 | Cardiovascular outcomes using doxazosin vs. chlorthalidone for the treatment of hypertension in older adults with and without glucose disorders: a report from the ALLHAT study. ( Barzilay, JI; Basile, JN; Bettencourt, J; Black, H; Ciocon, JO; Davis, BR; Ellsworth, A; Force, RW; Goff, DC; Habib, G; Margolis, KL; Wiegmann, T, 2004) |
| "chlorthalidone treatment with fasting glucose (P < 0." | 2.75 | Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study. ( Arnett, DK; Barzilay, JI; Boerwinkle, E; Davis, BR; Eckfeldt, JH; Ford, CE; Irvin, MR; Kabagambe, EK; Lynch, AI; Tiwari, HK, 2010) |
| "Chlorthalidone was superior to (1) doxazosin mesylate in preventing combined CVD (CCVD) (risk ratio [RR], 1." | 2.74 | ALLHAT findings revisited in the context of subsequent analyses, other trials, and meta-analyses. ( Alderman, MH; Black, HR; Cushman, WC; Cutler, JA; Davis, BR; Einhorn, PT; Ford, CE; Haywood, LJ; Margolis, KL; Oparil, S; Pressel, SL; Probstfield, JL; Rahman, M; Whelton, PK; Wright, JT, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (63.64) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (24.24) | 29.6817 |
| 2010's | 3 (9.09) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Gnanenthiran, SR | 1 |
| Webster, R | 1 |
| Silva, A | 1 |
| Maulik, PK | 1 |
| Salam, A | 1 |
| Selak, V | 1 |
| Guggilla, RK | 1 |
| Schutte, AE | 1 |
| Patel, A | 1 |
| Rodgers, A | 1 |
| Barzilay, JI | 5 |
| Lai, D | 1 |
| Davis, BR | 7 |
| Pressel, S | 1 |
| Previn, HE | 1 |
| Arnett, DK | 2 |
| Wright, JT | 2 |
| Probstfield, JL | 1 |
| Cushman, WC | 2 |
| Pressel, SL | 4 |
| Cutler, JA | 3 |
| Einhorn, PT | 2 |
| Rahman, M | 1 |
| Whelton, PK | 3 |
| Ford, CE | 3 |
| Haywood, LJ | 1 |
| Margolis, KL | 4 |
| Oparil, S | 2 |
| Black, HR | 2 |
| Alderman, MH | 1 |
| Irvin, MR | 1 |
| Lynch, AI | 1 |
| Kabagambe, EK | 1 |
| Tiwari, HK | 1 |
| Eckfeldt, JH | 1 |
| Boerwinkle, E | 1 |
| Moloo, J | 1 |
| Piller, LB | 1 |
| Simmons, DL | 1 |
| Sweeney, ME | 1 |
| Wong, ND | 1 |
| NICOLE, JC | 1 |
| PULVER, W | 1 |
| BOMPIANI, GD | 1 |
| PANVINO, C | 1 |
| WEISSEL, W | 1 |
| CARLINER, NH | 1 |
| SCHELLING, JL | 1 |
| RUSSELL, RP | 1 |
| OKUN, R | 1 |
| DAVIS, M | 1 |
| LUNDVALL, O | 1 |
| JOHNSSON, S | 1 |
| MORET, B | 2 |
| Bettencourt, J | 1 |
| Goff, DC | 1 |
| Black, H | 1 |
| Habib, G | 1 |
| Ellsworth, A | 1 |
| Force, RW | 1 |
| Wiegmann, T | 1 |
| Ciocon, JO | 1 |
| Basile, JN | 1 |
| Kostis, JB | 1 |
| Wilson, AC | 1 |
| Freudenberger, RS | 1 |
| Cosgrove, NM | 1 |
| Basile, J | 1 |
| Ong, ST | 1 |
| Sadler, LS | 1 |
| Summerson, J | 1 |
| Varughese, GI | 1 |
| Tahrani, AA | 1 |
| Scarpello, JH | 1 |
| Silver, A | 1 |
| Schiffl, H | 1 |
| Weidmann, P | 2 |
| Meier, A | 2 |
| Ziegler, WH | 2 |
| Beretta-Piccoli, C | 1 |
| Keusch, G | 1 |
| Glück, Z | 1 |
| Mujagic, M | 1 |
| Grimm, M | 1 |
| Curtis, J | 1 |
| Horrigan, F | 1 |
| Ahearn, D | 1 |
| Varney, R | 1 |
| Sandler, SG | 1 |
| Dejaco, RM | 1 |
| Hartl, O | 1 |
| Ikeda, T | 1 |
| Whitehouse, FW | 1 |
| Thomson, AE | 1 |
| Heimsoth, V | 1 |
| Bock, KD | 1 |
| Ott, H | 1 |
| Zahnd, G | 1 |
| Königstein, RP | 1 |
| Shah, BR | 1 |
| Desai, NH | 1 |
| Andersen, OO | 2 |
| Persson, I | 2 |
| Domenet, JG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00000542] | Phase 3 | 0 participants | Interventional | 1993-08-31 | Completed | ||
| [NCT00000514] | Phase 3 | 0 participants | Interventional | 1984-06-30 | Completed | ||
| Prevention of Hypertension Incidence and Diabetes Italian Assessment Study. Therapeutic Strategies of Prevention of Diabetes and Hypertension in Subjects With Metabolic Syndrome and High-Normal Blood Pressure.[NCT00456963] | Phase 4 | 3,000 participants (Anticipated) | Interventional | 2007-09-30 | Terminated (stopped due to Because of delay in approval of the protocol by a number of Ethics Commitees the trial was terminated on March 4, 2010. No patient had received any study drug.) | ||
| Effect of Combined Antihypertensive Therapy on Blood Pressure and Sexual Function in Patients With Essential Hypertension[NCT01238705] | Phase 4 | 280 participants (Anticipated) | Interventional | 2008-04-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for chlorthalidone and Diabetes Mellitus
| Article | Year |
|---|---|
[Hypertension--diuretics as antihypertensive agents].
Topics: Aged; Antihypertensive Agents; Arthritis; Benzothiadiazines; Blood Pressure; Chlorothiazide; Chlorth | 1970 |
10 trials available for chlorthalidone and Diabetes Mellitus
| Article | Year |
|---|---|
Reduced efficacy of blood pressure lowering drugs in the presence of diabetes mellitus-results from the TRIUMPH randomised controlled trial.
Topics: Amlodipine; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Diabetes Mellitus; Drug Combina | 2023 |
The Interaction of a Diabetes Gene Risk Score With 3 Different Antihypertensive Medications for Incident Glucose-level Elevation.
Topics: Alkadienes; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Calcium Channel Blo | 2019 |
ALLHAT findings revisited in the context of subsequent analyses, other trials, and meta-analyses.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; C | 2009 |
Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study.
Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Glucose; | 2010 |
Long-term effects of incident diabetes mellitus on cardiovascular outcomes in people treated for hypertension: the ALLHAT Diabetes Extension Study.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Cardiovascular Diseases; C | 2012 |
Cardiovascular outcomes using doxazosin vs. chlorthalidone for the treatment of hypertension in older adults with and without glucose disorders: a report from the ALLHAT study.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Cardiovascular Diseases; Chlorthalidone; Cohort Studi | 2004 |
Long-term effect of diuretic-based therapy on fatal outcomes in subjects with isolated systolic hypertension with and without diabetes.
Topics: Aged; Chlorthalidone; Diabetes Mellitus; Diuretics; Double-Blind Method; Female; Follow-Up Studies; | 2005 |
Long-term effect of diuretic-based therapy on fatal outcomes in subjects with isolated systolic hypertension with and without diabetes.
Topics: Aged; Chlorthalidone; Diabetes Mellitus; Diuretics; Double-Blind Method; Female; Follow-Up Studies; | 2005 |
Long-term effect of diuretic-based therapy on fatal outcomes in subjects with isolated systolic hypertension with and without diabetes.
Topics: Aged; Chlorthalidone; Diabetes Mellitus; Diuretics; Double-Blind Method; Female; Follow-Up Studies; | 2005 |
Long-term effect of diuretic-based therapy on fatal outcomes in subjects with isolated systolic hypertension with and without diabetes.
Topics: Aged; Chlorthalidone; Diabetes Mellitus; Diuretics; Double-Blind Method; Female; Follow-Up Studies; | 2005 |
Fasting glucose levels and incident diabetes mellitus in older nondiabetic adults randomized to receive 3 different classes of antihypertensive treatment: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHA
Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Glucose; | 2006 |
[Clinical trials with clonidine-chlorthalidone, a combined preparation in the treatment of hypertensive diseases].
Topics: Adult; Aged; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Clonidine; Diabetes Mellitus; | 1973 |
Carbohydrate metabolism during treatment with chlorthalidone and ethacrynic acid.
Topics: Aged; Blood Glucose; Carbohydrate Metabolism; Chlorthalidone; Cortisone; Diabetes Mellitus; Ethacryn | 1968 |
22 other studies available for chlorthalidone and Diabetes Mellitus
| Article | Year |
|---|---|
[Hyperglycemic effect by means of salidiuretics in diabetes mellitus].
Topics: Chlorthalidone; Diabetes Mellitus; Humans; Hydrochlorothiazide; Hyperglycemia | 1962 |
[The influence of sulfonamide diuretics on blood sugar regulation].
Topics: Blood Glucose; Chlorothiazide; Chlorthalidone; Diabetes Mellitus; Diuretics; Hydrochlorothiazide; Su | 1962 |
[Clinical contribution to the diabetogenic effect of saluretics].
Topics: Chlorothiazide; Chlorthalidone; Diabetes Mellitus; Diuretics; Humans; Hydrochlorothiazide | 1962 |
THIAZIDE- AND PHTHALIMIDINE-INDUCED HYPERGLYCEMIA IN HYPERTENSIVE PATIENTS.
Topics: Amylases; Blood Chemical Analysis; Chlorthalidone; Creatine; Creatinine; Diabetes Mellitus; Drug The | 1965 |
[INSULOMA TREATED WITH DIAZOXIDE].
Topics: Adenoma, Islet Cell; Antihypertensive Agents; Chlorthalidone; Diabetes Mellitus; Diazoxide; Geriatri | 1965 |
[ON THE DIABETOGENIC EFFECT OF SALURETIC DRUGS].
Topics: Chlorthalidone; Diabetes Mellitus; Diabetic Coma; Diuretics; Humans; Toxicology | 1965 |
[For every hypertensive patient a diuretic first? "Not advisable in diabetic patients"].
Topics: Antihypertensive Agents; Chlorthalidone; Contraindications; Coronary Disease; Diabetes Mellitus; Diu | 2003 |
Blood pressure drugs can boost blood sugar. Depending on the drug, though, it may not matter.
Topics: Amlodipine; Antihypertensive Agents; Blood Glucose; Chlorthalidone; Clinical Trials as Topic; Diabet | 2007 |
The putative link between glycemic control and cardiac arrhythmias.
Topics: Amlodipine; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Glucose; Chlorthalidone; Diabetes M | 2007 |
What if chlorthalidone-associated hyperglycemia develops?
Topics: Antihypertensive Agents; Chlorthalidone; Diabetes Mellitus; Diuretics; Humans; Hyperglycemia | 2007 |
Relationship between plasma catecholamines and urinary catecholamine excretion rates in normal subjects and certain diseased states.
Topics: Adult; Blood Pressure; Chlorthalidone; Creatinine; Diabetes Mellitus; Electrolytes; Epinephrine; Fem | 1981 |
Sodium-volume factor, cardiovascular reactivity and hypotensive mechanism of diuretic therapy in mild hypertension associated with diabetes mellitus.
Topics: Adult; Aged; Angiotensin II; Blood Pressure; Blood Volume; Chlorthalidone; Diabetes Complications; D | 1979 |
Chlorthalidone-induced hyperosmolar hyperglycemic nonketotic coma.
Topics: Adult; Chlorthalidone; Dehydration; Diabetes Mellitus; Diabetic Coma; Diabetic Ketoacidosis; Humans; | 1972 |
Two minutes with diabetes.
Topics: Aged; Blood Glucose; Chlorpropamide; Chlorthalidone; Diabetes Mellitus; Female; Humans | 1972 |
Chlorthalidone in the long term therapy of patients with hypertension.
Topics: Adult; Aged; Blood Chemical Analysis; Blood Glucose; Blood Pressure; Carbohydrate Metabolism, Inborn | 1970 |
[Nil nocere. Diabetic pre-coma during furosemide treatment].
Topics: Aged; Bradycardia; Chlorthalidone; Diabetes Mellitus; Diabetic Coma; Female; Furosemide; Humans; Uri | 1970 |
[Gout and diabetes induced by a salidiuretic treatment].
Topics: Aged; Chlorthalidone; Diabetes Mellitus; Diuretics; Female; Gout; Humans; Hyperglycemia; Uremia | 1967 |
[Iatrogenic diabetes mellitus and some important iatrogenic complications in diabetes].
Topics: Aged; Benzothiadiazines; Blood Glucose; Chlorthalidone; Diabetes Complications; Diabetes Mellitus; D | 1967 |
Diabetogenic effect of chlorthalidone and polythiazide.
Topics: Adolescent; Adult; Aged; Chlorthalidone; Diabetes Mellitus; Humans; Middle Aged; Polythiazide | 1968 |
Diabetogenic effect of oral diuretics.
Topics: Chlorthalidone; Diabetes Mellitus; Ethacrynic Acid; Glucose Tolerance Test; Humans | 1968 |
[Carbohydrate metabolism during treatment with chlorthalidone and ethacrynic acid].
Topics: Aged; Carbohydrate Metabolism; Chlorthalidone; Diabetes Mellitus; Ethacrynic Acid; Female; Humans; H | 1968 |
The diabetogenic effect of natriuretic diuretics.
Topics: Adult; Chlorthalidone; Diabetes Mellitus; Diuretics; Female; Glycosuria; Humans | 1966 |