chlorthalidone has been researched along with Diabetes Mellitus, Type 2 in 15 studies
Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the blood pressure (BP)-lowering efficacy of a chlorthalidone/amiloride combination pill with losartan, during initial management of JNC 7 Stage I hypertension in patients with type 2 diabetes mellitus." | 9.41 | Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial. ( Afiune Neto, A; Alves, JG; Berwanger, O; Bortolotto, LA; Brandão, AA; Castro, I; Cesarino, JE; Chaves, H; Consolim-Colombo, FM; de Sousa, MR; Figueiredo Neto, JA; Franco, RS; Fuchs, FC; Fuchs, FD; Fuchs, SC; Gomes, MM; Gus, M; Jardim, PC; Moreira, LB; Nobre, F; Nóbrega, AC; Pereira E Silva, R; Poli-de-Figueiredo, CE; Scala, LCN; Schlatter, RP; Sobral Filho, DC; Steffens, AA; Vilela-Martin, JF; Whelton, PK, 2021) |
| "To compare the blood pressure (BP)-lowering efficacy of a chlorthalidone/amiloride combination pill with losartan, during initial management of JNC 7 Stage I hypertension in patients with type 2 diabetes mellitus." | 5.41 | Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial. ( Afiune Neto, A; Alves, JG; Berwanger, O; Bortolotto, LA; Brandão, AA; Castro, I; Cesarino, JE; Chaves, H; Consolim-Colombo, FM; de Sousa, MR; Figueiredo Neto, JA; Franco, RS; Fuchs, FC; Fuchs, FD; Fuchs, SC; Gomes, MM; Gus, M; Jardim, PC; Moreira, LB; Nobre, F; Nóbrega, AC; Pereira E Silva, R; Poli-de-Figueiredo, CE; Scala, LCN; Schlatter, RP; Sobral Filho, DC; Steffens, AA; Vilela-Martin, JF; Whelton, PK, 2021) |
| " To determine whether thiazide-induced diabetes is mediated by changes in potassium, we analyzed data from 3790 nondiabetic participants in the Systolic Hypertension in Elderly Program, a randomized clinical trial of isolated systolic hypertension in individuals aged >or=60 years treated with chlorthalidone or placebo." | 5.13 | Changes in serum potassium mediate thiazide-induced diabetes. ( Appel, LJ; Klag, MJ; Miller, ER; Parekh, RS; Shafi, T, 2008) |
| " Therefore, the triad of metabolic neutrality with antihypertensive and antiproteinuric efficacy supports combined verapamil-trandolapril as a potentially valuable therapy for hypertension accompanying diabetes mellitus." | 5.08 | Metabolic neutrality of combined verapamil-trandolapril treatment in contrast to beta-blocker-low-dose chlortalidone treatment in hypertensive type 2 diabetes. ( Boehlen, L; Buechel, P; Lerch, M; Papiri, M; Risen, W; Schneider, M; Shaw, S; Weidmann, P, 1996) |
| "The authors conducted a clinical investigation in twenty-five patients affected with essential hypertension of mild or moderate grade associated with type II diabetes mellitus, the purpose being to assess the effect of 8 weeks of combined treatment with atenolol (100 mg) and chlorthalidone (25 mg) on arterial blood pressure, heart rate, and glycaemia." | 3.67 | Hypotensive effect of the association atenolol-chlorthalidone in hypertensive diabetics. ( Coltorti, M; Gentile, S, 1984) |
| "Chlorthalidone, 12." | 1.39 | Obesity and hypertension: It's about more than the numbers. ( Ferdinand, KC, 2013) |
| "Type 2 diabetes is increasing in prevalence and is predominantly managed in general practice." | 1.30 | A cautionary tale. ( Phillips, PJ; Popplewell, PY; Tallis, GA, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (13.33) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 4 (26.67) | 2.80 |
| Authors | Studies |
|---|---|
| Kunz, M | 1 |
| Götzinger, F | 1 |
| Emrich, I | 1 |
| Schwenger, V | 1 |
| Böhm, M | 1 |
| Mahfoud, F | 1 |
| Goldenberg, R | 2 |
| Bell, A | 2 |
| Cheng, W | 2 |
| Paron, E | 1 |
| Fils-Aimé, N | 2 |
| Burrows, M | 2 |
| Blavignac, J | 2 |
| Barakat, M | 2 |
| Parron, E | 1 |
| Fuchs, FD | 1 |
| Scala, LCN | 1 |
| Vilela-Martin, JF | 1 |
| Whelton, PK | 2 |
| Poli-de-Figueiredo, CE | 1 |
| Pereira E Silva, R | 1 |
| Gus, M | 1 |
| Bortolotto, LA | 1 |
| Consolim-Colombo, FM | 1 |
| Schlatter, RP | 1 |
| Cesarino, JE | 1 |
| Castro, I | 1 |
| Figueiredo Neto, JA | 1 |
| Chaves, H | 1 |
| Steffens, AA | 1 |
| Alves, JG | 1 |
| Brandão, AA | 1 |
| de Sousa, MR | 1 |
| Jardim, PC | 1 |
| Moreira, LB | 1 |
| Franco, RS | 1 |
| Gomes, MM | 1 |
| Afiune Neto, A | 1 |
| Fuchs, FC | 1 |
| Sobral Filho, DC | 1 |
| Nóbrega, AC | 1 |
| Nobre, F | 1 |
| Berwanger, O | 1 |
| Fuchs, SC | 1 |
| Ferdinand, KC | 1 |
| Shafi, T | 1 |
| Appel, LJ | 1 |
| Miller, ER | 1 |
| Klag, MJ | 1 |
| Parekh, RS | 1 |
| Holzgreve, H | 1 |
| Nakov, R | 1 |
| Beck, K | 1 |
| Janka, HU | 1 |
| Siebenhofer, A | 1 |
| Horvath, K | 1 |
| Kraly, B | 1 |
| Plank, J | 1 |
| Barzilay, J | 1 |
| Cushman, WC | 1 |
| Davis, BR | 2 |
| Iiamathi, E | 1 |
| Kostis, JB | 1 |
| Leenen, FH | 1 |
| Louis, GT | 1 |
| Margolis, KL | 1 |
| Mathis, DE | 1 |
| Moloo, J | 1 |
| Nwachuku, C | 1 |
| Panebianco, D | 1 |
| Parish, DC | 1 |
| Pressel, S | 1 |
| Simmons, DL | 1 |
| Thadani, U | 1 |
| Gentile, S | 1 |
| Coltorti, M | 1 |
| Schneider, M | 1 |
| Lerch, M | 1 |
| Papiri, M | 1 |
| Buechel, P | 1 |
| Boehlen, L | 1 |
| Shaw, S | 1 |
| Risen, W | 1 |
| Weidmann, P | 1 |
| Curb, JD | 1 |
| Pressel, SL | 1 |
| Cutler, JA | 1 |
| Savage, PJ | 1 |
| Applegate, WB | 1 |
| Black, H | 1 |
| Camel, G | 1 |
| Frost, PH | 1 |
| Gonzalez, N | 1 |
| Guthrie, G | 1 |
| Oberman, A | 1 |
| Rutan, GH | 1 |
| Stamler, J | 1 |
| Tallis, GA | 1 |
| Phillips, PJ | 1 |
| Popplewell, PY | 1 |
| Pagano, G | 1 |
| Dal Molin, V | 1 |
| Bozzo, C | 1 |
| Carta, Q | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Comparison Between Diuretics and Angiotensin-receptor Blocker Agents in Patients With Stage I Hypertension: PREVER-treatment Study[NCT00971165] | Phase 3 | 655 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| [NCT00000542] | Phase 3 | 0 participants | Interventional | 1993-08-31 | Completed | ||
| [NCT00000514] | Phase 3 | 0 participants | Interventional | 1984-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for chlorthalidone and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Cardio-renal interaction - Clinical trials update 2022.
Topics: Chlorthalidone; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Glucose; Humans; Kidney; Minera | 2022 |
[Diabetes and drug treatment of hypertension].
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benz | 2003 |
7 trials available for chlorthalidone and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial.
Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Blood Pressure; Brazil; Chlorthalidone; Diabetes Me | 2021 |
Changes in serum potassium mediate thiazide-induced diabetes.
Topics: Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Chlorthalidone; Diabetes Mellitus, Type 2; | 2008 |
Antihypertensive therapy with verapamil SR plus trandolapril versus atenolol plus chlorthalidone on glycemic control.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitor | 2003 |
Clinical outcomes in antihypertensive treatment of type 2 diabetes, impaired fasting glucose concentration, and normoglycemia: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Topics: Aged; Amlodipine; Antihypertensive Agents; Blood Glucose; Chlorthalidone; Coronary Disease; Diabetes | 2005 |
Metabolic neutrality of combined verapamil-trandolapril treatment in contrast to beta-blocker-low-dose chlortalidone treatment in hypertensive type 2 diabetes.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Carbohydrate Metabolism; Chlortha | 1996 |
Effect of diuretic-based antihypertensive treatment on cardiovascular disease risk in older diabetic patients with isolated systolic hypertension. Systolic Hypertension in the Elderly Program Cooperative Research Group.
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Cardiovascular Diseases; Chlor | 1996 |
Interference on metabolism induced by muzolimine and chlorthalidone in type II hypertensive diabetics.
Topics: Aldosterone; Blood Glucose; Blood Pressure; Carbohydrate Metabolism; Chlorthalidone; Clinical Trials | 1985 |
6 other studies available for chlorthalidone and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Regional variability in Canadian routine care of type 2 diabetes, hypercholesterolemia, and hypertension: Results from the The Cardio-Vascular and metabolic treatments in Canada: Assessment of REal-life therapeutic value (CV-CARE) registry.
Topics: Aged; Anticholesteremic Agents; Antihypertensive Agents; Benzimidazoles; Canada; Chlorthalidone; Col | 2020 |
Real-world effectiveness of treatments for type 2 diabetes, hypercholesterolemia, and hypertension in Canadian routine care - Results from the CardioVascular and metabolic treatment in Canada: Assessment of REal-life therapeutic value (CV-CARE) registry,
Topics: Aged; Anticholesteremic Agents; Antihypertensive Agents; Benzimidazoles; Canada; Cardiovascular Dise | 2020 |
Obesity and hypertension: It's about more than the numbers.
Topics: Antihypertensive Agents; Chlorthalidone; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug | 2013 |
Blood pressure drugs may raise the risk of adult diabetes. Potassium loss caused by hypertension drugs could place patients in the type 2 diabetes danger zone.
Topics: Aged; Antihypertensive Agents; Chlorthalidone; Controlled Clinical Trials as Topic; Diabetes Mellitu | 2009 |
Hypotensive effect of the association atenolol-chlorthalidone in hypertensive diabetics.
Topics: Adult; Aged; Atenolol; Blood Glucose; Blood Pressure; Chlorthalidone; Diabetes Mellitus, Type 2; Dia | 1984 |
A cautionary tale.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Calcium Channel Blockers; Ch | 1997 |