chlorthalidone has been researched along with Coronary Disease in 40 studies
Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In elderly hypertensive patients with coronary artery disease, chlorthalidone reduced myocardial ischemia similarly to diltiazem." | 9.09 | Effects of chlorthalidone and diltiazem on myocardial ischemia in elderly patients with hypertension and coronary artery disease. ( de Paula, RS; Gebara, O; Gruppi, C; Moffa, P; Nussbacher, A; Pereira-Barreto, AC; Pierri, H; Pinto, L; Serro-Azul, JB; Wajngarten, M, 2001) |
| "We conducted a subgroup analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) to compare metabolic, cardiovascular, and renal outcomes in individuals assigned to initial hypertension treatment with a thiazide-like diuretic (chlorthalidone), a calcium channel blocker (CCB; amlodipine), or an ACE inhibitor (lisinopril) in nondiabetic individuals with or without metabolic syndrome." | 7.74 | Metabolic and clinical outcomes in nondiabetic individuals with the metabolic syndrome assigned to chlorthalidone, amlodipine, or lisinopril as initial treatment for hypertension: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent ( Baimbridge, C; Barzilay, J; Basile, J; Black, HR; Dart, RA; Davis, B; Marginean, H; Nwachuku, C; Thadani, U; Whelton, P; Wong, ND; Wright, JT, 2008) |
| "The effects of chlorthalidone and metoprolol on fasting plasma lipids and lipoprotein levels were compared in two similar nonrandomized groups of patients with mild hypertension." | 7.67 | Different effects of metoprolol and chlorthalidone on serum lipoprotein levels in mild hypertension. Possible implications for coronary heart disease risk status. ( Goldbourt, U; Holtzman, E; Rosenthal, T; Segal, P, 1984) |
| "Stroke: common 'GG' homozygotes had higher risk on lisinopril versus amlodipine [hazard ratio (HR)=1." | 5.14 | Antihypertensive pharmacogenetic effect of fibrinogen-beta variant -455G>A on cardiovascular disease, end-stage renal disease, and mortality: the GenHAT study. ( Arnett, DK; Boerwinkle, E; Davis, BR; Eckfeldt, JH; Ford, CE; Leiendecker-Foster, C; Lynch, AI, 2009) |
| " Hypertensive participants 55 years or older with at least 1 other coronary heart disease risk factor were randomized to receive chlorthalidone, amlodipine, or lisinopril for a mean of 4." | 5.11 | Renal outcomes in high-risk hypertensive patients treated with an angiotensin-converting enzyme inhibitor or a calcium channel blocker vs a diuretic: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). ( Barzilay, J; Batuman, V; Davis, BR; Eckfeldt, JH; Farber, M; Henriquez, M; Kopyt, N; Louis, GT; Nwachuku, C; Pressel, S; Rahman, M; Saklayen, M; Stanford, C; Walworth, C; Ward, H; Whelton, PK; Wiegmann, T; Wright, JT, 2005) |
| "The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized, double-blind, active, controlled clinical trial conducted to determine whether newer antihypertensive agents, including doxazosin, an alpha-blocker, differ from chlorthalidone, a diuretic, with respect to coronary heart disease (CHD) and other cardiovascular disease (CVD) events in hypertensive patients at high risk of CHD." | 5.10 | Diuretic versus alpha-blocker as first-step antihypertensive therapy: final results from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). ( , 2003) |
| "In elderly hypertensive patients with coronary artery disease, chlorthalidone reduced myocardial ischemia similarly to diltiazem." | 5.09 | Effects of chlorthalidone and diltiazem on myocardial ischemia in elderly patients with hypertension and coronary artery disease. ( de Paula, RS; Gebara, O; Gruppi, C; Moffa, P; Nussbacher, A; Pereira-Barreto, AC; Pierri, H; Pinto, L; Serro-Azul, JB; Wajngarten, M, 2001) |
| " Thus, myocardial electrical excitability was measured in patients with mild essential hypertension and known coronary artery disease after 8 weeks of treatment with a potassium-conserving diuretic (amiloride) and a similar period on a potassium-losing diuretic (chlorthalidone) in a randomised study." | 5.06 | Diuretics, potassium and arrhythmias in hypertensive coronary disease. ( Espiner, EA; Ikram, H; Nicholls, MG, 1986) |
| "We conducted a subgroup analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) to compare metabolic, cardiovascular, and renal outcomes in individuals assigned to initial hypertension treatment with a thiazide-like diuretic (chlorthalidone), a calcium channel blocker (CCB; amlodipine), or an ACE inhibitor (lisinopril) in nondiabetic individuals with or without metabolic syndrome." | 3.74 | Metabolic and clinical outcomes in nondiabetic individuals with the metabolic syndrome assigned to chlorthalidone, amlodipine, or lisinopril as initial treatment for hypertension: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent ( Baimbridge, C; Barzilay, J; Basile, J; Black, HR; Dart, RA; Davis, B; Marginean, H; Nwachuku, C; Thadani, U; Whelton, P; Wong, ND; Wright, JT, 2008) |
| "The effects of chlorthalidone and metoprolol on fasting plasma lipids and lipoprotein levels were compared in two similar nonrandomized groups of patients with mild hypertension." | 3.67 | Different effects of metoprolol and chlorthalidone on serum lipoprotein levels in mild hypertension. Possible implications for coronary heart disease risk status. ( Goldbourt, U; Holtzman, E; Rosenthal, T; Segal, P, 1984) |
| "A regimen consisting of chlorthalidone, hydralazine and propranolol would be useful in some hypertensive patients with coronary artery disease or aortic dissection if it could be shown that reflex cardiac stimulation induced by hydralazine is completely neutralized by propranolol." | 3.66 | Echocardiographic assessment of the effect of an antihypertensive regimen on left ventricular performance. ( Belasco, RN; Moyer, JP; Pittman, AW; Woods, JW, 1979) |
| "The reduction in coronary disease is consistent with predictions based on prospective epidemiological studies and is concordant with other recent intervention trials." | 2.67 | Implications of the systolic hypertension in the elderly program. The Systolic Hypertension in the Elderly Program Cooperative Research Group. ( , 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (35.00) | 18.7374 |
| 1990's | 4 (10.00) | 18.2507 |
| 2000's | 16 (40.00) | 29.6817 |
| 2010's | 6 (15.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haywood, LJ | 3 |
| Davis, BR | 10 |
| Piller, LB | 3 |
| Simpson, LM | 1 |
| Ghosh, A | 1 |
| Einhorn, PT | 2 |
| Ford, CE | 8 |
| Probstfield, JL | 2 |
| Soliman, EZ | 1 |
| Wright, JT | 6 |
| Oparil, S | 3 |
| Cushman, WC | 4 |
| Furberg, CD | 4 |
| Habib, GB | 1 |
| Margolis, K | 1 |
| Whelton, PK | 5 |
| Lynch, AI | 2 |
| Boerwinkle, E | 3 |
| Eckfeldt, JH | 4 |
| Leiendecker-Foster, C | 3 |
| Arnett, DK | 3 |
| Barzilay, JI | 2 |
| Pressel, SL | 1 |
| Cutler, JA | 4 |
| Black, HR | 2 |
| Margolis, KL | 2 |
| Moloo, J | 2 |
| Simmons, DL | 2 |
| Sweeney, ME | 1 |
| Wong, ND | 2 |
| Rahman, M | 2 |
| Brown, CD | 1 |
| Colon, PJ | 1 |
| Fine, LJ | 1 |
| Grimm, RH | 1 |
| Gupta, AK | 1 |
| Baimbridge, C | 2 |
| Henriquez, MA | 1 |
| Ilamaythi, E | 1 |
| Preston, R | 1 |
| Proschan, M | 1 |
| Graumlich, JF | 1 |
| Pavlik, V | 1 |
| Alderman, MH | 1 |
| Gordon, D | 1 |
| Franklin, SS | 1 |
| Blumenthal, SS | 1 |
| Castaldo, RS | 1 |
| Preston, RA | 1 |
| Wepner, U | 1 |
| Siragy, HM | 1 |
| Reese, AM | 1 |
| Talbert, RL | 1 |
| Bussey, HI | 1 |
| OZDOGAN, E | 1 |
| JOHNSTON, LC | 1 |
| GRIEBLE, HG | 1 |
| SCHOENBERGER, JA | 1 |
| FULLER, JB | 1 |
| Kuwajima, I | 1 |
| Psaty, BM | 1 |
| Lumley, T | 1 |
| Pressel, S | 2 |
| Nwachuku, C | 3 |
| Barzilay, J | 3 |
| Batuman, V | 1 |
| Farber, M | 1 |
| Henriquez, M | 1 |
| Kopyt, N | 1 |
| Louis, GT | 2 |
| Saklayen, M | 1 |
| Stanford, C | 1 |
| Walworth, C | 1 |
| Ward, H | 1 |
| Wiegmann, T | 1 |
| Iiamathi, E | 1 |
| Kostis, JB | 1 |
| Leenen, FH | 1 |
| Mathis, DE | 1 |
| Panebianco, D | 1 |
| Parish, DC | 1 |
| Thadani, U | 2 |
| Miller, MB | 1 |
| Black, H | 1 |
| Davis, B | 1 |
| Marginean, H | 1 |
| Basile, J | 1 |
| Whelton, P | 1 |
| Dart, RA | 1 |
| Lowenstein, J | 1 |
| Holtzman, E | 1 |
| Rosenthal, T | 1 |
| Goldbourt, U | 1 |
| Segal, P | 1 |
| Borhani, NO | 1 |
| Morgan, DB | 1 |
| Davidson, C | 1 |
| Einecke, D | 1 |
| Koval, PG | 1 |
| McDiarmid, T | 1 |
| Schillaci, G | 1 |
| Verdecchia, P | 1 |
| Serro-Azul, JB | 1 |
| de Paula, RS | 1 |
| Gruppi, C | 1 |
| Pinto, L | 1 |
| Pierri, H | 1 |
| Nussbacher, A | 1 |
| Gebara, O | 1 |
| Moffa, P | 1 |
| Pereira-Barreto, AC | 1 |
| Wajngarten, M | 1 |
| de Pasquale, C | 1 |
| Currò, F | 1 |
| Amadeo, A | 1 |
| Moyer, JP | 1 |
| Pittman, AW | 1 |
| Belasco, RN | 1 |
| Woods, JW | 1 |
| Ménard, J | 1 |
| Chatellier, G | 1 |
| Cohen, JD | 2 |
| Petrovitch, H | 1 |
| Vogt, TM | 1 |
| Berge, KG | 1 |
| Kuller, LH | 1 |
| Hulley, SB | 1 |
| Neaton, J | 1 |
| Ikram, H | 2 |
| Espiner, EA | 2 |
| Nicholls, MG | 2 |
| Stewart, DE | 1 |
| Kuller, L | 1 |
| Farrier, N | 1 |
| Caggiula, A | 1 |
| Borhani, N | 1 |
| Dunkle, S | 1 |
| Kilcoyne, MM | 1 |
| Thomson, GE | 1 |
| Branche, G | 1 |
| Williams, M | 1 |
| Garnier, C | 1 |
| Chiles, B | 1 |
| Soland, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00000542] | Phase 3 | 0 participants | Interventional | 1993-08-31 | Completed | ||
| A Randomised Open Label, Blinded End Point Trial to Compare the Effects of Spironolactone With Chlortalidone on LV Mass in Stage 3 Chronic Kidney Disease (SPIRO-CKD)[NCT02502981] | Phase 4 | 154 participants (Actual) | Interventional | 2014-06-30 | Active, not recruiting | ||
| GenHAT - Genetics of Hypertension Associated Treatments - Ancillary to ALLHAT[NCT00563901] | 37,939 participants (Actual) | Observational | 2000-09-30 | Completed | |||
| [NCT00000514] | Phase 3 | 0 participants | Interventional | 1984-06-30 | Completed | ||
| [NCT00000487] | Phase 3 | 0 participants | Interventional | 1972-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for chlorthalidone and Coronary Disease
| Article | Year |
|---|---|
[ALLHAT trial--antithesis to the overuse of vasodilating antihypertensive drugs].
Topics: Adrenergic alpha-Antagonists; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypert | 2004 |
Meta-analysis of health outcomes of chlorthalidone-based vs nonchlorthalidone-based low-dose diuretic therapies.
Topics: Antihypertensive Agents; Chlorthalidone; Coronary Disease; Diuretics; Humans; Hypertension; Treatmen | 2004 |
[Importance of the continuity of anti-hypertension treatment in prevention of ischemic cardiovascular diseases: preliminary note. Controlled study of hypertensive patients treated with amiloride associated with hydrochlorothiazide and chlorthalidone].
Topics: Adult; Aged; Amiloride; Chlorthalidone; Coronary Disease; Drug Therapy, Combination; Female; Humans; | 1978 |
[Cooperative study of systolic arterial hypertension in the elderly patient (SHEP). Comments].
Topics: Adrenergic beta-Antagonists; Aged; Atenolol; Cerebrovascular Disorders; Chlorthalidone; Coronary Dis | 1992 |
Isolated systolic hypertension: lowering the risk of stroke in older patients. SHEP Cooperative Research Group.
Topics: Aged; Atenolol; Cerebrovascular Disorders; Chlorthalidone; Coronary Disease; Double-Blind Method; Hu | 1992 |
17 trials available for chlorthalidone and Coronary Disease
| Article | Year |
|---|---|
Risk Factors Influencing Outcomes of Atrial Fibrillation in ALLHAT.
Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Atrial Fibrillation; Atrial Flutter; C | 2018 |
Mortality and morbidity during and after Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial: results by sex.
Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Chlorthalido | 2013 |
Antihypertensive pharmacogenetic effect of fibrinogen-beta variant -455G>A on cardiovascular disease, end-stage renal disease, and mortality: the GenHAT study.
Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel | 2009 |
Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.
Topics: Aged; Amlodipine; Antihypertensive Agents; Chlorthalidone; Coronary Disease; Doxazosin; Female; Foll | 2012 |
Long-term effects of incident diabetes mellitus on cardiovascular outcomes in people treated for hypertension: the ALLHAT Diabetes Extension Study.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Cardiovascular Diseases; C | 2012 |
Long-term renal and cardiovascular outcomes in Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) participants by baseline estimated GFR.
Topics: Amlodipine; Antihypertensive Agents; Canada; Chlorthalidone; Chronic Disease; Coronary Disease; Doub | 2012 |
Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitors or calcium channel blocker vs diuretic. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Chlorthalidone | 2003 |
Diuretic versus alpha-blocker as first-step antihypertensive therapy: final results from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Blood Pressure; Chlorthalidone; Coronary Dise | 2003 |
Renal outcomes in high-risk hypertensive patients treated with an angiotensin-converting enzyme inhibitor or a calcium channel blocker vs a diuretic: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers | 2005 |
Renal outcomes in high-risk hypertensive patients treated with an angiotensin-converting enzyme inhibitor or a calcium channel blocker vs a diuretic: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers | 2005 |
Renal outcomes in high-risk hypertensive patients treated with an angiotensin-converting enzyme inhibitor or a calcium channel blocker vs a diuretic: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers | 2005 |
Renal outcomes in high-risk hypertensive patients treated with an angiotensin-converting enzyme inhibitor or a calcium channel blocker vs a diuretic: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers | 2005 |
Clinical outcomes in antihypertensive treatment of type 2 diabetes, impaired fasting glucose concentration, and normoglycemia: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Topics: Aged; Amlodipine; Antihypertensive Agents; Blood Glucose; Chlorthalidone; Coronary Disease; Diabetes | 2005 |
Antihypertensive therapy, the alpha-adducin polymorphism, and cardiovascular disease in high-risk hypertensive persons: the Genetics of Hypertension-Associated Treatment Study.
Topics: Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Calmodulin-Binding Proteins; Chlorthalido | 2007 |
Implications of the systolic hypertension in the elderly program. The Systolic Hypertension in the Elderly Program Cooperative Research Group.
Topics: Age Factors; Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Blood Pressure; Cerebrovasc | 1993 |
[ALLHAT Study: doxazosin arm is discontinued. Alpha blocker is less effective than a diuretic].
Topics: Adrenergic alpha-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Chlorthalidone; Coronary Dis | 2000 |
Effects of chlorthalidone and diltiazem on myocardial ischemia in elderly patients with hypertension and coronary artery disease.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Coronary Disease; Diltiazem; Diuretic | 2001 |
Isolated systolic hypertension: lowering the risk of stroke in older patients. SHEP Cooperative Research Group.
Topics: Aged; Atenolol; Cerebrovascular Disorders; Chlorthalidone; Coronary Disease; Double-Blind Method; Hu | 1992 |
Diuretics, potassium and arrhythmias in hypertensive coronary disease.
Topics: Chlorthalidone; Coronary Disease; Diuretics; Electric Stimulation; Electrocardiography; Humans; Hype | 1986 |
Drug treatment trials in hypertension: a review.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Coro | 1985 |
19 other studies available for chlorthalidone and Coronary Disease
| Article | Year |
|---|---|
How much effect of different antihypertensive medications on cardiovascular outcomes is attributable to their effects on blood pressure?
Topics: Amlodipine; Antihypertensive Agents; Biostatistics; Blood Pressure; Cardiovascular Diseases; Chlorth | 2013 |
[Established blood pressure drug wins out in a comparative study. In hypertension, a diuretic first!].
Topics: Adrenergic alpha-Antagonists; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypert | 2003 |
Angiotensin-converting-enzyme inhibitors and diuretics for hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Chlorthalidone; Coronary Disease; | 2003 |
[ON ION TRANSPORT BEFORE AND AFTER TREATMENT OF CONGESTIVE HEART FAILURE].
Topics: Chlorthalidone; Coronary Disease; Digitalis Glycosides; Diuretics; Electrolytes; Heart Failure; Huma | 1963 |
TREATMENT OF ARTERIAL HYPERTENSIVE DISEASE WITH DIURETICS. III. CHLORTHALIDONE ALONE AND IN COMBINATION WITH SPIRONOLACTONE.
Topics: Bendroflumethiazide; Cardiomegaly; Chlorides; Chlorthalidone; Coronary Disease; Creatine; Creatinine | 1964 |
[For every hypertensive patient a diuretic first? "Not advisable in diabetic patients"].
Topics: Antihypertensive Agents; Chlorthalidone; Contraindications; Coronary Disease; Diabetes Mellitus; Diu | 2003 |
Metabolic and clinical outcomes in nondiabetic individuals with the metabolic syndrome assigned to chlorthalidone, amlodipine, or lisinopril as initial treatment for hypertension: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent
Topics: Aged; Amlodipine; Antihypertensive Agents; Atherosclerosis; Blood Pressure; Chlorthalidone; Cohort S | 2008 |
Effects of prazosin on serum lipids in patients with essential hypertension: a review of the findings presented at the Satellite Symposium on coronary heart disease: hypertension and other risk factors, Milan, 1983.
Topics: Adrenergic beta-Antagonists; Benzothiadiazines; Chlorthalidone; Cholesterol; Cholesterol, HDL; Coron | 1984 |
Different effects of metoprolol and chlorthalidone on serum lipoprotein levels in mild hypertension. Possible implications for coronary heart disease risk status.
Topics: Body Weight; Chlorthalidone; Cholesterol; Coronary Disease; Female; Heart Rate; Humans; Hypertension | 1984 |
The practicing physician and control of hypertension.
Topics: Adult; Aged; Cerebrovascular Disorders; Chlorthalidone; Coronary Disease; Female; Heart Failure; Hum | 1980 |
Hypokalaemia and diuretics: an analysis of publications.
Topics: Chlorothiazide; Chlorthalidone; Coronary Disease; Diuretics; Dose-Response Relationship, Drug; Furos | 1980 |
How effective is doxazosin compared with chlorthalidone in the treatment of hypertension?
Topics: Aged; Antihypertensive Agents; Cardiovascular Diseases; Chlorthalidone; Coronary Disease; Diuretics; | 2000 |
[Are all antihypertensive agents equal? Cardiovascular events in hypertensive patients randomized to treatment with doxazosin or chlorthalidone. The ALLHAT study].
Topics: Adrenergic alpha-Antagonists; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive | 2000 |
Echocardiographic assessment of the effect of an antihypertensive regimen on left ventricular performance.
Topics: Adult; Antihypertensive Agents; Aortic Aneurysm; Aortic Dissection; Chlorthalidone; Coronary Disease | 1979 |
Abnormal electrocardiograms and cardiovascular risk: role of silent myocardial ischemia. Evidence from MRFIT.
Topics: Adult; Antihypertensive Agents; Chlorthalidone; Cholesterol, Dietary; Coronary Disease; Electrocardi | 1992 |
Unexpected effects of treating hypertension in men with electrocardiographic abnormalities: a critical analysis.
Topics: Adult; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiomegaly; Catecholamines; Chlorthalid | 1986 |
Arrhythmogenic potential of diuretic induced hypokalaemia in patients with mild hypertension and ischaemic heart disease.
Topics: Amiloride; Arrhythmias, Cardiac; Chlorthalidone; Coronary Disease; Cyclopenthiazide; Diuretics; Fema | 1985 |
Relationship of diuretic therapy and serum magnesium levels among participants in the Multiple Risk Factor Intervention Trial.
Topics: Adult; Blood Pressure; California; Chlorthalidone; Coronary Disease; Diet; Epidemiologic Methods; Hu | 1985 |
Characteristics of hypertension in the black population.
Topics: Adult; Angiotensin II; Animals; Black or African American; Cardiomegaly; Cerebrovascular Disorders; | 1974 |