Compounds > chlorthalidone
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chlorthalidone and Cerebrovascular Disorders

chlorthalidone has been researched along with Cerebrovascular Disorders in 11 studies

Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.

Cerebrovascular Disorders: A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.

Research Excerpts

ExcerptRelevanceReference
"In persons aged 60 years and over with isolated systolic hypertension, antihypertensive stepped-care drug treatment with low-dose chlorthalidone as step 1 medication reduced the incidence of total stroke by 36%, with 5-year absolute benefit of 30 events per 1000 participants."5.07Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group. ( , 1991)
"If atenolol was contraindicated, 0."2.67Impact of the treatment of isolated systolic hypertension on behavioral variables. Results from the systolic hypertension in the elderly program. ( Applegate, WB; Camel, GH; Greenlick, MR; Hadley, E; Luhr, J; Moye, L; Perry, HM; Pressel, S; Shekelle, RB; Wittes, J, 1994)
"The reduction in coronary disease is consistent with predictions based on prospective epidemiological studies and is concordant with other recent intervention trials."2.67Implications of the systolic hypertension in the elderly program. The Systolic Hypertension in the Elderly Program Cooperative Research Group. ( , 1993)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19903 (27.27)18.7374
1990's8 (72.73)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Borhani, NO2
Applegate, WB2
Pressel, S1
Wittes, J1
Luhr, J1
Shekelle, RB1
Camel, GH1
Greenlick, MR1
Hadley, E1
Moye, L1
Perry, HM1
Davis, BR2
Vogt, T1
Frost, PH1
Burlando, A1
Cohen, J1
Wilson, A1
Brass, LM1
Frishman, W1
Price, T1
Stamler, J1
Singer, RB1
Ménard, J1
Chatellier, G1
Petrovitch, H1
Vogt, TM1
Berge, KG1
Winker, MA1
Murphy, MB1
Probstfield, JL1
Curb, JD1
Cutler, JA1
Furberg, CD1
Hawkins, CM1
Lakatos, E1
Page, LB1
Kilcoyne, MM1
Thomson, GE1
Branche, G1
Williams, M1
Garnier, C1
Chiles, B1
Soland, T1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00000514]Phase 30 participants Interventional1984-06-30Completed
A Pivotal Study To Evaluate The Effectiveness of Isometric Handgrip Therapy In Prehypertensive And Hypertensive Patients[NCT04467879]146 participants (Actual)Interventional2020-06-01Terminated (stopped due to New Protocol and Outcome Measures in Review)
Hypertension Management and Outcomes in a Family Practice Setting[NCT03579108]200 participants (Anticipated)Observational2018-02-24Recruiting
Hypertension Prevalence, Treatment Patterns and Outcomes in Long-Term Care Facilities[NCT03046420]139 participants (Actual)Observational2017-01-26Completed
Strategy of Systolic Blood Pressure Intervention in the Elderly Hypertensive Patients: A Prospective Randomized Open-Label Blinded-Endpoint Trial[NCT03015311]8,000 participants (Anticipated)Interventional2017-01-15Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for chlorthalidone and Cerebrovascular Disorders

ArticleYear
[Cooperative study of systolic arterial hypertension in the elderly patient (SHEP). Comments].
    Presse medicale (Paris, France : 1983), 1992, Nov-07, Volume: 21, Issue:37

    Topics: Adrenergic beta-Antagonists; Aged; Atenolol; Cerebrovascular Disorders; Chlorthalidone; Coronary Dis

1992
Isolated systolic hypertension: lowering the risk of stroke in older patients. SHEP Cooperative Research Group.
    Geriatrics, 1992, Volume: 47, Issue:3

    Topics: Aged; Atenolol; Cerebrovascular Disorders; Chlorthalidone; Coronary Disease; Double-Blind Method; Hu

1992

Trials

6 trials available for chlorthalidone and Cerebrovascular Disorders

ArticleYear
Impact of the treatment of isolated systolic hypertension on behavioral variables. Results from the systolic hypertension in the elderly program.
    Archives of internal medicine, 1994, Oct-10, Volume: 154, Issue:19

    Topics: Activities of Daily Living; Aged; Aged, 80 and over; Atenolol; Cerebrovascular Disorders; Chlorthali

1994
Implications of the systolic hypertension in the elderly program. The Systolic Hypertension in the Elderly Program Cooperative Research Group.
    Hypertension (Dallas, Tex. : 1979), 1993, Volume: 21, Issue:3

    Topics: Age Factors; Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Blood Pressure; Cerebrovasc

1993
Risk factors for stroke and type of stroke in persons with isolated systolic hypertension. Systolic Hypertension in the Elderly Program Cooperative Research Group.
    Stroke, 1998, Volume: 29, Issue:7

    Topics: Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Brain Ischemia; Cerebral Hemorrhage; Cerebr

1998
Isolated systolic hypertension: lowering the risk of stroke in older patients. SHEP Cooperative Research Group.
    Geriatrics, 1992, Volume: 47, Issue:3

    Topics: Aged; Atenolol; Cerebrovascular Disorders; Chlorthalidone; Coronary Disease; Double-Blind Method; Hu

1992
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
    JAMA, 1991, Jun-26, Volume: 265, Issue:24

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Cause of Death; Cerebrovascular Disorder

1991
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
    JAMA, 1991, Jun-26, Volume: 265, Issue:24

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Cause of Death; Cerebrovascular Disorder

1991
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
    JAMA, 1991, Jun-26, Volume: 265, Issue:24

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Cause of Death; Cerebrovascular Disorder

1991
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
    JAMA, 1991, Jun-26, Volume: 265, Issue:24

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Cause of Death; Cerebrovascular Disorder

1991
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
    JAMA, 1991, Jun-26, Volume: 265, Issue:24

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Cause of Death; Cerebrovascular Disorder

1991
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
    JAMA, 1991, Jun-26, Volume: 265, Issue:24

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Cause of Death; Cerebrovascular Disorder

1991
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
    JAMA, 1991, Jun-26, Volume: 265, Issue:24

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Cause of Death; Cerebrovascular Disorder

1991
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
    JAMA, 1991, Jun-26, Volume: 265, Issue:24

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Cause of Death; Cerebrovascular Disorder

1991
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
    JAMA, 1991, Jun-26, Volume: 265, Issue:24

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Cause of Death; Cerebrovascular Disorder

1991
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
    JAMA, 1991, Jun-26, Volume: 265, Issue:24

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Cause of Death; Cerebrovascular Disorder

1991
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
    JAMA, 1991, Jun-26, Volume: 265, Issue:24

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Cause of Death; Cerebrovascular Disorder

1991
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
    JAMA, 1991, Jun-26, Volume: 265, Issue:24

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Cause of Death; Cerebrovascular Disorder

1991
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
    JAMA, 1991, Jun-26, Volume: 265, Issue:24

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Cause of Death; Cerebrovascular Disorder

1991
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
    JAMA, 1991, Jun-26, Volume: 265, Issue:24

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Cause of Death; Cerebrovascular Disorder

1991
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
    JAMA, 1991, Jun-26, Volume: 265, Issue:24

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Cause of Death; Cerebrovascular Disorder

1991
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
    JAMA, 1991, Jun-26, Volume: 265, Issue:24

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Cause of Death; Cerebrovascular Disorder

1991
The Systolic Hypertension in the Elderly Program (SHEP): an intervention trial on isolated systolic hypertension. SHEP Cooperative Research Group.
    Clinical and experimental hypertension. Part A, Theory and practice, 1989, Volume: 11, Issue:5-6

    Topics: Aged; Antihypertensive Agents; Atenolol; Cerebrovascular Disorders; Chlorthalidone; Double-Blind Met

1989
The Systolic Hypertension in the Elderly Program (SHEP): an intervention trial on isolated systolic hypertension. SHEP Cooperative Research Group.
    Clinical and experimental hypertension. Part A, Theory and practice, 1989, Volume: 11, Issue:5-6

    Topics: Aged; Antihypertensive Agents; Atenolol; Cerebrovascular Disorders; Chlorthalidone; Double-Blind Met

1989
The Systolic Hypertension in the Elderly Program (SHEP): an intervention trial on isolated systolic hypertension. SHEP Cooperative Research Group.
    Clinical and experimental hypertension. Part A, Theory and practice, 1989, Volume: 11, Issue:5-6

    Topics: Aged; Antihypertensive Agents; Atenolol; Cerebrovascular Disorders; Chlorthalidone; Double-Blind Met

1989
The Systolic Hypertension in the Elderly Program (SHEP): an intervention trial on isolated systolic hypertension. SHEP Cooperative Research Group.
    Clinical and experimental hypertension. Part A, Theory and practice, 1989, Volume: 11, Issue:5-6

    Topics: Aged; Antihypertensive Agents; Atenolol; Cerebrovascular Disorders; Chlorthalidone; Double-Blind Met

1989

Other Studies

4 other studies available for chlorthalidone and Cerebrovascular Disorders

ArticleYear
The practicing physician and control of hypertension.
    Comprehensive therapy, 1980, Volume: 6, Issue:3

    Topics: Adult; Aged; Cerebrovascular Disorders; Chlorthalidone; Coronary Disease; Female; Heart Failure; Hum

1980
Stroke in the elderly treated for systolic hypertension (SHEP).
    Journal of insurance medicine (New York, N.Y.), 1991,Winter, Volume: 23, Issue:4

    Topics: Actuarial Analysis; Age Factors; Aged; Aged, 80 and over; Atenolol; Cerebrovascular Disorders; Chlor

1991
Isolated systolic hypertension in the elderly.
    JAMA, 1991, Jun-26, Volume: 265, Issue:24

    Topics: Aged; Aged, 80 and over; Aging; Cerebrovascular Disorders; Chlorthalidone; Clinical Trials as Topic;

1991
Characteristics of hypertension in the black population.
    Circulation, 1974, Volume: 50, Issue:5

    Topics: Adult; Angiotensin II; Animals; Black or African American; Cardiomegaly; Cerebrovascular Disorders;

1974