chlorthalidone and Cardiovascular Stroke studies

Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.

Research Excerpts

Excerpt	Relevance	Reference
"We conducted a subgroup analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) to compare metabolic, cardiovascular, and renal outcomes in individuals assigned to initial hypertension treatment with a thiazide-like diuretic (chlorthalidone), a calcium channel blocker (CCB; amlodipine), or an ACE inhibitor (lisinopril) in nondiabetic individuals with or without metabolic syndrome."	7.74	Metabolic and clinical outcomes in nondiabetic individuals with the metabolic syndrome assigned to chlorthalidone, amlodipine, or lisinopril as initial treatment for hypertension: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent ( Baimbridge, C; Barzilay, J; Basile, J; Black, HR; Dart, RA; Davis, B; Marginean, H; Nwachuku, C; Thadani, U; Whelton, P; Wong, ND; Wright, JT, 2008)
" We sought to determine whether randomization to lisinopril reduces incident AF or atrial flutter (AFL) compared with chlorthalidone in a large clinical trial cohort with extended post-trial surveillance."	5.24	Pharmacologic Prevention of Incident Atrial Fibrillation: Long-Term Results From the ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial). ( Albert, CM; Alonso, A; Davis, BR; Dewland, TA; Haywood, LJ; Marcus, GM; Simpson, LM; Soliman, EZ; Yamal, JM, 2017)
"To compare the effect of doxazosin, an alpha-blocker, with chlorthalidone, a diuretic, on incidence of CVD in patients with hypertension as part of a study of 4 types of antihypertensive drugs: chlorthalidone, doxazosin, amlodipine, and lisinopril."	5.09	Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). ALLHAT Collaborative Research Group. ( , 2000)
"In older persons with isolated systolic hypertension, stepped-care treatment based on low-dose chlorthalidone exerted a strong protective effect in preventing heart failure."	5.08	Prevention of heart failure by antihypertensive drug treatment in older persons with isolated systolic hypertension. SHEP Cooperative Research Group. ( Applegate, WB; Berge, KG; Berkson, DM; Black, HR; Blaufox, MD; Cohen, JD; Curb, JD; Cutler, J; Davis, BR; Grimm, RH; Kostis, JB; Lacy, CR; McDonald, R; Perry, HM; Schron, E; Smith, WM; Wassertheil-Smoller, S, 1997)
"Amlodipine lowered long-term gout risk compared with lisinopril or chlorthalidone."	3.96	The effects of antihypertensive class on gout in older adults: secondary analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. ( Beach, JL; Davis, BR; Ishak, A; Juraschek, SP; Mukamal, KJ; Shmerling, RH; Simpson, LM, 2020)
"There is significant controversy around whether chlorthalidone (CTD) is superior to hydrochlorothiazide (HCTZ) in hypertension management."	3.77	Chlorthalidone reduces cardiovascular events compared with hydrochlorothiazide: a retrospective cohort analysis. ( Bleske, BE; Dorsch, MP; Erickson, SR; Gillespie, BW; Weder, AB, 2011)
"We conducted a subgroup analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) to compare metabolic, cardiovascular, and renal outcomes in individuals assigned to initial hypertension treatment with a thiazide-like diuretic (chlorthalidone), a calcium channel blocker (CCB; amlodipine), or an ACE inhibitor (lisinopril) in nondiabetic individuals with or without metabolic syndrome."	3.74	Metabolic and clinical outcomes in nondiabetic individuals with the metabolic syndrome assigned to chlorthalidone, amlodipine, or lisinopril as initial treatment for hypertension: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent ( Baimbridge, C; Barzilay, J; Basile, J; Black, HR; Dart, RA; Davis, B; Marginean, H; Nwachuku, C; Thadani, U; Whelton, P; Wong, ND; Wright, JT, 2008)
" Of 10,991 myocardial infarction survivors dispensed atenolol, metoprolol, propranolol, or timolol, 9458 (86."	3.70	Age- and gender-related use of low-dose drug therapy: the need to manufacture low-dose therapy and evaluate the minimum effective dose. ( Anderson, GM; Clark, JP; Gurwitz, JH; Lau, P; Rochon, PA; Shear, NH; Tu, JV, 1999)
"Hyperkalemia was associated with increased risk of combined cardiovascular disease (hazard ratio, 1."	2.77	Clinical significance of incident hypokalemia and hyperkalemia in treated hypertensive patients in the antihypertensive and lipid-lowering treatment to prevent heart attack trial. ( Alderman, MH; Calhoun, DA; Cushman, WC; Davis, BR; Eckfeldt, JH; Einhorn, PT; Ford, CE; Franklin, SS; Furberg, CD; Ong, ST; Oparil, S; Papademetriou, V; Piller, LB; Probstfield, JL, 2012)
"Chlorthalidone was superior to (1) doxazosin mesylate in preventing combined CVD (CCVD) (risk ratio [RR], 1."	2.74	ALLHAT findings revisited in the context of subsequent analyses, other trials, and meta-analyses. ( Alderman, MH; Black, HR; Cushman, WC; Cutler, JA; Davis, BR; Einhorn, PT; Ford, CE; Haywood, LJ; Margolis, KL; Oparil, S; Pressel, SL; Probstfield, JL; Rahman, M; Whelton, PK; Wright, JT, 2009)
"Hypertension is a major cause of heart failure (HF) and is antecedent in 91% of cases."	2.72	Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. ( Colon, P; Crow, R; Cutler, JA; Davis, BR; Dunn, K; Ellsworth, A; Franklin, S; Furberg, C; Goff, D; Golden, J; Leenen, F; Mohiuddin, S; Papademetriou, V; Piller, LB; Proschan, M, 2006)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (13.64)	18.7374
1990's	2 (4.55)	18.2507
2000's	20 (45.45)	29.6817
2010's	13 (29.55)	24.3611
2020's	3 (6.82)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
[NCT00000542]	Phase 3	0 participants	Interventional	1993-08-31	Completed
Effect of Combined Antihypertensive Therapy on Blood Pressure and Sexual Function in Patients With Essential Hypertension[NCT01238705]	Phase 4	280 participants (Anticipated)	Interventional	2008-04-30	Recruiting
[NCT00000514]	Phase 3	0 participants	Interventional	1984-06-30	Completed
Improving Hypertension Control in Individuals With Diabetes[NCT00743808]		11,510 participants (Actual)	Observational	2006-12-31	Completed
[NCT00000487]	Phase 3	0 participants	Interventional	1972-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
ALLHAT: still providing correct answers after 7 years. Current opinion in cardiology, 2010, Volume: 25, Issue:4 Topics: Adrenergic alpha-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Bla	2010
[Recent intervention studies with antihypertensive drugs and their influence on guidelines]. Medizinische Klinik (Munich, Germany : 1983), 2003, Dec-15, Volume: 98, Issue:12 Topics: Adrenergic beta-Antagonists; Aged; Amlodipine; Angiotensin Receptor Antagonists; Angiotensin-Convert	2003

Article	Year
Risk of hospitalized and non-hospitalized gastrointestinal bleeding in ALLHAT trial participants receiving diuretic, ACE-inhibitor, or calcium-channel blocker. PloS one, 2021, Volume: 16, Issue:11 Topics: Aged; Aged, 80 and over; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agen	2021
Pharmacologic Prevention of Incident Atrial Fibrillation: Long-Term Results From the ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial). Circulation. Arrhythmia and electrophysiology, 2017, Volume: 10, Issue:12 Topics: Amlodipine; Antihypertensive Agents; Atrial Fibrillation; Atrial Flutter; Chlorthalidone; Double-Bli	2017
Risk Factors Influencing Outcomes of Atrial Fibrillation in ALLHAT. Journal of the National Medical Association, 2018, Volume: 110, Issue:4 Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Atrial Fibrillation; Atrial Flutter; C	2018
Mortality and morbidity during and after Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial: results by sex. Hypertension (Dallas, Tex. : 1979), 2013, Volume: 61, Issue:5 Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Chlorthalido	2013
Risk of hospitalized gastrointestinal bleeding in persons randomized to diuretic, ACE-inhibitor, or calcium-channel blocker in ALLHAT. Journal of clinical hypertension (Greenwich, Conn.), 2013, Volume: 15, Issue:11 Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel	2013
Clinical and demographic correlates of medication and visit adherence in a large randomized controlled trial. BMC health services research, 2016, 07-08, Volume: 16 Topics: Aged; Amlodipine; Antihypertensive Agents; Appointments and Schedules; Black People; Chlorthalidone;	2016
Electrocardiographic measures of left ventricular hypertrophy in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Journal of the American Society of Hypertension : JASH, 2016, Volume: 10, Issue:12 Topics: Aged; Amlodipine; Antihypertensive Agents; Chlorthalidone; Electrocardiography; Female; Humans; Hype	2016
ALLHAT findings revisited in the context of subsequent analyses, other trials, and meta-analyses. Archives of internal medicine, 2009, May-11, Volume: 169, Issue:9 Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; C	2009
Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study. Pharmacogenetics and genomics, 2012, Volume: 22, Issue:5 Topics: Aged; Amlodipine; Antihypertensive Agents; Chlorthalidone; Coronary Disease; Doxazosin; Female; Foll	2012
Clinical significance of incident hypokalemia and hyperkalemia in treated hypertensive patients in the antihypertensive and lipid-lowering treatment to prevent heart attack trial. Hypertension (Dallas, Tex. : 1979), 2012, Volume: 59, Issue:5 Topics: Aged; Amlodipine; Antihypertensive Agents; Blood Chemical Analysis; Cardiovascular Diseases; Chlorth	2012
Long-term renal and cardiovascular outcomes in Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) participants by baseline estimated GFR. Clinical journal of the American Society of Nephrology : CJASN, 2012, Volume: 7, Issue:6 Topics: Amlodipine; Antihypertensive Agents; Canada; Chlorthalidone; Chronic Disease; Coronary Disease; Doub	2012
Are thiazide diuretics preferred as first-line therapy for hypertension? An appraisal of The Antihypertensive and Lipid-lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Internal medicine journal, 2003, Volume: 33, Issue:7 Topics: Aged; Amlodipine; Benzothiadiazines; Blood Chemical Analysis; Chlorthalidone; Diuretics; Dose-Respon	2003
Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Circulation, 2006, May-09, Volume: 113, Issue:18 Topics: Adrenergic beta-Antagonists; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihyperte	2006
Fasting glucose levels and incident diabetes mellitus in older nondiabetic adults randomized to receive 3 different classes of antihypertensive treatment: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHA Archives of internal medicine, 2006, Nov-13, Volume: 166, Issue:20 Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Glucose;	2006
Cost-effectiveness of chlorthalidone, amlodipine, and lisinopril as first-step treatment for patients with hypertension: an analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Journal of general internal medicine, 2008, Volume: 23, Issue:5 Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Chlorthalidone; Cost	2008
Prevention of heart failure by antihypertensive drug treatment in older persons with isolated systolic hypertension. SHEP Cooperative Research Group. JAMA, 1997, Jul-16, Volume: 278, Issue:3 Topics: Aged; Antihypertensive Agents; Atenolol; Chlorthalidone; Diuretics; Double-Blind Method; Electrocard	1997
National Heart, Lung, and Blood Institute halts part of antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT) Circulation, 2000, Mar-28, Volume: 101, Issue:12 Topics: Adrenergic alpha-Antagonists; Anticholesteremic Agents; Chlorthalidone; Diuretics; Doxazosin; Female	2000
Implications of discontinuation of doxazosin arm of ALLHAT. Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Lancet (London, England), 2000, Mar-11, Volume: 355, Issue:9207 Topics: Adverse Drug Reaction Reporting Systems; Anticholesteremic Agents; Antihypertensive Agents; Chlortha	2000
Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). ALLHAT Collaborative Research Group. JAMA, 2000, Apr-19, Volume: 283, Issue:15 Topics: Adrenergic alpha-Antagonists; Aged; Amlodipine; Anticholesteremic Agents; Antihypertensive Agents; C	2000
Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). ALLHAT Collaborative Research Group. JAMA, 2000, Apr-19, Volume: 283, Issue:15 Topics: Adrenergic alpha-Antagonists; Aged; Amlodipine; Anticholesteremic Agents; Antihypertensive Agents; C	2000
Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). ALLHAT Collaborative Research Group. JAMA, 2000, Apr-19, Volume: 283, Issue:15 Topics: Adrenergic alpha-Antagonists; Aged; Amlodipine; Anticholesteremic Agents; Antihypertensive Agents; C	2000
Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). ALLHAT Collaborative Research Group. JAMA, 2000, Apr-19, Volume: 283, Issue:15 Topics: Adrenergic alpha-Antagonists; Aged; Amlodipine; Anticholesteremic Agents; Antihypertensive Agents; C	2000
Hypokalemia associated with diuretic use and cardiovascular events in the Systolic Hypertension in the Elderly Program. Hypertension (Dallas, Tex. : 1979), 2000, Volume: 35, Issue:5 Topics: Aged; Aged, 80 and over; Blood Pressure; Chlorthalidone; Diuretics; Female; Humans; Hypertension; Hy	2000

Article	Year
Contributions of Systolic and Diastolic Blood Pressures to Cardiovascular Outcomes in the ALLHAT Study. Journal of the American College of Cardiology, 2021, 10-26, Volume: 78, Issue:17 Topics: Aged; Amlodipine; Blood Pressure; Blood Pressure Determination; Cardiovascular Diseases; Chlorthalid	2021
The effects of antihypertensive class on gout in older adults: secondary analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Journal of hypertension, 2020, Volume: 38, Issue:5 Topics: Aged; Amlodipine; Antihypertensive Agents; Atenolol; Blood Pressure; Chlorthalidone; Female; Gout; H	2020
ALLHAT findings revisited in the context of subsequent analyses, other trials, and meta-analyses. Archives of internal medicine, 2009, Oct-26, Volume: 169, Issue:19 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive	2009
Chlorthalidone reduces cardiovascular events compared with hydrochlorothiazide: a retrospective cohort analysis. Hypertension (Dallas, Tex. : 1979), 2011, Volume: 57, Issue:4 Topics: Adult; Angina Pectoris; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Cholesterol; Heart	2011
Initial choice of antihypertensive on long-term cardiovascular outcomes in CKD. Clinical journal of the American Society of Nephrology : CJASN, 2012, Volume: 7, Issue:6 Topics: Amlodipine; Antihypertensive Agents; Chlorthalidone; Female; Glomerular Filtration Rate; Humans; Hyp	2012
How much effect of different antihypertensive medications on cardiovascular outcomes is attributable to their effects on blood pressure? Statistics in medicine, 2013, Feb-28, Volume: 32, Issue:5 Topics: Amlodipine; Antihypertensive Agents; Biostatistics; Blood Pressure; Cardiovascular Diseases; Chlorth	2013
[Old or new antihypertensive drugs? Consequences from ALLHAT. Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial]. Deutsche medizinische Wochenschrift (1946), 2003, Jan-31, Volume: 128, Issue:5 Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel	2003
ALLHAT finds diuretics best for initial hypertension therapy. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2003, Feb-01, Volume: 60, Issue:3 Topics: Amlodipine; Antihypertensive Agents; Chlorthalidone; Clinical Trials as Topic; Diuretics; Humans; Hy	2003
ALLHAT--all hit or all miss? Key questions still remain. The American journal of cardiology, 2003, Aug-01, Volume: 92, Issue:3 Topics: Amlodipine; Antihypertensive Agents; Black People; Chlorthalidone; Humans; Hypolipidemic Agents; Lis	2003
[The new (old) knowledge in primary prevention of stroke. It depends on lowering of blood pressure]. MMW Fortschritte der Medizin, 2003, Volume: 145 Suppl 1 Topics: Adrenergic alpha-Antagonists; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive	2003
ALLHAT: what has it taught us so far? CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2004, Sep-28, Volume: 171, Issue:7 Topics: Amlodipine; Antihypertensive Agents; Chlorthalidone; Humans; Hypertension; Lisinopril; Myocardial In	2004
Preventing vascular events due to elevated blood pressure. Circulation, 2006, May-09, Volume: 113, Issue:18 Topics: Antihypertensive Agents; Cardiovascular Diseases; Chlorthalidone; Comorbidity; Doxazosin; Drug Thera	2006
Metabolic and clinical outcomes in nondiabetic individuals with the metabolic syndrome assigned to chlorthalidone, amlodipine, or lisinopril as initial treatment for hypertension: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Diabetes care, 2008, Volume: 31, Issue:2 Topics: Aged; Amlodipine; Antihypertensive Agents; Atherosclerosis; Blood Pressure; Chlorthalidone; Cohort S	2008
[Withdrawal syndrome following beta blocker therapy (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1981, Oct-16, Volume: 123, Issue:42 Topics: Adult; Angina Pectoris; Atenolol; Chlorthalidone; Female; Humans; Hypertension; Middle Aged; Myocard	1981
Some wrong-way chemical changes during antihypertensive treatment: comparison of indapamide and related agents. American heart journal, 1983, Volume: 106, Issue:1 Pt 2 Topics: Adult; Antihypertensive Agents; Chemical Phenomena; Chemistry; Chlorthalidone; Diuretics; Humans; Hy	1983
Age- and gender-related use of low-dose drug therapy: the need to manufacture low-dose therapy and evaluate the minimum effective dose. Journal of the American Geriatrics Society, 1999, Volume: 47, Issue:8 Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Aged, 80 and over; Atenolol; Chlorthalidone; Confide	1999
How effective is doxazosin compared with chlorthalidone in the treatment of hypertension? The Journal of family practice, 2000, Volume: 49, Issue:7 Topics: Aged; Antihypertensive Agents; Cardiovascular Diseases; Chlorthalidone; Coronary Disease; Diuretics;	2000
[Are all antihypertensive agents equal? Cardiovascular events in hypertensive patients randomized to treatment with doxazosin or chlorthalidone. The ALLHAT study]. Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology, 2000, Volume: 1, Issue:9 Topics: Adrenergic alpha-Antagonists; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive	2000
Treatment of mild hypertension. Preliminary results of a two-year feasibility trial. Circulation research, 1977, Volume: 40, Issue:5 Suppl 1 Topics: Adult; Blood Pressure; Chlorthalidone; Death, Sudden; Humans; Hypertension; Male; Mass Screening; Mi	1977
[Clinical experiences with hemodynamic treatment of ischemic heart disease]. Bollettino della Societa italiana di cardiologia, 1976, Volume: 21, Issue:12 Topics: Adult; Aged; Chlorthalidone; Female; Furosemide; Glucose; Humans; Insulin; Male; Middle Aged; Myocar	1976
Unexpected effects of treating hypertension in men with electrocardiographic abnormalities: a critical analysis. Circulation, 1986, Volume: 73, Issue:1 Topics: Adult; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiomegaly; Catecholamines; Chlorthalid	1986
[On combined therapy of hypertension and heart insufficiency. Advantages and disadvantages]. Wiener klinische Wochenschrift, 1966, Oct-07, Volume: 78, Issue:40 Topics: Arrhythmias, Cardiac; Chlorthalidone; Digitoxin; Drug Synergism; Heart Function Tests; Humans; Hyper	1966

chlorthalidone and Cardiovascular Stroke

Research Excerpts

Research

Studies (44)

Authors

Clinical Trials (5)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Itoga, NK	1
Tawfik, DS	1
Montez-Rath, ME	1
Chang, TI	1
Du, XL	1
Simpson, LM	4
Tandy, BC	1
Bettencourt, JL	1
Davis, BR	18
Juraschek, SP	1
Shmerling, RH	1
Beach, JL	1
Ishak, A	1
Mukamal, KJ	1
Dewland, TA	1
Soliman, EZ	3
Yamal, JM	2
Alonso, A	1
Albert, CM	1
Haywood, LJ	5
Marcus, GM	1
Piller, LB	5
Ghosh, A	2
Einhorn, PT	6
Ford, CE	9
Probstfield, JL	6
Wright, JT	6
Oparil, S	6
Cushman, WC	6
Furberg, CD	5
Habib, GB	1
Margolis, K	1
Whelton, PK	5
Phillips, W	1
Williamson, JD	2
Whittle, J	2
Jafri, SZ	1
Grimm, RH	4
Alderman, MH	4
Beard, BL	1
Marginean, H	2
Hamilton, BP	1
Suhan, PS	1
Ernst, ME	1
Prineas, RJ	1
Okin, PM	1
Pressel, SL	4
Cutler, JA	6
Rahman, M	3
Margolis, KL	2
Black, HR	3
Onuigbo, MA	1
Dorsch, MP	1
Gillespie, BW	1
Erickson, SR	1
Bleske, BE	1
Weder, AB	1
Lynch, AI	1
Eckfeldt, JH	2
Boerwinkle, E	1
Leiendecker-Foster, C	1
Arnett, DK	1
Franklin, SS	2
Papademetriou, V	2
Ong, ST	2
Calhoun, DA	1
Barzilay, JI	2
Brown, CD	1
Colon, PJ	1
Fine, LJ	1
Gupta, AK	1
Baimbridge, C	2
Henriquez, MA	1
Ilamaythi, E	1
Preston, R	1
Whaley-Connell, A	1
Sowers, JR	1
Proschan, M	2
Graumlich, JF	1
Pavlik, V	1
Gordon, D	1
Blumenthal, SS	1
Castaldo, RS	1
Preston, RA	1
Düsing, R	2
Traynor, K	1
Scott, I	1
Stowasser, M	1
Messerli, FH	2
Weber, MA	1
Rahn, KH	1
Leenen, FH	1
Furberg, C	1
Dunn, K	1
Franklin, S	1
Goff, D	1
Leenen, F	1
Mohiuddin, S	1
Ellsworth, A	1
Golden, J	1
Colon, P	1
Crow, R	1
Yusuf, S	1
Basile, J	2
Sadler, LS	1
Summerson, J	1
Davis, B	1
Barzilay, J	1
Nwachuku, C	2
Wong, ND	1
Whelton, P	1
Dart, RA	1
Thadani, U	1
Heidenreich, PA	1
Lairson, DR	1
Shlipak, MG	1
Goldman, L	1
Hausen, T	1
Perry, HM	3
Kostis, JB	1
Cutler, J	1
Berge, KG	1
Cohen, JD	2
Lacy, CR	1
Blaufox, MD	1
Wassertheil-Smoller, S	1
Schron, E	1
Berkson, DM	1
Curb, JD	1
Smith, WM	1
McDonald, R	1
Applegate, WB	2
Rochon, PA	1
Anderson, GM	1
Tu, JV	1
Gurwitz, JH	1
Clark, JP	1
Shear, NH	1
Lau, P	1
SoRelle, R	1
Franse, LV	1
Pahor, M	1
Di Bari, M	1
Somes, GW	1
Koval, PG	1
McDiarmid, T	1
Schillaci, G	1
Verdecchia, P	1
Raineri, A	1
Mercurio, G	1
Traina, M	1
Assennato, P	1
Hoffmann, E	1
Kuller, LH	1
Hulley, SB	1
Neaton, J	1
Hueber, EF	1