chlorthalidone has been researched along with Cardiomegaly in 17 studies
Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixteen patients with severe hypertension were treated for 1 year with extended release nifedipine, during which time serial changes in left ventricular mass index and associated alterations in left ventricular systolic function, left ventricular filling, plasma renin activity, atrial natriuretic peptide and catecholamines were evaluated." | 9.07 | Normalization of left ventricular mass and associated changes in neurohormones and atrial natriuretic peptide after 1 year of sustained nifedipine therapy for severe hypertension. ( Ardeljan, M; Eison, HB; Garbowit, DL; Goldman, ME; Krakoff, LR; Phillips, RA; Shimabukuro, S, 1991) |
| "Sixteen patients with severe hypertension were treated for 1 year with extended release nifedipine, during which time serial changes in left ventricular mass index and associated alterations in left ventricular systolic function, left ventricular filling, plasma renin activity, atrial natriuretic peptide and catecholamines were evaluated." | 5.07 | Normalization of left ventricular mass and associated changes in neurohormones and atrial natriuretic peptide after 1 year of sustained nifedipine therapy for severe hypertension. ( Ardeljan, M; Eison, HB; Garbowit, DL; Goldman, ME; Krakoff, LR; Phillips, RA; Shimabukuro, S, 1991) |
| "Chlorthalidone was given to one group during all 20 days of DOCA administration (preventive regimen) and to another group 20 days after DOCA treatment was initiated until the 40th day (therapeutic regimen)." | 1.29 | Effects of chlorthalidone on ventricular hypertrophy in deoxycorticosterone acetate-salt hypertensive rats. ( Cabral, AM; Carvalhinho, FB; Cicilini, MA; Vasquez, EC, 1994) |
| "To evaluate the effects of the chronic administration of the fixed combination slow-release, oxprenolol 160 mg and chlorthalidone 20 mg on left ventricular hypertrophy, ten hypertensive out-patients, with left ventricular hypertrophy documented by left ventricular mass index (LVMI) greater than 130 g/m2, were studied." | 1.27 | Effects of chronic administration of the fixed combination slow-release oxprenolol-chlorthalidone on left ventricular hypertrophy in hypertensive patients. Echocardiographic study. ( Alberti, D; Bertoni, T; De Ambroggi, L; Francucci, BM; Peloso, A, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (64.71) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| JOHNSTON, LC | 1 |
| GRIEBLE, HG | 1 |
| SCHOENBERGER, JA | 1 |
| FULLER, JB | 1 |
| Sonaglioni, G | 1 |
| Floris, B | 1 |
| Franchetta, G | 1 |
| Palestini, N | 1 |
| Verdecchia, P | 1 |
| Lombardo, M | 1 |
| Zaini, G | 1 |
| Pastori, F | 1 |
| Fusco, M | 1 |
| Pacini, S | 1 |
| Foppoli, C | 1 |
| Cabral, AM | 1 |
| Carvalhinho, FB | 1 |
| Vasquez, EC | 1 |
| Cicilini, MA | 1 |
| Manegold, C | 1 |
| Patzschke, U | 1 |
| Phillips, RA | 2 |
| Ardeljan, M | 2 |
| Shimabukuro, S | 2 |
| Goldman, ME | 2 |
| Garbowit, DL | 2 |
| Eison, HB | 2 |
| Krakoff, LR | 2 |
| González-Juanatey, JR | 1 |
| Amaro Cendón, A | 1 |
| Calvo Gómez, C | 1 |
| Vega Fernández, M | 1 |
| García Acuña, JM | 1 |
| Virgós Lamela, A | 1 |
| Gil de la Peña, M | 1 |
| Gerstenblith, G | 1 |
| Sau, F | 3 |
| Seguro, C | 3 |
| Pili, G | 1 |
| Basciu, M | 1 |
| Siddi, PP | 1 |
| Tamponi, R | 1 |
| Cherchi, A | 3 |
| Kuller, LH | 1 |
| Hulley, SB | 1 |
| Cohen, JD | 1 |
| Neaton, J | 1 |
| Alberti, D | 2 |
| Mohallen, KL | 1 |
| do Patrocínio, LL | 1 |
| Célnik, D | 1 |
| Kruczan, DD | 1 |
| Pinheiro, L | 1 |
| Weitzel, LH | 1 |
| Bosco, J | 1 |
| Sekeff, JA | 1 |
| Azevedo, Ade C | 1 |
| Bertoni, T | 1 |
| Peloso, A | 1 |
| Francucci, BM | 1 |
| De Ambroggi, L | 1 |
| Modai, D | 1 |
| Cohen, N | 1 |
| Weissgarten, J | 1 |
| Segal, B | 1 |
| Pik, A | 1 |
| Kilcoyne, MM | 1 |
| Thomson, GE | 1 |
| Branche, G | 1 |
| Williams, M | 1 |
| Garnier, C | 1 |
| Chiles, B | 1 |
| Soland, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00005122] | 0 participants | Observational | 1958-07-31 | Completed | |||
| [NCT00000487] | Phase 3 | 0 participants | Interventional | 1972-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 trials available for chlorthalidone and Cardiomegaly
| Article | Year |
|---|---|
Left ventricular mass and function before and after antihypertensive treatment.
Topics: Adult; Captopril; Cardiomegaly; Chlorthalidone; Drug Therapy, Combination; Echocardiography; Female; | 1983 |
[Regression of left ventricular mass in arterial hypertension. Efficacy of 3 different treatment protocols].
Topics: Adult; Aged; Atenolol; Blood Pressure; Cardiomegaly; Chlorthalidone; Electrocardiography; Enalapril; | 1992 |
Normalization of left ventricular mass and associated changes in neurohormones and atrial natriuretic peptide after 1 year of sustained nifedipine therapy for severe hypertension.
Topics: Atrial Natriuretic Factor; Cardiomegaly; Chlorthalidone; Delayed-Action Preparations; Echocardiograp | 1991 |
Special considerations in the elderly patient.
Topics: Age Factors; Aged; Aging; Atenolol; Blood Pressure; Cardiac Output; Cardiomegaly; Chlorthalidone; Do | 1990 |
[Electrocardiographic and echocardiographic changes during antihypertensive therapy].
Topics: Acebutolol; Adolescent; Adult; Aged; Antihypertensive Agents; Captopril; Cardiomegaly; Chlorthalidon | 1990 |
Possible regression of left ventricular hypertrophy during antihypertensive treatment with diuretics and/or beta blockers.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Cardiomegaly; Chlorthalidone; Clinical Trials as Topic; Fe | 1987 |
[Normalization of ventricular compliance and hypertrophy in arterial hypertension. Double-blind study with 2 combinations of a beta blocker and diuretic].
Topics: Adult; Atenolol; Blood Pressure; Cardiomegaly; Chlorthalidone; Clinical Trials as Topic; Double-Blin | 1987 |
10 other studies available for chlorthalidone and Cardiomegaly
| Article | Year |
|---|---|
TREATMENT OF ARTERIAL HYPERTENSIVE DISEASE WITH DIURETICS. III. CHLORTHALIDONE ALONE AND IN COMBINATION WITH SPIRONOLACTONE.
Topics: Bendroflumethiazide; Cardiomegaly; Chlorides; Chlorthalidone; Coronary Disease; Creatine; Creatinine | 1964 |
[Regression of left ventricular hypertrophy by a prolonged anti-hypertensive treatment].
Topics: Aged; Antihypertensive Agents; Cardiomegaly; Chlorthalidone; Female; Humans; Male; Metoprolol; Middl | 1982 |
Effects of chlorthalidone on ventricular hypertrophy in deoxycorticosterone acetate-salt hypertensive rats.
Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Chlorthalidone; Desoxycorticosterone; Dose-Respo | 1994 |
[Regression of left ventricular hypertophy in the ECG during antihypertensive treatment: preliminary observations (author's transl)].
Topics: Adult; Aged; Cardiomegaly; Chlorthalidone; Electrocardiography; Female; Humans; Hydralazine; Hyperte | 1979 |
Effects of nifedipine-GITS on left ventricular mass and left ventricular filling.
Topics: Atrial Natriuretic Factor; Cardiomegaly; Chlorthalidone; Delayed-Action Preparations; Drug Therapy, | 1992 |
Unexpected effects of treating hypertension in men with electrocardiographic abnormalities: a critical analysis.
Topics: Adult; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiomegaly; Catecholamines; Chlorthalid | 1986 |
[Reduction of left ventricular hypertrophy and increased tolerance to exertion in hypertensive patients after antihypertensive therapy with slow-release oxprenolol and chlorthalidone].
Topics: Adult; Cardiomegaly; Chlorthalidone; Delayed-Action Preparations; Drug Therapy, Combination; Exercis | 1986 |
Effects of chronic administration of the fixed combination slow-release oxprenolol-chlorthalidone on left ventricular hypertrophy in hypertensive patients. Echocardiographic study.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Cardiomegaly; Chlorthalidone; Creatinine; Delayed-Action | 1988 |
Symptomatic renal artery stenosis superimposed on chronic glomerulonephritis.
Topics: Antihypertensive Agents; Cardiomegaly; Chlorthalidone; Chronic Disease; Creatinine; Furosemide; Glom | 1985 |
Characteristics of hypertension in the black population.
Topics: Adult; Angiotensin II; Animals; Black or African American; Cardiomegaly; Cerebrovascular Disorders; | 1974 |