chlorthalidone and Cardiac Failure studies

Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.

Research Excerpts

Excerpt	Relevance	Reference
"In older persons with isolated systolic hypertension, stepped-care treatment based on low-dose chlorthalidone exerted a strong protective effect in preventing heart failure."	5.08	Prevention of heart failure by antihypertensive drug treatment in older persons with isolated systolic hypertension. SHEP Cooperative Research Group. ( Applegate, WB; Berge, KG; Berkson, DM; Black, HR; Blaufox, MD; Cohen, JD; Curb, JD; Cutler, J; Davis, BR; Grimm, RH; Kostis, JB; Lacy, CR; McDonald, R; Perry, HM; Schron, E; Smith, WM; Wassertheil-Smoller, S, 1997)
"There is significant controversy around whether chlorthalidone (CTD) is superior to hydrochlorothiazide (HCTZ) in hypertension management."	3.77	Chlorthalidone reduces cardiovascular events compared with hydrochlorothiazide: a retrospective cohort analysis. ( Bleske, BE; Dorsch, MP; Erickson, SR; Gillespie, BW; Weder, AB, 2011)
"Background Hypertension is a known risk factor for heart failure ( HF ), possibly via the mechanism of cardiac remodeling and left ventricular hypertrophy ( LVH )."	2.90	Prevention of Heart Failure in Hypertension-Disentangling the Role of Evolving Left Ventricular Hypertrophy and Blood Pressure Lowering: The ALLHAT Study. ( Davis, BR; Johnson, K; Oparil, S; Tereshchenko, LG, 2019)
"Chlorthalidone was superior to (1) doxazosin mesylate in preventing combined CVD (CCVD) (risk ratio [RR], 1."	2.74	ALLHAT findings revisited in the context of subsequent analyses, other trials, and meta-analyses. ( Alderman, MH; Black, HR; Cushman, WC; Cutler, JA; Davis, BR; Einhorn, PT; Ford, CE; Haywood, LJ; Margolis, KL; Oparil, S; Pressel, SL; Probstfield, JL; Rahman, M; Whelton, PK; Wright, JT, 2009)
"Hypertension is a major cause of heart failure (HF) and is antecedent in 91% of cases."	2.72	Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. ( Colon, P; Crow, R; Cutler, JA; Davis, BR; Dunn, K; Ellsworth, A; Franklin, S; Furberg, C; Goff, D; Golden, J; Leenen, F; Mohiuddin, S; Papademetriou, V; Piller, LB; Proschan, M, 2006)
"The doxazosin arm was terminated early, when the trial's safety and monitoring board noted a twofold higher incidence of congestive heart failure in patients receiving doxazosin than in those receiving chlorthalidone (8."	1.31	Alpha-blockers and congestive heart failure: early termination of an arm of the ALLHAT trial. ( Vidt, DG, 2000)
"Type 2 diabetes is increasing in prevalence and is predominantly managed in general practice."	1.30	A cautionary tale. ( Phillips, PJ; Popplewell, PY; Tallis, GA, 1997)
"Treatment with triamterene (100 mg/d; n = 10) over a period of 3 weeks led to an increase of serum potassium (from 4."	1.26	[Serum and total body potassium during treatment with chlortalidone and hydrochlorothiazide. Influence of triamterene (author's transl)]. ( Kaltenbach, M; Kober, G; Schäfer, GE; Werner, E, 1977)

Timeframe	Studies, this research(%)	All Research%
pre-1990	41 (57.75)	18.7374
1990's	3 (4.23)	18.2507
2000's	12 (16.90)	29.6817
2010's	11 (15.49)	24.3611
2020's	4 (5.63)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
[NCT00000542]	Phase 3	0 participants	Interventional	1993-08-31	Completed
Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension[NCT05593055]	Phase 4	75 participants (Anticipated)	Interventional	2023-08-25	Recruiting
Pharmacological Association of the Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism on Blood Pressure and Cardiovascular Risk in Relation to Anti-hypertensive Treatment[NCT00006294]		37,939 participants (Actual)	Observational	1999-09-30	Completed
[NCT00000514]	Phase 3	0 participants	Interventional	1984-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Effects of blood pressure lowering on outcome incidence in hypertension: 4. Effects of various classes of antihypertensive drugs--overview and meta-analyses. Journal of hypertension, 2015, Volume: 33, Issue:2 Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibit	2015
ALLHAT: still providing correct answers after 7 years. Current opinion in cardiology, 2010, Volume: 25, Issue:4 Topics: Adrenergic alpha-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Bla	2010
MANAGEMENT OF RENAL DYSFUNCTION IN CONGESTIVE HEART FAILURE. Biochemical clinics, 1963, Volume: 2 Topics: Acetazolamide; Benzothiadiazines; Chlorthalidone; Diuretics; Heart Failure; Humans; Kidney Diseases;	1963
[The clinical usefulness of diuretics for chronic heart failure in ALLHAT]. Nihon rinsho. Japanese journal of clinical medicine, 2007, Apr-28, Volume: 65 Suppl 4 Topics: Chlorthalidone; Clinical Trials as Topic; Diuretics; Heart Failure; Humans	2007
Combinations of diuretics in the treatment of edema. American heart journal, 1970, Volume: 80, Issue:3 Topics: Acetazolamide; Benzothiadiazines; Chlorthalidone; Diuretics; Edema; Ethacrynic Acid; Furosemide; Glu	1970

Article	Year
Diuretic Strategies in Acute Heart Failure and Renal Dysfunction: Conventional vs Carbohydrate Antigen 125-guided Strategy. Clinical Trial Design. Revista espanola de cardiologia (English ed.), 2017, Volume: 70, Issue:12 Topics: Acetazolamide; Acute Disease; CA-125 Antigen; Cardio-Renal Syndrome; Chlorthalidone; Creatinine; Diu	2017
Risk Factors Influencing Outcomes of Atrial Fibrillation in ALLHAT. Journal of the National Medical Association, 2018, Volume: 110, Issue:4 Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Atrial Fibrillation; Atrial Flutter; C	2018
Prevention of Heart Failure in Hypertension-Disentangling the Role of Evolving Left Ventricular Hypertrophy and Blood Pressure Lowering: The ALLHAT Study. Journal of the American Heart Association, 2019, 04-16, Volume: 8, Issue:8 Topics: Aged; Amlodipine; Antihypertensive Agents; Causality; Chlorthalidone; Doxazosin; Electrocardiography	2019
Prevention of Heart Failure in Hypertension-Disentangling the Role of Evolving Left Ventricular Hypertrophy and Blood Pressure Lowering: The ALLHAT Study. Journal of the American Heart Association, 2019, 04-16, Volume: 8, Issue:8 Topics: Aged; Amlodipine; Antihypertensive Agents; Causality; Chlorthalidone; Doxazosin; Electrocardiography	2019
Prevention of Heart Failure in Hypertension-Disentangling the Role of Evolving Left Ventricular Hypertrophy and Blood Pressure Lowering: The ALLHAT Study. Journal of the American Heart Association, 2019, 04-16, Volume: 8, Issue:8 Topics: Aged; Amlodipine; Antihypertensive Agents; Causality; Chlorthalidone; Doxazosin; Electrocardiography	2019
Prevention of Heart Failure in Hypertension-Disentangling the Role of Evolving Left Ventricular Hypertrophy and Blood Pressure Lowering: The ALLHAT Study. Journal of the American Heart Association, 2019, 04-16, Volume: 8, Issue:8 Topics: Aged; Amlodipine; Antihypertensive Agents; Causality; Chlorthalidone; Doxazosin; Electrocardiography	2019
Mortality and morbidity during and after Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial: results by sex. Hypertension (Dallas, Tex. : 1979), 2013, Volume: 61, Issue:5 Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Chlorthalido	2013
ALLHAT findings revisited in the context of subsequent analyses, other trials, and meta-analyses. Archives of internal medicine, 2009, May-11, Volume: 169, Issue:9 Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; C	2009
Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: the GenHAT study. PloS one, 2012, Volume: 7, Issue:3 Topics: Aged; Alleles; Amlodipine; Antihypertensive Agents; Cardiovascular Diseases; Chlorthalidone; Double-	2012
Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: the GenHAT study. PloS one, 2012, Volume: 7, Issue:3 Topics: Aged; Alleles; Amlodipine; Antihypertensive Agents; Cardiovascular Diseases; Chlorthalidone; Double-	2012
Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: the GenHAT study. PloS one, 2012, Volume: 7, Issue:3 Topics: Aged; Alleles; Amlodipine; Antihypertensive Agents; Cardiovascular Diseases; Chlorthalidone; Double-	2012
Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: the GenHAT study. PloS one, 2012, Volume: 7, Issue:3 Topics: Aged; Alleles; Amlodipine; Antihypertensive Agents; Cardiovascular Diseases; Chlorthalidone; Double-	2012
Long-term renal and cardiovascular outcomes in Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) participants by baseline estimated GFR. Clinical journal of the American Society of Nephrology : CJASN, 2012, Volume: 7, Issue:6 Topics: Amlodipine; Antihypertensive Agents; Canada; Chlorthalidone; Chronic Disease; Coronary Disease; Doub	2012
Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Circulation, 2006, May-09, Volume: 113, Issue:18 Topics: Adrenergic beta-Antagonists; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihyperte	2006
[Clinical evaluation of hygroton K (author's transl)]. Przeglad lekarski, 1981, Volume: 38, Issue:10 Topics: Adult; Aged; Antihypertensive Agents; Chlorthalidone; Clinical Trials as Topic; Diuretics; Female; H	1981
Prevention of heart failure by antihypertensive drug treatment in older persons with isolated systolic hypertension. SHEP Cooperative Research Group. JAMA, 1997, Jul-16, Volume: 278, Issue:3 Topics: Aged; Antihypertensive Agents; Atenolol; Chlorthalidone; Diuretics; Double-Blind Method; Electrocard	1997
National Heart, Lung, and Blood Institute halts part of antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT) Circulation, 2000, Mar-28, Volume: 101, Issue:12 Topics: Adrenergic alpha-Antagonists; Anticholesteremic Agents; Chlorthalidone; Diuretics; Doxazosin; Female	2000
Implications of discontinuation of doxazosin arm of ALLHAT. Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Lancet (London, England), 2000, Mar-11, Volume: 355, Issue:9207 Topics: Adverse Drug Reaction Reporting Systems; Anticholesteremic Agents; Antihypertensive Agents; Chlortha	2000
Alprenolol in hypertension. Acta medica Scandinavica. Supplementum, 1974, Volume: 554 Topics: Aged; Alprenolol; Benzothiadiazines; Chlorthalidone; Clinical Trials as Topic; Digitalis; Diuretics;	1974
[Mefrusid, a new diuretic. A clinical comparison with chlorthalidone with special reference to the water-electrolyte balance]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1970, Jul-01, Volume: 90, Issue:13 Topics: Aged; Chemical Phenomena; Chemistry; Chlorthalidone; Diuretics; Female; Heart Failure; Humans; Male;	1970

Article	Year
Contributions of Systolic and Diastolic Blood Pressures to Cardiovascular Outcomes in the ALLHAT Study. Journal of the American College of Cardiology, 2021, 10-26, Volume: 78, Issue:17 Topics: Aged; Amlodipine; Blood Pressure; Blood Pressure Determination; Cardiovascular Diseases; Chlorthalid	2021
Comparison of chlorthalidone and spironolactone as additional diuretic therapy in patients with acute heart failure and preserved ejection fraction. European heart journal. Acute cardiovascular care, 2022, Jun-07, Volume: 11, Issue:4 Topics: Aged, 80 and over; Chlorthalidone; Diuretics; Female; Heart Failure; Humans; Male; Sodium; Spironola	2022
CANDI study: chlorthalidone vs acetazolamide in patients with diuretic resistance in acute heart failure. Revista espanola de cardiologia (English ed.), 2023, Volume: 76, Issue:6 Topics: Acetazolamide; Chlorthalidone; Diuretics; Heart Failure; Humans	2023
CANDI study: chlorthalidone vs acetazolamide in patients with diuretic resistance in acute heart failure. Revista espanola de cardiologia (English ed.), 2023, Volume: 76, Issue:6 Topics: Acetazolamide; Chlorthalidone; Diuretics; Heart Failure; Humans	2023
CANDI study: chlorthalidone vs acetazolamide in patients with diuretic resistance in acute heart failure. Revista espanola de cardiologia (English ed.), 2023, Volume: 76, Issue:6 Topics: Acetazolamide; Chlorthalidone; Diuretics; Heart Failure; Humans	2023
CANDI study: chlorthalidone vs acetazolamide in patients with diuretic resistance in acute heart failure. Revista espanola de cardiologia (English ed.), 2023, Volume: 76, Issue:6 Topics: Acetazolamide; Chlorthalidone; Diuretics; Heart Failure; Humans	2023
Usefulness of urinary potassium to creatinine ratio to predict diuretic response in patients with acute heart failure and preserved ejection fraction. Clinical cardiology, 2023, Volume: 46, Issue:8 Topics: Aged, 80 and over; Chlorthalidone; Creatinine; Diuretics; Female; Heart Failure; Humans; Male; Potas	2023
Not just chlorthalidone: evidence-based, single tablet, diuretic alternatives to hydrochlorothiazide for hypertension. Current hypertension reports, 2015, Volume: 17, Issue:4 Topics: Animals; Blood Pressure; Chlorthalidone; Evidence-Based Practice; Heart Failure; Humans; Hypertensio	2015
Prevention of heart failure with chlorthalidone in ALLHAT: placing the results into perspective. Journal of clinical hypertension (Greenwich, Conn.), 2009, Volume: 11, Issue:9 Topics: Antihypertensive Agents; Chlorthalidone; Diuretics; Heart Failure; Humans; Hypertension; Sodium Chlo	2009
Chlorthalidone reduces cardiovascular events compared with hydrochlorothiazide: a retrospective cohort analysis. Hypertension (Dallas, Tex. : 1979), 2011, Volume: 57, Issue:4 Topics: Adult; Angina Pectoris; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Cholesterol; Heart	2011
How much effect of different antihypertensive medications on cardiovascular outcomes is attributable to their effects on blood pressure? Statistics in medicine, 2013, Feb-28, Volume: 32, Issue:5 Topics: Amlodipine; Antihypertensive Agents; Biostatistics; Blood Pressure; Cardiovascular Diseases; Chlorth	2013
[The ALLHAT study: contributions, limitations and prospectives]. Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology, 2003, Volume: 4, Issue:2 Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Cardiov	2003
[The new (old) knowledge in primary prevention of stroke. It depends on lowering of blood pressure]. MMW Fortschritte der Medizin, 2003, Volume: 145 Suppl 1 Topics: Adrenergic alpha-Antagonists; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive	2003
[Diuretic and saluretic activity of Hygroton in emphysematous and silicotic patients with cardiorespiratory insufficiency]. La Medicina del lavoro, 1961, Volume: 52 Topics: Chlorthalidone; Diuretics; Heart Failure; Humans; Pulmonary Emphysema; Silicosis	1961
[Clinical experiences in the treatment of edematous diseases with Hygroton]. Therapie der Gegenwart, 1961, Volume: 100 Topics: Ascites; Chlorthalidone; Diuretics; Edema; Heart Failure; Humans; Nephrosis	1961
[Diuretic and saluretic action of an aldosterone antagonist (spirolactone, SC-9420) associated with an iso-indoline derivative (Hygroton) in refractory cardiac edema]. Bollettino della Societa italiana di cardiologia, 1962, Volume: 7 Topics: Aldosterone; Antihypertensive Agents; Chlorthalidone; Diuretics; Edema, Cardiac; Heart Failure; Indo	1962
[Experiences with chlorthalidone (Hygroton)]. Geneeskundige gids, 1963, Apr-18, Volume: 41 Topics: Ascites; Chlorthalidone; Edema; Heart Failure; Liver Cirrhosis	1963
Comparison of meralluride with a new oral diuretic. The Illinois medical journal, 1963, Volume: 124 Topics: Chlorthalidone; Diuretics; Heart Failure; Hypertension; Liver Cirrhosis; Organomercury Compounds; Or	1963
Chlorthalidone, a new oral diuretic: preliminary report. Applied therapeutics, 1961, Volume: 3 Topics: Chlorthalidone; Diuretics; Heart Failure; Liver Cirrhosis	1961
TREATMENT OF EDEMA BY THE COMBINED ADMINISTRATION OF CHEMICALLY DIFFERENT DIURETIC AGENTS. The American journal of cardiology, 1963, Volume: 12 Topics: Ascites; Chlorthalidone; Diuretics; Edema; Heart Failure; Humans; Hydrochlorothiazide; Organomercury	1963
[ON ION TRANSPORT BEFORE AND AFTER TREATMENT OF CONGESTIVE HEART FAILURE]. Turk Tip Cemiyeti mecmuasi, 1963, Volume: 29 Topics: Chlorthalidone; Coronary Disease; Digitalis Glycosides; Diuretics; Electrolytes; Heart Failure; Huma	1963
[ON THE DOSAGE OF SALURETICS]. Wiener medizinische Wochenschrift (1946), 1963, Dec-07, Volume: 113 Topics: Alkalosis; Chlorthalidone; Diuretics; Edema; Female; Heart Failure; Liver Cirrhosis; Pregnancy; Preg	1963
TREATMENT OF ARTERIAL HYPERTENSIVE DISEASE WITH DIURETICS. III. CHLORTHALIDONE ALONE AND IN COMBINATION WITH SPIRONOLACTONE. The American journal of the medical sciences, 1964, Volume: 247 Topics: Bendroflumethiazide; Cardiomegaly; Chlorides; Chlorthalidone; Coronary Disease; Creatine; Creatinine	1964
NEUTROPENIA ASSOCIATED WITH CHLORTHALIDONE THERAPY. The Medical journal of Australia, 1964, Mar-07, Volume: 1 Topics: Agranulocytosis; Chlorthalidone; Geriatrics; Heart Failure; Neutropenia; Toxicology	1964
[THE TREATMENT OF EDEMA WITH SULFONAMIDE DIURETICS]. Vie medicale (Paris, France : 1920), 1964, Volume: 45 Topics: Acetazolamide; Acidosis; Benzothiadiazines; Chlorothiazide; Chlorthalidone; Dehydration; Diuretics;	1964
TRIAMTERENE COMBINED WITH OTHER DIURETICS IN CONGESTIVE HEART FAILURE. Acta cardiologica, 1964, Volume: 19 Topics: Chlorthalidone; Diuretics; Geriatrics; Heart Failure; Pterins; Spironolactone; Toxicology; Triamtere	1964
CARDIAC AND METABOLIC DISEASE, AND INFECTIONS IN THE OBSTETRIC PATIENT. Clinical obstetrics and gynecology, 1964, Volume: 13 Topics: Acetazolamide; Acid-Base Equilibrium; Blood Circulation; Chlorothiazide; Chlorthalidone; Diet, Sodiu	1964
[CLINICAL STUDY OF THE INTERACTION OF DIGITALIS AND A DIURETIC ON POTASSIUM AND SODIUM METABOLISM]. Acta clinica Belgica, 1964, Volume: 19 Topics: Chlorthalidone; Digitalis; Digitalis Glycosides; Diuretics; Heart Failure; Humans; Metabolism; Potas	1964
[URATIC ARTHRITIS AS A COMPLICATION OF DIURETIC THERAPY]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1964, Jul-15, Volume: 84 Topics: Arthritis; Chlorothiazide; Chlorthalidone; Diuretics; Gout; Heart Failure; Hypertension; Rheumatic H	1964
A NEW EFFECTIVE DIURETIC--LASIX. British medical journal, 1964, Oct-10, Volume: 2, Issue:5414 Topics: Chlorthalidone; Diuretics; Drug Therapy; Furosemide; Heart Failure; Hydrochlorothiazide; Hypokalemia	1964
A CLINICAL TRIAL OF FRUSEMIDE. Lancet (London, England), 1964, Nov-21, Volume: 2, Issue:7369 Topics: Biomedical Research; Blood Chemical Analysis; Chlorides; Chlorthalidone; Diuretics; Fluids and Secre	1964
CLINICAL AND BIOCHEMICAL STUDIES ON A NEW DIURETIC: CHLORTHALIDONE. The Journal of the Association of Physicians of India, 1964, Volume: 12 Topics: Adolescent; Chlorthalidone; Diuretics; Drug Therapy; Edema; Geriatrics; Heart Failure; Kidney Diseas	1964
CLINICAL EVALUATION OF POLYTHIAZIDE IN HYPERTENSION AND CONGESTIVE HEART FAILURE: A COMPARATIVE DOUBLE-BLIND STUDY. The American journal of the medical sciences, 1965, Volume: 249 Topics: Biomedical Research; Blood Chemical Analysis; Blood Pressure; Body Weight; Chlorthalidone; Diuresis;	1965
FUROSEMIDE (LASIX) AS A DIURETIC. Acta medica Scandinavica, 1965, Volume: 177 Topics: Chlorothiazide; Chlorthalidone; Diuretics; Drug Therapy; Furosemide; Heart Failure; Hydrochlorothiaz	1965
Preventing vascular events due to elevated blood pressure. Circulation, 2006, May-09, Volume: 113, Issue:18 Topics: Antihypertensive Agents; Cardiovascular Diseases; Chlorthalidone; Comorbidity; Doxazosin; Drug Thera	2006
Hypertensive vascular disease. The long term effect of rapid repeated reductions of arterial pressure with diazoxide. The American journal of cardiology, 1967, Volume: 19, Issue:3 Topics: Adult; Chlorthalidone; Diazoxide; Female; Heart Failure; Humans; Hydralazine; Hypertension; Injectio	1967
The practicing physician and control of hypertension. Comprehensive therapy, 1980, Volume: 6, Issue:3 Topics: Adult; Aged; Cerebrovascular Disorders; Chlorthalidone; Coronary Disease; Female; Heart Failure; Hum	1980
[Acute tubular necrosis caused by combination of diuretics in the treatment of several heart failure. A call to attention]. Revista clinica espanola, 1997, Volume: 197, Issue:8 Topics: Aged; Chlorthalidone; Diuretics; Furosemide; Heart Failure; Humans; Kidney Tubular Necrosis, Acute;	1997
A cautionary tale. Australian family physician, 1997, Volume: 26, Issue:10 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Calcium Channel Blockers; Ch	1997
Alpha-blockers and congestive heart failure: early termination of an arm of the ALLHAT trial. Cleveland Clinic journal of medicine, 2000, Volume: 67, Issue:6 Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Chlorthalidone; Doxazosin; Female; Heart Fail	2000
First-line antihypertensive therapy. Lancet (London, England), 2000, Aug-05, Volume: 356, Issue:9228 Topics: Antihypertensive Agents; Chlorthalidone; Doxazosin; Heart Failure; Humans; Myocardium; Randomized Co	2000
[Alpha-blockers in therapy of arterial hypertension. No longer the drug of first choice]. MMW Fortschritte der Medizin, 2001, May-31, Volume: 143, Issue:22 Topics: Adrenergic alpha-Antagonists; Aged; Antihypertensive Agents; Cause of Death; Chlorthalidone; Doxazos	2001
[Serum and total body potassium during treatment with chlortalidone and hydrochlorothiazide. Influence of triamterene (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1977, Dec-16, Volume: 102, Issue:50 Topics: Adult; Aged; Chlorthalidone; Drug Therapy, Combination; Female; Heart Failure; Humans; Hydrochloroth	1977
Carotid sinus hypersensitivity with alpha methyldopa. Annals of internal medicine, 1978, Volume: 88, Issue:2 Topics: Aged; Carotid Sinus; Chlorthalidone; Female; Heart Failure; Humans; Hypersensitivity; Methyldopa; Re	1978
Systemic hypertension complicating tetralogy of Fallot: effects of antihypertensive therapy. The American journal of cardiology, 1978, Volume: 42, Issue:2 Topics: Adult; Angiocardiography; Cardiac Catheterization; Chlorthalidone; Female; Heart Failure; Heart Sept	1978
[On the pathogenesis and treatment of cardiac insufficiency]. Recenti progressi in medicina, 1978, Volume: 65, Issue:2 Topics: Chlorthalidone; Digoxin; Furosemide; Heart Failure; Humans; Water-Electrolyte Balance	1978
[Combined treatment with furosemide, aldactone and hygroton in chronic right-ventricular circulatory failure]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 1977, Aug-01, Volume: 30, Issue:15 Topics: Chlorthalidone; Drug Therapy, Combination; Female; Furosemide; Heart Failure; Heart Ventricles; Huma	1977
[Use of saluretic preparation hygrotone for the treatment of patients with chronic circulatory insufficiency]. Kardiologiia, 1974, Volume: 14, Issue:7 Topics: Adult; Aged; Ammonia; Chlorthalidone; Chronic Disease; Diuresis; Female; Glomerular Filtration Rate;	1974
Importance of the adrenergic nervous system in the support of cardiac function in patients with primary arterial hypertension. Clinical science and molecular medicine. Supplement, 1973, Volume: 45 Suppl 1 Topics: Body Weight; Cardiac Output; Chlorthalidone; Digitalis Glycosides; Glomerular Filtration Rate; Guane	1973
[Cardiac insufficiency appearing in essential arterial hypertension]. Bulletin de l'Academie royale de medecine de Belgique, 1972, Volume: 12, Issue:2 Topics: Chlorthalidone; Guanethidine; Heart Failure; Humans; Hypertension; Reserpine	1972
Management of refractory heart failure. Progress in cardiovascular diseases, 1970, Volume: 12, Issue:6 Topics: Arrhythmias, Cardiac; Benzothiadiazines; Chlorthalidone; Digitalis Glycosides; Diuretics; Heart Fail	1970
[Some aspects of renal metabolism of citric acid]. Minerva medica, 1970, Sep-01, Volume: 61, Issue:70 Topics: Adult; Age Factors; Aged; Chlorthalidone; Citrates; Heart Failure; Humans; Hydrochlorothiazide; Hype	1970
Failure of repeated diazoxide injections to modify the course of severe hypertension. American heart journal, 1971, Volume: 81, Issue:5 Topics: Antihypertensive Agents; Blood Pressure; Chlorthalidone; Diazoxide; Diuretics; Guanethidine; Heart F	1971
[Furosemide in the treatment of cardiac insufficiency]. Medicina interna, 1967, Volume: 19, Issue:11 Topics: Adult; Aged; Chlorothiazide; Chlorthalidone; Diuresis; Electrolytes; Female; Furosemide; Heart Failu	1967
[Diuretic therapy with chlorthalidone in congestive heart failure caused by chronic cor pulmonale]. La Clinica terapeutica, 1967, Jul-15, Volume: 42, Issue:1 Topics: Adult; Aged; Chlorthalidone; Chronic Disease; Diuresis; Electrolytes; Heart Failure; Humans; Male; M	1967

chlorthalidone and Cardiac Failure

Research Excerpts

Research

Studies (71)

Authors

Clinical Trials (4)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Itoga, NK	1
Tawfik, DS	1
Montez-Rath, ME	1
Chang, TI	1
Llàcer, P	3
Núñez, J	3
García, M	2
Ruiz, R	2
López, G	2
Fabregate, M	2
Fernández, C	2
Croset, F	2
Del Hoyo, B	2
Gomis, A	2
Manzano, L	2
Vela Martín, P	2
Matutano Muñoz, A	2
Sánchez Ortiz, D	2
Domínguez, F	2
Royuela, A	2
Cobo Marcos, M	2
Campos, J	1
García-Blas, S	1
Bonanad, C	1
Ventura, S	1
Núñez, JM	1
Sánchez, R	1
Chamorro, C	1
Fácila, L	1
de la Espriella, R	1
Vaquer, JM	1
Cordero, A	1
Roqué, M	1
Ortiz, V	1
Racugno, P	1
Bodí, V	1
Valero, E	1
Santas, E	1
Moreno, MDC	1
Miñana, G	1
Carratalá, A	1
Bondanza, L	1
Payá, A	1
Cardells, I	1
Heredia, R	1
Pellicer, M	1
Valls, G	1
Palau, P	1
Bosch, MJ	1
Raso, R	1
Sánchez, A	1
Bertomeu-González, V	1
Bertomeu-Martínez, V	1
Montagud-Balaguer, V	1
Albiach-Montañana, C	1
Pendás-Meneau, J	1
Marcaida, G	1
Cervantes-García, S	1
San Antonio, R	1
de Mingo, E	1
Chorro, FJ	1
Sanchis, J	1
Haywood, LJ	4
Davis, BR	10
Piller, LB	3
Simpson, LM	1
Ghosh, A	1
Einhorn, PT	3
Ford, CE	6
Probstfield, JL	3
Soliman, EZ	1
Wright, JT	5
Johnson, K	1
Oparil, S	4
Tereshchenko, LG	1
Cushman, WC	3
Furberg, CD	2
Habib, GB	1
Margolis, K	1
Whelton, PK	4
Thomopoulos, C	1
Parati, G	1
Zanchetti, A	1
Roush, GC	1
Ernst, ME	1
Kostis, JB	2
Kaur, R	1
Sica, DA	1
Pressel, SL	2
Cutler, JA	4
Rahman, M	3
Margolis, KL	1
Black, HR	2
Alderman, MH	2
Massie, BM	1
Dorsch, MP	1
Gillespie, BW	1
Erickson, SR	1
Bleske, BE	1
Weder, AB	1
Zhang, X	1
Lynch, AI	1
Boerwinkle, E	1
Eckfeldt, JH	1
Leiendecker-Foster, C	1
Arnett, DK	1
Barzilay, JI	1
Brown, CD	1
Colon, PJ	1
Fine, LJ	1
Grimm, RH	2
Gupta, AK	1
Baimbridge, C	1
Henriquez, MA	1
Ilamaythi, E	1
Preston, R	1
Proschan, M	2
Graumlich, JF	1
Pavlik, V	1
Gordon, D	1
Franklin, SS	1
Blumenthal, SS	1
Castaldo, RS	1
Preston, RA	1
Mancia, G	1
Düsing, R	1
SARTORELLI, E	2
GRISLER, R	1
GRIECO, A	1
ZEDDA, S	1
GLASER, E	1
RUST, S	1
STRATA, A	1
PREIS, H	1
PISO, HJ	1
GOODMAN, RM	1
COMINGS, DE	1
STEIGMANN, F	1
VOLPE, R	1
MAUTNER, LS	1
SELLER, RH	1
FUCHS, M	1
SWARTZ, C	1
BREST, AN	2
MOYER, JH	1
THAYER, JM	1
HEALY, FA	1
OZDOGAN, E	1
WOLKERSTORFER, H	1
JOHNSTON, LC	1
GRIEBLE, HG	1
SCHOENBERGER, JA	1
FULLER, JB	1
TURNER, NA	1
WOODLIFF, HJ	1
BAGROS, P	1
JOOSSENS, JV	1
VERWILGEN, R	1
VERBERCKMOES, R	1
PLATT, MA	1
STAQUET, M	1
DEMANET, JC	1
MERCENIER, J	1
LIUM, O	1
TVETER, KJ	1
STOKES, W	1
VEREL, D	1
STENTIFORD, NH	1
RAHMAN, F	1
SAYNOR, R	1
RAO, CR	1
SAMSON, WE	1
PELTOLA, P	1
Furberg, C	1
Dunn, K	1
Franklin, S	1
Goff, D	1
Leenen, F	1
Mohiuddin, S	1
Papademetriou, V	1
Ellsworth, A	1
Golden, J	1
Colon, P	1
Crow, R	1
Yusuf, S	1
Taniguchi, I	1
Kawai, M	1
Finnerty, FA	2
Davidov, M	1
Kakaviatos, N	1
Rylski, M	1
Rawczyńska-Englert, I	1
Hoffman, M	1
Borhani, NO	1
Cutler, J	1
Berge, KG	1
Cohen, JD	1
Lacy, CR	1
Perry, HM	1
Blaufox, MD	1
Wassertheil-Smoller, S	1
Schron, E	1
Berkson, DM	1
Curb, JD	1
Smith, WM	1
McDonald, R	1
Applegate, WB	1
de Luis, DA	1
Liaño, F	1
Pascual, J	1
Ortuño, J	1
Tallis, GA	1
Phillips, PJ	1
Popplewell, PY	1
SoRelle, R	1
Messerli, FH	1
Vidt, DG	1
Osnes, JB	1
Aass, H	1
Andersen, GO	1
Skomedal, T	1
Faulhaber, HD	1
Schäfer, GE	1
Werner, E	1
Kober, G	1
Kaltenbach, M	1
Bauernfeind, R	1
Hall, C	1
Denes, P	1
Rosen, KM	1
Benge, W	1
White, CW	1
Majorano, G	1
Florkiewicz, H	1
Rymar, B	1
Rumiński, W	1
Staśkiewicz, J	1
Sidorenko, BA	1
Kharchenko, VI	1
Tol'stykh, AN	1
Guazzi, M	1
Polese, A	1
Fiorentini, C	1
Magrini, F	1
Johnsson, G	1
Leiter, L	1
Bartorelli, C	1
Gisholt, K	1
Berg, KJ	1
Gastaldi, L	1
Buccianti, G	1
Rizzato, G	1
Marazzini, L	1
Bucur, V	1
Bunghez, G	1
Tomasini, M	1