Compounds > chlorthalidone

Page last updated: 2024-10-25

chlorthalidone and Albuminuria

chlorthalidone has been researched along with Albuminuria in 1 studies

Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.

Albuminuria: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.

Research Excerpts

Excerpt	Relevance	Reference
"We randomly assigned patients with stage 4 chronic kidney disease and poorly controlled hypertension, as confirmed by 24-hour ambulatory blood-pressure monitoring, in a 1:1 ratio to receive chlorthalidone at an initial dose of 12."	9.41	Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease. ( Agarwal, R; Balmes-Fenwick, M; Cramer, AE; Dickinson, JH; Ouyang, F; Sinha, AD; Tu, W, 2021)
"We randomly assigned patients with stage 4 chronic kidney disease and poorly controlled hypertension, as confirmed by 24-hour ambulatory blood-pressure monitoring, in a 1:1 ratio to receive chlorthalidone at an initial dose of 12."	5.41	Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease. ( Agarwal, R; Balmes-Fenwick, M; Cramer, AE; Dickinson, JH; Ouyang, F; Sinha, AD; Tu, W, 2021)

Research

Studies (1)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (100.00)	2.80

Authors

Authors	Studies
Agarwal, R	1
Sinha, AD	1
Cramer, AE	1
Balmes-Fenwick, M	1
Dickinson, JH	1
Ouyang, F	1
Tu, W	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
[NCT02841280]			Phase 2	160 participants (Actual)	Interventional	2016-07-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline to 12 Weeks in Systolic Ambulatory Blood Pressure in the Chlorthalidone Group Compared to Placebo.

(NCT02841280)
Timeframe: Baseline to 12 weeks

Intervention	mm Hg (Mean)
Chlorthalidone	-11.0
Placebo	-0.5

Change From Baseline at Each 4 Week Visit in Body Volume in the Chlorthalidone Group Compared to Placebo. No Adjustments Will be Made for Multiple Comparisons.

(NCT02841280)
Timeframe: Baseline to 12 weeks

,

Intervention	Liters (Mean)
	Change in body volume 4 weeks from baseline	Change in body volume 8 weeks from baseline	Change in body volume 12 weeks from baseline
Chlorthalidone	-1.1	-1.7	-2
Placebo	0.2	0.3	0.3

Change From Baseline at Each 4 Week Visit in Log of Aldosterone and Log of Renin in the Chlorthalidone Group Compared to Placebo. No Adjustments Will be Made for Multiple Comparisons.

(NCT02841280)
Timeframe: Baseline to 12 weeks

,

Intervention	percentage of change (Geometric Mean)
	Percent change 4 weeks from baseline in aldosterone	Percent change 8 weeks from baseline in aldosterone	Percent change 12 weeks from baseline in aldosterone	Percent change 4 weeks from baseline in renin	Percent change 8 weeks from baseline in renin	Percent change 12 weeks from baseline in renin
Chlorthalidone	57	65	52	57	67	64
Placebo	16	12	8	14	5	15

Change From Baseline at Each 4 Week Visit in Log of N-terminal Pro B-type Natriuretic Peptide (NTproBNP) in the Chlorthalidone Group Compared to Placebo. No Adjustments Will be Made for Multiple Comparisons.

(NCT02841280)
Timeframe: Baseline to 12 weeks

,

Intervention	percentage of change in NTproBNP (Geometric Mean)
	Percent change from 4 weeks from baseline in NTproBNP	Percent change from 8 weeks from baseline in NTproBNP	Percent change from 12 weeks from baseline in NTproBNP
Chlorthalidone	-25	-32	-30
Placebo	-14	5	-11

Changes in Albuminuria From Baseline at Each 4 Week Visit in the Log Transformed Albumin/Creatinine Ratio in the Chlorthalidone Group Compared to Placebo

(NCT02841280)
Timeframe: Baseline to 12 weeks

,

Intervention	percentage of change in UACR (Mean)
	Percent change in albuminuria 4 weeks from baseline in UACR	Percent change in albuminuria 8 weeks from baseline in UACR	Percent change in albuminuria 12 weeks from baseline in UACR
Chlorthalidone	-41	-45	-52
Placebo	-7	-3	-4

Trials

1 trial available for chlorthalidone and Albuminuria

Article	Year
Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease. The New England journal of medicine, 2021, 12-30, Volume: 385, Issue:27 Topics: Aged; Albuminuria; Blood Pressure; Chlorthalidone; Creatinine; Diuretics; Double-Blind Method; Femal	2021