chlortetracycline and Urethritis

In a double-blind comparison of two regimens of triple tetracycline (Deteclo, Lederle) in the treatment of nongonococcal urethritis, 68 (88.6%) of 70 patients treated with one tablet twice for 21 days and seen four weeks after starting therapy had satisfactory results. This was significantly better than the findings among the 73 patients treated with one tablet twice daily for seven days and followed for four weeks, among whom only 47 (64.4%) had satisfactory results. Results were also better for the group treated with the 21-day regimen at three months afer the start of treatment. When analysed individually at four and 12 weeks, urethral discharge, urethral Gram-stained smears, and first-glass urine test all gave similar results, which were markedly better than those before treatment. It appears that the longer course of treatment it indicated where any regular partner may not be treated. Slightly fewer patients had satisfactory results among those who admitted consuming alcohol than among those who did not. Chlamydiae-negative patients, treated for seven days, had fewer clinically satisfactory results than other sub-groups.

Topics: Chlamydia trachomatis; Chlortetracycline; Clinical Trials as Topic; Demeclocycline; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; Humans; Male; Random Allocation; Recurrence; Tetracycline; Time Factors; Urethritis

Details are given of a double-blind trial involving 400 cases in which tetracycline 500 mg. four times a day for 7 days was compared with tetracycline 250 mg. four times a day for 14 days and also of the findings in 311 cases treated with Deteclo 300 mg. three times a day for 3 weeks. The treatment in the double-blind trial were equally effective and appeared to be as effective as the long-term Deteclo therapy. When the results of these treatments were compared with those obtained previously with tetracycline 250 mg. four times a day for 4 days and allowance was made for the time at which the latter results have been assessed, it was concluded that neither the treatment used in the double-blind trial nor Deteclo 300 mg. three times a day for 3 weeks offered any advantage over the customary treatment with tetracycline 250 mg, four times a day for 4 days.

Topics: Chlortetracycline; Clinical Trials as Topic; Demeclocycline; Humans; Oxytetracycline; Tetracycline; Tetracyclines; Time Factors; Urethritis

Topics: Anti-Bacterial Agents; Chlortetracycline; Clinical Trials as Topic; Demeclocycline; England; Erythromycin; Humans; Leucomycins; Male; Tetracycline; Troleandomycin; Urethritis; Wales

Topics: Chlortetracycline; Clinical Trials as Topic; Gonorrhea; Humans; Male; Nausea; Urethritis

Topics: Anti-Bacterial Agents; Azithromycin; Chlamydia Infections; Chlamydia trachomatis; Chlortetracycline; Contact Tracing; Demeclocycline; Doxycycline; Drug Therapy, Combination; Erythromycin; Humans; Male; Ofloxacin; Recurrence; Tetracycline; Urethritis

Chlamydial and non-chlamydial nonspecific or postgonococcal urethritis in 132 men was treated with different regimens of chlortetracycline and doxycycline. Chlortetracycline 250 mg four times daily for 12.5-18.5 days given to 70 men resulted in a clinical cure of urethritis in 80% of cases (56/70). There was no difference in the cure rate between chlamydia-positive (40) and chlamydia-negative (30) cases. In no instance was the treatment failure, i.e., re-appearance of urethritis, associated with re-isolation of C. trachomatis. Forty-two men received 4-10 days treatment with chlortetracycline and their cure rate was 67% (28/42). In this group 29 men were initially chlamydia-positive and among this group 12 relapsed. In four cases this relapse was associated with re-isolation of C. trachomatis. In a group of 20 men treated with doxycycline (100 mg daily up to 20 days) the cure rate was 45% (9/20)) only.

Topics: Chlamydia Infections; Chlamydia trachomatis; Chlortetracycline; Doxycycline; Drug Evaluation; Follow-Up Studies; Humans; Male; Time Factors; Urethritis

Topics: Administration, Oral; Anemia, Hemolytic; Blood-Brain Barrier; Chlortetracycline; Demeclocycline; Doxycycline; Drug Hypersensitivity; Female; Glucosephosphate Dehydrogenase Deficiency; Gonorrhea; Humans; Injections, Intramuscular; Intestinal Absorption; Male; Methacycline; Minocycline; Oxytetracycline; Penicillins; Tetracycline; Urethritis

Topics: Administration, Oral; Adolescent; Adult; Chlortetracycline; Demeclocycline; Drug Combinations; Humans; Male; Middle Aged; Oxytetracycline; Tetracycline; Time Factors; Urethritis

Topics: Administration, Oral; Adolescent; Adult; Chlortetracycline; Demeclocycline; Diarrhea; Drug Combinations; Gonorrhea; Humans; Male; Metoclopramide; Microbial Sensitivity Tests; Nausea; Promazine; Recurrence; Tetracycline; Urethritis; Vomiting

Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Chlortetracycline; Demeclocycline; Humans; Male; Middle Aged; Oxytetracycline; Penicillins; Streptomycin; Urethritis

Topics: Acute Disease; Chlortetracycline; Demeclocycline; Gonorrhea; Urethritis

Topics: Chloramphenicol; Chlortetracycline; Gonorrhea; Urethritis

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Chloramphenicol; Chlortetracycline; Dermatologic Agents; Humans; Incidence; Nitrofurantoin; Urethritis

Topics: Chlortetracycline; Humans; Oxytetracycline; Urethritis

Topics: Chlortetracycline; Urethritis

Topics: Chlortetracycline; Gonorrhea; Sulfanilamide; Sulfanilamides; Sulfonamides; Urethritis

Topics: Chlortetracycline; Urethritis

Topics: Chlortetracycline; Gonorrhea; Sulfanilamide; Sulfanilamides; Sulfonamides; Urethritis

Topics: Anti-Bacterial Agents; Chlortetracycline; Urethritis

Topics: Chlortetracycline; Urethritis

Topics: Biomedical Research; Chloramphenicol; Chlortetracycline; Gonorrhea; Humans; Penicillins; Urethritis

Topics: Chlortetracycline; Humans; Male; Streptomycin; Urethritis

Topics: Chlortetracycline; Urethritis

Topics: Chlortetracycline; Urethritis

Topics: Chlortetracycline; Urethritis

Topics: Chlortetracycline; Urethritis

Topics: Chlortetracycline; Disease; Hydrarthrosis; Knee; Knee Joint; Syndrome; Urethritis

Topics: Chlortetracycline; Probability; Urethritis

Topics: Chlortetracycline; Gonorrhea; Humans; Inflammation; Male; Urethra; Urethritis