chlortetracycline and Respiratory-Tract-Diseases

To determine effects of time of administration of tilmicosin and feeding of chlortetracycline on colonization of the nasopharynx of transported cattle by Mannheimia haemolytica (MH).. 454 steers (body weight, 200 kg).. 3 studies included 4 truckloads of steers assembled and processed in the southeastern United States. For each truckload of steers, a third received tilmicosin before transportation (PRIOR), then all were transported to a feedlot in New Mexico (23 hours). At arrival (day 0), another third received tilmicosin (ARR). The remaining third did not receive tilmicosin (control steers [CTR]). Steers in studies 1 and 2 were housed in a feedlot, and steers in study 3 were housed on wheat pasture. One half of the steers from each group in studies 2 and 3 were fed chlortetracycline on days 5 to 9. Steer with signs of respiratory tract disease were treated. Nasal swab specimens were examined for MH to determine colonization.. PRIOR and ARR steers had a lower incidence of respiratory tract disease and MH colonization than CTR steers, but PRIOR and ARR steers did not differ. Feeding chlortetracycline did not have an effect.. Tilmicosin can inhibit MH from colonizing the nasopharynx of cattle. Because tilmicosin inhibits the growth of MH in the respiratory tract, medication with tilmicosin prior to transport should reduce the incidence of acute respiratory tract disease during the first week at the feedlot when calves are most susceptible to infectious organisms.

Topics: Administration, Oral; Animal Feed; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cattle; Cattle Diseases; Chlortetracycline; Drug Administration Schedule; Macrolides; Male; Nasal Mucosa; New Mexico; Orchiectomy; Pasteurellaceae; Pasteurellaceae Infections; Respiratory Tract Diseases; Southeastern United States; Transportation; Tylosin

Topics: Acute Disease; Adolescent; Adult; Aged; Aminosalicylic Acids; Chlortetracycline; Chronic Disease; Dihydrostreptomycin Sulfate; Female; Furunculosis; Humans; Laryngitis; Male; Maxillary Sinus; Middle Aged; Nose Diseases; Otitis Media; Penicillin V; Pharyngitis; Respiratory Tract Diseases; Sinusitis; Tonsillitis

Topics: Anti-Bacterial Agents; Antitubercular Agents; Asthma; Bronchiectasis; Bronchitis; Chloramphenicol; Chlortetracycline; Chymotrypsin; Empyema; Humans; Hydrocortisone; Kanamycin; Oxytetracycline; Penicillins; Peptide Hydrolases; Pleurisy; Pneumonia; Pulmonary Emphysema; Respiratory System; Respiratory Tract Diseases; Tuberculosis; Tuberculosis, Pulmonary

Topics: Chlortetracycline; Rats; Respiration Disorders; Respiratory Tract Diseases; Sulfamerazine; Veterinary Medicine

Topics: Chlortetracycline; Demeclocycline; Disease; Hypersensitivity; Immune System Diseases; Respiration Disorders; Respiratory Hypersensitivity; Respiratory System; Respiratory Tract Diseases

Topics: Chlortetracycline; Humans; Respiratory System; Respiratory Tract Diseases; Respiratory Tract Infections