chlortetracycline and Plague

The effect of various antibiotics, such as streptomycin, gentamicin, ampicillin, benzylpenicillin, tetracycline, chlortetracycline and levomycetin on the plague bacteria (strain Y. pestis EV) located inside the cells was studied. Peritoneal macrophages of albino mice with aceptic inflammation of the abdominal cavity caused by intraperitoneal administration of 2 ml of sterile meat-peptone broth were used in the experiments. The ratio of the macrophages and microbes was 1 : 50. A part of the mice were treated with prodigiozan 24 hours before taking the exudate. The preparations of the macrophages of albino mice with the microbes absorbed by them served as the control. The effect of the antibiotics and their combinations with prodigiozan was stimated by the coefficient of multiplication suppression against the control. The observations were made in dynamics. The studies showed that the macrophage activity of the mice treated with prodigiozan after exposure to the antibiotics was reliably higher than that in the control and digestion of the microbes located inside the cells started earlier, providing more complete phagocytosis.

Topics: Ampicillin; Animals; Anti-Bacterial Agents; Chloramphenicol; Chlortetracycline; Drug Combinations; Gentamicins; In Vitro Techniques; Macrophages; Mice; Penicillin G; Plague; Prodigiosin; Streptomycin; Tetracycline

Topics: Animals; Anti-Bacterial Agents; Antitoxins; Chloramphenicol; Chlortetracycline; Depression, Chemical; Erythromycin Ethylsuccinate; Kanamycin; Mice; Neomycin; Oleandomycin; Oxytetracycline; Penicillins; Plague; Streptomycin; Tetracycline; Time Factors; Toxins, Biological; Viomycin; Virulence; Yersinia pestis

Topics: Anti-Bacterial Agents; Chloramphenicol; Chlortetracycline; Colistin; Drug Resistance, Microbial; Drug Synergism; Humans; Oleandomycin; Plague; Polymyxins; Streptomycin; Tetracycline; Yersinia pestis

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Chlortetracycline; gamma-Globulins; Humans; Plague; Streptomycin; Yersinia pestis

Topics: Anti-Bacterial Agents; Chloramphenicol; Chlortetracycline; Humans; Male; Plague; Streptomycin

Topics: Chloramphenicol; Chlortetracycline; Plague