chlortetracycline and Myocardial-Infarction

Topics: Chlortetracycline; Humans; Microscopy; Microscopy, Fluorescence; Myocardial Infarction; Neoplasms; Tetracycline; Trichloroacetic Acid; Ultraviolet Rays; Vitamin B 12

The suitability of various radiopharmaceuticals (99mTc-tetracycline analogs, 99mTc-glucoheptonate, 99mTc-diphosphonate, and 67Ga-citrate) for use in imaging acute myocardial infarction was assessed by determining their biologic distributions in experimentally infarcted dogs. The highest infarct-to-normal myocardial concentration ratio was found with 99mTc-diphosphonate (27.9:1); the highest infarct-to-liver ratio was also found with 99mTc-diphosphonate (15.9:1). The infarct-to-bone ratio, however, was 0.4:1 with 99mTc-diphosphonate. There was an excellent positive linear correlation between blood-flow reduction and uptake of the radiopharmaceutical after a threshold reduction in blood flow with 99mTc-glucoheptonate and 99mTc-tetracycline. Technetium-99m-tetracycline accumulated only in infarcted tissue while 99mTc-diphosphonate was increased in both ischemic and infarcted tissue. Thus, 99mTc-diphosphonate has characteristics best suited for scintigraphic imaging. Since 99mTc-tetracycline accumulates only in infarcted tissue, however, this tracer more accurately defines the size of an acute infarction.

Topics: Animals; Chlortetracycline; Dogs; Gallium Radioisotopes; Heptoses; Myocardial Infarction; Organophosphorus Compounds; Oxytetracycline; Radionuclide Imaging; Sugar Acids; Technetium; Tetracyclines

Topics: Alanine Transaminase; Animals; Anti-Bacterial Agents; Aspartate Aminotransferases; Chlortetracycline; Clinical Enzyme Tests; D-Alanine Transaminase; Diagnosis; Dogs; Electrocardiography; Fluorescence; Microscopy; Microscopy, Fluorescence; Myocardial Infarction; Myocardium; Pharmacology; Research; Tetracycline

Topics: Animals; Autoradiography; Chlortetracycline; Dogs; Fluorescence; Humans; Myocardial Infarction

Topics: Anti-Bacterial Agents; Cardiovascular Diseases; Chlortetracycline; Fluorescence; Myocardial Infarction; Oxytetracycline; Protein Synthesis Inhibitors; Tetracycline