chlortetracycline and Kidney-Diseases

Topics: Absorption; Acne Vulgaris; Bacteria; Bacteriuria; Bronchial Diseases; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Chlortetracycline; Demeclocycline; Drug Eruptions; Humans; Infections; Kidney Diseases; Methacycline; Oxytetracycline; Protein Binding; Tetracycline; Tooth Discoloration

Topics: Acute Disease; Animals; Blood Urea Nitrogen; Body Weight; Chlortetracycline; Cholesterol; Choline Deficiency; Cystine; Diet; Feces; Germ-Free Life; Hematocrit; Kidney Diseases; Lipid Metabolism; Liver; Male; Neomycin; Rats; Stimulation, Chemical; Vitamin B 12

Topics: Animals; Chlortetracycline; Dogs; Fluorescence; In Vitro Techniques; Ischemia; Kidney Diseases; Kidney Transplantation; Rabbits; Transplantation, Homologous

Topics: Anti-Bacterial Agents; Black People; Chemical and Drug Induced Liver Injury; Chlortetracycline; Demeclocycline; Female; Hepatitis; Hepatitis A; Humans; Kidney Diseases; Liver; Maternal-Fetal Exchange; Oxytetracycline; Pharmacology; Pregnancy; Pregnancy Complications; Tetracycline; Tetracyclines; Tooth; Toxicology; Urine

Topics: Anemia; Anemia, Aplastic; Anti-Bacterial Agents; Antibiotics, Antitubercular; Bacitracin; Chemical and Drug Induced Liver Injury; Chloramphenicol; Chlortetracycline; Erythromycin; Hearing Disorders; Hepatitis; Kidney Diseases; Neomycin; Oleandomycin; Streptomycin; Tetracycline; Toxicology

A strain of Leptospira zanoni was used to produce chronic renal infections in young white mice. A variant of this strain produced an acute disease with over 50% mortality. The responses of both forms of disease to chemotherapy were studied. When treatment of the acute disease was initiated before jaundice occurred, suitable single doses of streptomycin, chlortetracycline, tetracycline, erythromycin, oxytetracycline and oxytetracycline (in oil) prevented death and chronic renal infection in a high percentage of mice. Bicillin, a long-acting penicillin preparation, was more effective than other penicillins, but it prevented the development of chronic renal infection in only half the treated mice. Streptomycin was the only antibiotic of which a single administration regularly cured the chronic renal infections: chlortetracycline, tetracycline and oxytetracycline (in oil) were partially effective. Oxytetracycline, chloramphenicol, Bicillin, fortified penicillin, procaine penicillin and potassium penicillin had no permanent action. The suitability of mice as laboratory animals in the study of experimental leptospirosis and the need for complete cure of carriers of chronic renal infection are emphasized. The above findings indicate that streptomycin is the drug of choice for the treatment of leptospirosis in animals, and that it is worthy of further trial in man.

Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Chloramphenicol; Chlortetracycline; Erythromycin; Kidney Diseases; Leptospira; Leptospirosis; Mice; Oxytetracycline; Penicillin G Benzathine; Penicillins; Streptomycin; Tetracycline

Topics: Chlortetracycline; Humans; Kidney Diseases; Liver Diseases

Topics: Chlortetracycline; Disease; Inflammation; Kidney Diseases; Penicillins; Sulfadiazine; Ureter; Ureteral Diseases; Urinary Tract Infections

Topics: Chlortetracycline; Choline; Choline Deficiency; Hemorrhage; Kidney; Kidney Diseases; Lipids; Liver Diseases