chlortetracycline and Foot-Diseases

Sixty patients with persistent palmoplantar pustulosis (PPP) were treated with clomocycline (Megaclor) in a double-blind, cross-over trial in an attempt to establish whether the condition responds to tetracycline. Each patient received 3 months each of clomocycline and placebo in random order. Forty patients completed the trial. Twenty-two failed to respond to either treatment, fifteen improved on clomocycline, two improved on placebo and one placebo and one improbed on both treatments. These results are highly significant (P = 0-003) and suggest that clomocycline may suppress pustulation in some patients. The twenty-two 'non-responders' were compared with the eighteen 'responders' for sex, age, length of history and associated psoriasis but no significant differences were found. Difficulties in assessment and the possiblity of improvement deing due to spontaneous remission are discussed. Further follow-up of both groups suggested that clomocycline used over long periods favourably influenced the course of the disease in the 'responder' group.

Topics: Adult; Chlortetracycline; Clinical Trials as Topic; Female; Follow-Up Studies; Foot Diseases; Hand; Humans; Male; Middle Aged; Skin Diseases; Suppuration

A 6-year-old 895-kg Angus bull was evaluated for a 6-month history of left hind limb lameness that was refractory to antimicrobial treatment. On physical examination, there was soft-tissue swelling associated with the lateral digit. Radiography revealed septic arthritis of the distal interphalangeal joint and osteomyelitis of the distal and middle phalanges. Treatment included debridement and lavage. Bacteriologic culture of debrided tissues yielded aerobic and anaerobic organisms. Antimicrobials were administered parenterally and locally in the form of antimicrobial-impregnated polymethyl methacrylate beads. The limb also was placed in a cast to promote ankylosis. The bull recovered, and the digit was salvaged.

Topics: Actinomyces; Actinomycosis; Administration, Oral; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Infectious; Cattle; Cattle Diseases; Cefazolin; Cephalosporins; Chlortetracycline; Debridement; Foot Diseases; Hindlimb; Hoof and Claw; Male; Methylmethacrylates; Metronidazole; Microspheres; Osteomyelitis; Phenylbutazone; Therapeutic Irrigation

Topics: Chlortetracycline; Foot Diseases; Humans; Male; Middle Aged; Mycetoma; Oxytetracycline; Penicillins; Streptomycin

Topics: Animals; Chlortetracycline; Foot Diseases; Hoof and Claw; Sheep; Sheep Diseases

Topics: Animals; Birds; Chlortetracycline; Disease; Foot Diseases; Meat; Poultry; Staphylococcal Infections