chlortetracycline and Cross-Infection

Topics: Animal Feed; Animals; Anti-Bacterial Agents; Bacterial Infections; Cattle; Child; Chlortetracycline; Cross Infection; Drug Hypersensitivity; Drug Resistance, Microbial; Female; Food Preservation; Germ-Free Life; Growth; Humans; Male; Meat; Oxytetracycline; Public Health; Rats; Sulfonamides; Time Factors

We report a Streptobacillus moniliformis epizootic in barrier-maintained SPF mice. Although various inbred and F1 hybrid strains of mice have been kept in this animal facility, only C57BL/6J Han [corrected] mice showed clinical signs of disease. During the course of the epizootic, 825 breeding animals (approximately 36% of the breeders) died or had to be killed because of severe clinical signs. Although sequential treatment with ampicillin and chlortetracycline gave good therapeutic results, the animal facility was vacated in order to exclude any risk of cross-contamination of the other rodent colonies in our institute. The source and route of transmission of S. moniliformis could not be elucidated. To investigate strain dependent differences experimental infection of different strains of mice with our S. moniliformis isolate was performed. After oral infection only C57BL/6J showed the typical signs of a cervical lymphadenitis and gave an immunological response. BALB/cJ, C3H/He, DBA/2J, CB6F1 and B6D2F1 mice were not affected except in two cases of DBA/2J and B6D2F1 mice where seroconversion was observed. After intravenous infection of C57BL/6J, DBA/2J [corrected] and BALB/cJ all animals showed positive titers in the indirect immunofluorescence test (IIF). One hundred percent of the C57BL/6J, forty percent of the DBA/2J, and none of the BALB/cJ mice developed severe symptoms. The results demonstrate that the susceptibility to streptobacillosis is predominantly influenced by genetic factors.

Topics: Ampicillin; Animal Husbandry; Animals; Bacterial Infections; Chlortetracycline; Cross Infection; Disease Outbreaks; Female; Mice; Mice, Inbred C57BL; Streptobacillus

An outbreak of skin sepsis due to beta-haemolytic streptococcus group A M33, T3/13/B3264 occurred in a closed community. Staphylococcus aureus was also present in many of the lesions, but different strains were recognizable by phage typing. Environmental contamination was found. The outbreak was controlled by isolating infected boys and decontaminating the environment. Various aspects of the epidemiology and the pathogenesis of streptococcal infections are discussed.

Topics: Adolescent; Adult; Air Microbiology; Antibodies, Bacterial; Antistreptolysin; Bacteriophage Typing; Chlortetracycline; Cross Infection; Disease Outbreaks; Dust; Humans; Male; Penicillin Resistance; Penicillins; Prisons; Skin Diseases, Infectious; Staphylococcus; Streptococcal Infections; Streptococcus pyogenes

Topics: Anti-Bacterial Agents; Chloramphenicol; Chlortetracycline; Cross Infection; Erythromycin; Humans; Microbial Sensitivity Tests; Oxytetracycline; Penicillin Resistance; Penicillins; Poland; Staphylococcal Infections; Staphylococcus; Streptomycin; Tetracycline

Topics: Chlortetracycline; Cross Infection; Drug Resistance, Microbial; Humans; Oxytetracycline; Poland; Proteus; Pseudomonas; Staphylococcus; Tetracycline; Wound Infection

Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Child; Chlortetracycline; Cross Infection; Humans; Infant; Leukocyte Count; Neomycin; Oxytetracycline; Penicillins; Polymyxins; Pseudomonas aeruginosa; Pseudomonas Infections; Sepsis; Staphylococcal Infections; Statistics as Topic; Streptomycin

Topics: Anti-Bacterial Agents; Bacitracin; Chloramphenicol; Chlortetracycline; Cross Infection; Czechoslovakia; Drug Resistance; Drug Resistance, Microbial; Erythromycin; Hospitals; Kanamycin; Outpatient Clinics, Hospital; Pediatrics; Penicillin G; Staphylococcus; Streptomycin; Vancomycin

Topics: Chlortetracycline; Conjunctivitis; Cross Infection; Drug Resistance; Drug Resistance, Microbial; Female; Hospitalization; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Mastitis; Pregnancy; Pseudomonas Infections; Puerperal Disorders; Rhinitis; Staphylococcal Infections

Topics: Anti-Bacterial Agents; Bacteriophage Typing; Chloramphenicol; Chlortetracycline; Cross Infection; Drug Resistance; Drug Resistance, Microbial; Epidemiologic Studies; Epidemiology; Erythromycin; Humans; Kanamycin; Oxytetracycline; Penicillins; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus Phages; Streptomycin; Tetracycline

Topics: Anti-Bacterial Agents; Chlortetracycline; Cross Infection; Erythromycin; Humans; Neomycin; Penicillins; Staphylococcal Infections; Streptomycin; Surgical Wound Infection

Topics: Biomedical Research; Chlortetracycline; Cross Infection; Hospitals; Humans; Infant, Premature, Diseases