chlortetracycline and Chlamydia-Infections

A double-blind stratified trial was carried out on 85 patients to assess the efficacy of topical therapy with 1% chlortetracycline eye ointment in comparison with 1% rifampicin eye ointment in the treatment of chlamydial ocular infection of sexually transmitted origin (paratrachoma). Patients included were selected on the basis of positive culture for Chlamydia trachomatis. A 6-week course of treatment with chlortetracycline or rifampicin 3 times daily gave a clinical cure rate of 80% and 75% and a microbiological cure rate of 93% and 86% respectively. In patients who were not cured the intensity of inflammatory responses was considerably reduced.

Topics: Administration, Topical; Adolescent; Adult; Chlamydia Infections; Chlamydia trachomatis; Chlortetracycline; Clinical Trials as Topic; Conjunctivitis, Inclusion; Double-Blind Method; Female; Humans; Keratoconjunctivitis; Male; Middle Aged; Random Allocation; Rifampin; Trachoma

The efficacy of treating genital Chlamydia in women using Deteclo 300 mg twice daily for seven and 21 days has been studied. Forty-four patients were treated for seven days and 20 for 21 days. Seven days of treatment was as effective in eliminating Chlamydia trachomatis from the female genital tract as 21 days. The reproducibility of the technique of isolation of C. trachomatis was assessed by delaying treatment in 10 patients for up to 156 days and find C. trachomatis still present.

Topics: Chlamydia Infections; Chlamydia trachomatis; Chlortetracycline; Clinical Trials as Topic; Demeclocycline; Drug Combinations; Female; Humans; Tetracyclines; Urinary Tract Infections

Topics: Anti-Bacterial Agents; Azithromycin; Chlamydia Infections; Chlamydia trachomatis; Chlortetracycline; Contact Tracing; Demeclocycline; Doxycycline; Drug Therapy, Combination; Erythromycin; Humans; Male; Ofloxacin; Recurrence; Tetracycline; Urethritis

Chlamydial and non-chlamydial nonspecific or postgonococcal urethritis in 132 men was treated with different regimens of chlortetracycline and doxycycline. Chlortetracycline 250 mg four times daily for 12.5-18.5 days given to 70 men resulted in a clinical cure of urethritis in 80% of cases (56/70). There was no difference in the cure rate between chlamydia-positive (40) and chlamydia-negative (30) cases. In no instance was the treatment failure, i.e., re-appearance of urethritis, associated with re-isolation of C. trachomatis. Forty-two men received 4-10 days treatment with chlortetracycline and their cure rate was 67% (28/42). In this group 29 men were initially chlamydia-positive and among this group 12 relapsed. In four cases this relapse was associated with re-isolation of C. trachomatis. In a group of 20 men treated with doxycycline (100 mg daily up to 20 days) the cure rate was 45% (9/20)) only.

Topics: Chlamydia Infections; Chlamydia trachomatis; Chlortetracycline; Doxycycline; Drug Evaluation; Follow-Up Studies; Humans; Male; Time Factors; Urethritis

Topics: Cervix Uteri; Chlamydia; Chlamydia Infections; Chloramphenicol; Chlortetracycline; Conjunctivitis; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Neisseria gonorrhoeae

Topics: Animals; Cattle; Cattle Diseases; Chlamydia; Chlamydia Infections; Chlortetracycline; Complement Fixation Tests; Feces; Guinea Pigs; Intestinal Diseases; Mice; Swine; Turkeys

Topics: Animals; Anti-Infective Agents; Birds; Chlamydia Infections; Chlortetracycline; Immunization; Psittacosis; Vaccination