chlortetracycline and Abnormalities--Drug-Induced

Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Abortion, Threatened; Animals; Chlortetracycline; Embryo Implantation; Endometrium; Estradiol; Female; Follicle Stimulating Hormone; Luteinizing Hormone; Mice; Ovary; Pregnancy; Progesterone; Prolactin; Tetracycline; Time Factors; Vaginal Smears

Topics: Abnormalities, Drug-Induced; Child, Preschool; Chlortetracycline; Demeclocycline; Female; Humans; Infant; Infant, Newborn; Oxytetracycline; Pregnancy; Tetracycline; Tooth Discoloration

A possible relationship between stability of a tetracycline and persistence in the foetal skeleton is discussed; it seems that the greater the stability of a tetracycline, the more it may interfere with bone-forming processes. Therefore, assuming that limited instability does not impair antibiotic potency in vivo, the use of a low-stability tetracycline seems to be a safer form of treatment in order to avoid undesired effects on the foetal skeleton.

Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Bone Development; Chelating Agents; Chick Embryo; Chlortetracycline; Demeclocycline; Fetus; Fluorescence; Oxytetracycline; Research; Tetracycline; Toxicology