Page last updated: 2024-10-25

chlorpyrifos and Organophosphate Poisoning

chlorpyrifos has been researched along with Organophosphate Poisoning in 36 studies

Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.
chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.

Organophosphate Poisoning: Poisoning due to exposure to ORGANOPHOSPHORUS COMPOUNDS, such as ORGANOPHOSPHATES; ORGANOTHIOPHOSPHATES; and ORGANOTHIOPHOSPHONATES.

Research Excerpts

ExcerptRelevanceReference
"A 31-year-old male with a history of consuming a commercial chlorpyrifos formulation presented with acute organophosphate poisoning symptoms that improved with appropriate treatment."4.84Isolated Hypoglossal Nerve Palsy: A Rare Complication of Organophosphate Poisoning. ( Jati, M; Kaur, A, 2024)
"Bromocriptine treatment was offered, which resolved the clinical picture."1.72Neuroleptic malignant syndrome associated with acute organophosphate poisoning: Case report ( Angulo, NY; Castaño, PA; Gómez, CC; Quintero, S, 2022)
"The complications included respiratory failure (52."1.62Outcomes of elderly patients with organophosphate intoxication. ( Chan, MJ; Chen, CY; Fu, JF; Hou, YC; Hsu, CW; Huang, WH; Wang, IK; Weng, CH; Yang, HY; Yen, TH; Yu, JR, 2021)
"Chlorpyrifos was found to induce oxidative stress in the ARPE19 cells as seen by significant increase in ROS and decrease in glutathione (GSH) levels without causing cell death."1.40Paraoxonase enzyme protects retinal pigment epithelium from chlorpyrifos insult. ( Anandbabu, K; Angayarkanni, N; Bharathi, SR; Jasna, JM, 2014)
"Acute coronary syndrome is a rare occurrence in OP poisoning."1.40Acute organophosphorus poisoning complicated by acute coronary syndrome. ( Krishna, K; Pankaj, M, 2014)
"Melatonin pretreatment reduced the testicular and pituitary MDA concentrations and improves the SOD and CAT activities."1.38Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats. ( Ambali, SF; Ayo, JO; Mohammed, B; Uchendu, C; Umosen, AJ, 2012)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (5.56)29.6817
2010's24 (66.67)24.3611
2020's10 (27.78)2.80

Authors

AuthorsStudies
Joson, MVASG1
Castor, FRM1
Micu-Oblefias, CV1
Angulo, NY1
Castaño, PA1
Gómez, CC1
Quintero, S1
Jati, M1
Kaur, A1
Felippe, ISA1
Müller, CJT1
Siqueira, AA1
Dos Santos, L1
Cavadino, A1
Paton, JFR1
Beijamini, V1
Sampaio, KN1
Cui, Y1
Zhao, M1
Han, L1
Soria, ALG1
Ramirez, FR1
Pliego, AB1
Guadarrama, HRD1
Farrera, GPM1
Angel, GY1
Chagoyán, JCV1
Gomaa, RMM1
Tenorio-Borroto, E1
Nikbin, S1
Derakhshideh, A1
Kanozi, F1
Hozouri Tarighe, M1
Niknia, S1
Khojasteh, Z1
Barzegar Rahatlo, M1
Mousavi, N1
Ghodousi Johari, E1
Arabi, Y1
Afshar, T1
Tousi, H1
Jameie, SB1
Azarbayjani, MA1
Pannu, AK1
Bhalla, A1
Vishnu, RI1
Dhibar, DP1
Sharma, N1
Vijayvergiya, R1
Altaf, S1
Muhammad, F1
Aslam, B1
Faisal, MN1
Yu, JR1
Hou, YC1
Fu, JF1
Wang, IK1
Chan, MJ1
Chen, CY1
Weng, CH1
Huang, WH1
Yang, HY1
Hsu, CW1
Yen, TH1
Avci, B1
Bilge, SS1
Arslan, G1
Alici, O1
Darakci, O1
Baratzada, T1
Ciftcioglu, E1
Yardan, T1
Bozkurt, A1
Guo, X1
Zhong, CG1
Zhang, YF1
Liu, F1
He, J1
Lin, H1
Guo, MQ1
Alipour, V1
Hoseinpour, F1
Vatanparast, J1
Tripathi, S1
Suzuki, N1
Srivastav, AK1
Umosen, AJ1
Ambali, SF1
Ayo, JO1
Mohammed, B1
Uchendu, C1
Chaou, CH1
Lin, CC1
Chen, HY1
Lee, CH1
Chen, TH1
Cavari, Y1
Landau, D1
Sofer, S1
Leibson, T1
Lazar, I1
Schäfer, M1
Koppe, F1
Stenger, B1
Brochhausen, C1
Schmidt, A1
Steinritz, D1
Thiermann, H1
Kirkpatrick, CJ1
Pohl, C1
Peter, JV2
Thomas, L1
Graham, PL1
Moran, JL1
Abhilash, KP2
Jasmine, S2
Iyyadurai, R2
Immanuel, S1
Begum, A1
Zachariah, A1
Jasna, JM1
Anandbabu, K1
Bharathi, SR1
Angayarkanni, N1
Li, Q1
Yu, G1
Wang, J2
Sun, J1
Song, C2
Jian, X2
Kan, B1
Pankaj, M1
Krishna, K1
Mullins, RJ1
Xu, S1
Pereira, EF1
Pescrille, JD1
Todd, SW1
Mamczarz, J1
Albuquerque, EX1
Gullapalli, RP1
Faria, M2
Garcia-Reyero, N1
Padrós, F2
Babin, PJ1
Sebastián, D1
Cachot, J1
Prats, E2
Arick Ii, M1
Rial, E1
Knoll-Gellida, A1
Mathieu, G1
Le Bihanic, F1
Escalon, BL1
Zorzano, A1
Soares, AM2
Raldúa, D2
Kofod, DH1
Jørs, E1
Varma, A1
Bhatta, S1
Thomsen, JF1
Rathod, AL1
Garg, RK1
Matthews, AR1
Sutter, ME1
Rentz, DE1
Lein, PJ2
Bonner, MR2
Farahat, FM1
Olson, JR2
Rohlman, DS1
Fenske, RA1
Lattal, KM1
Lasarev, MR1
Galvin, K1
Farahat, TM1
Anger, WK1
Richendrfer, H1
Pelkowski, SD1
Colwill, RM1
Créton, R1
Ellison, CA1
Crane, AL1
Knaak, JB1
Browne, RW1
Rajasekharan, C1
Renjith, SW1
Jayapal, T1
Salles, JB1
Cunha Bastos, VL1
Silva Filho, MV1
Machado, OL1
Salles, CM1
Giovanni de Simone, S1
Cunha Bastos, J1
Eddleston, M1
Eyer, P1
Worek, F1
Sheriff, MH1
Buckley, NA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Use of Self-reported Symptoms as a Proxy for Acute Organophosphate Poisoning Among Nepali Farmers: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study[NCT02838303]42 participants (Actual)Interventional2014-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for chlorpyrifos and Organophosphate Poisoning

ArticleYear
Chlorpyrifos poisoning and its implications in human fatal cases: A forensic perspective with reference to Indian scenario.
    Journal of forensic and legal medicine, 2017, Volume: 47

    Topics: Accidents; Biotransformation; Chlorpyrifos; Environmental Exposure; Forensic Toxicology; Gas Chromat

2017
Serum paraoxonase-1 (PON-1) genotype and exposure to organophosphorous insectides--is there a high-risk population?
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2011, Volume: 7, Issue:3

    Topics: Agricultural Workers' Diseases; Animals; Aryldialkylphosphatase; Centers for Disease Control and Pre

2011

Trials

2 trials available for chlorpyrifos and Organophosphate Poisoning

ArticleYear
The use of self-reported symptoms as a proxy for acute organophosphate poisoning after exposure to chlorpyrifos 50% plus cypermethrin 5% among Nepali farmers: a randomized, double-blind, placebo-controlled, crossover study.
    Environmental health : a global access science source, 2016, 12-13, Volume: 15, Issue:1

    Topics: Adult; Chlorpyrifos; Cholinesterases; Cross-Over Studies; Double-Blind Method; Farmers; Humans; Inse

2016
Predicting outcome using butyrylcholinesterase activity in organophosphorus pesticide self-poisoning.
    QJM : monthly journal of the Association of Physicians, 2008, Volume: 101, Issue:6

    Topics: Acetylcholinesterase; Adult; Biomarkers; Butyrylcholinesterase; Chlorpyrifos; Cholinesterase Reactiv

2008

Other Studies

32 other studies available for chlorpyrifos and Organophosphate Poisoning

ArticleYear
Role of intravenous lipid emulsion therapy and packed red blood cell transfusion as adjuvant treatment in the management of a child with severe organophosphate poisoning (chlorpyrifos).
    BMJ case reports, 2022, Apr-08, Volume: 15, Issue:4

    Topics: Atropine; Child, Preschool; Chlorpyrifos; Erythrocyte Transfusion; Fat Emulsions, Intravenous; Femal

2022
Neuroleptic malignant syndrome associated with acute organophosphate poisoning: Case report
    Biomedica : revista del Instituto Nacional de Salud, 2022, 09-02, Volume: 42, Issue:3

    Topics: Antipsychotic Agents; Bromocriptine; Chlorpyrifos; Humans; Male; Middle Aged; Neuroleptic Malignant

2022
Isolated Hypoglossal Nerve Palsy: A Rare Complication of Organophosphate Poisoning.
    Acta neurologica Taiwanica, 2024, Sep-30, Volume: 33(3)

    Topics: Adult; Chlorpyrifos; Humans; Hypoglossal Nerve; Hypoglossal Nerve Diseases; Male; Organophosphate Po

2024
The antidotes atropine and pralidoxime distinctively recover cardiorespiratory components impaired by acute poisoning with chlorpyrifos in rats.
    Toxicology and applied pharmacology, 2020, 01-15, Volume: 389

    Topics: Animals; Antidotes; Atropine; Baroreflex; Blood Pressure; Bradycardia; Cardiovascular System; Chlorp

2020
Differences in biological activities between recombinant human paraoxonase 1 (rhPON1) subtype isozemys R/Q as antidotes against organophosphorus poisonings.
    Toxicology letters, 2020, Jun-01, Volume: 325

    Topics: Acetylcholinesterase; Animals; Antidotes; Aryldialkylphosphatase; Brain; Chlorpyrifos; Cholinesteras

2020
Evaluating Hemolytic and Photo Hemolytic Potential of Organophosphorus by In Vitro Method as an Alternative Tool Using Human Erythrocytes.
    Current topics in medicinal chemistry, 2020, Volume: 20, Issue:9

    Topics: Chlorpyrifos; Erythrocytes; Hemolysis; Humans; In Vitro Techniques; Malathion; Organophosphate Poiso

2020
Combination effect of exercise training and eugenol supplementation on the hippocampus apoptosis induced by chlorpyrifos.
    Molecular biology reports, 2020, Volume: 47, Issue:8

    Topics: Acetylcholinesterase; Adenosine Triphosphate; Animals; Apoptosis; Avoidance Learning; Brain-Derived

2020
Organophosphate induced delayed neuropathy after an acute cholinergic crisis in self-poisoning.
    Clinical toxicology (Philadelphia, Pa.), 2021, Volume: 59, Issue:6

    Topics: Acute Disease; Adolescent; Adult; Chlorpyrifos; Humans; Neural Conduction; Organophosphate Poisoning

2021
Cell membrane enveloped polymeric nanosponge for detoxification of chlorpyrifos poison: In vitro and in vivo studies.
    Human & experimental toxicology, 2021, Volume: 40, Issue:8

    Topics: Acetylcholinesterase; Animals; Chlorpyrifos; Cholinesterase Inhibitors; Erythrocyte Membrane; Kidney

2021
Outcomes of elderly patients with organophosphate intoxication.
    Scientific reports, 2021, 06-02, Volume: 11, Issue:1

    Topics: Acute Kidney Injury; Affect; Aged; Antidotes; Atropine; Chlorpyrifos; Female; Humans; Insecticides;

2021
Protective effects of dietary omega-3 fatty acid supplementation on organophosphate poisoning.
    Toxicology and industrial health, 2018, Volume: 34, Issue:2

    Topics: Animals; Antioxidants; Behavior, Animal; Biomarkers; Body Temperature Regulation; Brain; Chlorpyrifo

2018
In Vitro Evaluation of Hemoperfusion for Chlorpyrifos Poisoning.
    Biomedical and environmental sciences : BES, 2018, Volume: 31, Issue:12

    Topics: Adsorption; Adult; Charcoal; Chlorpyrifos; Female; Hemoperfusion; Humans; Insecticides; Male; Middle

2018
Persistent alterations in seizure susceptibility, drug responsiveness and comorbidities associated with chemical kindling after neonatal exposure to an organophosphate.
    Neurotoxicology, 2019, Volume: 73

    Topics: Affect; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Brain; Chlorpyrifos; Cholinest

2019
Response of serum minerals (calcium, phosphate, and magnesium) and endocrine glands (calcitonin cells and parathyroid gland) of Wistar rat after chlorpyrifos administration.
    Microscopy research and technique, 2013, Volume: 76, Issue:7

    Topics: Animals; Chlorpyrifos; Cholinesterase Inhibitors; Disease Models, Animal; Male; Minerals; Organophos

2013
Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats.
    Asian Pacific journal of tropical biomedicine, 2012, Volume: 2, Issue:8

    Topics: Animals; Antioxidants; Catalase; Chlorpyrifos; Cholinesterase Inhibitors; Male; Malondialdehyde; Mel

2012
Chlorpyrifos is associated with slower serum cholinesterase recovery in acute organophosphate-poisoned patients.
    Clinical toxicology (Philadelphia, Pa.), 2013, Volume: 51, Issue:5

    Topics: Acute Disease; Antidotes; Chlorpyrifos; Cholinesterases; Critical Illness; Female; Humans; Insectici

2013
Organophosphate poisoning-induced acute renal failure.
    Pediatric emergency care, 2013, Volume: 29, Issue:5

    Topics: Acute Kidney Injury; Adolescent; Chlorpyrifos; Female; Hemofiltration; Humans; Insecticides; Organop

2013
Influence of organophosphate poisoning on human dendritic cells.
    Chemico-biological interactions, 2013, Dec-05, Volume: 206, Issue:3

    Topics: Cell Death; Cell Differentiation; Cell Line; Chlorpyrifos; Cytokines; Dendritic Cells; Dimethoate; H

2013
Performance of clinical scoring systems in acute organophosphate poisoning.
    Clinical toxicology (Philadelphia, Pa.), 2013, Volume: 51, Issue:9

    Topics: Adult; APACHE; Chlorpyrifos; Cholinesterase Inhibitors; Cohort Studies; Health Status Indicators; Ho

2013
Organophosphate-pyrethroid combination pesticides may be associated with increased toxicity in human poisoning compared to either pesticide alone.
    Clinical toxicology (Philadelphia, Pa.), 2014, Volume: 52, Issue:5

    Topics: Adolescent; Adult; Chlorpyrifos; Female; Hospitalization; Humans; Length of Stay; Male; Organophosph

2014
Paraoxonase enzyme protects retinal pigment epithelium from chlorpyrifos insult.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Aryldialkylphosphatase; Cell Line; Chlorpyrifos; Glutathione; Humans; Insecticides; Organophosphate

2014
[A case of rhabdomyolysis caused by acute chlorpyrifos poisoning].
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2014, Volume: 32, Issue:5

    Topics: Acute Disease; Adult; Chlorpyrifos; Humans; Insecticides; Male; Organophosphate Poisoning; Rhabdomyo

2014
[2 cases of chlorpyrifos induced medicamentosa-like dermatitis].
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2014, Volume: 32, Issue:5

    Topics: Aged; Chlorpyrifos; Dermatitis, Occupational; Female; Humans; Insecticides; Middle Aged; Organophosp

2014
Acute organophosphorus poisoning complicated by acute coronary syndrome.
    The Journal of the Association of Physicians of India, 2014, Volume: 62, Issue:7

    Topics: Acute Coronary Syndrome; Adult; Alcoholic Intoxication; Chlorpyrifos; Echocardiography; Electrocardi

2014
Prenatal exposure of guinea pigs to the organophosphorus pesticide chlorpyrifos disrupts the structural and functional integrity of the brain.
    Neurotoxicology, 2015, Volume: 48

    Topics: Age Factors; Animals; Behavior, Animal; Brain; Chlorpyrifos; Cognition; Diffusion Tensor Imaging; Es

2015
Zebrafish Models for Human Acute Organophosphorus Poisoning.
    Scientific reports, 2015, Oct-22, Volume: 5

    Topics: Acetylcholinesterase; Animals; Chemical Terrorism; Chlorpyrifos; Disease Models, Animal; Humans; Org

2015
Zebrafish is a predictive model for identifying compounds that protect against brain toxicity in severe acute organophosphorus intoxication.
    Archives of toxicology, 2017, Volume: 91, Issue:4

    Topics: Animals; Antidotes; Brain; Chlorpyrifos; Disease Models, Animal; Lethal Dose 50; Neuroprotective Age

2017
Experimental strategy for translational studies of organophosphorus pesticide neurotoxicity based on real-world occupational exposures to chlorpyrifos.
    Neurotoxicology, 2012, Volume: 33, Issue:4

    Topics: Adolescent; Adult; Agricultural Workers' Diseases; Agriculture; Animals; Behavior, Animal; Biomarker

2012
Developmental sub-chronic exposure to chlorpyrifos reduces anxiety-related behavior in zebrafish larvae.
    Neurotoxicology and teratology, 2012, Volume: 34, Issue:4

    Topics: Animals; Anxiety Disorders; Behavior, Animal; Brain; Chlorpyrifos; Cholinesterase Inhibitors; Chroni

2012
PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos.
    Toxicology and applied pharmacology, 2012, Dec-15, Volume: 265, Issue:3

    Topics: Acetylcholinesterase; Agricultural Workers' Diseases; Agriculture; Aryldialkylphosphatase; Butyrylch

2012
Opsoclonus and lingual myoclonus due to organophosphate poisoning: images in clinical medicine.
    BMJ case reports, 2012, Sep-21, Volume: 2012

    Topics: Child; Chlorpyrifos; Female; Humans; Myoclonus; Ocular Motility Disorders; Organophosphate Poisoning

2012
A novel butyrylcholinesterase from serum of Leporinus macrocephalus, a Neotropical fish.
    Biochimie, 2006, Volume: 88, Issue:1

    Topics: Amino Acid Sequence; Animals; Butyrylcholinesterase; Butyrylthiocholine; Chlorpyrifos; Cholinesteras

2006