chlorpyrifos has been researched along with Nervous System Disorders in 16 studies
Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.
chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorpyrifos was detectable in serum until day 30 and urine metabolites for up to three months, supporting the hypothesis of a continuous chlorpyrifos release despite repeated surgical debridement." | 1.37 | Severe and prolonged neurologic toxicity following subcutaneous chlorpyrifos self-administration: a case report. ( Arbelot, C; Boroli, F; Fournier, E; Megarbane, B; Moesch, C; Rouby, JJ; Saleh, M; Soummer, A, 2011) |
| " In addition, half of each of these groups also received a bolus dosage of CPF in corn oil ("spiked" animals; 60 mg/kg initially and 45 mg/kg thereafter) every 2 months (0+CPF, 1+CPF, 5+CPF)." | 1.33 | Neurochemical effects of chronic dietary and repeated high-level acute exposure to chlorpyrifos in rats. ( Hunter, DL; Mailman, RB; Marshall, RS; Moser, VC; Oxendine, S; Padilla, S; Southerland, SB, 2005) |
| "Chlorpyrifos is a moderately toxic organophosphate pesticide." | 1.31 | Neurologic function among termiticide applicators exposed to chlorpyrifos. ( Chrislip, DW; Dick, RB; Hines, CJ; Howell, RJ; Knott, C; Krieg, EF; Laber, P; Lehman, E; Reid, TM; Steenland, K, 2000) |
| " The present study was designed to clarify the magnitude of neuropathic risk associated with CPS exposures by measuring hen brain AChE and NTE inhibition following dosing in vivo and determining the bimolecular rate constant of inhibition (ki) for each enzyme by the active metabolite, CPS oxon (CPO), in vitro." | 1.29 | Inhibition of hen brain acetylcholinesterase and neurotoxic esterase by chlorpyrifos in vivo and kinetics of inhibition by chlorpyrifos oxon in vitro: application to assessment of neuropathic risk. ( Fowke, JH; Kayyali, US; Moore, TB; Randall, JC; Richardson, RJ, 1993) |
| " We hypothesize that test compounds may compete for xenobiotic metabolizing enzymes in the liver and blood and may also compromise the integrity of the blood-brain barrier, leading to an increase in their "effective concentrations" in the nervous system to levels equivalent to the toxic doses of individual compounds." | 1.29 | Increased neurotoxicity following concurrent exposure to pyridostigmine bromide, DEET, and chlorpyrifos. ( Abdel-Rahman, AA; Abou-Donia, MB; Jensen, KF; Kurt, TL; Oehme, FW; Wilmarth, KR, 1996) |
| "Atropine and 2-PAM were administered to chlorpyrifos exposed cats one to two times a day for 14 to 24 days in response to the appearance of cholinergic signs." | 1.28 | Clinical, biochemical, electrophysiologic, and histologic assessment of chlorpyrifos induced delayed neuropathy in the cat. ( Beasley, VR; Fikes, JD; Parker, AJ; Zachary, JF, 1992) |
| "Chlorpyrifos was slowly absorbed after single oral doses and the threshold of inhibition (greater than 70%) of neuropathy target esterase (NTE), the putative target for delayed neuropathy, was reached within 5-6 days." | 1.28 | Chlorpyrifos-induced delayed polyneuropathy. ( Capodicasa, E; Caroldi, S; Lotti, M; Moretto, A; Scapellato, ML, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 7 (43.75) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khan, K | 1 |
| Ismail, AA | 1 |
| Abdel Rasoul, G | 1 |
| Bonner, MR | 1 |
| Lasarev, MR | 1 |
| Hendy, O | 1 |
| Al-Batanony, M | 1 |
| Crane, AL | 1 |
| Singleton, ST | 1 |
| Olson, JR | 1 |
| Rohlman, DS | 1 |
| Soummer, A | 1 |
| Megarbane, B | 1 |
| Boroli, F | 1 |
| Arbelot, C | 1 |
| Saleh, M | 1 |
| Moesch, C | 1 |
| Fournier, E | 1 |
| Rouby, JJ | 1 |
| Albers, JW | 1 |
| Berent, S | 1 |
| Garabrant, DH | 1 |
| Giordani, B | 1 |
| Schweitzer, SJ | 1 |
| Garrison, RP | 1 |
| Richardson, RJ | 2 |
| Padilla, S | 1 |
| Marshall, RS | 1 |
| Hunter, DL | 1 |
| Oxendine, S | 1 |
| Moser, VC | 1 |
| Southerland, SB | 1 |
| Mailman, RB | 1 |
| Aiuto, LA | 1 |
| Pavlakis, SG | 1 |
| Boxer, RA | 1 |
| Moore, TB | 1 |
| Kayyali, US | 1 |
| Fowke, JH | 1 |
| Randall, JC | 1 |
| Abou-Donia, MB | 1 |
| Wilmarth, KR | 1 |
| Abdel-Rahman, AA | 1 |
| Jensen, KF | 1 |
| Oehme, FW | 1 |
| Kurt, TL | 1 |
| Johnson, DE | 1 |
| Seidler, FJ | 2 |
| Slotkin, TA | 2 |
| Olson, CT | 1 |
| Blank, JA | 1 |
| Menton, RG | 1 |
| Steenland, K | 1 |
| Dick, RB | 1 |
| Howell, RJ | 1 |
| Chrislip, DW | 1 |
| Hines, CJ | 1 |
| Reid, TM | 1 |
| Lehman, E | 1 |
| Laber, P | 1 |
| Krieg, EF | 1 |
| Knott, C | 1 |
| Dam, K | 1 |
| Fikes, JD | 1 |
| Zachary, JF | 1 |
| Parker, AJ | 1 |
| Beasley, VR | 1 |
| Capodicasa, E | 1 |
| Scapellato, ML | 1 |
| Moretto, A | 1 |
| Caroldi, S | 1 |
| Lotti, M | 1 |
| Scheidt, AB | 1 |
| Long, GG | 1 |
| Knox, K | 1 |
| Hubbard, SE | 1 |
| Doury, P | 1 |
| Boisselier, P | 1 |
| Bernard, JG | 1 |
| Nolland, R | 1 |
| Erfmann, RK | 1 |
| Masson, JM | 1 |
| Moline, J | 1 |
| Martin, A | 1 |
16 other studies available for chlorpyrifos and Nervous System Disorders
| Article | Year |
|---|---|
Longitudinal assessment of chlorpyrifos exposure and self-reported neurological symptoms in adolescent pesticide applicators.
Topics: Adolescent; Adult; Agriculture; Biomarkers; Butyrylcholinesterase; Child; Chlorpyrifos; Developing C | 2014 |
Severe and prolonged neurologic toxicity following subcutaneous chlorpyrifos self-administration: a case report.
Topics: Antidotes; Atropine; Brain; Chlorpyrifos; Humans; Injections, Subcutaneous; Insecticides; Magnetic R | 2011 |
The effects of occupational exposure to chlorpyrifos on the neurologic examination of central nervous system function: a prospective cohort study.
Topics: Adult; Biomarkers; Butyrylcholinesterase; Case-Control Studies; Chemical Industry; Chlorpyrifos; Fem | 2004 |
Neurochemical effects of chronic dietary and repeated high-level acute exposure to chlorpyrifos in rats.
Topics: Acute Disease; Animals; Brain; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterases; Chronic Dis | 2005 |
Life-threatening organophosphate-induced delayed polyneuropathy in a child after accidental chlorpyrifos ingestion.
Topics: Child, Preschool; Chlorpyrifos; Humans; Intubation, Intratracheal; Male; Nervous System Diseases; Po | 1993 |
Inhibition of hen brain acetylcholinesterase and neurotoxic esterase by chlorpyrifos in vivo and kinetics of inhibition by chlorpyrifos oxon in vitro: application to assessment of neuropathic risk.
Topics: Acetylcholinesterase; Animals; Brain; Carboxylic Ester Hydrolases; Chickens; Chlorpyrifos; Cholinest | 1993 |
Increased neurotoxicity following concurrent exposure to pyridostigmine bromide, DEET, and chlorpyrifos.
Topics: Animals; Brain; Chickens; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterases; DEET; Drug Inter | 1996 |
Early biochemical detection of delayed neurotoxicity resulting from developmental exposure to chloropyrifos.
Topics: Animals; Brain; Brain Chemistry; Brain Stem; Chlorpyrifos; Cholinesterase Inhibitors; Female; Nervou | 1998 |
Neuromuscular effects of low level exposures to Sarin, pyridostigmine, DEET, and chlorpyrifos.
Topics: Animals; Behavior, Animal; Chlorpyrifos; DEET; Drug Interactions; Haplorhini; Nervous System Disease | 1998 |
Neurologic function among termiticide applicators exposed to chlorpyrifos.
Topics: Adult; Chlorpyrifos; Humans; Incidence; Insecticides; Male; Middle Aged; Nervous System Diseases; Oc | 2000 |
Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Chlorpyrifos; Cholinesterase Inhibitors; Choline | 2000 |
Clinical, biochemical, electrophysiologic, and histologic assessment of chlorpyrifos induced delayed neuropathy in the cat.
Topics: Animals; Antidotes; Atropine; Carboxylic Ester Hydrolases; Cats; Chlorpyrifos; Cholinesterases; Diaz | 1992 |
Chlorpyrifos-induced delayed polyneuropathy.
Topics: Animals; Carboxylic Ester Hydrolases; Chickens; Chlorpyrifos; Cholinesterase Inhibitors; Female; Let | 1991 |
Toxicosis in newborn pigs associated with cutaneous application of an aerosol spray containing chlorpyrifos.
Topics: Aerosols; Animals; Animals, Newborn; Chlorpyrifos; Nervous System Diseases; Swine; Swine Diseases; W | 1987 |
[Pathologic effects of U.H.F. electromagnetic radiation from Aeriens radar. A case report].
Topics: Blood Coagulation Disorders; Humans; Hypopituitarism; Magnetics; Male; Middle Aged; Military Medicin | 1970 |
[Autonomic reactions observed in 40 radar observers].
Topics: Adult; Autonomic Nervous System; Diaphragm; Electrophysiology; Female; Gastrointestinal Motility; He | 1974 |