chlorpyrifos has been researched along with Encephalopathy, Toxic in 50 studies
Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.
chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rapidly evolving delayed myelopathy is extremely uncommon." | 5.38 | Chlorpyrifos-induced delayed myelopathy and pure motor neuropathy: a case report. ( Gamage, R; Gooneratne, IK; Gunarathne, KS; Thivakaran, T, 2012) |
| " Unfortunately, they are also well known for the toxic effects that they can trigger in humans." | 2.55 | Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: from clinical findings to preclinical models and potential mechanisms. ( Albuquerque, EX; Burke, RD; Fawcett, WP; Gullapalli, RP; Lumsden, E; Mamczarz, J; Mullins, RJ; Pereira, EFR; Randall, WR; Todd, SW, 2017) |
| " Perturbations of these endpoints are described as common key events in adverse outcome pathways (AOPs) specific for DNT." | 1.62 | Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures. ( Bal-Price, A; Bopp, SK; Carpi, D; Mendoza-de Gyves, E; Paini, A; Pistollato, F; Worth, A, 2021) |
| "Chlorpyrifos (CPF) is a neurotoxic organophosphorus (OP) insecticide widely used for agricultural purposes." | 1.56 | Glutathione in Chlorpyrifos-and Chlorpyrifos-Oxon-Induced Toxicity: a Comparative Study Focused on Non-cholinergic Toxicity in HT22 Cells. ( Aschner, M; Colle, D; da Rocha, JBT; Dafré, AL; Farina, M; Leal, RB; Lopes, MW; Naime, AA; Suñol, C, 2020) |
| "Chlorpyrifos (CPF) is a widely used organophosphate insecticide with several harmful effects." | 1.51 | Potential role of N-acetylcysteine on chlorpyrifos-induced neurotoxicity in rats. ( Abdel Moneim, AE; El-Yamany, NA; Mahmoud, SM; Qayed, MM, 2019) |
| "Chlorpyrifos (CPF) is an organophosphorus pesticide that can damage the central nervous system in children upon exposure." | 1.51 | Protective mechanism of Taxifolin for chlorpyrifos neurotoxicity in BV2 cells. ( Dai, H; Deng, Y; Zhan, J; Zhang, C; Zhao, L; Zhao, M; Zhou, W, 2019) |
| "Exposure to organophosphorus toxicants (OP) can have chronic adverse effects that are not explained by inhibition of acetylcholinesterase, the cause of acute OP toxicity." | 1.48 | Chlorpyrifos oxon promotes tubulin aggregation via isopeptide cross-linking between diethoxyphospho-Lys and Glu or Asp: Implications for neurotoxicity. ( Lockridge, O; Schopfer, LM, 2018) |
| " Lethality was increased by AM251 with the higher dosage of PO, but no lethality was noted with either dosage of CPO, with or without AM251." | 1.42 | The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats. ( Liu, J; Pope, C, 2015) |
| " Major complications arise when these potent nerve agents access neuronal mechanisms causing adverse effect on acetylcholinesterase and brain lipids with generation of reactive oxygen species." | 1.40 | In vivo antioxidative and neuroprotective effect of 4-Allyl-2-methoxyphenol against chlorpyrifos-induced neurotoxicity in rat brain. ( Panwar, R; Singh, V, 2014) |
| "Chlorpyrifos is a widely used insecticide of organophosphate group, which causes severe toxicological effects in non target aquatic organisms especially in fish." | 1.40 | Genotoxicity of chlorpyrifos in freshwater fish Labeo rohita using Alkaline Single-cell Gel Electrophoresis (Comet) assay. ( Ali, R; Ali, T; Ismail, M; Khan, QM; Mobeen, A, 2014) |
| "Chlorpyrifos is a pesticide that is metabolically activated to chlorpyrifos oxon (acetylcholinesterase inhibitor) primarily by the cytochrome P450 2B (CYP2B) enzyme subfamily in the liver and brain." | 1.40 | Intracerebroventricularly and systemically delivered inhibitor of brain CYP2B (C8-Xanthate), even following chlorpyrifos exposure, reduces chlorpyrifos activation and toxicity in male rats. ( Khokhar, JY; Tyndale, RF, 2014) |
| " Similarly, animal data at high doses or routes of exposure not typical for humans also pose challenges to dose-response evaluations needed for risk assessments." | 1.38 | Integration of epidemiology and animal neurotoxicity data for risk assessment. ( Anger, WK; Burns, CJ; Levine, TE; Li, AA, 2012) |
| "Rapidly evolving delayed myelopathy is extremely uncommon." | 1.38 | Chlorpyrifos-induced delayed myelopathy and pure motor neuropathy: a case report. ( Gamage, R; Gooneratne, IK; Gunarathne, KS; Thivakaran, T, 2012) |
| " On day 39 of the study, shortly after the daily stress episode, one half of the rats in each group was dosed with 60 mg/kg chlorpyrifos subcutaneously." | 1.34 | The effect of stress on the acute neurotoxicity of the organophosphate insecticide chlorpyrifos. ( Ehrich, M; Hancock, S; Hinckley, J; Jortner, BS; Pung, T, 2007) |
| " Sea urchins use neurotransmitters as embryonic growth regulatory signals, so that adverse effects on neural substrates for mammalian brain development can be studied in this simple organism." | 1.34 | The sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: therapeutic interventions and a comparison with the monoamine depleter, reserpine. ( Bezuglov, VV; Buznikov, GA; Lauder, JM; Milosević, I; Nikitina, LA; Rakić, LM; Slotkin, TA, 2007) |
| " Their major mechanism of acute toxic action is the inhibition of acetylcholinesterase, which is responsible for the degradation of the neurotransmitter acetylcholine." | 1.33 | Long-term neurotoxicity of chlorpyrifos: spatial learning impairment on repeated acquisition in a water maze. ( Cañadas, F; Cardona, D; Dávila, E; Sánchez-Santed, F, 2005) |
| "Corticosterone was added to the drinking water at 400 microg/ml, to model aspects of chronic stress." | 1.33 | Neuropathological studies of rats following multiple exposure to tri-ortho-tolyl phosphate, chlorpyrifos and stress. ( Ehrich, M; Flory, L; Hancock, SK; Hinckley, J; Jortner, BS; Tobias, L; Williams, L, 2005) |
| "Chlorpyrifos (CPF) is a common organophosphate (OP) insecticide that has been widely used in extensive agriculture as a pesticide." | 1.33 | Vulnerability of long-term neurotoxicity of chlorpyrifos: effect on schedule-induced polydipsia and a delay discounting task. ( Cardona, D; Flores, P; López-Crespo, G; López-Grancha, M; Nieto-Escamez, F; Sánchez-Santed, F, 2006) |
| " To address the question of the difference in toxicity between parathion and chlorpyrifos, the toxic effects of their leaving groups, p-nitrophenol and trichloropyridinol, were studied in mixed-cell aggregates." | 1.32 | Involvement of glial cells in the neurotoxicity of parathion and chlorpyrifos. ( Costa, LG; Honegger, P; Monnet-Tschudi, F; Schilter, B; Zurich, MG, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (26.00) | 29.6817 |
| 2010's | 28 (56.00) | 24.3611 |
| 2020's | 9 (18.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nunes, C | 1 |
| Gorczyca, G | 1 |
| Mendoza-deGyves, E | 1 |
| Ponti, J | 1 |
| Bogni, A | 1 |
| Carpi, D | 2 |
| Bal-Price, A | 3 |
| Pistollato, F | 3 |
| Ireland, D | 1 |
| Rabeler, C | 1 |
| Gong, T | 1 |
| Collins, ES | 1 |
| van Melis, LVJ | 1 |
| Heusinkveld, HJ | 1 |
| Langendoen, C | 1 |
| Peters, A | 1 |
| Westerink, RHS | 1 |
| Wei, H | 1 |
| Zhang, X | 1 |
| Yang, X | 2 |
| Yu, Q | 1 |
| Deng, S | 1 |
| Guan, Q | 1 |
| Chen, D | 1 |
| Zhang, M | 1 |
| Gao, B | 1 |
| Xu, S | 3 |
| Xia, Y | 1 |
| Gu, J | 1 |
| Liu, Y | 1 |
| Chen, X | 1 |
| Naime, AA | 1 |
| Lopes, MW | 1 |
| Colle, D | 1 |
| Dafré, AL | 1 |
| Suñol, C | 1 |
| da Rocha, JBT | 1 |
| Aschner, M | 1 |
| Leal, RB | 1 |
| Farina, M | 1 |
| Di Consiglio, E | 1 |
| Mendoza-De Gyves, E | 2 |
| Testai, E | 1 |
| Anderson, FL | 1 |
| von Herrmann, KM | 1 |
| Young, AL | 1 |
| Havrda, MC | 1 |
| Paini, A | 1 |
| Bopp, SK | 1 |
| Worth, A | 1 |
| Wu, X | 1 |
| Majumder, A | 1 |
| Swetenburg, R | 1 |
| Goodfellow, FT | 1 |
| Bartlett, MG | 1 |
| Stice, SL | 1 |
| Burke, RD | 1 |
| Todd, SW | 2 |
| Lumsden, E | 1 |
| Mullins, RJ | 2 |
| Mamczarz, J | 2 |
| Fawcett, WP | 1 |
| Gullapalli, RP | 2 |
| Randall, WR | 1 |
| Pereira, EFR | 1 |
| Albuquerque, EX | 2 |
| Schopfer, LM | 2 |
| Lockridge, O | 4 |
| Mie, A | 1 |
| Rudén, C | 1 |
| Grandjean, P | 1 |
| Mahmoud, SM | 1 |
| Abdel Moneim, AE | 1 |
| Qayed, MM | 1 |
| El-Yamany, NA | 1 |
| Zhang, C | 1 |
| Zhan, J | 1 |
| Zhao, M | 1 |
| Dai, H | 1 |
| Deng, Y | 1 |
| Zhou, W | 1 |
| Zhao, L | 1 |
| Slotkin, TA | 5 |
| Cooper, EM | 1 |
| Stapleton, HM | 1 |
| Seidler, FJ | 4 |
| Singh, V | 1 |
| Panwar, R | 1 |
| Ismail, M | 1 |
| Khan, QM | 1 |
| Ali, R | 1 |
| Ali, T | 1 |
| Mobeen, A | 1 |
| Khokhar, JY | 1 |
| Tyndale, RF | 1 |
| Liu, J | 2 |
| Pope, C | 2 |
| Pereira, EF | 1 |
| Pescrille, JD | 1 |
| Zarei, MH | 1 |
| Soodi, M | 1 |
| Qasemian-Lemraski, M | 1 |
| Jafarzadeh, E | 1 |
| Taha, MF | 1 |
| Lee, I | 1 |
| Eriksson, P | 1 |
| Fredriksson, A | 1 |
| Buratovic, S | 1 |
| Viberg, H | 1 |
| Lee, YS | 1 |
| Lewis, JA | 1 |
| Ippolito, DL | 1 |
| Hussainzada, N | 1 |
| Lein, PJ | 3 |
| Jackson, DA | 1 |
| Stallings, JD | 1 |
| Grigoryan, H | 1 |
| Jiang, W | 1 |
| Duysen, EG | 2 |
| Hansen, H | 1 |
| Shlyakhtenko, L | 1 |
| Bozkurt, A | 1 |
| Yardan, T | 1 |
| Ciftcioglu, E | 1 |
| Baydin, A | 1 |
| Hakligor, A | 1 |
| Bitigic, M | 1 |
| Bilge, S | 1 |
| Baireddy, P | 1 |
| Hinsdale, M | 1 |
| Torres-Altoro, MI | 1 |
| Mathur, BN | 1 |
| Drerup, JM | 1 |
| Thomas, R | 1 |
| Lovinger, DM | 1 |
| O'Callaghan, JP | 1 |
| Bibb, JA | 1 |
| Prueitt, RL | 1 |
| Goodman, JE | 1 |
| Bailey, LA | 1 |
| Rhomberg, LR | 1 |
| Malhotra, A | 1 |
| Nair, P | 1 |
| Dhawan, DK | 1 |
| Flaskos, J | 1 |
| Bonner, MR | 1 |
| Farahat, FM | 1 |
| Olson, JR | 1 |
| Rohlman, DS | 1 |
| Fenske, RA | 1 |
| Lattal, KM | 1 |
| Lasarev, MR | 1 |
| Galvin, K | 1 |
| Farahat, TM | 1 |
| Anger, WK | 2 |
| Li, AA | 1 |
| Levine, TE | 1 |
| Burns, CJ | 1 |
| Thivakaran, T | 1 |
| Gamage, R | 1 |
| Gunarathne, KS | 1 |
| Gooneratne, IK | 1 |
| Venerosi, A | 1 |
| Ricceri, L | 1 |
| Tait, S | 1 |
| Calamandrei, G | 1 |
| Park, JH | 1 |
| Lee, JE | 1 |
| Shin, IC | 1 |
| Koh, HC | 1 |
| Schuh, RA | 1 |
| Beckles, RA | 1 |
| Jett, DA | 1 |
| Qiao, D | 1 |
| Violin, JD | 1 |
| Zurich, MG | 1 |
| Honegger, P | 1 |
| Schilter, B | 1 |
| Costa, LG | 1 |
| Monnet-Tschudi, F | 1 |
| Cañadas, F | 1 |
| Cardona, D | 2 |
| Dávila, E | 1 |
| Sánchez-Santed, F | 2 |
| Jortner, BS | 2 |
| Hancock, SK | 1 |
| Hinckley, J | 2 |
| Flory, L | 1 |
| Tobias, L | 1 |
| Williams, L | 1 |
| Ehrich, M | 3 |
| Moser, VC | 1 |
| Phillips, PM | 1 |
| McDaniel, KL | 1 |
| Marshall, RS | 1 |
| Hunter, DL | 1 |
| Padilla, S | 1 |
| López-Grancha, M | 1 |
| López-Crespo, G | 1 |
| Nieto-Escamez, F | 1 |
| Flores, P | 1 |
| Li, B | 1 |
| Darvesh, S | 1 |
| Hancock, S | 1 |
| Pung, T | 1 |
| Buznikov, GA | 1 |
| Nikitina, LA | 1 |
| Rakić, LM | 1 |
| Milosević, I | 1 |
| Bezuglov, VV | 1 |
| Lauder, JM | 1 |
| Barber, D | 1 |
| Hunt, J | 1 |
4 reviews available for chlorpyrifos and Encephalopathy, Toxic
| Article | Year |
|---|---|
Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: from clinical findings to preclinical models and potential mechanisms.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Chlorpyrifos; Cholinesterase Inhibitors; Humans; Insec | 2017 |
Hypothesis-based weight-of-evidence evaluation of the neurodevelopmental effects of chlorpyrifos.
Topics: Animals; Brain; Chlorpyrifos; Cholinesterase Inhibitors; Ecotoxicology; Epidemiologic Studies; Europ | 2011 |
The developmental neurotoxicity of organophosphorus insecticides: a direct role for the oxon metabolites.
Topics: Animals; Brain; Chlorpyrifos; Cholinesterase Inhibitors; Female; Humans; Insecticides; Neurotoxicity | 2012 |
Sex dimorphic behaviors as markers of neuroendocrine disruption by environmental chemicals: the case of chlorpyrifos.
Topics: Age Factors; Animals; Behavior, Animal; Brain; Chlorpyrifos; Dose-Response Relationship, Drug; Emoti | 2012 |
46 other studies available for chlorpyrifos and Encephalopathy, Toxic
| Article | Year |
|---|---|
Upscaling biological complexity to boost neuronal and oligodendroglia maturation and improve in vitro developmental neurotoxicity (DNT) evaluation.
Topics: Cell Differentiation; Chlorpyrifos; Humans; Induced Pluripotent Stem Cells; Neurons; Neurotoxicity S | 2022 |
Bioactivation and detoxification of organophosphorus pesticides in freshwater planarians shares similarities with humans.
Topics: Acetylcholinesterase; Animals; Aryldialkylphosphatase; Butyrylcholinesterase; Carboxylic Ester Hydro | 2022 |
Organophosphate insecticides disturb neuronal network development and function via non-AChE mediated mechanisms.
Topics: Acetylcholinesterase; Animals; Chlorpyrifos; Cholinesterase Inhibitors; Diazinon; Humans; Insecticid | 2023 |
Prenatal exposure to pesticides and domain-specific neurodevelopment at age 12 and 18 months in Nanjing, China.
Topics: Atrazine; Bayes Theorem; China; Chlorpyrifos; Female; Humans; Infant; Infant, Newborn; Maternal Expo | 2023 |
Chlorpyrifos-induced toxicity has no gender selectivity in the early fetal brain.
Topics: Acetylcholinesterase; Animals; Body Weight; Brain; Catalase; Chlorpyrifos; Cholinesterase Inhibitors | 2020 |
Glutathione in Chlorpyrifos-and Chlorpyrifos-Oxon-Induced Toxicity: a Comparative Study Focused on Non-cholinergic Toxicity in HT22 Cells.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Cell Survival; Chlorpyrifos; Cholinesterase | 2020 |
Integrating biokinetics and in vitro studies to evaluate developmental neurotoxicity induced by chlorpyrifos in human iPSC-derived neural stem cells undergoing differentiation towards neuronal and glial cells.
Topics: Biological Assay; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cells, Cultured; Chlorpyr | 2020 |
Bbc3 Loss Enhances Survival and Protein Clearance in Neurons Exposed to the Organophosphate Pesticide Chlorpyrifos.
Topics: Animals; Apoptosis; Chlorpyrifos; Insecticides; Mice; Neurons; Neurotoxicity Syndromes | 2021 |
Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures.
Topics: Astrocytes; Benzhydryl Compounds; Biological Assay; Brain-Derived Neurotrophic Factor; Cell Differen | 2021 |
From the Cover: AstrocytesAre Protective Against Chlorpyrifos Developmental Neurotoxicity in Human Pluripotent Stem Cell-Derived Astrocyte-Neuron Cocultures.
Topics: Astrocytes; Cell Differentiation; Chlorpyrifos; Coculture Techniques; Cytochrome P-450 Enzyme System | 2017 |
Chlorpyrifos oxon promotes tubulin aggregation via isopeptide cross-linking between diethoxyphospho-Lys and Glu or Asp: Implications for neurotoxicity.
Topics: Acetylcholinesterase; Amino Acid Sequence; Animals; Aspartic Acid; Chlorpyrifos; Cholinesterase Inhi | 2018 |
Response to Juberg et al.
Topics: Chlorpyrifos; Environmental Health; Humans; Neurotoxicity Syndromes; Pesticides | 2019 |
Potential role of N-acetylcysteine on chlorpyrifos-induced neurotoxicity in rats.
Topics: Acetylcysteine; Animals; Antioxidants; Brain; Chlorpyrifos; Insecticides; Male; Neurotoxicity Syndro | 2019 |
Protective mechanism of Taxifolin for chlorpyrifos neurotoxicity in BV2 cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; Cell Line; Cell Survival; Chlorpyrifos; | 2019 |
Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos?
Topics: Age Factors; Animals; Brain; Chlorpyrifos; Female; Gestational Age; Insecticides; Male; Maternal Exp | 2013 |
In vivo antioxidative and neuroprotective effect of 4-Allyl-2-methoxyphenol against chlorpyrifos-induced neurotoxicity in rat brain.
Topics: Acetylcholinesterase; Animals; Antioxidants; Brain; Caspase 3; Chlorpyrifos; Cholesterol; Cholineste | 2014 |
Genotoxicity of chlorpyrifos in freshwater fish Labeo rohita using Alkaline Single-cell Gel Electrophoresis (Comet) assay.
Topics: Animals; Behavior, Animal; Chlorpyrifos; Comet Assay; Cyprinidae; DNA Damage; Dose-Response Relation | 2014 |
Intracerebroventricularly and systemically delivered inhibitor of brain CYP2B (C8-Xanthate), even following chlorpyrifos exposure, reduces chlorpyrifos activation and toxicity in male rats.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Chlorpyrifos; Cholinesterase Inhibitors; Cyt | 2014 |
The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Ca | 2015 |
Prenatal exposure of guinea pigs to the organophosphorus pesticide chlorpyrifos disrupts the structural and functional integrity of the brain.
Topics: Age Factors; Animals; Behavior, Animal; Brain; Chlorpyrifos; Cognition; Diffusion Tensor Imaging; Es | 2015 |
Study of the chlorpyrifos neurotoxicity using neural differentiation of adipose tissue-derived stem cells.
Topics: Acetylcholinesterase; Adipose Tissue; Animals; Cell Differentiation; Cell Survival; Cells, Cultured; | 2016 |
Developmental neurotoxic effects of two pesticides: Behavior and biomolecular studies on chlorpyrifos and carbaryl.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; | 2015 |
Repeated exposure to neurotoxic levels of chlorpyrifos alters hippocampal expression of neurotrophins and neuropeptides.
Topics: Animals; CA1 Region, Hippocampal; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterases; Gene Exp | 2016 |
Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel.
Topics: Animals; Cell Differentiation; Chlorpyrifos; Diazinon; Dieldrin; Gene Expression Regulation; Insecti | 2008 |
Nanoimages show disruption of tubulin polymerization by chlorpyrifos oxon: implications for neurotoxicity.
Topics: Animals; Cattle; Chlorpyrifos; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Guanosin | 2009 |
Mice treated with chlorpyrifos or chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents.
Topics: Animals; Biotinylation; Body Temperature; Body Weight; Brain; Brain Chemistry; Chlorpyrifos; Choline | 2010 |
Time course of serum S100B protein and neuron-specific enolase levels of a single dose of chlorpyrifos in rats.
Topics: Animals; Butyrylcholinesterase; Chlorpyrifos; Dose-Response Relationship, Drug; Immunohistochemistry | 2010 |
Comparative effects of chlorpyrifos in wild type and cannabinoid Cb1 receptor knockout mice.
Topics: Acetylcholine; Animals; Cerebellum; Cerebral Cortex; Chlorpyrifos; Cholinesterase Inhibitors; Cholin | 2011 |
Organophosphates dysregulate dopamine signaling, glutamatergic neurotransmission, and induce neuronal injury markers in striatum.
Topics: Animals; Animals, Newborn; Biomarkers; Blotting, Western; Chlorpyrifos; Cholinesterase Inhibitors; C | 2011 |
Efficacy of zinc as a nutritional supplement in ameliorating chlorpyrifos-induced neurotoxicity in rats.
Topics: Animals; Behavior, Animal; Cerebellum; Cerebrum; Chlorpyrifos; Dietary Supplements; Female; Glutathi | 2011 |
Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro.
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Cell Cycle; Cell Differentiation; Cells, Cultured; Chlo | 2012 |
Experimental strategy for translational studies of organophosphorus pesticide neurotoxicity based on real-world occupational exposures to chlorpyrifos.
Topics: Adolescent; Adult; Agricultural Workers' Diseases; Agriculture; Animals; Behavior, Animal; Biomarker | 2012 |
Integration of epidemiology and animal neurotoxicity data for risk assessment.
Topics: Animals; Chlorpyrifos; Dose-Response Relationship, Drug; Epidemiologic Research Design; Humans; Mode | 2012 |
Chlorpyrifos-induced delayed myelopathy and pure motor neuropathy: a case report.
Topics: Adolescent; Chlorpyrifos; Electrophysiology; Female; Humans; Insecticides; Neurotoxicity Syndromes; | 2012 |
Autophagy regulates chlorpyrifos-induced apoptosis in SH-SY5Y cells.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Apoptosis; Autophagy; bcl-2-Associated X Protein; Blo | 2013 |
Noncholinesterase mechanisms of chlorpyrifos neurotoxicity: altered phosphorylation of Ca2+/cAMP response element binding protein in cultured neurons.
Topics: Acetylcholinesterase; Animals; Astrocytes; Blotting, Western; Cell Survival; Cells, Cultured; Cerebr | 2002 |
Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos.
Topics: Animals; Cell Differentiation; Cells, Cultured; Chlorpyrifos; Cholinesterase Inhibitors; DNA; Mecamy | 2003 |
Involvement of glial cells in the neurotoxicity of parathion and chlorpyrifos.
Topics: Acetylcholinesterase; Animals; Astrocytes; Brain; Cells, Cultured; Chlorpyrifos; Choline O-Acetyltra | 2004 |
Long-term neurotoxicity of chlorpyrifos: spatial learning impairment on repeated acquisition in a water maze.
Topics: Acetylcholinesterase; Animals; Brain; Chlorpyrifos; Insecticides; Male; Maze Learning; Neurotoxicity | 2005 |
Neuropathological studies of rats following multiple exposure to tri-ortho-tolyl phosphate, chlorpyrifos and stress.
Topics: Animals; Axons; Carboxylic Ester Hydrolases; Chlorpyrifos; Corticosterone; Dose-Response Relationshi | 2005 |
Neurobehavioral effects of chronic dietary and repeated high-level spike exposure to chlorpyrifos in rats.
Topics: Animals; Chlorpyrifos; Cholinesterase Inhibitors; Diet; Insecticides; Male; Maze Learning; Motor Act | 2005 |
Vulnerability of long-term neurotoxicity of chlorpyrifos: effect on schedule-induced polydipsia and a delay discounting task.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Chlorpyrifos; Cholinergic Agonists; Choliner | 2006 |
Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission.
Topics: Acetylcholine; Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Butyrylcholinesterase; C | 2007 |
The effect of stress on the acute neurotoxicity of the organophosphate insecticide chlorpyrifos.
Topics: Acetylcholinesterase; Acute Disease; Animals; Chlorpyrifos; Cholinesterase Inhibitors; Corticosteron | 2007 |
The sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: therapeutic interventions and a comparison with the monoamine depleter, reserpine.
Topics: Adrenergic Uptake Inhibitors; Animals; Chlorpyrifos; Disease Models, Animal; Dose-Response Relations | 2007 |
Inhibition of calcium-stimulated ATPase in the hen brain P2 synaptosomal fraction by organophosphorus esters: relevance to delayed neuropathy.
Topics: Analysis of Variance; Animals; Brain; Ca(2+) Mg(2+)-ATPase; Chickens; Chlorpyrifos; Cholinesterase I | 2001 |