Page last updated: 2024-10-25

chlorpyrifos and Delayed Effects, Prenatal Exposure

chlorpyrifos has been researched along with Delayed Effects, Prenatal Exposure in 104 studies

Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.
chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to investigate how chronic low-dose chlorpyrifos exposure of female Wistar rats before and during pregnancy affects behavioural parameters in their offspring."7.81ADHD-like behaviour in the offspring of female rats exposed to low chlorpyrifos doses before pregnancy. ( Grabovska, S; Salyha, Y, 2015)
" CPF combined with bacterial infection is a potential problem for children during their childhood development."5.48Evaluation of the effects of chlorpyrifos combined with lipopolysaccharide stress on neuroinflammation and spatial memory in neonatal rats. ( Bing, G; Dai, H; Deng, Y; Tian, J; Wang, P; Zhang, C; Zhao, L; Zhao, M, 2018)
"Chlorpyrifos is a pesticide, member of the organophosphate class, widely used in several countries to manage insect pests on many agricultural crops."5.46Chlorpyrifos induces anxiety-like behavior in offspring rats exposed during pregnancy. ( Boareto, AC; Dalsenter, PR; Gambeta, E; Morais, H; Redivo, DD; Schreiber, AK; Silva, JG; Vergara, F; Zanoveli, JM, 2017)
" Six non-specific organophosphate metabolites (dialkylphosphates, DAPs), one metabolite relatively specific to chlorpyrifos (3,5,6-trichloro-2-pyridinol, TCPy) and a common metabolite to several pyrethroids (3-phenoxybenzoic acid, 3-PBA) were measured in maternal urine from the 1st and 3rd pregnancy trimesters."4.31Effect of prenatal exposure to organophosphates and pyrethroid pesticides on neonatal anthropometric measures and gestational age. ( Aguilar-Garduño, C; Boada, LD; García-Cortés, H; Gimenez-Asensio, MJ; Gonzalez-Alzaga, B; Henríquez-Hernández, LA; Hernandez, AF; Lacasaña, M; Lopez-Flores, I; Luzardo, OP; Romero-Molina, D; Sanchez-Piedra, MD, 2023)
"The aim of this study was to investigate how chronic low-dose chlorpyrifos exposure of female Wistar rats before and during pregnancy affects behavioural parameters in their offspring."3.81ADHD-like behaviour in the offspring of female rats exposed to low chlorpyrifos doses before pregnancy. ( Grabovska, S; Salyha, Y, 2015)
" Neurobehavioural effects likely involving serotonin (5-hydroxytryptamine, 5HT) transmission were assessed both in males and females, through the light-dark exploration test to assess CPF effects on anxiety profiles and the forced swimming test to evaluate the response to the 5HT transporter (5HTT) inhibitor fluvoxamine (30 mg/kg)."3.76Gestational exposure to the organophosphate chlorpyrifos alters social-emotional behaviour and impairs responsiveness to the serotonin transporter inhibitor fluvoxamine in mice. ( Calamandrei, G; Ricceri, L; Rungi, A; Sanghez, V; Venerosi, A, 2010)
"Cigarette smoking and environmental exposure to chlorpyrifos during pregnancy could lead to developmental toxicity in the offspring."3.72Increased expression of glial fibrillary acidic protein in cerebellum and hippocampus: differential effects on neonatal brain regional acetylcholinesterase following maternal exposure to combined chlorpyrifos and nicotine. ( Abdel-Rahman, A; Abou-Donia, M; Dechkovskaia, A; Guan, X; Khan, W; Mehta-Simmons, H, 2003)
" For postnatal exposures, behavioral effects found in more than one study at 1 mg/kg-d were decreased errors on a radial arm maze in female rats and increased errors in males dosed subcutaneously from postnatal day (PND) 1 to 4."2.48Evaluation of epidemiology and animal data for risk assessment: chlorpyrifos developmental neurobehavioral outcomes. ( Li, AA; Lowe, KA; McIntosh, LJ; Mink, PJ, 2012)
"Results showed that the sleep apnea index was higher in CPF-exposed rats than in controls."1.48Impact of chronic exposure to the pesticide chlorpyrifos on respiratory parameters and sleep apnea in juvenile and adult rats. ( Bach, V; Darwiche, W; Delanaud, S; El Khayat El Sabbouri, H; Gay-Quéheillard, J; Joumaa, W; Khachfe, H; Ramadan, W, 2018)
"Behaviours relevant to mental retardation were measured in the surface righting, negative geotaxis and grip strength at post-natal days (PND) 3 and 7."1.48Developmental neurotoxicity in the progeny after maternal gavage with chlorpyrifos. ( Bach, V; Gay-Quéheillard, J; Laporte, B; Villégier, AS, 2018)
" CPF combined with bacterial infection is a potential problem for children during their childhood development."1.48Evaluation of the effects of chlorpyrifos combined with lipopolysaccharide stress on neuroinflammation and spatial memory in neonatal rats. ( Bing, G; Dai, H; Deng, Y; Tian, J; Wang, P; Zhang, C; Zhao, L; Zhao, M, 2018)
"For chlorpyrifos, scores were 0."1.46Prenatal naled and chlorpyrifos exposure is associated with deficits in infant motor function in a cohort of Chinese infants. ( Chen, M; Kaciroti, N; Lozoff, B; Meeker, JD; Shao, J; Silver, MK; Xia, Y; Zhu, B, 2017)
"Chlorpyrifos (CPF) is a widely used organophosphorus acetylcholinesterase (AChE)-inhibiting insecticide."1.46Impact of prenatal and postnatal exposure to the pesticide chlorpyrifos on the contraction of rat ileal muscle strips: involvement of an inducible nitric oxide synthase-dependent pathway. ( Bach, V; Darwiche, W; Delanaud, S; Dupont, S; Gay-Quéheillard, J; Ghamlouch, H; Joumaa, W; Ramadan, W, 2017)
"Chlorpyrifos (CPF) is a widely used organophosphorus pesticide with developmental neurotoxicity such as morphogenesis toxicity."1.46Mother gestational exposure to organophosphorus pesticide induces neuron and glia loss in daughter adult brain. ( Chao, YS; Chen, WZ; Chen, XP; Dong, JY, 2017)
"Chlorpyrifos is a pesticide, member of the organophosphate class, widely used in several countries to manage insect pests on many agricultural crops."1.46Chlorpyrifos induces anxiety-like behavior in offspring rats exposed during pregnancy. ( Boareto, AC; Dalsenter, PR; Gambeta, E; Morais, H; Redivo, DD; Schreiber, AK; Silva, JG; Vergara, F; Zanoveli, JM, 2017)
" We evaluated indices for acetylcholine (ACh) synaptic function throughout adolescence, young adulthood and later adulthood, in brain regions possessing the majority of ACh projections and cell bodies; we measured nicotinic ACh receptor binding, hemicholinium-3 binding to the presynaptic choline transporter and choline acetyltransferase activity, all known targets for the adverse developmental effects of nicotine and chlorpyrifos given individually."1.42Prenatal nicotine alters the developmental neurotoxicity of postnatal chlorpyrifos directed toward cholinergic systems: better, worse, or just "different?". ( Seidler, FJ; Slotkin, TA, 2015)
" High-exposure children also showed frontal and parietal cortical thinning, and an inverse dose-response relationship between CPF and cortical thickness."1.38Brain anomalies in children exposed prenatally to a common organophosphate pesticide. ( Bansal, R; Barr, DB; Hao, X; Horton, MK; Liu, J; Perera, FP; Peterson, BS; Rauh, VA; Slotkin, TA; Whyatt, RM, 2012)
" Prenatal dosing was more effective in causing metabolic alterations than CPF postnatal treatment; no potentiation was observed in mice experiencing pre- plus post-natal CPF administration."1.37Foetal and neonatal exposure to chlorpyrifos: biochemical and metabolic alterations in the mouse liver at different developmental stages. ( Buratti, FM; Calamandrei, G; De Angelis, G; Ricceri, L; Testai, E; Venerosi, A, 2011)
"Chlorpyrifos (CPF) is a non-persistent organophosphate (OP) largely used as pesticide."1.35Prenatal chlorpyrifos exposure alters motor behavior and ultrasonic vocalization in CD-1 mouse pups. ( Calamandrei, G; Ricceri, L; Scattoni, ML; Venerosi, A, 2009)
"Chlorpyrifos is an irreversible inhibitor of cholinesterase (ChE), and inhibition of ChE is believed to be the most sensitive effect in all animal species evaluated and in humans."1.33Lower birth weight as a critical effect of chlorpyrifos: a comparison of human and animal data. ( Dourson, M; Gadagbui, B; Zhao, Q, 2005)
" The present findings indicate a wide window of vulnerability of cholinergic systems to CPF, extending from prenatal through postnatal periods, occurring independently of adverse effects on general cellular neurotoxicity."1.32Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood. ( Cousins, MM; Qiao, D; Seidler, FJ; Slotkin, TA; Tate, CA, 2003)
" Pregnant rats were dosed daily with CPS (0, 3, or 7 mg/kg) in corn oil from gestation days (GD) 6-20."1.32Neurochemical effects of repeated gestational exposure to chlorpyrifos in developing rats. ( Chambers, JE; Richardson, JR, 2004)
"Nicotine treatment on postnatal days (PN) 1-4 had little or no effect on alpha7 nAChRs but treatment during the second (PN11-14) or third (PN21-24) weeks elicited significant decrements in receptor expression in brainstem and cerebellum, regions containing cell bodies that project to the forebrain."1.32Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos. ( Adam, SJ; Cousins, MM; Seidler, FJ; Slotkin, TA; Southard, MC, 2004)
" Toxicity was limited to the highest dosage level (5 mg/kg/day) and, in the dams, consisted of muscle fasciculation, hyperpnea, and hyperreactivity."1.31Lack of selective developmental neurotoxicity in rat pups from dams treated by gavage with chlorpyrifos. ( Garman, RH; Hanley, TR; Hoberman, AM; Maurissen, JP, 2000)
" The present investigation was designed to study selected toxicokinetic and toxicodynamic factors surrounding the toxicity of chlorpyrifos (CPF; [O,O'-diethyl O-3,5,6-trichloro-2-pyridyl] phosphorothionate) in pregnant rats dosed repeatedly or singly during late gestation."1.30Gestational exposure to chlorpyrifos: apparent protection of the fetus? ( Barone, S; Chanda, SM; Lassiter, TL; Mortensen, SR; Moser, VC; Padilla, S, 1998)
" Whereas similar reductions in brain muscarinic receptor binding were noted at GD20 and PND3 in dams and developing brain between acute and repeated dosing regimens, greater changes in [3H]CD and [3H]cytisine binding were evident following repeated exposures."1.29Neurochemical and neurobehavioral effects of repeated gestational exposure to chlorpyrifos in maternal and developing rats. ( Chanda, SM; Pope, CN, 1996)

Research

Studies (104)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (1.92)18.2507
2000's36 (34.62)29.6817
2010's50 (48.08)24.3611
2020's16 (15.38)2.80

Authors

AuthorsStudies
Lizé, M1
Monfort, C1
Rouget, F1
Limon, G1
Durand, G1
Tillaut, H1
Chevrier, C1
Biosca-Brull, J2
Guardia-Escote, L1
Blanco, J1
Basaure, P1
Cabré, M1
Sánchez-Santed, F3
Domingo, JL1
Colomina, MT2
Gunier, RB1
Deardorff, J1
Rauch, S1
Bradshaw, PT1
Kogut, K1
Sagiv, S1
Hyland, C1
Mora, AM1
Eskenazi, B1
Djekkoun, N3
Depeint, F3
Guibourdenche, M3
Sabbouri, HEKE2
Corona, A2
Rhazi, L3
Gay-Queheillard, J6
Rouabah, L2
Biendo, M2
Al-Salameh, A2
Lalau, JD2
Bach, V7
Khorsi-Cauet, H3
Wei, H1
Zhang, X1
Yang, X1
Yu, Q1
Deng, S1
Guan, Q1
Chen, D1
Zhang, M1
Gao, B1
Xu, S2
Xia, Y3
Gimenez-Asensio, MJ1
Hernandez, AF1
Romero-Molina, D1
Gonzalez-Alzaga, B1
Luzardo, OP1
Henríquez-Hernández, LA1
Boada, LD1
García-Cortés, H1
Lopez-Flores, I1
Sanchez-Piedra, MD1
Aguilar-Garduño, C1
Lacasaña, M1
Sharma, AR1
Batra, G1
Dhir, N1
Jain, A1
Modi, T1
Saini, L1
Thakur, N1
Mishra, A1
Singh, RS1
Singh, A1
Singla, R1
Prakash, A1
Goyal, M1
Bhatia, A1
Medhi, B1
Modi, M1
El Khayat El Sabbouri, H2
Joumaa, WH1
Delanaud, S3
Darwiche, W3
Ramadan, W3
Morales-Navas, M1
Castaño-Castaño, S1
Pérez-Fernández, C2
Sánchez-Gil, A1
Teresa Colomina, M1
Leinekugel, X1
Kofman, O3
Lan, A3
Raykin, E1
Zega, K1
Brodski, C1
Berg, EL1
Ching, TM1
Bruun, DA1
Rivera, JK1
Careaga, M1
Ellegood, J1
Lerch, JP1
Wöhr, M1
Lein, PJ1
Silverman, JL1
Chiu, KC1
Sisca, F1
Ying, JH1
Tsai, WJ1
Hsieh, WS1
Chen, PC1
Liu, CY1
Andersen, HR2
Dalsager, L2
Jensen, IK1
Timmermann, CAG1
Olesen, TS1
Trecca, F1
Nielsen, F2
Schoeters, G1
Kyhl, HB2
Grandjean, P2
Bilenberg, N2
Bleses, D1
Jensen, TK2
Mora, S1
Carrillo, B1
Pinos, H1
Conejo, NM1
Collado, P1
Arias, JL1
Martín-Sánchez, F1
Balalian, AA1
Liu, X1
Herbstman, JB1
Daniel, S1
Whyatt, R3
Rauh, V2
Calafat, AM1
Wapner, R1
Factor-Litvak, P1
He, X1
Tu, Y1
Song, Y1
Yang, G1
You, M1
Kalimian, M1
Amram, B1
Silver, MK2
Shao, J2
Zhu, B2
Chen, M2
Kaciroti, N2
Lozoff, B2
Meeker, JD3
Khachfe, H1
Joumaa, W2
Ji, C1
Xu, L1
Li, M1
Laporte, B1
Villégier, AS1
Wang, P1
Dai, H1
Zhang, C1
Tian, J1
Deng, Y1
Zhao, M2
Bing, G1
Zhao, L1
Stein, D1
Portillo, M1
Toiber, D1
Guo, J1
Zhang, J1
Wu, C1
Lv, S1
Lu, D1
Qi, X1
Jiang, S1
Feng, C1
Yu, H1
Liang, W1
Chang, X1
Zhang, Y1
Xu, H1
Cao, Y1
Wang, G1
Zhou, Z1
Fage-Larsen, B1
Slotkin, TA28
Skavicus, S3
Ko, A1
Levin, ED3
Seidler, FJ25
Wang, L1
Ohishi, T1
Akane, H1
Shiraki, A1
Itahashi, M1
Mitsumori, K1
Shibutani, M2
Cooper, EM1
Stapleton, HM1
Fortenberry, GZ1
Sánchez, BN1
Barr, DB5
Panuwet, P1
Bellinger, D1
Schnaas, L1
Solano-González, M1
Ettinger, AS1
Hernandez-Avila, M1
Hu, H1
Tellez-Rojo, MM1
Card, J1
Chen, XP5
Chen, WF1
Wang, DW1
Williams, AL1
DeSesso, JM1
Naseh, M2
Vatanparast, J2
Mullins, RJ1
Pereira, EF1
Pescrille, JD2
Todd, SW1
Mamczarz, J2
Albuquerque, EX2
Gullapalli, RP1
De Felice, A3
Scattoni, ML2
Ricceri, L7
Calamandrei, G9
Venerosi, A6
Tait, S2
Stecca, L1
Chiarotti, F1
Cometa, MF2
Volpe, MT1
Grabovska, S1
Salyha, Y1
Rauh, VA4
Garcia, WE1
Whyatt, RM2
Horton, MK2
Louis, ED1
Gavrushenko, L1
Burke, RD1
Fawcett, WP1
DeTolla, LJ1
Chen, H1
Pereira, EFR1
Greco, A1
Minghetti, L1
Mullen, BR1
Ross, B1
Chou, JW1
Khankan, R1
Khialeeva, E1
Bui, K1
Carpenter, EM1
Dupont, S1
Ghamlouch, H1
Reygner, J1
Lichtenberger, L1
Elmhiri, G1
Dou, S1
Bahi-Jaber, N1
Abdennebi-Najar, L1
Chao, YS1
Chen, WZ2
Dong, JY2
Silva, JG1
Boareto, AC1
Schreiber, AK1
Redivo, DD1
Gambeta, E1
Vergara, F1
Morais, H1
Zanoveli, JM1
Dalsenter, PR1
Billauer-Haimovitch, H1
Dotan, S1
Langford, R2
Pinkas, A2
Yanai, J2
Haviland, JA1
Butz, DE1
Porter, WP1
Rungi, A1
Sanghez, V1
Jin, JL1
Li, CW1
Wang, FS2
Lovasi, GS1
Quinn, JW1
Perera, FP3
Andrews, HF2
Garfinkel, R2
Hoepner, L3
Rundle, A1
Wang, X1
Buratti, FM1
De Angelis, G1
Testai, E1
Chen, W1
Jiang, H1
Wang, M1
Jin, J1
Feng, S1
Bi, Y1
Wang, H1
Mao, Y1
Shou, Z1
Chen, J1
Arunajadai, S1
Horton, M1
Perera, F1
Turgeman, G1
Tfilin, M1
Nakamura, R2
Kimura, Y1
Matsuoka, H1
Hachisuka, A1
Nakamura, A1
Teshima, R1
Li, AA1
Lowe, KA1
McIntosh, LJ1
Mink, PJ1
Bansal, R1
Hao, X1
Liu, J1
Peterson, BS1
Saunders, M1
Magnanti, BL1
Correia Carreira, S1
Yang, A1
Alamo-Hernández, U1
Riojas-Rodriguez, H1
Koppe, JG1
Krayer von Krauss, M1
Keune, H1
Bartonova, A1
Biello, D1
Juberg, DR1
Liu, JX1
Baniasadi, M1
Haghdoost-Yazdi, H1
Qiao, D4
Padilla, S2
Garcia, SJ3
Tate, CA4
Cousins, MM6
Freeman, K1
Abdel-Rahman, A3
Dechkovskaia, A1
Mehta-Simmons, H2
Guan, X2
Khan, W1
Abou-Donia, M1
Richardson, JR1
Chambers, JE1
Meyer, A6
Aldridge, JE5
Abreu-Villaça, Y1
Roy, TS1
Renner, R1
Berkowitz, GS1
Wetmur, JG1
Birman-Deych, E1
Obel, J1
Lapinski, RH1
Godbold, JH1
Holzman, IR1
Wolff, MS1
Dechkovskaia, AM2
Sutton, JM1
Khan, WA2
Abou-Donia, MB2
Southard, MC1
Adam, SJ1
Zhao, Q1
Gadagbui, B1
Dourson, M1
Oliver, CA1
Jeong, SH1
Kim, BY1
Kang, HG1
Ku, HO1
Cho, JH1
Goldstein, LB1
Bullman, SL1
Capone, F1
Lorenzini, P1
Fortuna, S1
Whitehead, R1
Tang, D1
Whyatt, RW1
Barrett, JR1
Cicchetti, DV1
Chanda, SM2
Pope, CN1
Lassiter, TL1
Mortensen, SR1
Moser, VC1
Barone, S1
Maurissen, JP1
Hoberman, AM1
Garman, RH1
Hanley, TR1
Crumpton, TL1

Reviews

7 reviews available for chlorpyrifos and Delayed Effects, Prenatal Exposure

ArticleYear
Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models.
    International journal of environmental research and public health, 2021, 05-13, Volume: 18, Issue:10

    Topics: Autism Spectrum Disorder; Chlorpyrifos; Female; Humans; Pesticides; Pregnancy; Prenatal Exposure Del

2021
The relationship between pesticide exposure during critical neurodevelopment and autism spectrum disorder: A narrative review.
    Environmental research, 2022, Volume: 203

    Topics: Acetylcholinesterase; Autism Spectrum Disorder; Chlorpyrifos; Female; Humans; Pesticides; Pregnancy;

2022
Gestational/perinatal chlorpyrifos exposure is not associated with autistic-like behaviors in rodents.
    Critical reviews in toxicology, 2014, Volume: 44, Issue:6

    Topics: Animals; Autistic Disorder; Behavior, Animal; Chlorpyrifos; Disease Models, Animal; Female; Humans;

2014
Evaluation of epidemiology and animal data for risk assessment: chlorpyrifos developmental neurobehavioral outcomes.
    Journal of toxicology and environmental health. Part B, Critical reviews, 2012, Volume: 15, Issue:2

    Topics: Animals; Behavior, Animal; Biomarkers; Child; Child Behavior; Child Development; Chlorpyrifos; Dose-

2012
Chlorpyrifos and neurodevelopmental effects: a literature review and expert elicitation on research and policy.
    Environmental health : a global access science source, 2012, Jun-28, Volume: 11 Suppl 1

    Topics: Child; Child Development; Chlorpyrifos; Environmental Exposure; Environmental Health; European Union

2012
Sex dimorphic behaviors as markers of neuroendocrine disruption by environmental chemicals: the case of chlorpyrifos.
    Neurotoxicology, 2012, Volume: 33, Issue:6

    Topics: Age Factors; Animals; Behavior, Animal; Brain; Chlorpyrifos; Dose-Response Relationship, Drug; Emoti

2012
Fetal nicotinic overload, blunted sympathetic responsivity, and obesity.
    Birth defects research. Part A, Clinical and molecular teratology, 2005, Volume: 73, Issue:7

    Topics: Adipose Tissue; Animals; Central Nervous System; Chlorpyrifos; Energy Metabolism; Female; Nicotine;

2005

Other Studies

97 other studies available for chlorpyrifos and Delayed Effects, Prenatal Exposure

ArticleYear
Prenatal exposure to organophosphate pesticides and autism spectrum disorders in 11-year-old children in the French PELAGIE cohort.
    Environmental research, 2022, Volume: 212, Issue:Pt C

    Topics: Acetylcholinesterase; Autism Spectrum Disorder; Child; Chlorpyrifos; Diazinon; Female; Humans; Insec

2022
Prenatal, but not postnatal exposure to chlorpyrifos affects social behavior of mice and the excitatory-inhibitory balance in a sex-dependent manner.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2022, Volume: 169

    Topics: Animals; Behavior, Animal; Chlorpyrifos; Corn Oil; Female; gamma-Aminobutyric Acid; Humans; Male; Mi

2022
Residential proximity to agricultural pesticide use and risk-taking behaviors in young adults from the CHAMACOS study.
    Environmental research, 2022, Volume: 215, Issue:Pt 2

    Topics: Adolescent; Bayes Theorem; California; Chlorpyrifos; Dimethoate; Environmental Exposure; Female; Hum

2022
Perigestational exposure of a combination of a high-fat diet and pesticide impacts the metabolic and microbiotic status of dams and pups; a preventive strategy based on prebiotics.
    European journal of nutrition, 2023, Volume: 62, Issue:3

    Topics: Chlorpyrifos; Diet, High-Fat; Female; Humans; Inulin; Lipids; Pesticides; Prebiotics; Pregnancy; Pre

2023
Perigestational exposure of a combination of a high-fat diet and pesticide impacts the metabolic and microbiotic status of dams and pups; a preventive strategy based on prebiotics.
    European journal of nutrition, 2023, Volume: 62, Issue:3

    Topics: Chlorpyrifos; Diet, High-Fat; Female; Humans; Inulin; Lipids; Pesticides; Prebiotics; Pregnancy; Pre

2023
Perigestational exposure of a combination of a high-fat diet and pesticide impacts the metabolic and microbiotic status of dams and pups; a preventive strategy based on prebiotics.
    European journal of nutrition, 2023, Volume: 62, Issue:3

    Topics: Chlorpyrifos; Diet, High-Fat; Female; Humans; Inulin; Lipids; Pesticides; Prebiotics; Pregnancy; Pre

2023
Perigestational exposure of a combination of a high-fat diet and pesticide impacts the metabolic and microbiotic status of dams and pups; a preventive strategy based on prebiotics.
    European journal of nutrition, 2023, Volume: 62, Issue:3

    Topics: Chlorpyrifos; Diet, High-Fat; Female; Humans; Inulin; Lipids; Pesticides; Prebiotics; Pregnancy; Pre

2023
Prenatal exposure to pesticides and domain-specific neurodevelopment at age 12 and 18 months in Nanjing, China.
    Environment international, 2023, Volume: 173

    Topics: Atrazine; Bayes Theorem; China; Chlorpyrifos; Female; Humans; Infant; Infant, Newborn; Maternal Expo

2023
Effect of prenatal exposure to organophosphates and pyrethroid pesticides on neonatal anthropometric measures and gestational age.
    Environmental research, 2023, Sep-01, Volume: 232

    Topics: Birth Weight; Chlorpyrifos; Environmental Exposure; Female; Gestational Age; Humans; Infant; Infant,

2023
"Comparative evaluation of different chemical agents induced Autism Spectrum Disorder in experimental Wistar rats".
    Behavioural brain research, 2024, Feb-26, Volume: 458

    Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Chlorpyrifos; Cytokines; Dioxins; Disease Model

2024
Does the perigestational exposure to chlorpyrifos and/or high-fat diet affect respiratory parameters and diaphragmatic muscle contractility in young rats?
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2020, Volume: 140

    Topics: Acetylcholinesterase; Animals; Chlorpyrifos; Diaphragm; Diet, High-Fat; Female; Gene Expression Prof

2020
Similarities between the Effects of Prenatal Chlorpyrifos and Valproic Acid on Ultrasonic Vocalization in Infant Wistar Rats.
    International journal of environmental research and public health, 2020, 09-01, Volume: 17, Issue:17

    Topics: Animals; Autism Spectrum Disorder; Chlorpyrifos; Disease Models, Animal; Enzyme Inhibitors; Female;

2020
Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults.
    PloS one, 2020, Volume: 15, Issue:9

    Topics: Animals; Aryldialkylphosphatase; Chlorpyrifos; Cholinesterase Inhibitors; Developmental Disabilities

2020
Translational outcomes relevant to neurodevelopmental disorders following early life exposure of rats to chlorpyrifos.
    Journal of neurodevelopmental disorders, 2020, 12-16, Volume: 12, Issue:1

    Topics: Animals; Autism Spectrum Disorder; Brain; Chlorpyrifos; Female; Male; Pregnancy; Prenatal Exposure D

2020
Prenatal chlorpyrifos exposure in association with PPARγ H3K4me3 and DNA methylation levels and child development.
    Environmental pollution (Barking, Essex : 1987), 2021, Apr-01, Volume: 274

    Topics: Child; Child Development; Child, Preschool; Chlorpyrifos; DNA Methylation; Epigenesis, Genetic; Fema

2021
Prenatal exposure to pyrethroid and organophosphate insecticides and language development at age 20-36 months among children in the Odense Child Cohort.
    International journal of hygiene and environmental health, 2021, Volume: 235

    Topics: Child; Child, Preschool; Chlorpyrifos; Environmental Exposure; Female; Humans; Infant; Insecticides;

2021
Prenatal exposure to organophosphate and pyrethroid insecticides and the herbicide 2,4-dichlorophenoxyacetic acid and size at birth in urban pregnant women.
    Environmental research, 2021, Volume: 201

    Topics: 2,4-Dichlorophenoxyacetic Acid; Birth Weight; Child; Chlorpyrifos; Female; Herbicides; Humans; Infan

2021
Prenatal chlorpyrifos leads to autism-like deficits in C57Bl6/J mice.
    Environmental health : a global access science source, 2017, 05-02, Volume: 16, Issue:1

    Topics: Animals; Autistic Disorder; Behavior, Animal; Chlorpyrifos; Conditioning, Psychological; Female; Ins

2017
Prenatal naled and chlorpyrifos exposure is associated with deficits in infant motor function in a cohort of Chinese infants.
    Environment international, 2017, Volume: 106

    Topics: China; Chlorpyrifos; Cohort Studies; Developmental Disabilities; Female; Fetal Blood; Humans; Infant

2017
Impact of chronic exposure to the pesticide chlorpyrifos on respiratory parameters and sleep apnea in juvenile and adult rats.
    PloS one, 2018, Volume: 13, Issue:1

    Topics: Acetylcholinesterase; Animals; Chlorpyrifos; Cholinesterase Inhibitors; Diaphragm; Female; Male; Mus

2018
Prenatal organophosphate insecticide exposure and infant sensory function.
    International journal of hygiene and environmental health, 2018, Volume: 221, Issue:3

    Topics: Adult; Chlorpyrifos; Cohort Studies; Developmental Disabilities; Environmental Pollutants; Evoked Po

2018
Developmental neurotoxicity in the progeny after maternal gavage with chlorpyrifos.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2018, Volume: 113

    Topics: Animals; Animals, Newborn; Behavior, Animal; Chlorpyrifos; Dose-Response Relationship, Drug; Fear; F

2018
Evaluation of the effects of chlorpyrifos combined with lipopolysaccharide stress on neuroinflammation and spatial memory in neonatal rats.
    Toxicology, 2018, 12-01, Volume: 410

    Topics: Animals; Animals, Newborn; Astrocytes; Chlorpyrifos; Female; Gene Expression; HMGB1 Protein; Hydroge

2018
Impaired innate and conditioned social behavior in adult C57Bl6/J mice prenatally exposed to chlorpyrifos.
    Behavioral and brain functions : BBF, 2019, Mar-01, Volume: 15, Issue:1

    Topics: Animals; Behavior, Animal; Chlorpyrifos; Female; Hypothalamus; Male; Mice; Mice, Inbred C57BL; Oxyto

2019
Associations of prenatal and childhood chlorpyrifos exposure with Neurodevelopment of 3-year-old children.
    Environmental pollution (Barking, Essex : 1987), 2019, Volume: 251

    Topics: Adult; Child; Child Behavior; Child, Preschool; China; Chlorpyrifos; Environmental Exposure; Female;

2019
Maternal urinary concentrations of pyrethroid and chlorpyrifos metabolites and attention deficit hyperactivity disorder (ADHD) symptoms in 2-4-year-old children from the Odense Child Cohort.
    Environmental research, 2019, Volume: 176

    Topics: Attention Deficit Disorder with Hyperactivity; Child, Preschool; Chlorpyrifos; Denmark; Female; Huma

2019
Perinatal diazinon exposure compromises the development of acetylcholine and serotonin systems.
    Toxicology, 2019, 08-01, Volume: 424

    Topics: Acetylcholine; Animals; Animals, Newborn; Brain Chemistry; Chlorpyrifos; Cholinesterase Inhibitors;

2019
Reversible effect of developmental exposure to chlorpyrifos on late-stage neurogenesis in the hippocampal dentate gyrus in mouse offspring.
    Reproductive toxicology (Elmsford, N.Y.), 2013, Volume: 38

    Topics: Animals; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterases; Dentate Gyrus; Doublecortin Prote

2013
Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos?
    Environmental toxicology and pharmacology, 2013, Volume: 36, Issue:2

    Topics: Age Factors; Animals; Brain; Chlorpyrifos; Female; Gestational Age; Insecticides; Male; Maternal Exp

2013
Urinary 3,5,6-trichloro-2-pyridinol (TCPY) in pregnant women from Mexico City: distribution, temporal variability, and relationship with child attention and hyperactivity.
    International journal of hygiene and environmental health, 2014, Volume: 217, Issue:2-3

    Topics: Adult; Agriculture; Attention; Attention Deficit Disorder with Hyperactivity; Child; Child Behavior;

2014
Prenatal dexamethasone, as used in preterm labor, worsens the impact of postnatal chlorpyrifos exposure on serotonergic pathways.
    Brain research bulletin, 2014, Volume: 100

    Topics: Animals; Brain; Chlorpyrifos; Dexamethasone; Female; Glucocorticoids; Humans; Insecticides; Male; Ob

2014
Prenatal organophosphates exposure alternates the cleavage plane orientation of apical neural progenitor in developing neocortex.
    PloS one, 2014, Volume: 9, Issue:4

    Topics: Animals; Chlorpyrifos; Diazinon; Embryo, Mammalian; Female; Injections, Subcutaneous; Insecticides;

2014
Enhanced expression of hypothalamic nitric oxide synthase in rats developmentally exposed to organophosphates.
    Brain research, 2014, Sep-04, Volume: 1579

    Topics: Animals; Cell Count; Chlorpyrifos; Diazinon; Female; Hypothalamus; Neurons; Nitric Oxide Synthase; P

2014
Prenatal nicotine alters the developmental neurotoxicity of postnatal chlorpyrifos directed toward cholinergic systems: better, worse, or just "different?".
    Brain research bulletin, 2015, Volume: 110

    Topics: Acetylcholine; Animals; Animals, Newborn; Brain; Chlorpyrifos; Choline O-Acetyltransferase; Choliner

2015
Prenatal nicotine changes the response to postnatal chlorpyrifos: Interactions targeting serotonergic synaptic function and cognition.
    Brain research bulletin, 2015, Volume: 111

    Topics: Animals; Brain; Chlorpyrifos; Cognition; Drug Interactions; Female; Male; Nicotine; Pregnancy; Prena

2015
Prenatal exposure of guinea pigs to the organophosphorus pesticide chlorpyrifos disrupts the structural and functional integrity of the brain.
    Neurotoxicology, 2015, Volume: 48

    Topics: Age Factors; Animals; Behavior, Animal; Brain; Chlorpyrifos; Cognition; Diffusion Tensor Imaging; Es

2015
Prenatal exposure to a common organophosphate insecticide delays motor development in a mouse model of idiopathic autism.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Animals; Animals, Newborn; Autistic Disorder; Chlorpyrifos; Female; Grooming; Insecticides; Interper

2015
Effects of maternal chlorpyrifos diet on social investigation and brain neuroendocrine markers in the offspring - a mouse study.
    Environmental health : a global access science source, 2015, Apr-02, Volume: 14

    Topics: Acetylcholinesterase; Amygdala; Animals; Biomarkers; Chlorpyrifos; Female; Gene Expression; Hypothal

2015
ADHD-like behaviour in the offspring of female rats exposed to low chlorpyrifos doses before pregnancy.
    Arhiv za higijenu rada i toksikologiju, 2015, Volume: 66, Issue:2

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Chlorpyrifos; Cholinestera

2015
Prenatal exposure to the organophosphate pesticide chlorpyrifos and childhood tremor.
    Neurotoxicology, 2015, Volume: 51

    Topics: Adolescent; Child; Chlorpyrifos; Female; Fetal Blood; Humans; Insecticides; Male; Maternal Exposure;

2015
Prenatal drug exposures sensitize noradrenergic circuits to subsequent disruption by chlorpyrifos.
    Toxicology, 2015, Dec-02, Volume: 338

    Topics: Adrenergic Neurons; Animals; Cerebellum; Cerebral Cortex; Chlorpyrifos; Dexamethasone; Female; Gesta

2015
Spatial learning impairment in prepubertal guinea pigs prenatally exposed to the organophosphorus pesticide chlorpyrifos: Toxicological implications.
    Neurotoxicology, 2016, Volume: 56

    Topics: Age Factors; Animals; Chlorpyrifos; Cholinesterases; Exploratory Behavior; Female; Guinea Pigs; Inse

2016
Prenatal exposure to the organophosphate insecticide chlorpyrifos enhances brain oxidative stress and prostaglandin E2 synthesis in a mouse model of idiopathic autism.
    Journal of neuroinflammation, 2016, 06-14, Volume: 13, Issue:1

    Topics: Animals; Animals, Newborn; Autistic Disorder; Brain; Chlorpyrifos; Cholinesterase Inhibitors; Dinopr

2016
A Complex Interaction Between Reduced Reelin Expression and Prenatal Organophosphate Exposure Alters Neuronal Cell Morphology.
    ASN neuro, 2016, Volume: 8, Issue:3

    Topics: Age Factors; Animals; Brain; Carrier Proteins; Cell Adhesion Molecules, Neuronal; Cell Cycle Protein

2016
Impact of prenatal and postnatal exposure to the pesticide chlorpyrifos on the contraction of rat ileal muscle strips: involvement of an inducible nitric oxide synthase-dependent pathway.
    Neurogastroenterology and motility, 2017, Volume: 29, Issue:2

    Topics: Animals; Animals, Newborn; Chlorpyrifos; Enzyme Inhibitors; Female; Gastrointestinal Transit; Ileum;

2017
Inulin Supplementation Lowered the Metabolic Defects of Prolonged Exposure to Chlorpyrifos from Gestation to Young Adult Stage in Offspring Rats.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Animals; Body Weight; Chlorpyrifos; Dietary Supplements; Drinking; Female; Gastrointestinal Microbio

2016
Mother gestational exposure to organophosphorus pesticide induces neuron and glia loss in daughter adult brain.
    Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 2017, Volume: 52, Issue:2

    Topics: Animals; Body Weight; Brain; Chlorpyrifos; Female; Male; Maternal Exposure; Mice, Inbred ICR; Neurog

2017
Chlorpyrifos induces anxiety-like behavior in offspring rats exposed during pregnancy.
    Neuroscience letters, 2017, 02-22, Volume: 641

    Topics: Animals; Anxiety; Behavior, Animal; Chlorpyrifos; Depression; Female; Male; Maternal Exposure; Maze

2017
Prenatal chlorpyrifos exposure alters motor behavior and ultrasonic vocalization in CD-1 mouse pups.
    Environmental health : a global access science source, 2009, Mar-30, Volume: 8

    Topics: Animals; Behavior, Animal; Central Nervous System; Chlorpyrifos; Cholinesterase Inhibitors; Female;

2009
Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by nicotine administration and neural stem cell transplantation.
    Behavioural brain research, 2009, Dec-28, Volume: 205, Issue:2

    Topics: Aging; Animals; Brain; Chlorpyrifos; Dose-Response Relationship, Drug; Female; Insecticides; Learnin

2009
Long-term sex selective hormonal and behavior alterations in mice exposed to low doses of chlorpyrifos in utero.
    Reproductive toxicology (Elmsford, N.Y.), 2010, Volume: 29, Issue:1

    Topics: Animals; Behavior, Animal; Chlorpyrifos; Female; Gestational Age; Insecticides; Male; Mice; Pregnanc

2010
Gestational exposure to the organophosphate chlorpyrifos alters social-emotional behaviour and impairs responsiveness to the serotonin transporter inhibitor fluvoxamine in mice.
    Psychopharmacology, 2010, Volume: 208, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Chlorpyrifos; Disease Models, Animal; Female; Fluvoxamine; Insec

2010
[Effects of low concentration of chlorpyrifos prenatal exposure on generation mouse brain hippocampus and somatosensory cortex].
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2009, Volume: 27, Issue:9

    Topics: Animals; Chlorpyrifos; Female; Hippocampus; Insecticides; Male; Mice; Mice, Inbred ICR; Pregnancy; P

2009
Chlorpyrifos exposure and urban residential environment characteristics as determinants of early childhood neurodevelopment.
    American journal of public health, 2011, Volume: 101, Issue:1

    Topics: Adult; Child, Preschool; Chlorpyrifos; Developmental Disabilities; Female; Follow-Up Studies; Humans

2011
Different reaction patterns of dopamine content to prenatal exposure to chlorpyrifos in different periods.
    Journal of applied toxicology : JAT, 2011, Volume: 31, Issue:4

    Topics: Animals; Brain; Chlorpyrifos; Dopamine; Female; Gestational Age; Insecticides; Male; Mice; Mice, Inb

2011
Foetal and neonatal exposure to chlorpyrifos: biochemical and metabolic alterations in the mouse liver at different developmental stages.
    Toxicology, 2011, Feb-27, Volume: 280, Issue:3

    Topics: Age Factors; Animals; Animals, Newborn; Chlorpyrifos; Female; Liver; Male; Mice; Microsomes, Liver;

2011
Effects of chlorpyrifos exposure on kidney Notch2-Jagged1 pathway of early prenatal embryo.
    Birth defects research. Part B, Developmental and reproductive toxicology, 2011, Volume: 92, Issue:2

    Topics: Animals; Calcium-Binding Proteins; Chlorpyrifos; Embryonic Development; Female; Insecticides; Interc

2011
Developmental neurotoxicity targeting hepatic and cardiac sympathetic innervation: effects of organophosphates are distinct from those of glucocorticoids.
    Brain research bulletin, 2011, May-30, Volume: 85, Issue:3-4

    Topics: Analysis of Variance; Animals; Animals, Newborn; Chlorpyrifos; Dexamethasone; Female; Glucocorticoid

2011
Seven-year neurodevelopmental scores and prenatal exposure to chlorpyrifos, a common agricultural pesticide.
    Environmental health perspectives, 2011, Volume: 119, Issue:8

    Topics: Adolescent; Adult; Child; Chlorpyrifos; Female; Humans; Intelligence; Male; Memory; Pesticides; Preg

2011
Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by allographic transplantation of adult subventricular zone-derived neural stem cells.
    Journal of neuroscience research, 2011, Volume: 89, Issue:8

    Topics: Animals; Behavior, Animal; Cerebral Ventricles; Chlorpyrifos; Female; Maze Learning; Mice; Neural St

2011
[Effects of transplacental and trans-breast milk exposure to the organophosphate compound chlorpyrifos on the developing immune system of mice].
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2011, Issue:129

    Topics: Animals; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Chlorpyrifos; Female; Immune System; Mate

2011
Brain anomalies in children exposed prenatally to a common organophosphate pesticide.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, May-15, Volume: 109, Issue:20

    Topics: Adult; Brain; Child; Chlorpyrifos; Cognition; Cohort Studies; Female; Fetal Blood; Humans; Intellige

2012
Bad for bugs and brains? A common pesticide may interfere with a child's brain development.
    Scientific American, 2012, Volume: 307, Issue:1

    Topics: Brain; Child; Chlorpyrifos; Female; Humans; Insecticides; Male; Pregnancy; Prenatal Exposure Delayed

2012
Differentiating experimental animal doses from human exposures to chlorpyrifos.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, Aug-14, Volume: 109, Issue:33

    Topics: Brain; Chlorpyrifos; Female; Humans; Nervous System Malformations; Organophosphates; Pesticides; Pre

2012
Selective cognitive impairments are related to selective hippocampus and prefrontal cortex deficits after prenatal chlorpyrifos exposure.
    Brain research, 2012, Sep-20, Volume: 1474

    Topics: Animals; Chlorpyrifos; Cognition Disorders; Female; Hippocampus; Insecticides; Male; Mice; Mice, Inb

2012
Developmental exposure to chlorpyrifos and diazinon differentially affect passive avoidance performance and nitric oxide synthase-containing neurons in the basolateral complex of the amygdala.
    Brain research, 2013, Feb-04, Volume: 1494

    Topics: Age Factors; Amygdala; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Chlorpyrifos

2013
Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period?
    Environmental health perspectives, 2002, Volume: 110, Issue:11

    Topics: Animals; Body Weight; Brain; Chlorpyrifos; Choline O-Acetyltransferase; Cholinesterases; DNA; Female

2002
Developmental neurotoxicity elicited by prenatal or postnatal chlorpyrifos exposure: effects on neurospecific proteins indicate changing vulnerabilities.
    Environmental health perspectives, 2003, Volume: 111, Issue:3

    Topics: Animals; Axons; Behavior, Animal; Biomarkers; Chlorpyrifos; Female; Insecticides; Male; Myelin Basic

2003
Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood.
    Environmental health perspectives, 2003, Volume: 111, Issue:4

    Topics: Animals; Biomarkers; Brain; Chlorpyrifos; Choline O-Acetyltransferase; Cholinesterases; Cognition Di

2003
Effect of SNPs on OPs. Age and race variations explored.
    Environmental health perspectives, 2003, Volume: 111, Issue:11

    Topics: Adult; Age Factors; Aryldialkylphosphatase; Child Development; Chlorpyrifos; Female; Genotype; Human

2003
Increased expression of glial fibrillary acidic protein in cerebellum and hippocampus: differential effects on neonatal brain regional acetylcholinesterase following maternal exposure to combined chlorpyrifos and nicotine.
    Journal of toxicology and environmental health. Part A, 2003, Nov-14, Volume: 66, Issue:21

    Topics: Acetylcholinesterase; Administration, Topical; Animals; Cell Death; Cerebellum; Chlorpyrifos; Drug I

2003
Neurochemical effects of repeated gestational exposure to chlorpyrifos in developing rats.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 77, Issue:1

    Topics: Administration, Oral; Animals; Animals, Newborn; Brain; Brain Chemistry; Chlorpyrifos; Choline O-Ace

2004
Developmental neurotoxicity elicited by gestational exposure to chlorpyrifos: when is adenylyl cyclase a target?
    Environmental health perspectives, 2003, Volume: 111, Issue:16

    Topics: Adenylyl Cyclases; Animals; Brain; Chlorpyrifos; Dose-Response Relationship, Drug; Embryonic and Fet

2003
Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling.
    Environmental health perspectives, 2004, Volume: 112, Issue:2

    Topics: Animals; Carrier Proteins; Cell Differentiation; Central Nervous System; Chlorpyrifos; Female; Insec

2004
Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling.
    Environmental health perspectives, 2004, Volume: 112, Issue:2

    Topics: Adenylyl Cyclases; Animals; Chlorpyrifos; Female; Heart; Homeostasis; Insecticides; Liver; Myocardiu

2004
Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood.
    Brain research. Developmental brain research, 2004, Jan-31, Volume: 148, Issue:1

    Topics: Acetyl Coenzyme A; Acetylcholine; Age Factors; Analysis of Variance; Animals; Binding Sites; Biomark

2004
Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: regionally selective alterations in neurons and glia.
    Brain research. Developmental brain research, 2004, Feb-20, Volume: 148, Issue:2

    Topics: Analysis of Variance; Animals; Animals, Newborn; Brain; Cell Count; Cell Size; Chi-Square Distributi

2004
A new mechanism for chlorpyrifos? Implicating serotonin.
    Environmental health perspectives, 2004, Volume: 112, Issue:2

    Topics: Animals; Animals, Newborn; Biomarkers; Brain; Chlorpyrifos; Dose-Response Relationship, Drug; Female

2004
Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure.
    Environmental health perspectives, 2004, Volume: 112, Issue:3

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Brain; Chlorpyrifos; Dose-Response Relationshi

2004
In utero pesticide exposure, maternal paraoxonase activity, and head circumference.
    Environmental health perspectives, 2004, Volume: 112, Issue:3

    Topics: Adult; Aryldialkylphosphatase; Birth Weight; Cephalometry; Chlorpyrifos; Cohort Studies; Environment

2004
Maternal exposure to nicotine and chlorpyrifos, alone and in combination, leads to persistently elevated expression of glial fibrillary acidic protein in the cerebellum of the offspring in late puberty.
    Archives of toxicology, 2004, Volume: 78, Issue:8

    Topics: Alkaloids; Animals; Azocines; Bungarotoxins; Cerebellum; Chlorpyrifos; Cholinesterases; Drug Synergi

2004
Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos.
    Brain research bulletin, 2004, Sep-30, Volume: 64, Issue:3

    Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Binding, Competit

2004
Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions.
    Toxicology and applied pharmacology, 2005, Mar-01, Volume: 203, Issue:2

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Animals, Newborn; Brain; Chlorpyrifos; Fema

2005
Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos.
    Toxicology and applied pharmacology, 2005, Mar-01, Volume: 203, Issue:2

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Animals, Newborn; Brain; Chlorpyrifos; Female;

2005
Lower birth weight as a critical effect of chlorpyrifos: a comparison of human and animal data.
    Regulatory toxicology and pharmacology : RTP, 2005, Volume: 42, Issue:1

    Topics: Animals; Chlorpyrifos; Cholinesterase Inhibitors; Female; Humans; Infant, Newborn; Infant, Very Low

2005
Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination.
    Brain research. Developmental brain research, 2005, Jun-30, Volume: 157, Issue:2

    Topics: Adrenergic beta-Agonists; Age Factors; Animals; Animals, Newborn; Brain; Brain Damage, Chronic; Cell

2005
Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure.
    Environmental health perspectives, 2005, Volume: 113, Issue:8

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Animals, Newborn; Brain; Chlorpyrifos; Dopamine; Female; Ho

2005
Effect of chlorpyrifos-methyl on steroid and thyroid hormones in rat F0- and F1-generations.
    Toxicology, 2006, Mar-15, Volume: 220, Issue:2-3

    Topics: Adrenal Glands; Androgen Antagonists; Animals; Chlorpyrifos; Estradiol; Female; Hypothyroidism; Inse

2006
In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats.
    Archives of toxicology, 2006, Volume: 80, Issue:9

    Topics: Administration, Topical; Animals; Behavior, Animal; Cell Death; Chlorpyrifos; Cholinesterase Inhibit

2006
Developmental neurotoxicity of organophosphorous pesticides: fetal and neonatal exposure to chlorpyrifos alters sex-specific behaviors at adulthood in mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 93, Issue:1

    Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Chlorpyrifos; Female; Male; Mice; Pesticides

2006
Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children.
    Pediatrics, 2006, Volume: 118, Issue:6

    Topics: Adult; Child, Preschool; Chlorpyrifos; Cognition; Female; Humans; Infant; Insecticides; Male; Motor

2006
Pesticides: toxic legacy.
    Environmental health perspectives, 2007, Volume: 115, Issue:4

    Topics: Child; Child Behavior Disorders; Chlorpyrifos; Cognition Disorders; Cohort Studies; Environmental Ex

2007
Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats.
    Brain research bulletin, 2007, Jul-12, Volume: 73, Issue:4-6

    Topics: Adolescent; Adrenergic beta-Agonists; Adult; Age Factors; Animals; Brain; Child; Chlorpyrifos; Femal

2007
Prenatal chlorpyrifos and early neurodevelopment: how good is the science?
    Pediatrics, 2007, Volume: 120, Issue:1

    Topics: Attention Deficit Disorder with Hyperactivity; Child Development; Child, Preschool; Chlorpyrifos; Ch

2007
Neurochemical and neurobehavioral effects of repeated gestational exposure to chlorpyrifos in maternal and developing rats.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:4

    Topics: Acetylcholinesterase; Animals; Avoidance Learning; Behavior, Animal; Body Weight; Brain; Brain Chemi

1996
Gestational exposure to chlorpyrifos: apparent protection of the fetus?
    Toxicology and applied pharmacology, 1998, Volume: 152, Issue:1

    Topics: Animals; Brain; Brain Diseases; Carboxylesterase; Carboxylic Ester Hydrolases; Chlorpyrifos; Choline

1998
Lack of selective developmental neurotoxicity in rat pups from dams treated by gavage with chlorpyrifos.
    Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 57, Issue:2

    Topics: Administration, Oral; Animals; Animals, Newborn; Animals, Suckling; Behavior, Animal; Body Weight; B

2000
Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells.
    Brain research, 2001, Feb-09, Volume: 891, Issue:1-2

    Topics: Adenylyl Cyclases; Animals; Brain; Chlorpyrifos; Environmental Exposure; Female; Humans; Insecticide

2001
Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein.
    Brain research. Developmental brain research, 2002, Feb-28, Volume: 133, Issue:2

    Topics: Age Factors; Animals; Brain; Cell Differentiation; Chlorpyrifos; Dose-Response Relationship, Drug; D

2002
Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure.
    Brain research. Developmental brain research, 2002, Feb-28, Volume: 133, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Brain; Catecholamines; Chlorpyrifos; Dopamine; Dose-Response Relat

2002