chlorpropamide has been researched along with Stevens-Johnson Syndrome in 4 studies
Chlorpropamide: A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)
chlorpropamide : An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.
Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dramatic response of our patients to cyclophosphamide, which is known to inhibit cell-mediated cytotoxicity by inhibiting both the recognition and lethal hit stages, together with the rapid regrowth of the epidermis within 4 days to a week in patients who received adequate dosage of the drug, supports the preceding concepts." | 1.28 | Efficacy of cyclophosphamide in toxic epidermal necrolysis. Clinical and pathophysiologic aspects. ( Allen, SG; Heng, MC, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| YAFFEE, HS | 1 |
| Kanefsky, TM | 1 |
| Medoff, SJ | 1 |
| Heng, MC | 1 |
| Allen, SG | 1 |
| Coursin, DB | 1 |
4 other studies available for chlorpropamide and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
Stevens-Johnson syndrome caused by chlorpropamide. Report of a case.
Topics: Chlorpropamide; Erythema Multiforme; Humans; Hypoglycemic Agents; Stevens-Johnson Syndrome | 1960 |
Stevens-Johnson syndrome and neutropenia with chlorpropamide therapy.
Topics: Aged; Agranulocytosis; Chlorpropamide; Female; Humans; Hyperglycemia; Neutropenia; Stevens-Johnson S | 1980 |
Efficacy of cyclophosphamide in toxic epidermal necrolysis. Clinical and pathophysiologic aspects.
Topics: Adult; Aged; Allopurinol; Ampicillin; Basement Membrane; Cell Membrane; Chlorpropamide; Cyclophospha | 1991 |
Stevens-Johnson syndrome: nonspecific parasensitivity reaction?
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anti-Bacterial Agents; Chlorpropamide; Diagnos | 1966 |