chlorpropamide has been researched along with Neoplasms in 9 studies
Chlorpropamide: A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)
chlorpropamide : An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In AZD6244-resistant cancer cells, we observed the impaired nuclear localization of FOXO3a, reduced FOXO3a-mediated transcriptional activity, and decreased the expression of FOXO3a target gene Bim after cell treatment with AZD6244." | 1.36 | Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer. ( Andreeff, M; Chang, CJ; Du, Y; Engelman, JA; Hortobagyi, GN; Hung, MC; Wang, Y; Wong, KK; Xia, W; Yang, JY, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 1 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Shimura, T | 1 |
| Noma, N | 1 |
| Sano, Y | 1 |
| Ochiai, Y | 1 |
| Oikawa, T | 1 |
| Fukumoto, M | 1 |
| Kunugita, N | 1 |
| Noh, KH | 1 |
| Kang, TH | 1 |
| Kim, JH | 1 |
| Pai, SI | 1 |
| Lin, KY | 1 |
| Hung, CF | 1 |
| Wu, TC | 1 |
| Kim, TW | 1 |
| Yang, JY | 1 |
| Chang, CJ | 1 |
| Xia, W | 1 |
| Wang, Y | 1 |
| Wong, KK | 1 |
| Engelman, JA | 1 |
| Du, Y | 1 |
| Andreeff, M | 1 |
| Hortobagyi, GN | 1 |
| Hung, MC | 1 |
| Mukoyama, M | 1 |
| Nakao, K | 1 |
| Wilkin, JK | 1 |
| Sládek, NE | 2 |
| Rekha, GK | 2 |
| Lee, MJ | 2 |
| Nagasawa, HT | 2 |
3 reviews available for chlorpropamide and Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
[Syndrome of inappropriate secretion of antidiuretic hormone].
Topics: Central Nervous System Diseases; Chlorpropamide; Diagnosis, Differential; Furosemide; Humans; Inappr | 2006 |
Flushing reactions: consequences and mechanisms.
Topics: Chlorpropamide; Disulfiram; Drug Interactions; Endorphins; Ethanol; Female; Glutamates; Hot Temperat | 1981 |
6 other studies available for chlorpropamide and Neoplasms
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
AKT-mediated enhanced aerobic glycolysis causes acquired radioresistance by human tumor cells.
Topics: Aerobiosis; Cell Death; Chlorpropamide; Deoxyglucose; Glucose; Glucose Transporter Type 1; Glycolysi | 2014 |
Activation of Akt as a mechanism for tumor immune evasion.
Topics: Animals; Apoptosis; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Chlorpropamide; Enzyme Activation; | 2009 |
Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer.
Topics: Animals; Apoptosis; Benzimidazoles; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Chlor | 2010 |
Inhibition of ALDH3A1-catalyzed oxidation by chlorpropamide analogues.
Topics: Aldehyde Dehydrogenase; Chlorpropamide; Enzyme Inhibitors; Gastric Mucosa; Humans; In Vitro Techniqu | 2001 |
Inhibition of ALDH3A1-catalyzed oxidation by chlorpropamide analogues.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Aldehyde Dehydrogenase, Mitochondrial; Chlo | 2001 |