chlorpropamide and Flushing studies

Chlorpropamide: A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)
chlorpropamide : An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.

Flushing: A transient reddening of the face that may be due to fever, certain drugs, exertion, or stress.

Research Excerpts

Excerpt	Relevance	Reference
"The relationship between chlorpropamide alcohol flushing and non-insulin dependent diabetes remains uncertain."	9.06	Chlorpropamide alcohol flushing: a normal response? ( Hoskins, PJ; Pyke, DA; Volkmann, HP; Wiles, PG, 1987)
"An epidemiological study was carried out to compare the prevalence of facial flushing in non-diabetics, patients with insulin dependent diabetes, and patients with non-insulin dependent diabetes in response to 40 ml sherry taken 12 hours after 250 mg chlorpropamide or placebo, administered double blind in randomised order."	9.05	Epidemiological study of prevalence of chlorpropamide alcohol flushing in insulin dependent diabetics, non-insulin dependent diabetics, and non-diabetics. ( Jarrett, RJ; Keen, H; Marsden, P; Murrells, T; Ng Tang Fui, S; Stott, R; Strakosch, C, 1983)
"Body weight was significantly (p less than 0."	5.27	On plasma chlorpropamide, body weight and sex difference in chlorpropamide alcohol flush (CPAF). ( Almér, LO; Jerntorp, P, 1984)
"It has been suggested that raised post-ethanol plasma acetaldehyde levels, from inhibition of aldehyde dehydrogenase, underlie the liability to chlorpropamide, alcohol flushing (CPAF)."	5.07	The formation of acetate from ethanol with and without prior chlorpropamide intake in diabetic and non-diabetic subjects. ( Akanji, AO; Hockaday, TD, 1991)
"The effects of ethanol and subsequent administration of intravenous naloxone were studied in double-blind, placebo-controlled fashion with a group of six male chlorpropamide alcohol flushers (CPAF) and a group of 13 nonflushing males."	5.06	Naloxone, ethanol, and the chlorpropamide alcohol flush. ( Baraniuk, JN; Mabbee, WG; Murray, RB, 1987)
"An epidemiological study was carried out to compare the prevalence of facial flushing in non-diabetics, patients with insulin dependent diabetes, and patients with non-insulin dependent diabetes in response to 40 ml sherry taken 12 hours after 250 mg chlorpropamide or placebo, administered double blind in randomised order."	5.05	Epidemiological study of prevalence of chlorpropamide alcohol flushing in insulin dependent diabetics, non-insulin dependent diabetics, and non-diabetics. ( Jarrett, RJ; Keen, H; Marsden, P; Murrells, T; Ng Tang Fui, S; Stott, R; Strakosch, C, 1983)
"Among 53 patients with noninsulin-dependent diabetes (NIDD), chlorpropamide alcohol flushing (CPAF) was more prevalent than among 18 patients with insulin-dependent diabetes (64 vs."	3.67	Prevalence of chlorpropamide alcohol flush in Jewish Israeli diabetics. The role of serum chlorpropamide concentrations. ( Almog, S; Berezin, M; Brazu-Albu, J; Segal, P, 1985)
"Body weight was significantly (p less than 0."	1.27	On plasma chlorpropamide, body weight and sex difference in chlorpropamide alcohol flush (CPAF). ( Almér, LO; Jerntorp, P, 1984)

Timeframe	Studies, this research(%)	All Research%
pre-1990	35 (97.22)	18.7374
1990's	1 (2.78)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Johnston, C	5
Owerbach, D	1
Leslie, RD	2
Pyke, DA	7
Nerup, J	1
Guillausseau, PJ	3
Akoka, C	2
Lubetzki, J	3
Groop, L	3
Koskimies, S	1
Tolppanen, EM	1
Wiles, PG	6
Ng Tang Fui, S	1
Keen, H	1
Jarrett, RJ	1
Strakosch, C	1
Murrells, T	1
Marsden, P	1
Stott, R	1
Hoskins, P	1
Babadzhanova, GIu	1
Mazovetskiĭ, AG	1
Kuraeva, TL	1
Mukhamedov, KhA	1
Eriksson, CJ	2
Wåhlin-Boll, E	1
Melander, A	1
Medbak, S	1
Bowcock, S	1
Cooke, ED	1
Rees, LH	1
Jerntorp, P	4
Almér, LO	3
Carey, F	1
Forder, RA	1
Haworth, D	1
Zahr, M	1
de los Ríos, MG	1
Mella, I	1
Carrasco, E	1
Waldhäusl, W	1
Huupponen, R	2
Ylikahri, R	1
Pelkonen, R	1
Hillson, RM	2
Hockaday, TD	3
Nuorva, K	1
Laakso, M	1
Aro, A	1
Uusitupa, M	1
Siitonen, O	1
Akanji, AO	1
Conget, JI	1
Vendrell, J	1
Esmatjes, E	1
Halperin, I	1
Ehrenreich, H	1
Goebel, FD	1
Baraniuk, JN	1
Murray, RB	1
Mabbee, WG	1
Bońkowska, M	1
Sroczyński, J	1
Ting, HH	1
Smith, RF	1
Yajnik, CS	1
Crabbe, J	1
Hoskins, PJ	1
Volkmann, HP	1
Saunders, JB	1
Barnett, AH	1
Ricciardi, BR	1
Hopkinson, DA	1
Ohlin, H	2
Sundkvist, G	1
Sabán, J	2
Ordóñez, A	2
Navascués, I	2
Suárez Terry, R	2
Serrano Ríos, M	2
Dempe, A	1
Jordan, A	1
Segal, P	1
Brazu-Albu, J	1
Almog, S	1
Berezin, M	1
Wolfsthal, SD	1
Wiser, TH	1
Severino, R	1
Lipp, A	1
Tang, A	1

Article	Year
Chlorpropamide--alcohol flush: the case in favour. Diabetologia, 1984, Volume: 26, Issue:1 Topics: Acetaldehyde; Alcohol Drinking; Biomechanical Phenomena; Chlorpropamide; Diabetic Angiopathies; Drug	1984
The chlorpropamide alcohol flush. Clinical science (London, England : 1979), 1984, Volume: 67, Issue:4 Topics: Acetaldehyde; Alcohol Drinking; Chlorpropamide; Diabetes Mellitus, Type 2; Dose-Response Relationshi	1984
The role of opioids in the endocrine function of the pancreas. Diabetes research (Edinburgh, Scotland), 1986, Volume: 3, Issue:2 Topics: Animals; beta-Endorphin; Biomechanical Phenomena; Chlorpropamide; Dogs; Eating; Endocrine Glands; En	1986
[Flush induced by chlorpropamide-alcohol (CAF): a genetic marker of diabetes mellitus or an undesirable effect of the drug?]. Revista clinica espanola, 1985, Volume: 176, Issue:3 Topics: Acetaldehyde; Alcohol Drinking; Chlorpropamide; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2	1985

Article	Year
Epidemiological study of prevalence of chlorpropamide alcohol flushing in insulin dependent diabetics, non-insulin dependent diabetics, and non-diabetics. British medical journal (Clinical research ed.), 1983, Nov-19, Volume: 287, Issue:6404 Topics: Adult; Aged; Alcoholic Beverages; Chlorpropamide; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type	1983
Prostacyclin and thromboxane in non-insulin dependent diabetes: the chlorpropamide alcohol flush reaction revisited. Clinical science (London, England : 1979), 1984, Volume: 67, Issue:6 Topics: 6-Ketoprostaglandin F1 alpha; Adult; Chlorpropamide; Diabetes Mellitus, Type 2; Ethanol; Female; Flu	1984
Roles of chlorpropamide, alcohol and acetaldehyde in determining the chlorpropamide-alcohol flush. Diabetologia, 1984, Volume: 26, Issue:1 Topics: Acetaldehyde; Adult; Alcohol Drinking; Chlorpropamide; Diabetes Mellitus, Type 2; Dose-Response Rela	1984
The formation of acetate from ethanol with and without prior chlorpropamide intake in diabetic and non-diabetic subjects. African journal of medicine and medical sciences, 1991, Volume: 20, Issue:2 Topics: Acetates; Adult; Alcohol Drinking; Chlorpropamide; Diabetes Mellitus, Type 2; Ethanol; Female; Flush	1991
Naloxone, ethanol, and the chlorpropamide alcohol flush. Alcoholism, clinical and experimental research, 1987, Volume: 11, Issue:6 Topics: Adult; Alcoholic Intoxication; Chlorpropamide; Double-Blind Method; Ethanol; Flushing; Humans; Male;	1987
Chlorpropamide alcohol flushing: a normal response? Clinical science (London, England : 1979), 1987, Volume: 73, Issue:1 Topics: Adult; Body Temperature; Chlorpropamide; Double-Blind Method; Ethanol; Female; Flushing; Heart Rate;	1987
Facial skin temperature in chlorpropamide alcohol flush. Acta medica Scandinavica, 1985, Volume: 217, Issue:2 Topics: Adolescent; Adult; Aged; Chlorpropamide; Diabetes Mellitus, Type 2; Ethanol; Face; Female; Flushing;	1985

Article	Year
Mason-type diabetes and DNA insertion polymorphism. Lancet (London, England), 1984, Feb-04, Volume: 1, Issue:8371 Topics: Adult; Chlorpropamide; Diabetes Mellitus, Type 2; DNA Transposable Elements; Female; Flushing; Human	1984
[The alcohol-chlorpropamide test. Study and diagnostic value of changes in cutaneous temperature]. Presse medicale (Paris, France : 1983), 1984, May-12, Volume: 13, Issue:20 Topics: Chlorpropamide; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Ethanol; Face; Flushing; Human	1984
[The alcohol-chlorpropamide test: its contribution to the knowledge of non-insulin-dependent diabetes]. Presse medicale (Paris, France : 1983), 1984, May-12, Volume: 13, Issue:20 Topics: Adolescent; Adult; Child; Chlorpropamide; Diabetes Mellitus, Type 2; Ethanol; Flushing; Genes, Domin	1984
Characterization of patients with chlorpropamide-alcohol flush. Acta medica Scandinavica, 1984, Volume: 215, Issue:2 Topics: Adult; Aged; Antibodies; Chlorpropamide; Diabetes Mellitus, Type 2; Ethanol; Flushing; HLA Antigens;	1984
Prevalence of chlorpropamide alcohol flushing. British medical journal (Clinical research ed.), 1984, Jan-28, Volume: 288, Issue:6413 Topics: Chlorpropamide; Ethanol; Female; Flushing; Humans; Male	1984
[The chlorpropamide-alcohol test in diabetes mellitus]. Sovetskaia meditsina, 1984, Issue:7 Topics: Adult; Chlorpropamide; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential	1984
Chlorpropamide-alcohol flush: significance of body weight, sex and serum chlorpropamide level. European journal of clinical pharmacology, 1984, Volume: 26, Issue:6 Topics: Body Weight; Chlorpropamide; Diabetes Mellitus, Type 1; Drug Interactions; Ethanol; Female; Flushing	1984
The role of endogenous opioids in the chlorpropamide alcohol flush. Clinical endocrinology, 1984, Volume: 21, Issue:5 Topics: Administration, Oral; Adult; Aged; Chlorpropamide; Diabetes Mellitus, Type 2; Drug Interactions; Enk	1984
[Facial vasomotor flushing due to alcohol-chlorpropamide. Prevalence in diabetic and non-diabetic patients]. La Revue de medecine interne, 1984, Volume: 5, Issue:3 Topics: Adult; Aged; Chlorpropamide; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2	1984
On plasma chlorpropamide, body weight and sex difference in chlorpropamide alcohol flush (CPAF). Diabetes research (Edinburgh, Scotland), 1984, Volume: 1, Issue:4 Topics: Adolescent; Adult; Aged; Body Weight; Chlorpropamide; Ethanol; Female; Flushing; Humans; Male; Middl	1984
[Is there an association between diabetic retinopathy and the chlorpropamide-alcohol-flushing syndrome?]. Revista medica de Chile, 1983, Volume: 111, Issue:3 Topics: Adult; Aged; Chlorpropamide; Diabetic Retinopathy; Ethanol; Female; Flushing; Humans; Male; Middle A	1983
To flush or not to flush? Comments on the chlorpropamide-alcohol flush. Diabetologia, 1984, Volume: 26, Issue:1 Topics: Alcohol Drinking; Chlorpropamide; Diabetes Mellitus, Type 2; Drug Interactions; Flushing; Humans; Va	1984
Chlorpropamide-alcohol flush: a critical reappraisal. Diabetologia, 1984, Volume: 26, Issue:1 Topics: Adult; Alcohol Drinking; Biomechanical Phenomena; Chlorpropamide; Diabetes Mellitus, Type 2; Drug In	1984
[Chlorpropamide and the alcohol flush reaction and coronary artery disease in adult diabetics]. Duodecim; laaketieteellinen aikakauskirja, 1984, Volume: 100, Issue:5 Topics: Adult; Chlorpropamide; Coronary Disease; Diabetes Mellitus, Type 2; Ethanol; Female; Flushing; Human	1984
Gliclazide alcohol flush. Diabetes care, 1989, Volume: 12, Issue:1 Topics: Chlorpropamide; Diabetes Mellitus, Type 2; Ethanol; Flushing; Gliclazide; Humans; Male; Middle Aged;	1989
[Value of the chlorpropamide-alcohol test for determining the type of diabetes mellitus]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 1987, Nov-15, Volume: 40, Issue:22 Topics: Adolescent; Adult; Aged; Chlorpropamide; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagn	1987
Erythrocyte aldehyde dehydrogenase, plasma chlorpropamide concentrations and the chlorpropamide alcohol flush. Diabete & metabolisme, 1987, Volume: 13, Issue:1 Topics: Alcohol Drinking; Aldehyde Dehydrogenase; Chlorpropamide; Erythrocytes; Female; Flushing; Humans; Ma	1987
Chlorpropamide-alcohol flush reaction and isoenzyme profiles of alcohol dehydrogenase and aldehyde dehydrogenase. Clinical science (London, England : 1979), 1986, Volume: 71, Issue:5 Topics: Alcohol Dehydrogenase; Alcohol Drinking; Aldehyde Dehydrogenase; Chlorpropamide; Ethanol; Female; Fl	1986
Effects of chlorpropamide and alcohol on aldehyde dehydrogenase activity and blood acetaldehyde concentration. Diabetes research (Edinburgh, Scotland), 1986, Volume: 3, Issue:7 Topics: Acetaldehyde; Adult; Aged; Aldehyde Dehydrogenase; Chlorpropamide; Diabetes Mellitus, Type 1; Diabet	1986
Aldehyde dehydrogenase activity and large vessel disease in diabetes mellitus. A preliminary study. Diabetes, 1986, Volume: 35, Issue:3 Topics: Acetaldehyde; Aged; Aldehyde Dehydrogenase; Chlorpropamide; Diabetes Mellitus, Type 2; Diabetic Angi	1986
[Frequency of a positive result in the chlorpropamide-alcohol flush test in type I and type II diabetes]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1986, Feb-01, Volume: 41, Issue:3 Topics: Adolescent; Adult; Aged; Chlorpropamide; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagn	1986
Prevalence of chlorpropamide alcohol flush in Jewish Israeli diabetics. The role of serum chlorpropamide concentrations. Israel journal of medical sciences, 1985, Volume: 21, Issue:2 Topics: Adult; Aged; Alcohol Drinking; Body Temperature; Chlorpropamide; Diabetes Mellitus, Type 1; Diabetes	1985
Chlorpropamide and an Antabuse-like reaction. Annals of internal medicine, 1985, Volume: 103, Issue:1 Topics: Adult; Chlorpropamide; Disulfiram; Drug Interactions; Ethanol; Female; Flushing; Humans	1985
[The blush or flush caused by chlorpropamide/alcohol (CAF) in non-insulin-dependent diabetes mellitus]. Revista clinica espanola, 1985, Volume: 176, Issue:9 Topics: Adolescent; Adult; Aged; Chlorpropamide; Diabetes Mellitus, Type 2; Ethanol; Female; Flushing; HLA A	1985
Chlorpropamide alcohol flushing at high chlorpropamide dose is not specific for non-insulin dependent diabetes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1985, Volume: 17, Issue:9 Topics: Adult; Chlorpropamide; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Ethanol; Female;	1985

chlorpropamide and Flushing

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