chlorpropamide has been researched along with Colonic Neoplasms in 2 studies
Chlorpropamide: A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)
chlorpropamide : An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In AZD6244-resistant cancer cells, we observed the impaired nuclear localization of FOXO3a, reduced FOXO3a-mediated transcriptional activity, and decreased the expression of FOXO3a target gene Bim after cell treatment with AZD6244." | 1.36 | Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer. ( Andreeff, M; Chang, CJ; Du, Y; Engelman, JA; Hortobagyi, GN; Hung, MC; Wang, Y; Wong, KK; Xia, W; Yang, JY, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, JY | 1 |
| Chang, CJ | 1 |
| Xia, W | 1 |
| Wang, Y | 1 |
| Wong, KK | 1 |
| Engelman, JA | 1 |
| Du, Y | 1 |
| Andreeff, M | 1 |
| Hortobagyi, GN | 1 |
| Hung, MC | 1 |
| Tenbaum, SP | 1 |
| Ordóñez-Morán, P | 1 |
| Puig, I | 1 |
| Chicote, I | 1 |
| Arqués, O | 1 |
| Landolfi, S | 1 |
| Fernández, Y | 1 |
| Herance, JR | 1 |
| Gispert, JD | 1 |
| Mendizabal, L | 1 |
| Aguilar, S | 1 |
| Ramón y Cajal, S | 1 |
| Schwartz, S | 1 |
| Vivancos, A | 1 |
| Espín, E | 1 |
| Rojas, S | 1 |
| Baselga, J | 1 |
| Tabernero, J | 1 |
| Muñoz, A | 1 |
| Palmer, HG | 1 |
2 other studies available for chlorpropamide and Colonic Neoplasms
| Article | Year |
|---|---|
Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer.
Topics: Animals; Apoptosis; Benzimidazoles; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Chlor | 2010 |
β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer.
Topics: Animals; Apoptosis; beta Catenin; Cell Line, Tumor; Cell Nucleus; Chlorpropamide; Colonic Neoplasms; | 2012 |