chlorpropamide and Body Weight studies

Chlorpropamide: A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)
chlorpropamide : An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.

Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Research Excerpts

Excerpt	Relevance	Reference
"To investigate the effect of hyperglycemia on normal islets, rats were made diabetic by a 95% partial pancreatectomy and treated with insulin, saline, or chlorpropamide for 3 mo."	7.66	Islet changes induced by hyperglycemia in rats. Effect of insulin or chlorpropamide therapy. ( Bown, E; Clark, A; King, T; Turner, RC; Vanhegan, RI, 1982)
"1 The effect of a combination of chloropropamide and chlorothiazide in Brattleboro rats with hereditary hypothalamic diabetes insipidus (DI) treated with low doses of vasopressin (Pitressin tannate in oil) was investigated with particular reference to the time course of response from the initiation of treatment."	7.65	Potentiation of the response to vasopressin (pitressin) by treatment with a combination of chlorpropamide and chlorothiazide in Brattleboro rats with hereditary hypothalamic diabetes insipidus. ( Laycock, JF; Lewis, AF, 1977)
"Body weight was significantly (p less than 0."	5.27	On plasma chlorpropamide, body weight and sex difference in chlorpropamide alcohol flush (CPAF). ( Almér, LO; Jerntorp, P, 1984)
"To investigate the effect of hyperglycemia on normal islets, rats were made diabetic by a 95% partial pancreatectomy and treated with insulin, saline, or chlorpropamide for 3 mo."	3.66	Islet changes induced by hyperglycemia in rats. Effect of insulin or chlorpropamide therapy. ( Bown, E; Clark, A; King, T; Turner, RC; Vanhegan, RI, 1982)
"1 The effect of a combination of chloropropamide and chlorothiazide in Brattleboro rats with hereditary hypothalamic diabetes insipidus (DI) treated with low doses of vasopressin (Pitressin tannate in oil) was investigated with particular reference to the time course of response from the initiation of treatment."	3.65	Potentiation of the response to vasopressin (pitressin) by treatment with a combination of chlorpropamide and chlorothiazide in Brattleboro rats with hereditary hypothalamic diabetes insipidus. ( Laycock, JF; Lewis, AF, 1977)
" To determine an optimal glyburide dosage schedule, the effects of glyburide once (every morning) or twice daily and chlorpropamide once daily (every morning) were compared in 18 men with non-insulin-dependent diabetes mellitus in a randomized, double-blind fashion."	2.66	Once-daily use of glyburide. ( Fajardo, F; Ginier, P; Levin, SR; Madan, S, 1985)
"Body weight was significantly (p less than 0."	1.27	On plasma chlorpropamide, body weight and sex difference in chlorpropamide alcohol flush (CPAF). ( Almér, LO; Jerntorp, P, 1984)
" A wide interindividual variation in chlorpropamide levels was observed and thus, the prediction of drug concentration was difficult from the dosage alone, despite a statistically significant correlation between the dose per body weight and the serum drug level."	1.26	Chlorpropamide and glibenclamide serum concentrations in hospitalized patients. ( Huupponen, R; Saarimaa, H; Viikari, J, 1982)
"Ten Type 2 diabetics were examined during long-term treatment, at two dosage levels, with chlorpropamide once daily and glipizide t."	1.26	Impaired effect of sulfonylurea following increased dosage. ( Melander, A; Sartor, G; Scherstén, B; Wåhlin-Boll, E, 1982)
" The changes in weight were similar and both drugs were devoid of serious toxic effects in the dosage prescribed."	1.26	Comparative study of glibenclamide & chlorpropamide in newly diagnosed maturity onset diabetics. ( Haider, Z; Obaidullah, S, 1976)

Timeframe	Studies, this research(%)	All Research%
pre-1990	46 (92.00)	18.7374
1990's	2 (4.00)	18.2507
2000's	1 (2.00)	29.6817
2010's	1 (2.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Oyagbemi, AA	1
Odetola, AA	1
Azeez, OI	1
WOLFF, FW	1
LANGDON, RG	1
TRIPATHY, BB	1
KAR, BC	1
Fuentes, NL	1
Sagua, H	1
Morales, G	1
Borquez, J	1
San Martin, A	1
Soto, J	1
Loyola, LA	1
Gershbein, LL	1
Power, L	1
Groop, L	1
Eriksson, CJ	1
Wåhlin-Boll, E	2
Melander, A	2
Jerntorp, P	1
Almér, LO	1
Clark, A	1
Bown, E	1
King, T	1
Vanhegan, RI	1
Turner, RC	1
Sönksen, PH	1
Lowy, C	1
Perkins, JR	1
West, TE	1
Billingham, MS	1
Hall, RA	1
Simpson, S	1
Bailey, CJ	1
Huupponen, R	1
Viikari, J	1
Saarimaa, H	1
Sartor, G	1
Scherstén, B	1
Clarke, BF	4
Campbell, IW	3
Malerbi, DA	1
Paiva, ES	1
Duarte, AL	1
Wajchenberg, BL	1
Luntz, GR	1
Streda, M	1
Haider, Z	1
Obaidullah, S	1
Laycock, JF	1
Lewis, AF	1
Boden, G	1
Reaven, GM	1
Ginier, P	1
Madan, S	1
Fajardo, F	1
Levin, SR	1
Duncan, LJ	1
Butterfield, WJ	1
Whichelow, MJ	1
Goodner, CJ	1
Ogilvie, JT	1
Dumas, JC	1
Mas, D	1
Roux, G	1
Göschke, H	1
Denes, A	1
Girard, J	1
Collard, F	1
Berger, W	1
Logie, AW	1
Stowers, JM	2
Dingwall-Fordyce, I	1
Blohmé, G	1
Wachholz, DE	1
Wahlstrom, RC	1
Sheldon, J	1
Coleman, T	1
Wigger, W	1
Scheler, F	1
Creutzfeldt, W	1
Tomkins, AM	1
Bloom, A	1
Christensen, E	1
Rahbek, KS	1
Abramson, E	1
Arky, RA	1
Varandani, PT	1
Whitehouse, FW	1
Hamblin, JJ	1
Ismay, G	1
Good, MS	1
Wynne-Williams, CJ	1
Baum, G	1
Wilson, IV	1
Bengtsson, C	1
Duncan, GG	1
Elliott, FA	1
Duncan, TG	1
Schatanoff, J	1
Fox, OJ	1
Boshell, BR	1
DiPlacido, J	1
Bowers, CY	1
Hawley, WD	1
Hershman, JM	1
Konerding, K	1
Parrow, A	1
Powell, T	1
Howells, L	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
A Randomized Phase 3 Trial of Metformin in Patients Initiating Androgen Deprivation Therapy as Prevention and Intervention of Metabolic Syndrome: The Prime Study[NCT03031821]			Phase 3	168 participants (Actual)	Interventional	2018-07-12	Terminated (stopped due to Manufacturer discontinued the production of study drugs.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Glucose tolerance tests in the clinical picture of chronic liver diseases. Acta Universitatis Carolinae. Medica. Monographia, 1975, Issue:67 Topics: Adolescent; Adult; Age Factors; Aged; Alanine Transaminase; Aspartate Aminotransferases; Body Weight	1975
Treatment strategies for patients with non-insulin-dependent diabetes mellitus. The American journal of medicine, 1985, Aug-23, Volume: 79, Issue:2B Topics: Arginine; Blood Glucose; Blood Proteins; Body Weight; Chlorpropamide; Diabetes Mellitus, Type 2; Die	1985

Article	Year
United Kingdom Prospective Diabetes Study (UKPDS). 13: Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years. BMJ (Clinical research ed.), 1995, Jan-14, Volume: 310, Issue:6972 Topics: Adult; Aged; Blood Glucose; Body Weight; Chlorpropamide; Diabetes Mellitus; Diabetes Mellitus, Type	1995
Comparison of metformin and chlorpropamide in non-obese, maturity-onset diabetics uncontrolled by diet. British medical journal, 1977, Dec-17, Volume: 2, Issue:6102 Topics: Administration, Oral; Adult; Age Factors; Aged; Body Weight; Chlorpropamide; Diabetes Mellitus; Diet	1977
Once-daily use of glyburide. The American journal of medicine, 1985, Sep-20, Volume: 79, Issue:3B Topics: Blood Glucose; Body Weight; Chlorpropamide; Diabetes Mellitus, Type 2; Drug Administration Schedule;	1985
Comparison of chlorpropamide and metformin treatment on weight and blood-glucose response of uncontrolled obese diabetics. Lancet (London, England), 1968, Jan-20, Volume: 1, Issue:7534 Topics: Adult; Aged; Blood Glucose; Body Weight; Chlorpropamide; Diabetes Mellitus; Diet Therapy; Female; Hu	1968
Effect of diet, sulphonylureas, and phenformin on peripheral glucose uptake in diabetes and obesity. Lancet (London, England), 1968, Oct-12, Volume: 2, Issue:7572 Topics: Adult; Aged; Blood Flow Velocity; Body Weight; Chlorpropamide; Diabetes Mellitus; Diet Therapy; Fema	1968
Longitudinal study of untreated chemical diabetes. British medical journal, 1974, Dec-14, Volume: 4, Issue:5945 Topics: Adult; Blood Glucose; Body Weight; Chlorpropamide; Clinical Trials as Topic; Diabetes Mellitus; Gluc	1974
Treatment of the obese diabetic. A comparative study of placebo, sulfonylurea and phenformin. Metabolism: clinical and experimental, 1967, Volume: 16, Issue:3 Topics: Blood Glucose; Body Weight; Chlorpropamide; Cholesterol; Clinical Trials as Topic; Diabetes Mellitus	1967
A comparative study of glibenclamide and chlorpropamide. (Preliminary report). Postgraduate medical journal, 1970 Topics: Adult; Aged; Body Weight; Chlorpropamide; Cyclohexanes; Diabetes Mellitus; Humans; Hypoglycemic Agen	1970

chlorpropamide and Body Weight

Research Excerpts

Research

Studies (50)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Antidiabetic properties of ethanolic extract of Cnidoscolus aconitifolius on alloxan induced diabetes mellitus in rats. African journal of medicine and medical sciences, 2010, Volume: 39 Suppl Topics: Alloxan; Animals; Blood Glucose; Body Weight; Chlorpropamide; Cholesterol; Diabetes Mellitus, Experi	2010
CONJOINT CLINIC ON DRUGS AND DIABETES. Journal of chronic diseases, 1964, Volume: 17 Topics: Adrenalectomy; Antihypertensive Agents; Benzothiadiazines; Biomedical Research; Blood; Blood Glucose	1964
OBSERVATIONS ON CLINICAL PATTERNS OF DIABETES MELLITUS IN INDIA. Diabetes, 1965, Volume: 14 Topics: Acidosis; Aging; Body Height; Body Weight; Carbutamide; Chlorpropamide; Diabetes Mellitus; Diabetic	1965
Experimental antihyperglycemic effect of diterpenoids of llareta Azorella compacta (Umbelliferae) Phil in rats. Phytotherapy research : PTR, 2005, Volume: 19, Issue:8 Topics: Animals; Apiaceae; Blood Glucose; Body Weight; Chlorpropamide; Diabetes Mellitus, Experimental; Dite	2005
Effect of hypoglycemic agents on liver regeneration. Biochemical pharmacology, 1967, Volume: 16, Issue:6 Topics: Acetohexamide; Animals; Body Weight; Carbutamide; Chlorpropamide; Glucagon; Hypoglycemia; Hypoglycem	1967
Group approach to diabetes care. A preliminary note. Postgraduate medicine, 1983, Volume: 73, Issue:2 Topics: Blood Glucose; Body Weight; Chlorpropamide; Diabetes Mellitus; Glycated Hemoglobin; Group Processes;	1983
Chlorpropamide-alcohol flush: significance of body weight, sex and serum chlorpropamide level. European journal of clinical pharmacology, 1984, Volume: 26, Issue:6 Topics: Body Weight; Chlorpropamide; Diabetes Mellitus, Type 1; Drug Interactions; Ethanol; Female; Flushing	1984
On plasma chlorpropamide, body weight and sex difference in chlorpropamide alcohol flush (CPAF). Diabetes research (Edinburgh, Scotland), 1984, Volume: 1, Issue:4 Topics: Adolescent; Adult; Aged; Body Weight; Chlorpropamide; Ethanol; Female; Flushing; Humans; Male; Middl	1984
Islet changes induced by hyperglycemia in rats. Effect of insulin or chlorpropamide therapy. Diabetes, 1982, Volume: 31, Issue:4 Pt 1 Topics: Animals; Blood Glucose; Body Weight; Chlorpropamide; Dogs; Hyperglycemia; Insulin; Islets of Langerh	1982
Hormonal and metabolic effects of chlorpropamide, glibenclamide and placebo in a cross-over study in diabetics not controlled by diet alone. Diabetologia, 1981, Volume: 20, Issue:1 Topics: Adult; Aged; Body Weight; Chlorpropamide; Diabetes Mellitus; Diet, Diabetic; Fatty Acids, Nonesterif	1981
Plasma high density lipoprotein cholesterol in streptozotocin diabetic and non-diabetic mice after prolonged administration of glibenclamide, chlorpropamide and metformin. Diabete & metabolisme, 1981, Volume: 7, Issue:4 Topics: Animals; Blood Glucose; Body Weight; Chlorpropamide; Cholesterol; Cholesterol, HDL; Diabetes Mellitu	1981
Chlorpropamide and glibenclamide serum concentrations in hospitalized patients. Annals of clinical research, 1982, Volume: 14, Issue:3 Topics: Aged; Body Weight; Chlorpropamide; Diabetes Mellitus; Dose-Response Relationship, Drug; Female; Glyb	1982
Impaired effect of sulfonylurea following increased dosage. European journal of clinical pharmacology, 1982, Volume: 22, Issue:1 Topics: Aged; Blood Glucose; Body Weight; Chlorpropamide; Diabetes Mellitus; Dose-Response Relationship, Dru	1982
Long-term comparative trial of glibenclamide and chlorpropamide in diet-failed, maturity-onset diabetics. Lancet (London, England), 1975, Feb-01, Volume: 1, Issue:7901 Topics: Adult; Blood Glucose; Body Weight; Chlorpropamide; Diabetes Mellitus, Type 2; Glyburide; Humans; Hyp	1975
Metabolic effects of dietary sucrose and fructose in type II diabetic subjects. Diabetes care, 1996, Volume: 19, Issue:11 Topics: Adult; Aged; Blood Glucose; Blood Proteins; Body Weight; C-Peptide; Chlorpropamide; Cholesterol; Cho	1996
Letter: Treatment of maturity-onset diabetes. Lancet (London, England), 1975, Mar-08, Volume: 1, Issue:7906 Topics: Adult; Age Factors; Aged; Blood Glucose; Body Weight; Chlorpropamide; Diabetes Mellitus; Diet, Diabe	1975
Letter: Treatment of maturity-onset diabetes. Lancet (London, England), 1975, Mar-29, Volume: 1, Issue:7909 Topics: Adult; Blood Glucose; Body Weight; Chlorpropamide; Diabetes Mellitus; Glyburide; Humans	1975
Comparative study of glibenclamide & chlorpropamide in newly diagnosed maturity onset diabetics. JPMA. The Journal of the Pakistan Medical Association, 1976, Volume: 26, Issue:2 Topics: Adult; Aged; Blood Glucose; Body Weight; Chlorpropamide; Diabetes Mellitus; Drug Evaluation; Female;	1976
Potentiation of the response to vasopressin (pitressin) by treatment with a combination of chlorpropamide and chlorothiazide in Brattleboro rats with hereditary hypothalamic diabetes insipidus. British journal of pharmacology, 1977, Volume: 59, Issue:1 Topics: Animals; Body Weight; Chlorothiazide; Chlorpropamide; Diabetes Insipidus; Drinking; Female; Hypothal	1977
Beneficial effect of moderate weight loss in older patients with non-insulin-dependent diabetes mellitus poorly controlled with insulin. Journal of the American Geriatrics Society, 1985, Volume: 33, Issue:2 Topics: Aged; Body Weight; Chlorpropamide; Diabetes Mellitus, Type 2; Diet, Diabetic; Diet, Reducing; Female	1985
Homeostasis of body weight in a diabetes clinic population. Diabetes, 1974, Volume: 23, Issue:4 Topics: Acetohexamide; Adolescent; Adult; Age Factors; Aged; Appetite Regulation; Blood Glucose; Body Weight	1974
[Participation of the antidiuretic hormone (ADH) in the activity of chlorpropamide on water metabolism, in toads]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1971, Volume: 165, Issue:1 Topics: Animals; Anura; Body Weight; Chlorpropamide; Drug Synergism; Vasopressins; Water	1971
Circadian variations of carbohydrate tolerance in maturity onset diabetics treated with sulfonylureas. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1974, Volume: 6, Issue:5 Topics: Aged; Blood Glucose; Body Weight; Camphanes; Capillaries; Chlorpropamide; Circadian Rhythm; Diabetes	1974
[Glibenclamide--a better antidiabetic agent?]. Lakartidningen, 1972, Dec-20, Volume: 69, Issue:52 Topics: Aged; Blood Glucose; Body Weight; Chlorpropamide; Cholesterol; Diabetes Mellitus; Female; Glyburide;	1972
Diabetes mellitus: the thin maturity-onset diabetic. British medical journal, 1972, Sep-16, Volume: 3, Issue:5828 Topics: Acetohexamide; Body Weight; Chlorpropamide; Diabetes Mellitus; Glyburide; Humans; Hypoglycemia; Hypo	1972
Effect of chlorpropamide on gravid swine and blood glucose and fructose in the fetal pig. Journal of animal science, 1973, Volume: 37, Issue:1 Topics: Administration, Oral; Animal Feed; Animals; Blood Glucose; Body Weight; Chlorpropamide; Corpus Luteu	1973
Remission of diabetes mellitus during pregnancy. British medical journal, 1974, Jan-12, Volume: 1, Issue:5897 Topics: Adult; Birth Weight; Blood Glucose; Body Weight; Chlorpropamide; Diet Therapy; Female; Glucose Toler	1974
[ADH-like mechanism of action of chlorpropamide in diabetes insipidus (a comparison with the antidiuretic effect of other blood glucose decreasing sulfonamides and hydrochlorothiazide)]. Klinische Wochenschrift, 1970, Jul-15, Volume: 48, Issue:14 Topics: Aged; Blood Glucose; Body Weight; Chlorpropamide; Depression, Chemical; Diabetes Insipidus; Diuresis	1970
Assessment of the need for continued oral therapy in diabetics. British medical journal, 1972, Mar-11, Volume: 1, Issue:5801 Topics: Administration, Oral; Adult; Aged; Blood Glucose; Body Weight; Chlorpropamide; Diabetes Mellitus; Fe	1972
[Water intoxication as a side effect of chlorpropamide therapy]. Ugeskrift for laeger, 1971, Oct-15, Volume: 133, Issue:41 Topics: Adult; Body Weight; Chlorpropamide; Diabetes Insipidus; Diabetes Mellitus; Diuresis; Edema; Female;	1971
Urinary excretion of insulin A chain by normal and diabetic subjects. Diabetes, 1970, Volume: 19, Issue:2 Topics: Adult; Age Factors; Antibodies; Binding Sites; Body Height; Body Weight; Chlorpropamide; Chromatogra	1970
Two minutes with diabetes. Medical times, 1970, Volume: 98, Issue:4 Topics: Body Weight; Chlorpropamide; Diabetes Mellitus; Female; Humans; Insulin; Middle Aged	1970
[Oral combined treatment of diabetes mellitus (chlorpropamide--phenethylbiguanice)]. Nordisk medicin, 1968, Jan-11, Volume: 79, Issue:2 Topics: Adult; Aged; Body Weight; Chlorpropamide; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Phen	1968
Some clinical potentials of chlorophenoxyisobutyrate (clofibrate) therapy (hyperlipidemia--angina pectoris--blood sludging-diabetic neuropathy). Metabolism: clinical and experimental, 1968, Volume: 17, Issue:5 Topics: Acetohexamide; Adult; Agglutination; Angina Pectoris; Anticholesteremic Agents; Arteriosclerosis; Bo	1968
A clinical evaluation of the comparative effectiveness of chlorpropamide and acetohexamide. Journal of the Medical Association of the State of Alabama, 1968, Volume: 37, Issue:10 Topics: Acetohexamide; Body Weight; Chemical Phenomena; Chemistry; Chlorpropamide; Glucose Tolerance Test; H	1968
The treatment of chemical diabetes mellitus. Geriatrics, 1968, Volume: 23, Issue:6 Topics: Aged; Blood Glucose; Body Weight; Chlorpropamide; Diabetes Mellitus; Female; Glucose Tolerance Test;	1968
Effects of sulfonylurea drugs on the thyroid and serum protein binding of thyroxine in the rat. Endocrinology, 1968, Volume: 83, Issue:1 Topics: Acetohexamide; Animals; Blood Proteins; Body Weight; Carbutamide; Chlorpropamide; Diiodotyrosine; Io	1968
[Treatment of diabetes mellitus with metformin]. Lakartidningen, 1968, Nov-20, Volume: 65, Issue:47 Topics: Adult; Aged; Body Weight; Chlorpropamide; Diabetes Mellitus; Drug Synergism; Female; Humans; Male; M	1968
Diabetes mellitus treated with chlorpropamide and tolbutamide. A four-year clinical study. Diabetes, 1966, Volume: 15, Issue:4 Topics: Aged; Alkaline Phosphatase; Biopsy; Blood Protein Electrophoresis; Body Weight; Chlorpropamide; Diab	1966
Treatment of subclinical diabetes. Proceedings of the Royal Society of Medicine, 1966, Volume: 59, Issue:11 Part 2 Topics: Adolescent; Adult; Aged; Body Weight; Child; Chlorpropamide; Diabetes Mellitus; Female; Glucose Tole	1966