chlorpropamide has been researched along with Alloxan Diabetes in 23 studies
Chlorpropamide: A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)
chlorpropamide : An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Knowing that hyperglycemia is a hallmark of vascular dysfunction in diabetes and that neonatal streptozotocin-induced diabetic rats (n-STZ) present reduced inflammatory response, we decided to evaluate the effect of chlorpropamide-lowered blood glucose levels on carrageenan-induced rat paw edema and pleural exudate in n-STZ." | 7.74 | Chlorpropamide treatment restores the reduced carrageenan-induced paw edema and pleural exudate volume in diabetic rats. ( Bersani-Amado, CA; Carvalho, MH; Cuman, RK; Fortes, ZB; Melo, GA; Nigro, D; Oliveira, MA; Passaglia, RT; Santos, RA; Sartoretto, JL, 2008) |
| "Knowing that hyperglycemia is a hallmark of vascular dysfunction in diabetes and that neonatal streptozotocin-induced diabetic rats (n-STZ) present reduced inflammatory response, we decided to evaluate the effect of chlorpropamide-lowered blood glucose levels on carrageenan-induced rat paw edema and pleural exudate in n-STZ." | 3.74 | Chlorpropamide treatment restores the reduced carrageenan-induced paw edema and pleural exudate volume in diabetic rats. ( Bersani-Amado, CA; Carvalho, MH; Cuman, RK; Fortes, ZB; Melo, GA; Nigro, D; Oliveira, MA; Passaglia, RT; Santos, RA; Sartoretto, JL, 2008) |
| "When phenformin was added to isolated rat hepatocytes of normal rats, induction of ALA-S and ferrochelatase activities and cytochrome P-450 content was observed only in the presence of added dibutyryl cAMP." | 1.28 | Studies on induction of delta-aminolevulinic acid synthase, ferrochelatase, cytochrome P-450 and cyclic AMP by phenformin. Chlorpropamide, allylisopropylacetamide and lead in hepatocytes from normal and experimental diabetic rats. ( Cánepa, ET; Grinstein, M; Llambías, EB, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (69.57) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 3 (13.04) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sartoretto, JL | 2 |
| Melo, GA | 1 |
| Bersani-Amado, CA | 1 |
| Oliveira, MA | 1 |
| Santos, RA | 2 |
| Passaglia, RT | 1 |
| Nigro, D | 2 |
| Cuman, RK | 2 |
| Carvalho, MH | 2 |
| Fortes, ZB | 2 |
| Azeez, OI | 2 |
| Oyagbemi, AA | 2 |
| Oyeyemi, MO | 1 |
| Odetola, AA | 2 |
| GRANDE, F | 1 |
| MARTINEZ, C | 1 |
| ANDREWS, MM | 1 |
| DEROETTH, A | 1 |
| PEI, YF | 1 |
| YAMAGATA, S | 1 |
| OHNEDA, A | 1 |
| UESUGI, Y | 1 |
| LOUBATIERES, A | 1 |
| MARIANI, MM | 1 |
| ALRIC, R | 1 |
| FRUTEAUDELACLOS, C | 1 |
| FOGLIA, VG | 1 |
| YABO, R | 1 |
| Fuentes, NL | 1 |
| Sagua, H | 1 |
| Morales, G | 1 |
| Borquez, J | 1 |
| San Martin, A | 1 |
| Soto, J | 1 |
| Loyola, LA | 1 |
| Scavone, C | 1 |
| Tostes, RC | 1 |
| McDonald, HJ | 1 |
| DeChatelet, LR | 1 |
| Billingham, MS | 1 |
| Hall, RA | 1 |
| Simpson, S | 1 |
| Bailey, CJ | 1 |
| Nishihata, T | 4 |
| Yata, N | 4 |
| Kamada, A | 3 |
| Sakai, K | 1 |
| Tsutsumi, A | 1 |
| Fukui, M | 1 |
| Cánepa, ET | 1 |
| Llambías, EB | 1 |
| Grinstein, M | 1 |
| Oke, JM | 1 |
| Olowookorun, MO | 1 |
| Foy, JM | 1 |
| Standing, VF | 1 |
| Creutzfeldt, W | 1 |
| Bänder, A | 1 |
| Pfaff, W | 1 |
| Schmidt, FH | 1 |
| Stork, H | 1 |
| Schröder, HG | 1 |
1 review available for chlorpropamide and Alloxan Diabetes
| Article | Year |
|---|---|
[Current views on the mode of action of hypoglycemic sulfonamides].
Topics: Amino Acids; Animals; Blood Glucose; Chlorpropamide; Diabetes Insipidus; Diabetes Mellitus, Experime | 1969 |
22 other studies available for chlorpropamide and Alloxan Diabetes
| Article | Year |
|---|---|
Chlorpropamide treatment restores the reduced carrageenan-induced paw edema and pleural exudate volume in diabetic rats.
Topics: Animals; Blood Glucose; Carrageenan; Chlorpropamide; Diabetes Mellitus, Experimental; Edema; Hypogly | 2008 |
Ameliorative effects of Cnidoscolus aconitifolius on alloxan toxicity in Wistar rats.
Topics: Alloxan; Animals; Blood Cells; Blood Glucose; Chlorpropamide; Diabetes Mellitus, Experimental; Eupho | 2010 |
Antidiabetic properties of ethanolic extract of Cnidoscolus aconitifolius on alloxan induced diabetes mellitus in rats.
Topics: Alloxan; Animals; Blood Glucose; Body Weight; Chlorpropamide; Cholesterol; Diabetes Mellitus, Experi | 2010 |
The effect of chlorpropamide on alloxan diabetes in mice.
Topics: Animals; Chlorpropamide; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Mice | 1959 |
Some effects of salicylate, chlorpropamide and insulin on carbohydrate metabolism in normal and diabetic rats.
Topics: Animals; Carbohydrate Metabolism; Chlorpropamide; Diabetes Mellitus, Experimental; Hypoglycemic Agen | 1961 |
METABOLISM OF THE ALLOXAN DIABETIC RAT RETINA.
Topics: Adrenalectomy; Alloxan; Animals; Chlorpropamide; Diabetes Mellitus, Experimental; Diabetic Retinopat | 1964 |
HISTOLOGICAL CHANGES IN NORMAL AND ALLOXANIZED RATS WITH PROLONGED ADMINISTRATION OF SULFONYLUREAS.
Topics: Adrenal Glands; Animals; Carbutamide; Chlorpropamide; Diabetes Mellitus, Experimental; Islets of Lan | 1963 |
[EFFECTS OF VARIOUS NATURAL ORGANIC SUBSTANCES AND AMINO ACIDS ON THE BLOOD SURGAR LEVEL AND EXPERIMENTAL STUDIES ON ORAL HYPOGLYCEMIC AGENTS].
Topics: Amino Acids; Animals; Bile Acids and Salts; Blood Chemical Analysis; Blood Glucose; Caffeine; Chlorp | 1963 |
[ANTIDIABETIC ACTION OF HYPOGLYCEMIC SULFONAMIDE (CHLORPROPAMIDE) ON EXPERIMENTAL LATENT DIABETES IN DOGS].
Topics: Animals; Chlorpropamide; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dogs; Glucose Intoleran | 1963 |
[ACTION OF CHLORPROPAMIDE ON NORMAL, PREDIABETIC AND DIABETIC RATS].
Topics: Animals; Carbohydrate Metabolism; Chlorpropamide; Diabetes Mellitus; Diabetes Mellitus, Experimental | 1964 |
Experimental antihyperglycemic effect of diterpenoids of llareta Azorella compacta (Umbelliferae) Phil in rats.
Topics: Animals; Apiaceae; Blood Glucose; Body Weight; Chlorpropamide; Diabetes Mellitus, Experimental; Dite | 2005 |
The influence of improved glycaemic control with chlorpropamide on microvascular reactivity and nitric oxide synthase activity in diabetic rats.
Topics: Acetylcholine; Animals; Blood Glucose; Bradykinin; Chlorpropamide; Diabetes Mellitus, Experimental; | 2007 |
The effects of three oral hypoglycemic agents on the incorporation of leucine-C14 into protein by liver microsomes of normal and alloxan-diabetic rats.
Topics: Animals; Biguanides; Carbon Isotopes; Chlorpropamide; Diabetes Mellitus, Experimental; Female; Leuci | 1967 |
Plasma high density lipoprotein cholesterol in streptozotocin diabetic and non-diabetic mice after prolonged administration of glibenclamide, chlorpropamide and metformin.
Topics: Animals; Blood Glucose; Body Weight; Chlorpropamide; Cholesterol; Cholesterol, HDL; Diabetes Mellitu | 1981 |
Role of acetone bodies in the abnormal pharmacokinetic behavior of chlorpropamide in alloxan diabetic rabbits.
Topics: Animals; Chlorpropamide; Diabetes Mellitus, Experimental; Ketone Bodies; Kinetics; Male; Rabbits | 1979 |
Pharmacokinetic behavior of chlorpropamide and sulfadimethoxine in alloxan diabetic rabbits.
Topics: Animals; Chlorpropamide; Diabetes Mellitus, Experimental; Kidney; Rabbits; Sulfadimethoxine | 1978 |
On the mechanism of increased renal tubular reabsorption of drugs in alloxan diabetic rabbits.
Topics: Absorption; Ammonium Chloride; Animals; Chlorpropamide; Diabetes Mellitus, Experimental; Kidney Tubu | 1978 |
The effect of serum Ca2+ compensation on the efficacy of chlorpropamide in alloxan-diabetic rabbits.
Topics: Animals; Blood Glucose; Calcium; Calcium Chloride; Chlorpropamide; Diabetes Mellitus, Experimental; | 1992 |
Studies on induction of delta-aminolevulinic acid synthase, ferrochelatase, cytochrome P-450 and cyclic AMP by phenformin. Chlorpropamide, allylisopropylacetamide and lead in hepatocytes from normal and experimental diabetic rats.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Bucladesine; Chlorpropamide; Cyclic | 1990 |
The oral hypoglycemic activity of 2,5-dioxamide derivatives of 1,3,4-thiadiazole.
Topics: Administration, Oral; Animals; Blood Glucose; Chlorpropamide; Diabetes Mellitus, Experimental; Dioxo | 1989 |
The effect of glibenclamide on non-esterified fatty acid levels in the plasma of the severely alloxan diabetic rat.
Topics: Animals; Blood Glucose; Chlorpropamide; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; | 1973 |
[Pharmacology of HB 419, a new strongly effective oral antidiabetic].
Topics: Adrenalectomy; Animals; Blood Glucose; Carbutamide; Chlorpropamide; Depression, Chemical; Diabetes M | 1969 |