Compounds > chlorpropamide
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chlorpropamide and Acute Liver Injury, Drug-Induced

chlorpropamide has been researched along with Acute Liver Injury, Drug-Induced in 28 studies

Chlorpropamide: A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)
chlorpropamide : An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.

Research Excerpts

ExcerptRelevanceReference
" We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts."1.37FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011)
" An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems."1.36Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199016 (57.14)18.7374
1990's1 (3.57)18.2507
2000's0 (0.00)29.6817
2010's11 (39.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Greene, N1
Fisk, L1
Naven, RT1
Note, RR1
Patel, ML1
Pelletier, DJ1
Morgan, RE2
Trauner, M1
van Staden, CJ2
Lee, PH1
Ramachandran, B1
Eschenberg, M1
Afshari, CA2
Qualls, CW1
Lightfoot-Dunn, R1
Hamadeh, HK2
Ekins, S1
Williams, AJ1
Xu, JJ1
Chen, M2
Vijay, V1
Shi, Q2
Liu, Z2
Fang, H2
Tong, W3
Dawson, S1
Stahl, S2
Paul, N1
Barber, J1
Kenna, JG2
Ding, D1
Kelly, R1
Sakatis, MZ1
Reese, MJ1
Harrell, AW1
Taylor, MA1
Baines, IA1
Chen, L1
Bloomer, JC1
Yang, EY1
Ellens, HM1
Ambroso, JL1
Lovatt, CA1
Ayrton, AD1
Clarke, SE1
Warner, DJ1
Chen, H1
Cantin, LD1
Walker, CL1
Noeske, T1
Chen, Y1
Kalyanaraman, N1
Kalanzi, J1
Dunn, RT1
Suzuki, A1
Thakkar, S1
Yu, K1
Hu, C1
CABARROU, A1
HAUNZ, EA1
CORNATZER, WE1
LUPER, M1
FORKS, G1
CIAMMAICHELLA, A2
CANTERA, N2
VARGA, F1
MOLNAR, Z1
Schneider, HL1
Hornbach, KD1
Kniaz, JL1
Efrusy, ME1
Bell, RL1
Crespo Valadés, E1
Ortega Gómez, A1
Alvarado Izquierdo, MI1
Magro Ledesma, D1
Rigberg, LA1
Robinson, MJ1
Espiritu, CR1
Geubel, AP1
Nakad, A1
Rahier, J1
Dive, C1
Nakao, NL1
Gelb, AM1
Stenger, RJ1
Siegel, JH1
De Matteis, F1
Schaffner, F1
Popper, H1
Abdullaev, NKh1
Gauthier, A1
Gerolami, A1
Camatte, R1
Chamlian, A1
Sarles, H1
Grottum, KA1
Leĭtes, SM1
Abdulaev, NKh1

Reviews

2 reviews available for chlorpropamide and Acute Liver Injury, Drug-Induced

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr

2016
Toxic hepatic porphyrias.
    Seminars in hematology, 1968, Volume: 5, Issue:4

    Topics: Alcoholism; Antifungal Agents; Chemical and Drug Induced Liver Injury; Chlorpropamide; Hexachlorocyc

1968

Other Studies

26 other studies available for chlorpropamide and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship;

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des

2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily

2013
[THE LIVER IN DIABETES].
    Prensa medica argentina, 1963, May-31, Volume: 50

    Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chlorpropamide; Diabetes Mellitus; Hepatitis; Hypogl

1963
LIVER FUNCTION IN CHLORPROPAMIDE THERAPY. FIVE YEAR CLINICAL STUDY OF 181 PATIENTS.
    JAMA, 1964, Apr-20, Volume: 188

    Topics: Agranulocytosis; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Biomedical

1964
[JAUNDICE DURING ORAL ANTIDIABETIC THERAPY].
    Il Fegato, 1963, Volume: 18

    Topics: Chemical and Drug Induced Liver Injury; Chlorpropamide; Hepatitis; Hypoglycemic Agents; Jaundice; Ph

1963
[THE PROTECTIVE EFFECT OF ANTIDIABETIC SULFOCARBAMIDES IN THE LIVER].
    Arzneimittel-Forschung, 1963, Volume: 13

    Topics: Carbon Tetrachloride Poisoning; Carbutamide; Chemical and Drug Induced Liver Injury; Chlorpropamide;

1963
[CONTRIBUTION TO THE STUDY OF THE TOXIC EFFECTS DUE TO HYPOGLYCEMIC SULFONYLUREAS].
    Minerva medica, 1964, Mar-03, Volume: 55

    Topics: Carbutamide; Chemical and Drug Induced Liver Injury; Chlorpropamide; Diabetes Mellitus; Drug Eruptio

1964
Chlorpropamide hepatotoxicity: report of a case and review of the literature.
    The American journal of gastroenterology, 1984, Volume: 79, Issue:9

    Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chlorpropamide; Female; Humans; Liver; Middle Aged

1984
Chlorpropamide hepatitis.
    Alabama medicine : journal of the Medical Association of the State of Alabama, 1984, Volume: 53, Issue:9

    Topics: Aged; Chemical and Drug Induced Liver Injury; Chlorpropamide; Diabetes Mellitus, Type 2; Female; Hum

1984
[Hepatotoxic reaction associated with metformin and chlorpropamide treatment].
    Revista clinica espanola, 1999, Volume: 199, Issue:2

    Topics: Aged; Chemical and Drug Induced Liver Injury; Chlorpropamide; Cholestasis; Diabetes Mellitus, Type 2

1999
Chlorpropamide-induced granulomas. A probable hypersensitivity reaction in liver and bone marrow.
    JAMA, 1976, Jan-26, Volume: 235, Issue:4

    Topics: Biopsy; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Chlorpropamide; Dermatitis, Ex

1976
Prolonged cholestasis and disappearance of interlobular bile ducts following chlorpropamide and erythromycin ethylsuccinate. Case of drug interaction?
    Liver, 1988, Volume: 8, Issue:6

    Topics: Bile Ducts, Intrahepatic; Chemical and Drug Induced Liver Injury; Chlorpropamide; Cholestasis, Intra

1988
A case of chronic liver disease due to tolazamide.
    Gastroenterology, 1985, Volume: 89, Issue:1

    Topics: Aged; Chemical and Drug Induced Liver Injury; Chlorpropamide; Diabetes Mellitus; Female; Humans; Jau

1985
Morphologic studies of cholestasis.
    Gastroenterology, 1968, Volume: 54, Issue:4

    Topics: Bile Ducts, Intrahepatic; Chemical and Drug Induced Liver Injury; Chlorpromazine; Chlorpropamide; Ch

1968
[The effect of chlorpropamide on liver tissue respiration in experimental chronic toxic hepatitis].
    Biulleten' eksperimental'noi biologii i meditsiny, 1967, Volume: 63, Issue:1

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorpropamide; Chr

1967
[Drug-induced hepatitis].
    Marseille medical, 1968, Volume: 105, Issue:1

    Topics: Adult; Chemical and Drug Induced Liver Injury; Chlorpropamide; Estrogens; Female; Humans; Male; Midd

1968
[Liver damage due to phenylbutazone and chlorpropamide].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1966, Aug-15, Volume: 86, Issue:16

    Topics: Aged; Chemical and Drug Induced Liver Injury; Chlorpropamide; Female; Humans; Liver Function Tests;

1966
[The influence of chloropropamide on certain biochemical indices of the liver under normal conditions and in experimental toxic hepatitis].
    Biulleten' eksperimental'noi biologii i meditsiny, 1966, Volume: 61, Issue:3

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorpropamide; Lip

1966