chlorpromazine has been researched along with Ventricular Fibrillation in 21 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a case of primary ventricular fibrillation following withdrawal of lithium in a patient concurrently taking chlorpromazine." | 7.67 | Ventricular fibrillation due to lithium withdrawal--an interaction with chlorpromazine? ( Blanshard, C; Patterson, DL; Stevenson, RN, 1989) |
| "To investigate the mechanism of chlorpromazine(CPZ)-induced ventricular arrhythmia, the changes in ventricular fibrillation threshold (VFT) were followed after intravenous injection of CPZ (1 mg/Kg) in dogs." | 7.66 | Protection of chlorpromazine-induced arrhythmia by flavin-adenine-dinucleotide in canine heart. ( Ozawa, T; Sugiyama, S, 1979) |
| "Combination of chlorpromazine (CPZ) and verapamil (Ver) was found to decrease the incidence of ventricular arrhythmias and ventricular fibrillation induced by myocardial ischemia and reperfusion, lower serum creatine phosphokinase (CPK) and decrease the content of malondialdehyde (MDA) in heart tissue homogenate especially in mitochondria; and increase the phospholipid content and the phospholipid/cholesterol ratio; and decrease the myocardial "cell calcium" content in the reperfused area." | 3.68 | [Protective effects of combination of chlorpromazine and verapamil on ischemia-reperfusion induced injury in rat myocardium]. ( Deng, Y; Zhang, ZS, 1993) |
| "To investigate the mechanism of chlorpromazine(CPZ)-induced ventricular arrhythmia, the changes in ventricular fibrillation threshold (VFT) were followed after intravenous injection of CPZ (1 mg/Kg) in dogs." | 3.66 | Protection of chlorpromazine-induced arrhythmia by flavin-adenine-dinucleotide in canine heart. ( Ozawa, T; Sugiyama, S, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (90.48) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| VANLERENBERGHE, J | 1 |
| ROBELET, A | 1 |
| MILBLED, G | 1 |
| RILEY, PA | 1 |
| MIXON, BM | 1 |
| BARILA, TG | 1 |
| SHEN, TC | 1 |
| LEE, ZW | 1 |
| YELNOSKY, J | 1 |
| KATZ, R | 1 |
| DIETRICH, EV | 1 |
| LUCHERINI, M | 1 |
| MELCHIORRI, P | 1 |
| DUNDEE, JW | 1 |
| CLARKE, RS | 1 |
| HOLLISTER, LE | 1 |
| KOSEK, JC | 1 |
| BEAULNES, A | 1 |
| LAVALLEE, M | 1 |
| Deng, Y | 1 |
| Zhang, ZS | 1 |
| Hoehns, JD | 1 |
| Stanford, RH | 1 |
| Geraets, DR | 1 |
| Skelly, KS | 1 |
| Lee, HC | 1 |
| Gaul, BL | 1 |
| Sugiyama, S | 1 |
| Ozawa, T | 1 |
| Cointe, R | 1 |
| Dussarat, GV | 1 |
| Mafart, B | 1 |
| Bru, P | 1 |
| Levy, S | 1 |
| Stevenson, RN | 1 |
| Blanshard, C | 1 |
| Patterson, DL | 1 |
| Singh, KP | 1 |
| Himeno, K | 1 |
| Claborn, LD | 1 |
| Szabuniewicz, M | 2 |
| Wiersig, DO | 1 |
| Davis, RH | 1 |
| Denman, JH | 1 |
| Hingson, RA | 1 |
| Tomaro, AJ | 1 |
| Stein, H | 1 |
| Rubin, S | 1 |
| Merin, G | 1 |
| Cotev, S | 1 |
| Borman, JB | 1 |
| Miller, DS | 1 |
| Blount, AW | 1 |
| Gunning, JF | 1 |
| Shanahan, MX | 1 |
| Windsor, HM | 1 |
1 review available for chlorpromazine and Ventricular Fibrillation
| Article | Year |
|---|---|
Torsades de pointes associated with chlorpromazine: case report and review of associated ventricular arrhythmias.
Topics: Antipsychotic Agents; Chlorpromazine; Humans; Male; Middle Aged; Torsades de Pointes; Ventricular Fi | 2001 |
20 other studies available for chlorpromazine and Ventricular Fibrillation
| Article | Year |
|---|---|
Adrenaline chloroform fibrillation protective role of chlorpromazine.
Topics: Chloroform; Chlorpromazine; Epinephrine; Ventricular Fibrillation | 1956 |
Antifibrillary drugs for deep hypothermia in the dog.
Topics: Animals; Autonomic Agents; Chlorpromazine; Dogs; Humans; Hypothermia; Neostigmine; Ventricular Fibri | 1957 |
Further studies on the benzol-adrenaline cardio-ventricular fibrillation.
Topics: Benzene; Chlorpromazine; Epinephrine; Heart; Norepinephrine; Procaine; Thiamine; Ventricular Fibrill | 1962 |
A STUDY OF SOME OF THE PHARMACOLOGIC ACTIONS OF DROPERIDOL.
Topics: Benzimidazoles; Blood Pressure; Cardiovascular System; Chlorpromazine; Dogs; Droperidol; Heart; Hypn | 1964 |
ANGIOCARDIOGRAPHIC EVIDENCE FOR HEART FAILURE IN ADRENALIN PULMONARY EDEMA IN RABBITS.
Topics: Angiocardiography; Angiotensins; Animals; Chlorpromazine; Dibenzylchlorethamine; Electrocardiography | 1964 |
PHARMACOLOGY OF HYPOTHERMIA.
Topics: Acetylcholine; Acid-Base Equilibrium; Anesthetics; Anti-Bacterial Agents; Carbohydrate Metabolism; C | 1964 |
SUDDEN DEATH DURING TREATMENT WITH PHENOTHIAZINE DERIVATIVES.
Topics: Adams-Stokes Syndrome; Antipsychotic Agents; Asphyxia; Chlorpromazine; Death, Sudden; Diagnosis, Dif | 1965 |
DIFFERENTIAL EFFECTS OF SOME PHENOTHIAZINE DERIVATIVES AGAINST CALCIUM-INDUCED VENTRICULAR ARRHYTHMIAS IN THE ISOLATED RABBIT HEART.
Topics: Antipsychotic Agents; Arrhythmias, Cardiac; Brugada Syndrome; Calcium; Calcium Chloride; Cardiac Con | 1964 |
[Protective effects of combination of chlorpromazine and verapamil on ischemia-reperfusion induced injury in rat myocardium].
Topics: Animals; Chlorpromazine; Drug Therapy, Combination; Female; Male; Mitochondria, Heart; Myocardial Re | 1993 |
Protection of chlorpromazine-induced arrhythmia by flavin-adenine-dinucleotide in canine heart.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Chlorpromazine; Dogs; Flavin-Adenine Dinucleotide; Mi | 1979 |
[Arrhythmogenic effects of antidepressive agents demonstrated by programmed ventricular pacing].
Topics: Antidepressive Agents, Tricyclic; Cardiac Pacing, Artificial; Chlorpromazine; Clomipramine; Electroc | 1989 |
Ventricular fibrillation due to lithium withdrawal--an interaction with chlorpromazine?
Topics: Chlorpromazine; Drug Interactions; Drug Therapy, Combination; Electrocardiography; Female; Humans; L | 1989 |
Cardiovascular effects of some phenothiazine derivatives following intracoronary injection in dogs.
Topics: Animals; Blood Pressure; Cardiac Catheterization; Cardiac Complexes, Premature; Chlorpromazine; Coro | 1969 |
[Mechanism of the ventricular fibrillation following intravenous adrenaline administration under halothane anesthesia].
Topics: Aminophylline; Anesthesia, Inhalation; Angiotensin II; Animals; Atropine; Blood Pressure; Chlorproma | 1971 |
Prevention of chloroform and thiobarbiturate cardiac sensitization to catecholamines in dogs.
Topics: Acepromazine; Anesthesia; Anesthesia, Inhalation; Animals; Catecholamines; Chloroform; Chlorpromazin | 1973 |
Prevention of induced ventricular fibrillation in dogs anesthetized with ultrashort acting barbiturates and halothane.
Topics: Acepromazine; Anesthesia, Inhalation; Animals; Barbiturates; Chlorpromazine; Dog Diseases; Dogs; Ele | 1974 |
Cardiac resuscitation in the dental office: report of case.
Topics: Adult; Anesthesia, Dental; Anesthesia, Inhalation; Bicarbonates; Chlorpromazine; Cyclopropanes; Elec | 1968 |
Successful prolonged resuscitation after open heart surgery.
Topics: Adult; Arrhythmias, Cardiac; Atrial Fibrillation; Blood Gas Analysis; Blood Pressure; Bradycardia; B | 1971 |
Quinidine-induced recurrent ventricular fibrillation: (quinidine syncope) treated with transvenous pacemaker.
Topics: Adult; Atrial Fibrillation; Atropine; Blood Cell Count; Chlorpromazine; Coumarins; Creatine Kinase; | 1971 |
Use of isoprenaline as an antiarrhythmic agent after valve replacement surgery.
Topics: Anti-Arrhythmia Agents; Chlorpromazine; Delirium; Female; Heart Valve Diseases; Heart Valve Prosthes | 1969 |