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chlorpromazine and Thrombosis

chlorpromazine has been researched along with Thrombosis in 19 studies

Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.

Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.

Research Excerpts

ExcerptRelevanceReference
"Since amphiphilic drugs are known to interact with biomembranes, we investigated local vessel damage and thrombosis which might be brought about by intravenous dosing using chlorpromazine (CPZ) as a representative compound."3.70Local thrombus formation in the site of intravenous injection of chlorpromazine: possible colloid-osmotic lysis of the local endothelial cells. ( Kanamaru, H; Kaneko, H; Nishibe, H; Tani, N; Yabuki, M; Yoshioka, T, 2000)
"In the presence of GT-12, average thrombus size and number of platelets per thrombus were both strikingly lowered."1.27Effects of a novel antiplatelet agent in mural thrombogenesis on collagen-coated glass. ( Folie, BJ; Lasslo, A; McIntire, LV, 1988)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199016 (84.21)18.7374
1990's1 (5.26)18.2507
2000's2 (10.53)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
GRAHMANN, H1
SUCHENWIRTH, R1
KUDRIASHOV, BA2
USHAKOVA, MD1
BAZAZIAN, GG1
SYTINA, NP1
YAMAGUCHI, Y1
HAMILTON, UH1
EINBINDER, JM1
WALZER, RA1
NELSON, CT1
ROLANDI, L1
DE DOMINICIS, E1
Ota, S1
Yamada, N1
Nakano, T1
Born, GV5
Görög, P1
Kratzer, MA2
Wehmeier, A1
Yabuki, M1
Tani, N1
Yoshioka, T1
Nishibe, H1
Kanamaru, H1
Kaneko, H1
Liapina, LA1
Parant, M1
Canoso, RT1
de Oliveira, RM1
Folie, BJ1
McIntire, LV1
Lasslo, A1
Bollinger, A1
Michal, F1
Penglis, F1

Reviews

2 reviews available for chlorpromazine and Thrombosis

ArticleYear
[Thrombosis--adverse effect of drugs].
    Nihon rinsho. Japanese journal of clinical medicine, 2007, Oct-28, Volume: 65 Suppl 8

    Topics: Antipsychotic Agents; Chlorpromazine; Contraceptives, Oral, Hormonal; Estrogens; Heparin; Humans; Pr

2007
Possible mediators in endotoxin-induced abortion.
    Research in immunology, 1990, Volume: 141, Issue:2

    Topics: Abortion, Spontaneous; Animals; Biological Factors; Chlorpromazine; Cytokines; Endotoxins; Female; G

1990

Other Studies

17 other studies available for chlorpromazine and Thrombosis

ArticleYear
[Thrombosis hazard in chlorpromazine and reserpine therapy of endogenous psychoses].
    Der Nervenarzt, 1959, May-20, Volume: 30, Issue:5

    Topics: Chlorpromazine; Electroconvulsive Therapy; Mental Disorders; Psychotherapy; Psychotic Disorders; Res

1959
[DETERMINATION OF THE POSSIBILITY OF DICOUMARIN PREVENTION OF THROMBUS FORMATION CAUSED BY INTRAVENOUS ADMINISTRATION OF MASSIVE DOSES OF THROMBOPLASTIN].
    Biulleten' eksperimental'noi biologii i meditsiny, 1964, Volume: 57

    Topics: Administration, Intravenous; Atherosclerosis; Chlorides; Chlorpromazine; Dicumarol; Diet; Diet, Athe

1964
A STUDY ON MICROCIRCULATION IN RELATION TO REILLY'S PHENOMENA.
    Acta pathologica japonica, 1963, Volume: 13

    Topics: Animals; Autonomic Nervous System Diseases; Capillaries; Chlorpromazine; Collateral Circulation; Ele

1963
COMA DUE TO FAT-EMBOLISM TREATED WITH HYPOTHERMIA AND DEHYDRATION.
    Lancet (London, England), 1964, Nov-07, Volume: 2, Issue:7367

    Topics: Chlorpromazine; Coma; Dehydration; Diuresis; Embolism; Embolism, Fat; Fibula; Fracture Fixation; Hum

1964
THE ROLE OF THE MAST CELL IN ANAPHYLAXIS IN THE MOUSE.
    Journal of immunology (Baltimore, Md. : 1950), 1964, Volume: 93

    Topics: Anaphylaxis; Animals; Antibodies; Chlorpromazine; Heparin; Iproniazid; Lysergic Acid Diethylamide; M

1964
[Interference of a nerve blocking agent on the blood coagulation process].
    Acta anaesthesiologica, 1955, Volume: 6, Issue:1

    Topics: Blood Coagulation; Chlorpromazine; Humans; Thrombosis

1955
Aggregation of platelets in damaged vessels.
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1981, Aug-18, Volume: 294, Issue:1072

    Topics: Adenosine Diphosphate; Animals; Arteries; Arteriosclerosis; Blood Platelets; Chlorpromazine; Collage

1981
Possible approaches to the pharmacological prevention of myocardial ischaemia.
    Acta medica Scandinavica. Supplementum, 1980, Volume: 642

    Topics: Arteriosclerosis; Blood Platelets; Blood Vessels; Chlorpromazine; Coronary Disease; Hemolysis; Human

1980
Endogenous agents in platelet thrombosis.
    Acta medica Scandinavica. Supplementum, 1981, Volume: 651

    Topics: Adenosine Diphosphate; Arteriosclerosis; Blood Vessels; Chlorpromazine; Collagen; Epoprostenol; Huma

1981
Thrombosis in arteries: mechanisms and prevention.
    Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie, 1980, Volume: 42, Issue:3-4

    Topics: Adenosine Diphosphate; Chlorpromazine; Hemodynamics; Humans; Platelet Adhesiveness; Platelet Aggrega

1980
The haemodynamics of arterial thrombosis.
    Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1981, Volume: 87

    Topics: Blood Platelets; Chlorpromazine; Hemodynamics; Humans; Thrombosis

1981
Local thrombus formation in the site of intravenous injection of chlorpromazine: possible colloid-osmotic lysis of the local endothelial cells.
    Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:8

    Topics: Animals; Cells, Cultured; Chlorpromazine; Colloids; Endothelium, Vascular; Hemolysis; Injections, In

2000
[Heparin-urea complex and its biological properties].
    Nauchnye doklady vysshei shkoly. Biologicheskie nauki, 1975, Issue:10

    Topics: Animals; Autonomic Nervous System; Chlorpromazine; Drug Combinations; Fibrinogen; Fibrinolysis; Hepa

1975
Chlorpromazine-induced anticardiolipin antibodies and lupus anticoagulant: absence of thrombosis.
    American journal of hematology, 1988, Volume: 27, Issue:4

    Topics: Autoantibodies; Blood Coagulation Factors; Cardiolipins; Chlorpromazine; Follow-Up Studies; Humans;

1988
Effects of a novel antiplatelet agent in mural thrombogenesis on collagen-coated glass.
    Blood, 1988, Volume: 72, Issue:4

    Topics: Chlorpromazine; Collagen; Glass; Humans; In Vitro Techniques; Kinetics; Nipecotic Acids; Platelet Ad

1988
[Internal therapy of peripheral arterial blood circulation disorders].
    Schweizerische medizinische Wochenschrift, 1970, May-02, Volume: 100, Issue:18

    Topics: Adenosine Triphosphate; Aged; Angiotensin II; Anti-Bacterial Agents; Blood Pressure; Chlorpromazine;

1970
Inhibition of serotonin-induced platelet aggregation in relation to thrombus production.
    The Journal of pharmacology and experimental therapeutics, 1969, Volume: 166, Issue:2

    Topics: Adenine Nucleotides; Animals; Atropa belladonna; Atropine; Blood Coagulation; Blood Platelets; Chlor

1969