chlorpromazine has been researched along with Stroke in 10 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "While the addition of low dose chlorpromazine and promethazine to standard of care for acute ischemic stroke did not have any significant improvement in functional outcomes, there were no serious adverse effects." | 9.30 | Low dose concomitant treatment with chlorpromazine and promethazine is safe in acute ischemic stroke. ( Chandra, A; Cheng, Z; Ding, Y; Du, H; Geng, X; Tong, Y; Zhu, H, 2019) |
| "This study is aimed at investigating the clinical efficacy of anisodamine combined with chlorpromazine on intractable hiccups after stroke." | 8.12 | Observation of Clinical Efficacy of Anisodamine and Chlorpromazine in the Treatment of Intractable Hiccup after Stroke. ( Wang, J; Wang, L; Wen, L; Zhang, S; Zhu, Q, 2022) |
| "While the addition of low dose chlorpromazine and promethazine to standard of care for acute ischemic stroke did not have any significant improvement in functional outcomes, there were no serious adverse effects." | 5.30 | Low dose concomitant treatment with chlorpromazine and promethazine is safe in acute ischemic stroke. ( Chandra, A; Cheng, Z; Ding, Y; Du, H; Geng, X; Tong, Y; Zhu, H, 2019) |
| " The present study determined whether neuroprotective PH with chlorpromazine and promethazine (C + P), plus dihydrocapsaicin (DHC) improved glucose metabolism in acute ischemic stroke." | 4.12 | Neuroprotective Effects of Pharmacological Hypothermia on Hyperglycolysis and Gluconeogenesis in Rats after Ischemic Stroke. ( Ding, Y; Du, H; Geng, X; Guan, L; Ji, Y; Lee, H; Li, F; Peng, C; Shen, J, 2022) |
| "This study is aimed at investigating the clinical efficacy of anisodamine combined with chlorpromazine on intractable hiccups after stroke." | 4.12 | Observation of Clinical Efficacy of Anisodamine and Chlorpromazine in the Treatment of Intractable Hiccup after Stroke. ( Wang, J; Wang, L; Wen, L; Zhang, S; Zhu, Q, 2022) |
| "A much greater risk of ischemic stroke was observed in patients who used chlorpromazine and haloperidol compared to risperidone." | 3.81 | Risk of ischemic stroke associated with the use of antipsychotic drugs in elderly patients: a retrospective cohort study in Korea. ( Choi, NK; Lee, J; Lee, SH; Park, BJ; Park, MJ; Seong, JM; Shin, JY, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guan, L | 1 |
| Lee, H | 1 |
| Geng, X | 5 |
| Li, F | 3 |
| Shen, J | 2 |
| Ji, Y | 1 |
| Peng, C | 2 |
| Du, H | 2 |
| Ding, Y | 6 |
| Wang, J | 1 |
| Zhu, Q | 1 |
| Zhang, S | 1 |
| Wen, L | 1 |
| Wang, L | 1 |
| An, H | 1 |
| Duan, Y | 1 |
| Wu, D | 1 |
| Yip, J | 3 |
| Elmadhoun, O | 2 |
| Wright, JC | 1 |
| Shi, W | 1 |
| Liu, K | 1 |
| He, X | 1 |
| Shi, J | 1 |
| Jiang, F | 1 |
| Ji, X | 3 |
| Zhu, H | 1 |
| Chandra, A | 1 |
| Cheng, Z | 1 |
| Tong, Y | 1 |
| Shin, JY | 1 |
| Choi, NK | 1 |
| Lee, J | 1 |
| Seong, JM | 1 |
| Park, MJ | 1 |
| Lee, SH | 1 |
| Park, BJ | 1 |
| Liu, S | 1 |
| Forreider, B | 1 |
| Xiao, Y | 1 |
| Kong, Q | 1 |
| BERGOUIGNAN, M | 1 |
| D'AULNAY, J | 1 |
| MALINEAU, R | 1 |
| POURSINES, Y | 1 |
| ALLIEZ, J | 1 |
| TOGA, M | 1 |
1 trial available for chlorpromazine and Stroke
| Article | Year |
|---|---|
Low dose concomitant treatment with chlorpromazine and promethazine is safe in acute ischemic stroke.
Topics: Adult; Aged; Aspirin; Atorvastatin; Chlorpromazine; Double-Blind Method; Drug Therapy, Combination; | 2019 |
9 other studies available for chlorpromazine and Stroke
| Article | Year |
|---|---|
Neuroprotective Effects of Pharmacological Hypothermia on Hyperglycolysis and Gluconeogenesis in Rats after Ischemic Stroke.
Topics: Adenosine Triphosphate; Animals; Chlorpromazine; Gluconeogenesis; Glucose; Hypothermia; Infarction, | 2022 |
Observation of Clinical Efficacy of Anisodamine and Chlorpromazine in the Treatment of Intractable Hiccup after Stroke.
Topics: Algorithms; Chlorpromazine; Hiccup; Humans; Solanaceous Alkaloids; Stroke; Treatment Outcome | 2022 |
Phenothiazines Enhance Mild Hypothermia-induced Neuroprotection via PI3K/Akt Regulation in Experimental Stroke.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Combined Modality Therapy; Disease Models, Animal; Hy | 2017 |
Therapeutic Target and Cell-signal Communication of Chlorpromazine and Promethazine in Attenuating Blood-Brain Barrier Disruption after Ischemic Stroke.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Chlorpromazine; Male; Promethazine; Rats; Rats, Spragu | 2019 |
Risk of ischemic stroke associated with the use of antipsychotic drugs in elderly patients: a retrospective cohort study in Korea.
Topics: Aged; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Cohort Studies; Dose-Response Relations | 2015 |
Enhanced beneficial effects of mild hypothermia by phenothiazine drugs in stroke therapy.
Topics: Animals; Body Temperature; Brain; Brain Ischemia; Chlorpromazine; Hypothermia, Induced; Male; Motor | 2015 |
Neuroprotection by Chlorpromazine and Promethazine in Severe Transient and Permanent Ischemic Stroke.
Topics: Animals; Chlorpromazine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ischemic Attac | 2017 |
[A few retouching strokes in our experience with largactil in psychiatry].
Topics: Chlorpromazine; Mental Disorders; Psychiatry; Psychosurgery; Psychotherapy; Stroke | 1955 |
[Parkinsonian syndrome following prolonged administration of chlorpromazine with fatal concomitant stroke. Appearance of pallidal lesions].
Topics: Basal Ganglia; Chlorpromazine; Ganglia; Globus Pallidus; Humans; Parkinson Disease; Parkinsonian Dis | 1959 |