chlorpromazine has been researched along with Sensitivity and Specificity in 26 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To perform a cost-effectiveness analysis (CEA) between a standard antiemetic regimen-chlorpromazine + dexamethasone (CPM-DEX)- and a 5-HT3 receptor antagonist-tropisetron (TROP)--in the control of acute emesis induced by highly emetogenic chemotherapy in children, considering two analytic perspectives: hospital and patients." | 7.70 | Cost-effectiveness analysis of tropisetron vs. chlorpromazine-dexamethasone in the control of acute emesis induced by highly emetogenic chemotherapy in children. ( Giráldez, J; Idoate, A; Jiménez, M; Sierrasesumaga, L; Tejedor, I, 1999) |
| "To perform a cost-effectiveness analysis (CEA) between a standard antiemetic regimen-chlorpromazine + dexamethasone (CPM-DEX)- and a 5-HT3 receptor antagonist-tropisetron (TROP)--in the control of acute emesis induced by highly emetogenic chemotherapy in children, considering two analytic perspectives: hospital and patients." | 3.70 | Cost-effectiveness analysis of tropisetron vs. chlorpromazine-dexamethasone in the control of acute emesis induced by highly emetogenic chemotherapy in children. ( Giráldez, J; Idoate, A; Jiménez, M; Sierrasesumaga, L; Tejedor, I, 1999) |
| "A simple method has been proposed for the determination of clozapine (CLZ) and chlorpromazine (CPZ) in human urine by dispersive liquid-liquid microextraction (DLLME) in combination with high-performance liquid chromatography-ultraviolet detector (HPLC-UV)." | 1.37 | Dispersive liquid-liquid microextraction combined with high-performance liquid chromatography for the determination of clozapine and chlorpromazine in urine. ( Chen, J; Ruan, J; Su, Z; Xiong, C, 2011) |
| "Chlorpromazine was extracted from rat plasma and brain homogenate using liquid-liquid extraction." | 1.34 | Sensitive liquid chromatography/tandem mass spectrometry method for the determination of the lipophilic antipsychotic drug chlorpromazine in rat plasma and brain tissue. ( Bartlett, MG; Terry, AV; Zhang, G, 2007) |
| " Vasoconstriction was induced by epinephrine in all groups in a dose-response fashion." | 1.30 | Vascular effects of epinephrine, lisinopril, and chlorpromazine in diabetic and non-diabetic rats. ( Aygit, AC; Ayhan, MS; Demiralay, A; Yildirim, I, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (30.77) | 18.2507 |
| 2000's | 13 (50.00) | 29.6817 |
| 2010's | 5 (19.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, H | 1 |
| Sun, J | 1 |
| Sui, X | 1 |
| Liu, J | 1 |
| Yan, Z | 1 |
| Liu, X | 1 |
| Sun, Y | 1 |
| He, Z | 1 |
| Elje, E | 1 |
| Hesler, M | 1 |
| Rundén-Pran, E | 1 |
| Mann, P | 1 |
| Mariussen, E | 1 |
| Wagner, S | 1 |
| Dusinska, M | 1 |
| Kohl, Y | 1 |
| de Jong, M | 1 |
| Sleegers, N | 1 |
| Florea, A | 1 |
| Van Loon, J | 1 |
| van Nuijs, ALN | 1 |
| Samyn, N | 1 |
| De Wael, K | 1 |
| Qi, L | 1 |
| Duan, LM | 1 |
| Sun, XH | 1 |
| Zhang, J | 1 |
| Zhang, ZQ | 1 |
| Chen, J | 1 |
| Xiong, C | 1 |
| Ruan, J | 1 |
| Su, Z | 1 |
| Zheng, SQ | 1 |
| Wang, W | 1 |
| Liang, C | 1 |
| Wang, R | 1 |
| Gong, FJ | 1 |
| Wu, ZP | 1 |
| Chen, YS | 1 |
| Zhang, YR | 1 |
| Zhang, RS | 1 |
| Santano, E | 1 |
| Pinto, Mdel C | 1 |
| Macías, P | 1 |
| Petris, MJ | 1 |
| Smith, K | 1 |
| Lee, J | 1 |
| Thiele, DJ | 1 |
| Chen, JY | 1 |
| Brunauer, LS | 1 |
| Chu, FC | 1 |
| Helsel, CM | 1 |
| Gedde, MM | 1 |
| Huestis, WH | 1 |
| Tomiyasu, T | 1 |
| Nonaka, M | 1 |
| Uchikado, M | 1 |
| Anazawa, K | 1 |
| Sakamoto, H | 1 |
| van der Ven, K | 1 |
| De Wit, M | 1 |
| Keil, D | 1 |
| Moens, L | 1 |
| Van Leemput, K | 1 |
| Naudts, B | 1 |
| De Coen, W | 1 |
| Niu, W | 1 |
| Feng, N | 1 |
| Nie, F | 1 |
| Lu, J | 1 |
| Zhang, G | 1 |
| Terry, AV | 1 |
| Bartlett, MG | 1 |
| Al-Shatti, LA | 1 |
| Marafie, HM | 1 |
| Shoukry, AF | 1 |
| Arneth, W | 1 |
| Roy, BP | 1 |
| Archibald, F | 1 |
| Adamczyk, M | 1 |
| Fishpaugh, J | 1 |
| Harrington, C | 1 |
| Hartter, D | 1 |
| Johnson, D | 1 |
| Vanderbilt, A | 1 |
| Tamamizu, S | 1 |
| Todd, AP | 1 |
| McNamee, MG | 1 |
| Cunningham, SL | 1 |
| Winkelman, JW | 1 |
| Dorsey, CM | 1 |
| Lukas, SE | 1 |
| Richardson, GS | 1 |
| Sholar, MB | 1 |
| Hunt, A | 1 |
| Mou, C | 1 |
| Ganju, N | 1 |
| Sridhar, KS | 1 |
| Krishan, A | 1 |
| Tejedor, I | 1 |
| Idoate, A | 1 |
| Jiménez, M | 1 |
| Sierrasesumaga, L | 1 |
| Giráldez, J | 1 |
| Aygit, AC | 1 |
| Ayhan, MS | 1 |
| Demiralay, A | 1 |
| Yildirim, I | 1 |
| Kimura, H | 1 |
| Mukaida, M | 1 |
| Wang, G | 1 |
| Yuan, J | 1 |
| Matsumoto, K | 1 |
| Schminke, G | 1 |
| Seubert, A | 1 |
| Lue, AJ | 1 |
| Zhao, HB | 1 |
| Brownell, WE | 1 |
| Owen, RR | 1 |
| Thrush, CR | 1 |
| Hudson, TJ | 1 |
| Mallory, SR | 1 |
| Fischer, EP | 1 |
| Clardy, JA | 1 |
| Williams, DK | 1 |
26 other studies available for chlorpromazine and Sensitivity and Specificity
| Article | Year |
|---|---|
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metab | 2009 |
The comet assay applied to HepG2 liver spheroids.
Topics: Cell Culture Techniques; Cell Survival; Chlorpromazine; Colchicine; Comet Assay; DNA Damage; DNA, Ne | 2019 |
Unraveling the Mechanisms Behind the Complete Suppression of Cocaine Electrochemical Signals by Chlorpromazine, Promethazine, Procaine, and Dextromethorphan.
Topics: Anesthetics, Local; Antiemetics; Antipruritics; Antitussive Agents; Chlorpromazine; Cocaine; Dextrom | 2019 |
Simultaneous determination of three banned psychiatric drugs in pig feed and tissue using solid-phase reactor on-line oxidizing and HPLC-fluorescence detection.
Topics: Animal Feed; Animals; Calibration; Chlorpromazine; Chromatography, High Pressure Liquid; Fluorescenc | 2015 |
Dispersive liquid-liquid microextraction combined with high-performance liquid chromatography for the determination of clozapine and chlorpromazine in urine.
Topics: Antipsychotic Agents; Chlorpromazine; Chromatography, High Pressure Liquid; Clozapine; Humans; Liqui | 2011 |
[Simultaneous determination of trihexyphenidyl, chlorpromazine and clozapine in blood by GC-MS].
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Clozapine; Female; Forensic Toxicology; Gas Chromatogra | 2011 |
Chlorpromazine oxidation by hydroperoxidase activity of covalent immobilized lipoxygenase.
Topics: Chlorpromazine; Enzyme Activation; Enzyme Stability; Enzymes, Immobilized; Ethylene Oxide; Glycine m | 2002 |
Copper-stimulated endocytosis and degradation of the human copper transporter, hCtr1.
Topics: Animals; Blotting, Western; Cation Transport Proteins; Cell Line; Cell Membrane; Chlorpromazine; CHO | 2003 |
Selective amphipathic nature of chlorpromazine binding to plasma membrane bilayers.
Topics: Adenosine Triphosphate; Cell Membrane; Chlorpromazine; Erythrocyte Membrane; Humans; Hydrogen-Ion Co | 2003 |
Kinetic determination of total iodine in urine and foodstuffs using a mixed acid as a pretreatment agent.
Topics: Acids; Catalysis; Chlorpromazine; Food Analysis; Hydrogen Peroxide; Iodine; Kinetics; Reproducibilit | 2004 |
Development and application of a brain-specific cDNA microarray for effect evaluation of neuro-active pharmaceuticals in zebrafish (Danio rerio).
Topics: Animals; Brain; Central Nervous System Agents; Chlorpromazine; Female; Gene Expression Regulation; M | 2005 |
Investigating the post-chemiluminescence behavior of phenothiazine medications in the luminol-potassium ferricyanide system: molecular imprinting-post-chemiluminescence method for the determination of chlorpromazine hydrochloride.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Ferricyanides; Luminescence; Luminol; Phenothiazines; | 2006 |
Sensitive liquid chromatography/tandem mass spectrometry method for the determination of the lipophilic antipsychotic drug chlorpromazine in rat plasma and brain tissue.
Topics: Animals; Antipsychotic Agents; Brain; Calibration; Chlorpromazine; Chromatography, High Pressure Liq | 2007 |
Surface analysis of new chlorpromazinium plastic membrane electrodes.
Topics: Chlorpromazine; Electrodes; Hydrogen-Ion Concentration; Microscopy, Electron; Plastics; Sensitivity | 2008 |
[Analysis of some neuroleptics and carazolol in pork kidneys].
Topics: Acepromazine; Adrenergic beta-Antagonists; Animals; Antipsychotic Agents; Azaperone; Chlorpromazine; | 1995 |
An indirect free radical-based assay for the enzyme cellobiose:quinone oxidoreductase.
Topics: Carbohydrate Dehydrogenases; Chlorpromazine; Free Radicals; Glucose Oxidase; Laccase; Oxidation-Redu | 1994 |
Immunoassay reagents for psychoactive drugs. I. The method for the development of antibodies specific to amitriptyline and nortriptyline.
Topics: Amitriptyline; Animals; Antibodies; Antibody Specificity; Chlorpromazine; Cross Reactions; Fluoresce | 1993 |
Mutations in the M1 region of the nicotinic acetylcholine receptor alter the sensitivity to inhibition by quinacrine.
Topics: Acetylcholine; Amino Acid Sequence; Amino Acids; Animals; Bungarotoxins; Chlorpromazine; Enzyme Inhi | 1995 |
An electromyographic marker for neuroleptic-induced akathisia: preliminary measures of sensitivity and specificity.
Topics: Adolescent; Adult; Age Factors; Aged; Antipsychotic Agents; Chlorpromazine; Electromyography; Female | 1996 |
Simultaneous quantitation of plasma doxorubicin and prochlorperazine content by high-performance liquid chromatography.
Topics: Antibiotics, Antineoplastic; Chlorpromazine; Chromatography, High Pressure Liquid; Circadian Rhythm; | 1997 |
Cost-effectiveness analysis of tropisetron vs. chlorpromazine-dexamethasone in the control of acute emesis induced by highly emetogenic chemotherapy in children.
Topics: Adolescent; Age Factors; Antiemetics; Child; Child, Preschool; Chlorpromazine; Cost-Benefit Analysis | 1999 |
Vascular effects of epinephrine, lisinopril, and chlorpromazine in diabetic and non-diabetic rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Chlorpromazine; Diabetes Mellitus, Experimental; | 1999 |
Dual-label time-resolved fluoroimmunoassay of psychopharmaceuticals and stimulants in serum.
Topics: Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Calibration; Central Nervous System | 2000 |
Comparison of ion chromatographic methods based on conductivity detection, post-column-reaction and on-line-coupling IC-ICP-MS for the determination of bromate.
Topics: Anions; Bromates; Bromides; Carcinogens; Chlorpromazine; Chromatography; Chromatography, High Pressu | 2000 |
Chlorpromazine alters outer hair cell electromotility.
Topics: Animals; Cell Movement; Cells, Cultured; Chlorpromazine; Cochlea; Dose-Response Relationship, Drug; | 2001 |
Using an explicit guideline-based criterion and implicit review to assess antipsychotic dosing performance for schizophrenia.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Data Collection; Double-Blind Method; Drug Utilization; | 2002 |