Compounds > chlorpromazine
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chlorpromazine and Porphyrias

chlorpromazine has been researched along with Porphyrias in 27 studies

Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.

Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.

Research Excerpts

ExcerptRelevanceReference
"First, 3 cases of aplastic anemia (chlorpromazine, chloramphenicol and probably autoantibodytypes) are discussed."1.25[Clinical-hematological demonstrations: aplastic anemia, acute leukemias, polyneuropathy in Waldenstrom's disease, acute porphyria]. ( Moeschlin, S, 1975)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-199027 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
DURAN, P1
VAILHE, J1
JUDEAU, P1
JUILLET, P1
BERNOT, J1
GIBERT, J1
CALVY, GL2
LEEPER, RD2
MONACO, RN2
ROBBINS, JJ2
SWEENEY, JE1
TAXAY, EP1
GERBAUT, P1
LOCHARD, J1
HARTEMANN, P1
LORRAIN, J1
WEBER, M1
BAGGIO, J1
MICHIE, I1
KELLEHER, MF1
GOLDBERG, A2
CASTROMENDOZA, H1
DELABARREDA, P1
BARKAY, M1
THYS, O1
DELCROIX, G1
DURET, RL1
JEANSONNE, WO1
MILLER, HJ1
MULE, JG1
LANGHOF, H1
FRANKEN, E1
KLUGE, K1
Mays, JE1
Dean, G1
Catania, A1
Caimi, G1
Moeschlin, S1
Diukov, VA1
Sumner, E1
Chen, MH1
Carney, MW1
Rees, HA1
Cochrane, AL1
Williams, MJ1
Donald, KW1
Trux, F1
Grossmann, K1
Giegler, I1
Cripps, DJ1
Peters, HA1
Vannotti, A1
Burg, G1
Mertens, H1
Böhme, H1
Zeană, C1
Mihăilescu, N1
Clipea, N1
Ushio, K1
Taguchi, I1
Suwa, K1
Uehara, K1
Ishida, K1

Reviews

2 reviews available for chlorpromazine and Porphyrias

ArticleYear
[Pharmacogenetic research in clinical psychiatry].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1976, Volume: 76, Issue:4

    Topics: Antidepressive Agents, Tricyclic; Biotransformation; Bipolar Disorder; Chlorpromazine; Cholinesteras

1976
[Diagnosis and traditional Chinese medicine combined with Western medicine in the treatment of hepatic porphyria].
    Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine, 1988, Volume: 8, Issue:9

    Topics: Chlorpromazine; Diagnostic Errors; Drugs, Chinese Herbal; Humans; Liver Diseases; Porphyrias

1988

Trials

1 trial available for chlorpromazine and Porphyrias

ArticleYear
Mefenamic acid and chlorpromazine in porphyria variegata.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1967, Sep-30, Volume: 41, Issue:37

    Topics: Adolescent; Adult; Anti-Inflammatory Agents; Body Weight; Chlorpromazine; Female; Humans; Male; Mefe

1967

Other Studies

24 other studies available for chlorpromazine and Porphyrias

ArticleYear
[Important electroencephalographic changes in acute porphyria treated with chlorpromazine].
    Revue neurologique, 1955, Volume: 92, Issue:6

    Topics: Chlorpromazine; Electroencephalography; Humans; Porphyria, Acute Intermittent; Porphyrias

1955
Intermittent acute porphyria treated with chlorpromazine.
    The New England journal of medicine, 1957, Feb-14, Volume: 256, Issue:7

    Topics: Chlorpromazine; Humans; Porphyria, Acute Intermittent; Porphyrias

1957
Intermittent acute porphyria treated with chlorpromazine.
    The New England journal of medicine, 1957, Feb-14, Volume: 256, Issue:7

    Topics: Chlorpromazine; Humans; Porphyria, Acute Intermittent; Porphyrias

1957
Intermittent acute porphyria treated with chlorpromazine.
    The New England journal of medicine, 1957, Feb-14, Volume: 256, Issue:7

    Topics: Chlorpromazine; Humans; Porphyria, Acute Intermittent; Porphyrias

1957
Intermittent acute porphyria treated with chlorpromazine.
    The New England journal of medicine, 1957, Feb-14, Volume: 256, Issue:7

    Topics: Chlorpromazine; Humans; Porphyria, Acute Intermittent; Porphyrias

1957
Acute intermittent porphyria; report of a case treated with chlorpromazine.
    The Journal of the Kansas Medical Society, 1957, Volume: 58, Issue:10

    Topics: Animals; Chlorpromazine; Humans; Porifera; Porphyria, Acute Intermittent; Porphyrias

1957
Tetanus and porphyria.
    The West Indian medical journal, 1960, Volume: 9

    Topics: Barbiturates; Chlorpromazine; Porphyrias; Tetanus

1960
[ACUTE IDIOPATHIC PORPHYRIA. APROPOS OF A CASE USING A RESPIRATORY LASTING 4 MONTHS].
    Annales medicales de Nancy, 1963, Volume: 2

    Topics: Blood Pressure; Chlorpromazine; Humans; Muscular Atrophy; Paralysis; Porphyria, Acute Intermittent;

1963
PORPHYRIA: A CASE WITH ACUTE ASCENDING PARALYSIS.
    Journal of the Royal Army Medical Corps, 1963, Volume: 109

    Topics: Chlorpromazine; Humans; Paresis; Porphyrias

1963
THERAPEUTIC CONSIDERATIONS IN THE DISEASES OF PORPHYRIN METABOLISM.
    South African journal of laboratory and clinical medicine. Suid-Afrikaanse tydskrif vir laboratorium- en kliniekwerk, 1963, Volume: 14

    Topics: Adenine Nucleotides; Adrenocorticotropic Hormone; Anti-Allergic Agents; Barbiturates; Chelating Agen

1963
[ACUTE PORPHYRIA].
    Revista espanola de las enfermedades del aparato digestivo y de la nutricion, 1963, Volume: 22

    Topics: Adrenocorticotropic Hormone; Body Fluids; Chlorpromazine; Feces; Humans; Neurologic Manifestations;

1963
[A CASE OF INTERMITTENT ACUTE PORPHYRIA IN A 52-YEAR-OLD WOMAN, TRIGGERED BY THE INGESTION OF AN ALLYL BARBITURATE].
    Acta chirurgica Belgica, 1964, Volume: 63

    Topics: Barbiturates; Chlorpromazine; Porphyria, Acute Intermittent; Porphyrias; Promethazine; Sorbitol; Tox

1964
ACUTE INTERMITTENT PORPHYRIA IN PREGNANCY; REPORT OF A CASE.
    Obstetrics and gynecology, 1965, Volume: 25

    Topics: Chlorpromazine; Diagnosis, Differential; Drug Therapy; Female; Humans; Porphyria, Acute Intermittent

1965
[COMBINED HEREDITARY PORPHYRIA HEPATICA (HEREDITARY COPROPORPHYRIA)].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1965, Volume: 16

    Topics: Chlorpromazine; Coproporphyria, Hereditary; Drug Therapy; Female; Genetics, Medical; Humans; Hypokal

1965
Acute intermittent porphyria in childhood.
    The Journal of the Oklahoma State Medical Association, 1967, Volume: 60, Issue:5

    Topics: Amino Acids; Child; Child, Preschool; Chlorpromazine; Diagnosis, Differential; Female; Humans; Levul

1967
[Acute intermittent porphyria].
    Minerva medica, 1983, Nov-10, Volume: 74, Issue:43

    Topics: Acute Disease; Chlorpromazine; Diarrhea; Heme; Hemin; Humans; Intestinal Obstruction; Mitochondria,

1983
[Clinical-hematological demonstrations: aplastic anemia, acute leukemias, polyneuropathy in Waldenstrom's disease, acute porphyria].
    Schweizerische medizinische Wochenschrift, 1975, Oct-04, Volume: 105, Issue:40

    Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Autoantibodies; Chloramphenicol; Chlorpromazine; Cortison

1975
Porphyria in relation to surgery and anaesthesia.
    Annals of the Royal College of Surgeons of England, 1975, Volume: 56, Issue:2

    Topics: 5-Aminolevulinate Synthetase; Adult; Anesthesia; Barbiturates; Chlorpromazine; Contraceptives, Oral;

1975
Hepatic porphyria with mental symptoms. Four missed cases.
    Lancet (London, England), 1972, Jul-15, Volume: 2, Issue:7768

    Topics: Adult; Chlorpromazine; Diagnostic Errors; Female; Follow-Up Studies; Humans; Liver Diseases; Male; M

1972
Renal haemodialysis in porphyria.
    Lancet (London, England), 1967, Apr-29, Volume: 1, Issue:7496

    Topics: Adult; Amobarbital; Blood Chemical Analysis; Chlorpromazine; Female; Humans; Male; Mental Disorders;

1967
[Acute intermittent porphyria (our personal observations in a family)].
    Zeitschrift fur arztliche Fortbildung, 1971, Feb-15, Volume: 65, Issue:4

    Topics: Acute Disease; Adrenocorticotropic Hormone; Adult; Biopsy; Chlorpromazine; Cytochromes; Dimercaprol;

1971
Stool porphyrins in acute intermittent and hereditary coproporphyria. Adverse effect of tranquilizers.
    Archives of neurology, 1970, Volume: 23, Issue:1

    Topics: Acute Disease; Adult; Chemical Phenomena; Chemistry; Chlorpromazine; Chromatography; Feces; Female;

1970
[Treatment of the porphyrias].
    Bibliotheca psychiatrica et neurologica, 1969, Volume: 139

    Topics: Adenine Nucleotides; Barbiturates; Catalase; Cathartics; Chlorpromazine; Cholagogues and Choleretics

1969
[Therapy of porphyrias].
    Minerva medica, 1972, Apr-25, Volume: 63, Issue:31

    Topics: Acute Disease; Bone Marrow Diseases; Chlorpromazine; Deferoxamine; Erythropoiesis; Humans; Phospholi

1972
[Effect of ovulation inhibitors on acute intermittent porphyria].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1970, Mar-01, Volume: 25, Issue:5

    Topics: Acute Disease; Adenosine Monophosphate; Adult; Chlorpromazine; Contraceptives, Oral; Depression, Che

1970
[Current status of the treatment of intermittent acute porphyrias (I.A.P.). (Considerations on 11 cases)].
    Medicina interna, 1969, Volume: 21, Issue:4

    Topics: Adult; Anti-Bacterial Agents; Chlorpromazine; Female; Humans; Hypnotics and Sedatives; Male; Middle

1969
[6 recent cases of toxic hepatitis].
    Naika. Internal medicine, 1966, Volume: 18, Issue:2

    Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Chlorpromazine; Erythromycin; Femal

1966