chlorpromazine has been researched along with Pituitary Neoplasms in 35 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case is reported of a prolactin-secreting pituitary adenoma in a young woman who had been referred for evaluation of amenorrhea with a history of in utero exposure to diethylstilbestrol." | 7.66 | Prolactin-secreting pituitary adenoma: occurrence following prenatal exposure to diethylstilbestrol. ( Cunningham, JR; Duchesneau, PM; Gidwani, GP; Gupta, MS; Schumacher, OP, 1982) |
| "TRH, metoclopramide (MCP), chlorpromazine (CPZ), and insulin (ITT) stimulation tests of PRL secretion were carried out in age-matched controls and before and after successful removal of pituitary prolactinomas in women with the galactorrhea-amenorrhea syndrome." | 3.66 | Persistent defect in regulation of prolactin secretion after successful pituitary tumor removal in women with the galactorrhea-amenorrhea syndrome. ( Blackard, WG; Gardner, DF; Lankford, HV; Tucker, HS, 1980) |
| "A case is reported of a prolactin-secreting pituitary adenoma in a young woman who had been referred for evaluation of amenorrhea with a history of in utero exposure to diethylstilbestrol." | 3.66 | Prolactin-secreting pituitary adenoma: occurrence following prenatal exposure to diethylstilbestrol. ( Cunningham, JR; Duchesneau, PM; Gidwani, GP; Gupta, MS; Schumacher, OP, 1982) |
| "When trifluoperazine was incubated with cytosol, both the high and low affinity forms of cyclic AMP phosphodiesterase were inhibited competitively with calculated Ki of 4." | 1.27 | Effects of calmodulin antagonists on hormone release and cyclic AMP levels in GH3 pituitary cells. ( Gautvik, KM; Gordeladze, J; Haug, E; Sand, O; Sletholt, K, 1987) |
| "The 39% recurrence rate of hyperprolactinemia and persistent abnormalities in pituitary-hypothalamic regulation of PRL secretion after transsphenoidal surgery raise important questions about the choice of primary therapy for patients with PRL-secreting tumors." | 1.27 | Long term follow-up of women with surgically treated prolactin-secreting pituitary tumors. ( Chapler, FK; Schlechte, JA; Sherman, BM; VanGilder, J, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (97.14) | 18.7374 |
| 1990's | 1 (2.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tucker, HS | 2 |
| Lankford, HV | 2 |
| Gardner, DF | 1 |
| Blackard, WG | 2 |
| Grubb, SR | 1 |
| Wigand, JP | 1 |
| Taylon, A | 1 |
| Becker, DP | 1 |
| Cunningham, JR | 1 |
| Gidwani, GP | 1 |
| Gupta, MS | 1 |
| Duchesneau, PM | 1 |
| Schumacher, OP | 1 |
| Ho Yuen, B | 1 |
| Cannon, W | 1 |
| Lewis, J | 1 |
| Sy, L | 1 |
| Woolley, S | 1 |
| Ranta, T | 1 |
| Lehtovirta, P | 1 |
| Stenman, UH | 1 |
| Laatikainen, T | 1 |
| Seppälä, M | 1 |
| Heindel, JJ | 3 |
| Clement-Cormier, YC | 2 |
| Ansari, AH | 1 |
| Pearson, OH | 1 |
| Husami, N | 1 |
| Idriss, W | 1 |
| Jewelewicz, R | 1 |
| Ferin, M | 1 |
| Vande Wiele, RL | 1 |
| Ayalon, D | 1 |
| Persitz, E | 1 |
| Ravid, R | 1 |
| Jedwab, G | 1 |
| Avidan, S | 1 |
| Cordova, T | 1 |
| Harell, A | 1 |
| Gala, RR | 1 |
| Van de Walle, C | 1 |
| Hoffman, WH | 1 |
| Boyd, AE | 2 |
| Reichlin, S | 1 |
| Turksoy, RN | 1 |
| Lombardi, G | 1 |
| Panza, N | 1 |
| Cei, S | 1 |
| Cosimato, F | 1 |
| Minozzi, M | 1 |
| Silverman, VE | 1 |
| McCrary, JA | 1 |
| Kohler, PO | 1 |
| Williams, E | 1 |
| Robison, GA | 2 |
| Strada, SJ | 1 |
| Schaison, G | 1 |
| Nathan, C | 1 |
| L'Hermite, M | 1 |
| Schwinn, G | 1 |
| von zur Mühlen, A | 1 |
| Köbberling, J | 1 |
| Halves, E | 1 |
| Wenzel, KW | 1 |
| Meinhold, H | 1 |
| Schermann, J | 1 |
| Archer, DF | 1 |
| Josimovich, JB | 1 |
| Maroon, JC | 1 |
| Malarkey, WB | 1 |
| Johnson, JC | 1 |
| Suchmanová, I | 1 |
| Trejbal, D | 1 |
| Trejbalová, L | 1 |
| Mechír, J | 1 |
| Pokorná, I | 1 |
| Machánová, Y | 1 |
| Wolfe, SE | 2 |
| Brostrom, MA | 2 |
| Sletholt, K | 1 |
| Haug, E | 1 |
| Gordeladze, J | 1 |
| Sand, O | 1 |
| Gautvik, KM | 1 |
| Schlechte, JA | 1 |
| Sherman, BM | 1 |
| Chapler, FK | 1 |
| VanGilder, J | 1 |
| Muechler, EK | 1 |
| Huang, KE | 1 |
| McDonald, JV | 1 |
| Tang, L | 1 |
| Brostrom, CO | 1 |
| Frantz, AG | 1 |
| Suh, HK | 1 |
| Woolf, PD | 1 |
| Schenk, EA | 1 |
| Lehmann, LS | 1 |
| Kwa, HG | 1 |
| van der Gugten, AA | 1 |
| Sala, M | 1 |
| Verhofstad, F | 1 |
| Vander Laan, WP | 1 |
| Martín Zurro, A | 1 |
| Sánchez Franco, F | 1 |
| Cerdán Vallejo, A | 1 |
| Lazorthes, Y | 1 |
| Bayard, F | 1 |
| Zadeh, J | 1 |
| Louvet, JP | 1 |
| Théret, C | 1 |
| Lalégerie, P | 1 |
| Tamboise, E | 1 |
| Turkington, RW | 1 |
2 reviews available for chlorpromazine and Pituitary Neoplasms
| Article | Year |
|---|---|
L-DOPA and the control of prolactin secretion.
Topics: Adenoma, Chromophobe; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Brain Diseases; Breast | 1974 |
Changing concepts of prolactin in man.
Topics: Chlorpromazine; Female; Growth Hormone; Humans; Hypothalamus; Lactation; Lactation Disorders; Pituit | 1973 |
33 other studies available for chlorpromazine and Pituitary Neoplasms
| Article | Year |
|---|---|
Persistent defect in regulation of prolactin secretion after successful pituitary tumor removal in women with the galactorrhea-amenorrhea syndrome.
Topics: Amenorrhea; Chlorpromazine; Female; Galactorrhea; Humans; Insulin; Lactation Disorders; Metocloprami | 1980 |
Galactorrhea-amenorrhea syndrome: follow-up of forty-five patients after pituitary tumor removal.
Topics: Adenoma; Adult; Amenorrhea; Chlorpromazine; Female; Follow-Up Studies; Galactorrhea; Humans; Lactati | 1981 |
Prolactin-secreting pituitary adenoma: occurrence following prenatal exposure to diethylstilbestrol.
Topics: Adenoma; Adolescent; Bromocriptine; Chlorpromazine; Diethylstilbestrol; Female; Humans; Levodopa; Pi | 1982 |
A possible role for prolactin in the control of human chorionic gonadotropin and estrogen secretion by the fetoplacental unit.
Topics: Adult; Anovulation; Bromocriptine; Chlorpromazine; Chorionic Gonadotropin; Estrogens; Female; Fetus; | 1980 |
Acute changes in serum prolactin concentration have no effect on the secretion of progesterone, estradiol, or chorionic gonadotropin during early pregnancy.
Topics: Bromocriptine; Chlorpromazine; Chorionic Gonadotropin; Estradiol; Female; Humans; Pituitary Neoplasm | 1980 |
Regulation of adenylate cyclase activity in GH1 cells by chlorpromazine and a heat-stable factor.
Topics: Adenylyl Cyclases; Animals; Calcium; Cell Line; Chelating Agents; Chlorpromazine; Enzyme Activation; | 1981 |
Recent advances in diagnosis and management of galactorrhea.
Topics: Adult; Chlorpromazine; Clomiphene; Female; Galactorrhea; Humans; Lactation Disorders; Levodopa; Pitu | 1978 |
Lack of acute effects of pyridoxine on prolactin secretion and lactation.
Topics: Adenoma; Animals; Chlorpromazine; Female; Haplorhini; Humans; Lactation; Macaca mulatta; Pituitary N | 1978 |
The diagnostic value of pharmacodynamic tests in the hyperprolactinaemic syndrome.
Topics: Adult; Bromocriptine; Chlorpromazine; Female; Follicular Phase; Galactorrhea; Humans; Levodopa; Pitu | 1979 |
Alterations in serum prolactin heterogeneity by provocative tests in a patient with a pituitary tumour.
Topics: Adenoma, Acidophil; Child; Chlorpromazine; Glucose Tolerance Test; Growth Hormone; Humans; Insulin; | 1977 |
Galactorrhea-amenorrhea syndrome: diagnosis and therapy.
Topics: Adenoma; Adult; Amenorrhea; Chlorpromazine; Contraceptives, Oral, Synthetic; Estradiol; Female; Foll | 1977 |
Radioimmunoassay of thyrotrophin-releasing hormone (TRH) in normal subjects, in abnormal thyroid states and under catecholaminergic influences.
Topics: Adenoma; Adult; Bromocriptine; Child; Chlorpromazine; Female; Humans; Hyperthyroidism; Hypothyroidis | 1978 |
Pituitary apoplexy following chlorpromazine stimulation.
Topics: Adenoma, Chromophobe; Adult; Chlorpromazine; Humans; Hypotension; Male; Pituitary Diseases; Pituitar | 1978 |
Inhibition of GH1 rat pituitary tumor cell adenylyl cyclase activity by somatostatin.
Topics: Adenylyl Cyclase Inhibitors; Animals; Calcium; Cells, Cultured; Chlorpromazine; Epinephrine; Fibrobl | 1978 |
[ Study of prolactin and blood gonadotropins in amenorrheas-galactorrhea. Dynamic exploation in 13 cases].
Topics: Adenoma; Adult; Amenorrhea; Chlorpromazine; Dihydroxyphenylalanine; Female; Follicle Stimulating Hor | 1975 |
Plasma prolactin levels after TRH and chlorpromazine in normal subjects and patients with impaired pituitary function.
Topics: Adult; Aged; Chlorpromazine; Female; Humans; Hypopituitarism; Male; Middle Aged; Pituitary Diseases; | 1975 |
[Abnormal galactorrhea and the amenorrhea-galactorrhea syndrome].
Topics: Amenorrhea; Chiari-Frommel Syndrome; Chlorpromazine; Female; Galactorrhea; Humans; Hypothyroidism; I | 1976 |
Chlorpromazine-induced changes in serum prolactin in women with oligomenorrhea, amenorrhea, and pituitary adenoma.
Topics: Adenoma; Amenorrhea; Chlorpromazine; Female; Humans; Hypothalamus; Menstruation Disturbances; Oligom | 1977 |
Adenylyl cyclase from a prolactin producing tumor cell: the effect of phenothiazines.
Topics: Adenylyl Cyclases; Cell Line; Chlorpromazine; Enzyme Activation; Fluorides; Guanylyl Imidodiphosphat | 1977 |
Pituitary tumors and hyperprolactinemia.
Topics: Adolescent; Adult; Aged; Chlorpromazine; Female; Growth Hormone; Humans; Levodopa; Male; Pituitary N | 1976 |
[The prolactin and TSH response to stimulation in patients with hypophyseal tumors].
Topics: Adenoma, Chromophobe; Adult; Aged; Chlorpromazine; Female; Humans; Male; Middle Aged; Pituitary Func | 1990 |
Mechanisms of action of inhibitors of prolactin secretion in GH3 pituitary cells. II. Blockade of voltage-dependent Ca2+ channels.
Topics: Action Potentials; Amino Acids; Animals; Calcium; Cell Line; Chlorpromazine; Ion Channels; Membrane | 1986 |
Effects of calmodulin antagonists on hormone release and cyclic AMP levels in GH3 pituitary cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Cell Division; Cell Line; Chlorprom | 1987 |
Long term follow-up of women with surgically treated prolactin-secreting pituitary tumors.
Topics: Adenoma; Adolescent; Adult; Chlorpromazine; Female; Follow-Up Studies; Humans; Hyperprolactinemia; I | 1986 |
In vivo and in vitro modulation of growth hormone and prolactin of a mixed somatotropic-lactotropic pituitary microadenoma.
Topics: Adenoma, Chromophobe; Adult; Bromocriptine; Chlorpromazine; Depression, Chemical; Female; Growth Hor | 1987 |
Mechanisms of action of inhibitors of prolactin secretion in GH3 pituitary cells. I. Ca2+-dependent inhibition of amino acid incorporation.
Topics: Acetylcholine; Amino Acids; Animals; Bromocriptine; Calcium; Carbachol; Cell Line; Chlorpromazine; I | 1986 |
An FSH-producing pituitary tumor in a patient with hypogonadism.
Topics: Adenoma, Chromophobe; Adrenocorticotropic Hormone; Adult; Chlorpromazine; Dihydroxyphenylalanine; Es | 1974 |
Depersonalization.
Topics: Adrenal Insufficiency; Adult; Anger; Anxiety; Cannabis; Chlorpromazine; Compulsive Behavior; Defense | 1974 |
Effect of pituitary tumours and grafts on plasma prolactin levels.
Topics: Animals; Chlorpromazine; Estrone; Female; Male; Mice; Neoplasm Transplantation; Pituitary Gland; Pit | 1972 |
[Treatment of pituitary adenomas with chlorpromazine].
Topics: Adenoma; Administration, Oral; Chlorpromazine; Female; Growth Hormone; Humans; Hypothalamo-Hypophyse | 1973 |
[Use of chlorpromazine and trans-sphenoidal micro-surgery in the treatment of acromegaly (dynamic study of growth hormone secretion)].
Topics: Acromegaly; Adenoma; Adult; Aged; Chlorpromazine; Female; Growth Hormone; Humans; Male; Microsurgery | 1973 |
[Ultrastructure of adenohypophysial tumors of gonadotropic type resulting from the combined effects of radioiodine (I-131) and chlorpromazine].
Topics: Animals; Chlorpromazine; In Vitro Techniques; Iodine Isotopes; Mice; Pituitary Neoplasms; Thyroidect | 1965 |
Serum prolactin levels in patients with gynecomastia.
Topics: Adolescent; Adult; Amenorrhea; Animals; Caseins; Cell Line; Chlorpromazine; Choriocarcinoma; Gynecom | 1972 |