chlorpromazine has been researched along with Parkinson Disease, Secondary in 55 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Parkinson Disease, Secondary: Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorpromazine, a widely available and inexpensive antipsychotic drug, is considered the benchmark treatment for schizophrenia worldwide." | 8.95 | Chlorpromazine versus metiapine for schizophrenia. ( Bazrafshan, A; Zare, M, 2017) |
| "A Parkinsonian-like tremor can be induced by a combined application of chlorpromazine and pentobarbitone in cats." | 7.68 | Parkinsonian-like tremor induced by a combined application of chlorpromazine and pentobarbitone in cats with left-paw preference. ( Cankaya, A; Gepdiremen, A; Kutlu, N; Tan, U, 1992) |
| "Chlorpromazine, a widely available and inexpensive antipsychotic drug, is considered the benchmark treatment for schizophrenia worldwide." | 4.95 | Chlorpromazine versus metiapine for schizophrenia. ( Bazrafshan, A; Zare, M, 2017) |
| "A Parkinsonian-like tremor can be induced by a combined application of chlorpromazine and pentobarbitone in cats." | 3.68 | Parkinsonian-like tremor induced by a combined application of chlorpromazine and pentobarbitone in cats with left-paw preference. ( Cankaya, A; Gepdiremen, A; Kutlu, N; Tan, U, 1992) |
| "Pimozide was found to exert somewhat less of an overall therapeutic effect than chlorpromazine, particularly in highly agitated patients." | 2.65 | Pimozide in the treatment of newly admitted schizophrenic patients. ( Annable, L; Chouinard, G, 1982) |
| "Postural hypotension was observed in both patient groups." | 2.65 | Single daily dose chlorpromazine therapy in psychosis. An evaluation. ( Kalyanasundaram, S; Kapur, RL; Machado, TA; Shrikhande, SA, 1981) |
| " Improvement was recorded in a double blind study of 18 patients treated with maximum tolerated dosage (mean 18." | 2.64 | Tardive dyskinesia treated with pimozide. ( Calne, DB; Claveria, LE; Haskayne, L; Lodge-Patch, IC; Pallis, CA; Petrie, A; Teychenne, PF, 1975) |
| "Risperidone (4 mg/day) was added to her drug regimen and after increasing the dosage to 6 mg/day, she began to exhibit retrocollis." | 1.31 | Tardive dystonia provoked by concomitantly administered risperidone. ( Hori, M; Hori, T; Kawanishi, Y; Shiraishi, H; Suzuki, T; Tachikawa, H, 2000) |
| "Levodopa-induced dyskinesias (LID) in Parkinson's disease (PD) may be classified into three main categories: "On" dyskinesias, diphasic dyskinesias (DD), and "off" periods." | 1.28 | Levodopa-induced dyskinesias in Parkinson's disease: clinical and pharmacological classification. ( Gershanik, O; Luquin, MR; Obeso, JA; Scipioni, O; Vaamonde, J, 1992) |
| "A historical review of the adverse reactions to neuroleptic agents--extrapyramidal side effects--is presented." | 1.27 | Extrapyramidal side effects: a historical perspective. ( Rifkin, A, 1987) |
| "Tetrabenazine alone, was restarted after 48 hours to control her Huntington's Chorea and there was no recurrence of parkinsonism." | 1.27 | Iatrogenic parkinsonism in Huntington's chorea. ( Moss, JH; Stewart, DE, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (80.00) | 18.7374 |
| 1990's | 5 (9.09) | 18.2507 |
| 2000's | 4 (7.27) | 29.6817 |
| 2010's | 1 (1.82) | 24.3611 |
| 2020's | 1 (1.82) | 2.80 |
| Authors | Studies |
|---|---|
| Olofinnade, AT | 1 |
| Onaolapo, TM | 1 |
| Oladimeji, S | 1 |
| Fatoki, AM | 1 |
| Balogun, CI | 1 |
| Onaolapo, AY | 1 |
| Onaolapo, OJ | 1 |
| Zare, M | 1 |
| Bazrafshan, A | 1 |
| Dean, CE | 1 |
| Kuskowski, MA | 1 |
| Caligiuri, MP | 1 |
| Costentin, J | 1 |
| Weiden, PJ | 1 |
| Sheppard, C | 1 |
| Merlis, S | 1 |
| Rubin, RT | 1 |
| Hays, SE | 1 |
| Ringwald, E | 1 |
| Lustig, A | 1 |
| Moscovici, M | 1 |
| Spiegel, R | 1 |
| Vamos, E | 1 |
| Bowers, MB | 3 |
| Heninger, GR | 1 |
| Rajput, AH | 1 |
| Rozdilsky, B | 1 |
| Hornykiewicz, O | 1 |
| Shannak, K | 1 |
| Lee, T | 1 |
| Seeman, P | 1 |
| Luchins, DJ | 1 |
| Jackman, H | 1 |
| Meltzer, HY | 1 |
| Hershey, LA | 1 |
| Gift, T | 1 |
| Atkins, RW | 1 |
| Rivera-Calimlim, L | 1 |
| Chouinard, G | 1 |
| Annable, L | 1 |
| Atadzhanov, M | 1 |
| Kalyanasundaram, S | 1 |
| Shrikhande, SA | 1 |
| Machado, TA | 1 |
| Kapur, RL | 1 |
| Tachikawa, H | 1 |
| Suzuki, T | 1 |
| Kawanishi, Y | 1 |
| Hori, M | 1 |
| Hori, T | 1 |
| Shiraishi, H | 1 |
| Vatsek, Ia | 1 |
| Kolakowska, T | 1 |
| Wiles, DH | 1 |
| Gelder, MG | 1 |
| McNeilly, AS | 1 |
| Claveria, LE | 1 |
| Teychenne, PF | 1 |
| Calne, DB | 1 |
| Haskayne, L | 1 |
| Petrie, A | 1 |
| Pallis, CA | 1 |
| Lodge-Patch, IC | 1 |
| Martin, IC | 1 |
| Tan, U | 1 |
| Gepdiremen, A | 1 |
| Kutlu, N | 1 |
| Cankaya, A | 1 |
| Sandyk, R | 1 |
| Kay, SR | 1 |
| Luquin, MR | 1 |
| Scipioni, O | 1 |
| Vaamonde, J | 1 |
| Gershanik, O | 1 |
| Obeso, JA | 1 |
| Keepers, GA | 1 |
| Casey, DE | 1 |
| Luo, S | 1 |
| Rao, JM | 1 |
| Cowie, VA | 1 |
| Mathew, B | 1 |
| Goswami, U | 1 |
| Dutta, S | 1 |
| Kuruvilla, K | 1 |
| Papp, E | 1 |
| Perenyi, A | 1 |
| Rifkin, A | 1 |
| Moss, JH | 1 |
| Stewart, DE | 1 |
| Kamianov, IM | 1 |
| Kupisk, AG | 1 |
| Katsen, IZ | 1 |
| Forrest, FM | 1 |
| Van Woert, MH | 2 |
| Sethy, VH | 1 |
| Ambani, LM | 2 |
| Steg, G | 1 |
| Carlsson, A | 1 |
| Bruck, H | 1 |
| Gerstenbrand, F | 1 |
| Gnad, H | 1 |
| Gründig, E | 1 |
| Prosenz, P | 1 |
| Klawans, HL | 1 |
| Bordeleau, JM | 1 |
| Tétreault, L | 1 |
| Kelly, JT | 1 |
| Zimmermann, RL | 1 |
| Abuzzahab, FS | 1 |
| Schiele, BC | 1 |
| Schulterbrandt, JG | 1 |
| Raskin, A | 1 |
| Reatig, N | 1 |
| Messiha, FS | 1 |
| Turek, I | 1 |
| De Maio, D | 1 |
| Morrison, AB | 1 |
| Webster, RA | 1 |
| Crane, GE | 1 |
| Maickel, RP | 1 |
| Braunstein, MC | 1 |
| McGlynn, M | 1 |
| Snodgrass, WR | 1 |
| Webb, RW | 1 |
| Kingstone, E | 1 |
| Kolivakis, T | 1 |
| Kossatz, I | 1 |
| O'Keeffe, R | 1 |
| Sharman, DF | 1 |
| Vogt, M | 1 |
| Demars, JP | 1 |
| Bruno, A | 1 |
| Bruno, SC | 1 |
| Zolotnitskii, RI | 1 |
| Kutsenok, BM | 1 |
| Gastev, MD | 1 |
| Ridges, AP | 1 |
| Harper, P | 1 |
| Dogliani, P | 1 |
| Senini, G | 1 |
| Bertuzzi, F | 1 |
| Oehme, P | 1 |
| Schwarz, K | 1 |
| Ekdawi, MY | 1 |
| Fowke, R | 1 |
7 reviews available for chlorpromazine and Parkinson Disease, Secondary
| Article | Year |
|---|---|
Chlorpromazine versus metiapine for schizophrenia.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Dibenzothiazepines; Humans; Parkinson Disease, Secondar | 2017 |
The prolactin secretory response to neuroleptic drugs: mechanisms, applications and limitations.
Topics: Animals; Antipsychotic Agents; Blood-Brain Barrier; Cerebral Cortex; Chlorpromazine; Dopamine; Drug | 1980 |
[Modeling parkinsonism (review)].
Topics: Aluminum; Animals; Carbachol; Cats; Caudate Nucleus; Chlorides; Chlorpromazine; Disease Models, Anim | 1982 |
[Extrapyramidal movement disorders arising during treatment of psychoses with drugs].
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Chlorpromazine; Humans; Hyperkinesis; Movement Disorde | 1976 |
Pathological aspects on Parkinson's syndrome.
Topics: Animals; Basal Ganglia; Basal Ganglia Diseases; Central Nervous System; Chlorpromazine; Corpus Stria | 1972 |
Biochemical and pharmacological aspects of Parkinsonism.
Topics: Animals; Blood-Brain Barrier; Brain; Central Nervous System; Chemoreceptor Cells; Chlorpromazine; Co | 1972 |
The pharmacology of parkinsonism (a review).
Topics: Acetylcholine; Animals; Atropa belladonna; Atropine; Central Nervous System; Chlorpromazine; Dextroa | 1968 |
10 trials available for chlorpromazine and Parkinson Disease, Secondary
| Article | Year |
|---|---|
Pimozide in the treatment of newly admitted schizophrenic patients.
Topics: Acute Disease; Adult; Chlorpromazine; Double-Blind Method; Dyskinesia, Drug-Induced; Female; Humans; | 1982 |
Single daily dose chlorpromazine therapy in psychosis. An evaluation.
Topics: Adolescent; Adult; Chlorpromazine; Clinical Trials as Topic; Consciousness Disorders; Double-Blind M | 1981 |
Clinical significance of plasma chlorpromazine levels. II. Plasma levels of the drug, some of its metabolites and prolactin in patients receiving long-term phenothiazine treatment.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Drug Tolerance; Female; Humans; Male; Middle Aged; Park | 1976 |
Tardive dyskinesia treated with pimozide.
Topics: Aged; Antipsychotic Agents; Bipolar Disorder; Chlorpromazine; Clinical Trials as Topic; Consciousnes | 1975 |
Implications of phenothiazine side effects: a study of antiparkinsonian agents in an older population.
Topics: Adult; Aged; Antipsychotic Agents; Chlorpromazine; Clinical Trials as Topic; Delayed-Action Preparat | 1975 |
A double-blind study of amantadine hydrochloride versus benztropine mesylate in drug-induced parkinsonism.
Topics: Administration, Oral; Amantadine; Antiparkinson Agents; Benztropine; Capsules; Chlorpromazine; Clini | 1974 |
True and apparent side effects in a controlled trial of chlorpromazine and imipramine in depression.
Topics: Adult; Agranulocytosis; Chlorpromazine; Clinical Trials as Topic; Depression; Dermatitis; Edema; Eva | 1974 |
Double blind study of clopenthixol and chlorpromazine in acute hospitalized schizophrenics.
Topics: Acute Disease; Adolescent; Adult; Aged; Aspartate Aminotransferases; Blood Pressure; Body Weight; Ch | 1970 |
Neuromuscular effects of long-term phenothiazine medication, electroconvulsive therapy and leucotomy.
Topics: Aged; Chlorpromazine; Clinical Trials as Topic; Electric Stimulation Therapy; Female; Haloperidol; H | 1966 |
Effects of L-DOPA on pharmacological parkinsonism.
Topics: Adolescent; Adult; Chlorpromazine; Clinical Trials as Topic; Dihydroxyphenylalanine; Female; Haloper | 1966 |
38 other studies available for chlorpromazine and Parkinson Disease, Secondary
| Article | Year |
|---|---|
An Evaluation of the Effects of Pyridoxal Phosphate in Chlorpromazineinduced Parkinsonism using Mice.
Topics: Animals; Antioxidants; Antiparkinson Agents; Antipsychotic Agents; Behavior, Animal; Body Weight; Ca | 2020 |
Predictors of neuroleptic-induced dyskinesia and parkinsonism: the influence of measurement methods and definitions.
Topics: Adult; Age Distribution; Age Factors; Aged; Aging; Antipsychotic Agents; Chlorpromazine; Craniocereb | 2006 |
[Seeing a new classification of active medications in psychoses].
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Chlorpromazine; Dopamine D2 Receptor Antagonists; Huma | 2007 |
Antipsychotic-induced movement disorders - forgotten but not gone.
Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Brain; Chlorpromazine; Clozapine; Dopamine; Dyskinesi | 2008 |
Drug-induced extrapyramidal symptoms: their incidence and treatment.
Topics: Chlorpromazine; Chlorprothixene; Extrapyramidal Tracts; Female; Fluphenazine; Humans; Male; Parasymp | 1967 |
[Effect of high single doses of bromocriptine in schizophrenic patients with elevated serum prolactin levels and extrapyramidal side effects associated with neuroleptic treatment (author's transl)].
Topics: Adult; Antipsychotic Agents; Bromocriptine; Chlorpromazine; Chronic Disease; Dose-Response Relations | 1980 |
Cerebrospinal fluid homovanillic acid patterns during neuroleptic treatment.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Female; Haloperidol; Homovanillic Acid; Humans; Male; P | 1981 |
Reversible drug-induced parkinsonism. Clinicopathologic study of two cases.
Topics: Aged; Antipsychotic Agents; Chlorpromazine; Haloperidol; Humans; Male; Middle Aged; Parkinson Diseas | 1982 |
Lateral ventricular size and drug-induced Parkinsonism.
Topics: Adolescent; Adult; Antiparkinson Agents; Cerebral Ventricles; Chlorpromazine; Female; Humans; Male; | 1983 |
Effect of a drug holiday on plasma chlorpromazine levels in chronic schizophrenic patients.
Topics: Adult; Chlorpromazine; Chronic Disease; Humans; Male; Middle Aged; Parkinson Disease, Secondary; Phe | 1981 |
Tardive dystonia provoked by concomitantly administered risperidone.
Topics: Adolescent; Antipsychotic Agents; Chlorpromazine; Drug Therapy, Combination; Dyskinesia, Drug-Induce | 2000 |
Parkinsonian-like tremor induced by a combined application of chlorpromazine and pentobarbitone in cats with left-paw preference.
Topics: Animals; Atropine; Baclofen; Biperiden; Cats; Chlorpromazine; Feedback; Female; Functional Lateralit | 1992 |
"Positive" and "negative" movement disorders in schizophrenia.
Topics: Adult; Chlorpromazine; Dyskinesia, Drug-Induced; Female; Humans; Male; Parkinson Disease, Secondary; | 1992 |
Levodopa-induced dyskinesias in Parkinson's disease: clinical and pharmacological classification.
Topics: Aged; Apomorphine; Chlorpromazine; Dopamine Agents; Dose-Response Relationship, Drug; Dyskinesia, Dr | 1992 |
Use of neuroleptic-induced extrapyramidal symptoms to predict future vulnerability to side effects.
Topics: Adult; Age Factors; Antipsychotic Agents; Basal Ganglia Diseases; Benztropine; Chlorpromazine; Disea | 1991 |
[A control study of some hair trace elements content of schizophrenics before and after treatment].
Topics: Adolescent; Adult; Chlorpromazine; Female; Hair; Humans; Male; Middle Aged; Parkinson Disease, Secon | 1991 |
Neuroleptic-induced parkinsonian side effects in the mentally handicapped.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Dyskinesia, Drug-Induced; Female; Humans; Intellectual | 1989 |
Electroconvulsive therapy in neuroleptic-induced parkinsonism.
Topics: Adolescent; Adult; Antipsychotic Agents; Chlorpromazine; Dose-Response Relationship, Drug; Electroco | 1989 |
Cerebrospinal fluid homovanillic acid and hypokinetic side effects of neuroleptics.
Topics: Acetylcholine; Adolescent; Adult; Antipsychotic Agents; Catatonia; Chlorpromazine; Dopamine; Female; | 1985 |
Extrapyramidal side effects: a historical perspective.
Topics: Adult; Antipsychotic Agents; Attitude to Health; Basal Ganglia Diseases; Chlorpromazine; Depressive | 1987 |
Iatrogenic parkinsonism in Huntington's chorea.
Topics: Chlorpromazine; Drug Interactions; Female; Humans; Huntington Disease; Middle Aged; Parkinson Diseas | 1986 |
[Experience with the use of midantan for treatment and prevention of the neuroleptic syndrome].
Topics: Adult; Amantadine; Antiparkinson Agents; Antipsychotic Agents; Catatonia; Chlorpromazine; Facial Mus | 1973 |
Evolutionary origin of extrapyramidal disorders in drug-treated mental patients, its significance, and the role of neuromelanin.
Topics: Amphibians; Animals; Antipsychotic Agents; Basal Ganglia Diseases; Biological Evolution; Chlorpromaz | 1974 |
Effect of phenothiazines on central cholinergic activity.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Basal Ganglia Diseases; Brain; Brain Chemistry; Chlorp | 1974 |
[Comparative biochemical studies in organic parkinsonian syndromes and drug induced parkinsonian syndromes].
Topics: Alanine Transaminase; Aspartate Aminotransferases; Biochemical Phenomena; Biochemistry; Chlorpromazi | 1966 |
[Study of extrapyramidal manifestations induced by neuroleptics].
Topics: Antiparkinson Agents; Chlorpromazine; Drug Synergism; Extrapyramidal Tracts; Fluphenazine; Haloperid | 1972 |
Decreased dopamine and homovanillic acid excretion in a case with chlorpromazine-induced Parkinsonism.
Topics: Chlorpromazine; Dopamine; Homovanillic Acid; Humans; Male; Parkinson Disease; Parkinson Disease, Sec | 1973 |
Letter: Withdrawal syndrome after neuroleptics.
Topics: Adult; Chlorpromazine; Haloperidol; Humans; Male; Parkinson Disease, Secondary; Substance Withdrawal | 1973 |
Drug-induced experimental Parkinsonism.
Topics: Animals; Atropine; Benztropine; Butyrophenones; Cats; Chlorpromazine; Dose-Response Relationship, Dr | 1973 |
Physostigmine effects on phenothiazine-induced extrapyramidal reactions.
Topics: Adult; Antiparkinson Agents; Chlorpromazine; Drug Hypersensitivity; Extrapyramidal Tracts; Female; H | 1973 |
Factors predisposing to drug-induced neurologic effects.
Topics: Age Factors; Antiparkinson Agents; Central Nervous System Diseases; Chlorpromazine; Chronic Disease; | 1974 |
Behavioral, biochemical, and pharmacological effects of chronic dosage of phenothiazine tranquilizers in rats.
Topics: Animals; Avoidance Learning; Behavior, Animal; Body Weight; Brain Chemistry; Chlorpromazine; Dose-Re | 1974 |
Effect of drugs used in psychoses on cerebral dopamine metabolism.
Topics: Animals; Atropine; Brain; Butyrophenones; Cats; Chlorpromazine; Dogs; Dopamine; Female; Haloperidol; | 1970 |
[On the results of treatment and complications during the use of haloperidol in patients with long-term schizophrenia].
Topics: Adult; Blood Pressure; Cardiovascular Diseases; Catatonia; Chlorpromazine; Cognition Disorders; Hall | 1969 |
Pink spot--is it a drug artefact?
Topics: Amitriptyline; Amobarbital; Chlorpromazine; Chromatography; Haloperidol; Humans; Mental Disorders; P | 1970 |
Clinical observations on the therapeutic activity of flupentixol in the treatment of chronic schizophrenia.
Topics: Adult; Aged; Blood; Body Weight; Chlorpromazine; Chronic Disease; Delusions; Depression, Chemical; F | 1970 |
[Etiology and therapy of Parkinson's syndrome and related pharmacological concepts shown in experimental models].
Topics: Animals; Brain Chemistry; Chlorpromazine; Dihydroxyphenylalanine; Dopamine; Humans; Hypothermia; Mic | 1966 |
A controlled trial of anti-Parkinson drugs in drug-induced Parkinsonism.
Topics: Adolescent; Adult; Chlorpromazine; Haloperidol; Humans; Middle Aged; Orphenadrine; Parasympatholytic | 1966 |