chlorpromazine has been researched along with Niemann-Pick Diseases in 7 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Niemann-Pick Diseases: A group of autosomal recessive disorders in which harmful quantities of lipids accumulate in the viscera and the central nervous system. They can be caused by deficiencies of enzyme activities (SPHINGOMYELIN PHOSPHODIESTERASE) or defects in intracellular transport, resulting in the accumulation of SPHINGOMYELINS and CHOLESTEROL. There are various subtypes based on their clinical and genetic differences.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lange, Y | 1 |
| Ye, J | 1 |
| Steck, TL | 1 |
| Fox, JT | 1 |
| Kane, FJ | 1 |
| Maor, I | 1 |
| Mandel, H | 1 |
| Aviram, M | 1 |
| Mikami, T | 1 |
| Takahashi, T | 1 |
| Ishida, A | 1 |
| Minamiya, Y | 1 |
| Ida, H | 1 |
| Takada, G | 1 |
| Masson, M | 1 |
| Spezzatti, B | 1 |
| Chapman, J | 1 |
| Battisti, C | 1 |
| Baumann, N | 2 |
| Clerici, C | 1 |
| Lacronique, J | 1 |
| Kemeny, J | 1 |
| Albouz, S | 1 |
| Le Saux, F | 1 |
| Wenger, D | 1 |
| Hauw, JJ | 1 |
7 other studies available for chlorpromazine and Niemann-Pick Diseases
| Article | Year |
|---|---|
Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells.
Topics: Androstenes; Biological Transport; Cells, Cultured; Chlorpromazine; Cholesterol; Cholesterol Oxidase | 2012 |
Niemann-Pick's disease manifesting as schizophrenia.
Topics: Adolescent; Chlorpromazine; Diagnosis, Differential; Humans; Male; Niemann-Pick Diseases; Schizophre | 1967 |
Macrophage uptake of oxidized LDL inhibits lysosomal sphingomyelinase, thus causing the accumulation of unesterified cholesterol-sphingomyelin-rich particles in the lysosomes. A possible role for 7-Ketocholesterol.
Topics: Animals; Cell Line; Cell Membrane; Chlorpromazine; Cholesterol; Cholesterol Esters; Humans; Ketochol | 1995 |
Signaling pathway for radiation-induced apoptosis in the lymphoblasts from neuronopathic (type A) and non-neuronopathic (type B) forms of Niemann-Pick disease.
Topics: Amino Acid Substitution; Animals; Apoptosis; Cell Line, Transformed; Child, Preschool; Chlorpromazin | 2002 |
Calmodulin antagonists chlorpromazine and W-7 inhibit exogenous cholesterol esterification and sphingomyelinase activity in human skin fibroblast cultures. Similarities between drug-induced and Niemann-Pick type C lipidoses.
Topics: Calmodulin; Chlorpromazine; Cholesterol; Cholesterol Esters; Depression, Chemical; Fibroblasts; Huma | 1992 |
[Bioclinical conference in pneumology. Hôpital Laënnec. Case n. 4--February 1985. Interstitial pneumopathy associated with pulmonary infiltration by foamy macrophages].
Topics: Adult; Chlorpromazine; Humans; Lung; Macrophages; Male; Niemann-Pick Diseases; Pulmonary Alveoli; Pu | 1986 |
Modifications of sphingomyelin and phosphatidylcholine metabolism by tricyclic antidepressants and phenothiazines.
Topics: Animals; Antidepressive Agents, Tricyclic; Cell Line; Chlorpromazine; Desipramine; Dose-Response Rel | 1986 |