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chlorpromazine and Niemann-Pick Disease

chlorpromazine has been researched along with Niemann-Pick Disease in 7 studies

Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19903 (42.86)18.7374
1990's2 (28.57)18.2507
2000's1 (14.29)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lange, Y1
Ye, J1
Steck, TL1
Fox, JT1
Kane, FJ1
Maor, I1
Mandel, H1
Aviram, M1
Mikami, T1
Takahashi, T1
Ishida, A1
Minamiya, Y1
Ida, H1
Takada, G1
Masson, M1
Spezzatti, B1
Chapman, J1
Battisti, C1
Baumann, N2
Clerici, C1
Lacronique, J1
Kemeny, J1
Albouz, S1
Le Saux, F1
Wenger, D1
Hauw, JJ1

Other Studies

7 other studies available for chlorpromazine and Niemann-Pick Disease

ArticleYear
Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells.
    PloS one, 2012, Volume: 7, Issue:1

    Topics: Androstenes; Biological Transport; Cells, Cultured; Chlorpromazine; Cholesterol; Cholesterol Oxidase

2012
Niemann-Pick's disease manifesting as schizophrenia.
    Diseases of the nervous system, 1967, Volume: 28, Issue:3

    Topics: Adolescent; Chlorpromazine; Diagnosis, Differential; Humans; Male; Niemann-Pick Diseases; Schizophre

1967
Macrophage uptake of oxidized LDL inhibits lysosomal sphingomyelinase, thus causing the accumulation of unesterified cholesterol-sphingomyelin-rich particles in the lysosomes. A possible role for 7-Ketocholesterol.
    Arteriosclerosis, thrombosis, and vascular biology, 1995, Volume: 15, Issue:9

    Topics: Animals; Cell Line; Cell Membrane; Chlorpromazine; Cholesterol; Cholesterol Esters; Humans; Ketochol

1995
Signaling pathway for radiation-induced apoptosis in the lymphoblasts from neuronopathic (type A) and non-neuronopathic (type B) forms of Niemann-Pick disease.
    Journal of the neurological sciences, 2002, Jul-15, Volume: 199, Issue:1-2

    Topics: Amino Acid Substitution; Animals; Apoptosis; Cell Line, Transformed; Child, Preschool; Chlorpromazin

2002
Calmodulin antagonists chlorpromazine and W-7 inhibit exogenous cholesterol esterification and sphingomyelinase activity in human skin fibroblast cultures. Similarities between drug-induced and Niemann-Pick type C lipidoses.
    Journal of neuroscience research, 1992, Volume: 31, Issue:1

    Topics: Calmodulin; Chlorpromazine; Cholesterol; Cholesterol Esters; Depression, Chemical; Fibroblasts; Huma

1992
[Bioclinical conference in pneumology. Hôpital Laënnec. Case n. 4--February 1985. Interstitial pneumopathy associated with pulmonary infiltration by foamy macrophages].
    Revue de pneumologie clinique, 1986, Volume: 42, Issue:6

    Topics: Adult; Chlorpromazine; Humans; Lung; Macrophages; Male; Niemann-Pick Diseases; Pulmonary Alveoli; Pu

1986
Modifications of sphingomyelin and phosphatidylcholine metabolism by tricyclic antidepressants and phenothiazines.
    Life sciences, 1986, Jan-27, Volume: 38, Issue:4

    Topics: Animals; Antidepressive Agents, Tricyclic; Cell Line; Chlorpromazine; Desipramine; Dose-Response Rel

1986