chlorpromazine has been researched along with Niemann-Pick Disease, Type C in 2 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Niemann-Pick Disease, Type C: An autosomal recessive lipid storage disorder that is characterized by accumulation of CHOLESTEROL and SPHINGOMYELINS in cells of the VISCERA and the CENTRAL NERVOUS SYSTEM. Type C (or C1) and type D are allelic disorders caused by mutation of the NPC1 gene, which encodes a protein that mediates intracellular cholesterol transport from LYSOSOMES. Clinical signs include hepatosplenomegaly and chronic neurological symptoms. Type D is a variant in people with a Nova Scotia ancestry.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schwerd, T | 1 |
| Pandey, S | 1 |
| Yang, HT | 1 |
| Bagola, K | 1 |
| Jameson, E | 1 |
| Jung, J | 1 |
| Lachmann, RH | 1 |
| Shah, N | 1 |
| Patel, SY | 1 |
| Booth, C | 1 |
| Runz, H | 1 |
| Düker, G | 1 |
| Bettels, R | 1 |
| Rohrbach, M | 1 |
| Kugathasan, S | 1 |
| Chapel, H | 1 |
| Keshav, S | 1 |
| Elkadri, A | 1 |
| Platt, N | 1 |
| Muise, AM | 1 |
| Koletzko, S | 1 |
| Xavier, RJ | 1 |
| Marquardt, T | 1 |
| Powrie, F | 1 |
| Wraith, JE | 1 |
| Gyrd-Hansen, M | 1 |
| Platt, FM | 1 |
| Uhlig, HH | 1 |
| Wehrmann, ZT | 1 |
| Hulett, TW | 1 |
| Huegel, KL | 1 |
| Vaughan, KT | 1 |
| Wiest, O | 1 |
| Helquist, P | 1 |
| Goodson, H | 1 |
2 other studies available for chlorpromazine and Niemann-Pick Disease, Type C
| Article | Year |
|---|---|
Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adolescent; Adult; Anti-Bacterial Agents; Autophagy; Bacteria; Ce | 2017 |
Quantitative comparison of the efficacy of various compounds in lowering intracellular cholesterol levels in Niemann-Pick type C fibroblasts.
Topics: Azacitidine; beta-Cyclodextrins; Cells, Cultured; Child; Child, Preschool; Chloroquine; Chlorpromazi | 2012 |