chlorpromazine has been researched along with Neuroleptic Malignant Syndrome in 46 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A patient with myeloma nephropathy and acute, probably diclofenac-induced renal failure developed a neuroleptic malignant syndrome (NMS) during treatment with metoclopramide and neuroleptics." | 7.68 | [Malignant neuroleptic syndrome under metoclopramide and neuroleptics in anuria]. ( Herren, T; Krähenbühl, S; Raisin, J, 1993) |
| "We report a case of neuroleptic malignant syndrome (NMS)." | 5.28 | Lithium toxicity--a risk factor for neuroleptic malignant syndrome. ( Joseph, JK; Thomas, K, 1991) |
| "A case of the neuroleptic malignant syndrome occurred in a 40-year-old male after administration of chlorpromazine while on an Intensive Therapy Unit." | 4.78 | Neuroleptic malignant syndrome in the intensive therapy unit. ( Ironside, JW; Montgomery, JN, 1990) |
| "5-100 microM chlorpromazine hydrochloride (CPZ) on the major steps of the excitation-contraction (E-C) coupling to elucidate the involvement of skeletal muscle in the neuroleptic malignant syndrome (NMS)." | 3.72 | Effects of chlorpromazine on excitation-contraction coupling events in fast-twitch skeletal muscle fibres of the rat. ( Fink, RH; Stephenson, DG; Wagner, R, 2004) |
| " He developed neuroleptic malignant syndrome (NMS) which was treated successfully with intravenous diazepam." | 3.69 | Catatonic syndrome following recovery from neuroleptic malignant syndrome. ( Dent, J, 1995) |
| "A patient with myeloma nephropathy and acute, probably diclofenac-induced renal failure developed a neuroleptic malignant syndrome (NMS) during treatment with metoclopramide and neuroleptics." | 3.68 | [Malignant neuroleptic syndrome under metoclopramide and neuroleptics in anuria]. ( Herren, T; Krähenbühl, S; Raisin, J, 1993) |
| " The in vitro halothane-caffeine contracture tests are the most reliable method of identifying individuals susceptible to MH." | 3.67 | The association between the neuroleptic malignant syndrome and malignant hyperthermia. ( Adamantidis, MM; Adnet, PJ; Adnet-Bonte, CA; Dupuis, BA; Haudecoeur, G; Krivosic-Horber, RM; Saulnier, F, 1989) |
| "Chlorpromazine was stopped due to concern of NMS." | 1.46 | Neuroleptic malignant syndrome with thyroid disorder: An unusual case report. ( Goldman, J; Kanzali, P; Paras, C; Rubin, V; Zhang, F, 2017) |
| "On arrival, the Japan coma scale, pulse, respiratory rate, body temperature, and Sp(O2) were 300, 114 beats x min(-1), 26 breaths x min(-1), 39." | 1.38 | [Comatose patient with neuroleptic malignant syndrome brought by ambulance]. ( Kuroda, Y; Takinami, Y, 2012) |
| "We report a case of neuroleptic malignant syndrome where the catatonia clearly followed the administration of neuroleptics and where the neurovegetative disturbance was remarkably severe, including episodes of tracheal spasm, apnoea and episodes of bradycardia, and sinus arrest requiring insertion of a temporary external pacing wire." | 1.29 | Recurrent sinus arrest in association with neuroleptic malignant syndrome. ( Hamlin, GW; Ormerod, LP; Parry, AK; Saleem, PT, 1994) |
| "Separate episodes of both catatonia and the so-called 'neuroleptic malignant syndrome' (NMS) occurred within the same patient." | 1.28 | Catatonia and the neuroleptic malignant syndrome--a single entity? ( White, DA, 1992) |
| "She underwent hemodialysis for treatment of acute renal failure and recovered from it after 16 sessions of hemodialysis." | 1.28 | [A case of neuroleptic malignant syndrome with acute renal failure]. ( Hayashi, M; Koya, J; Shiono, A; Yajima, H; Yamanaka, H, 1992) |
| "We report a case of neuroleptic malignant syndrome (NMS)." | 1.28 | Lithium toxicity--a risk factor for neuroleptic malignant syndrome. ( Joseph, JK; Thomas, K, 1991) |
| "Development of neuroleptic malignant syndrome (NMS) following discontinuation of high-dose and high-potency neuroleptic agents is described." | 1.28 | Neuroleptic malignant syndrome during abrupt reduction of neuroleptic treatment. ( Hermesh, H; Munitz, H; Spivak, B; Tyano, S; Weizman, A; Wolovick, L, 1990) |
| "Five patients with neuroleptic malignant syndrome (NMS) are described." | 1.28 | Neuroleptic malignant syndrome. ( Krishnamurthy, SG; Murugappan, M; Sayeed, ZA; Srinivasan, AV, 1990) |
| "We present a patient with neuroleptic malignant syndrome and intestinal pseudo-obstruction misdiagnosed as being secondary to septicaemia." | 1.28 | Neuroleptic malignant syndrome: another medical cause of acute abdomen. ( Dymock, IW; Lo, TC; Unwin, MR, 1989) |
| "The neuroleptic malignant syndrome is a rare but dangerous complication of treatment with neuroleptics." | 1.28 | Neuroleptic malignant syndrome: a case report with post-mortem brain and muscle pathology. ( Dawson, A; Jones, EM, 1989) |
| "A case of neuroleptic malignant syndrome (NMS) treated successfully with electroconvulsive therapy (ETC) is described." | 1.27 | A successful electroconvulsive treatment of neuroleptic malignant syndrome. ( Aizenberg, D; Hermesh, H; Weizman, A, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (26.09) | 18.7374 |
| 1990's | 23 (50.00) | 18.2507 |
| 2000's | 8 (17.39) | 29.6817 |
| 2010's | 3 (6.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, F | 1 |
| Kanzali, P | 1 |
| Rubin, V | 1 |
| Paras, C | 1 |
| Goldman, J | 1 |
| Jouali, T | 1 |
| Boukatta, B | 1 |
| Bechri, B | 1 |
| Houari, N | 1 |
| Bouazzaoui, A | 1 |
| Sbai, H | 1 |
| Kanjaa, N | 1 |
| Shim, G | 1 |
| Kang, DH | 1 |
| Kwon, JS | 1 |
| Morris, E | 1 |
| Green, D | 1 |
| Graudins, A | 1 |
| Matsusue, A | 1 |
| Hara, K | 1 |
| Kageura, M | 1 |
| Kashiwagi, M | 1 |
| Lu, W | 1 |
| Ishigami, A | 1 |
| Gotohda, T | 1 |
| Tokunaga, I | 1 |
| Nisimura, A | 1 |
| Sugimura, T | 1 |
| Kubo, S | 1 |
| Gillman, K | 1 |
| Takinami, Y | 1 |
| Kuroda, Y | 1 |
| Wagner, R | 1 |
| Fink, RH | 1 |
| Stephenson, DG | 1 |
| Rais, AR | 1 |
| Kimmel, S | 1 |
| Shrestha, N | 1 |
| Rais, TB | 1 |
| Coffey, BJ | 1 |
| Singh, D | 1 |
| Forlano, R | 1 |
| Athey, R | 1 |
| Hollister, LE | 1 |
| Parry, AK | 1 |
| Ormerod, LP | 1 |
| Hamlin, GW | 1 |
| Saleem, PT | 1 |
| Krähenbühl, S | 1 |
| Raisin, J | 1 |
| Herren, T | 1 |
| Swartz, CM | 1 |
| Baker, RW | 1 |
| Chengappa, KN | 1 |
| Dent, J | 1 |
| Schneider, JM | 1 |
| Roger, DJ | 1 |
| Uhl, RL | 1 |
| Hanel, RA | 1 |
| Sandmann, MC | 1 |
| Kranich, M | 1 |
| De Bittencourt, PR | 1 |
| Leber, K | 1 |
| Malek, A | 1 |
| D'Agostino, A | 1 |
| Adelman, HM | 1 |
| Hatch, CD | 1 |
| Lund, BC | 1 |
| Perry, PJ | 1 |
| Fekadu, A | 1 |
| Wakwoya, A | 1 |
| White, DA | 2 |
| de Boer, C | 1 |
| Gaete, HP | 1 |
| Shiono, A | 1 |
| Hayashi, M | 1 |
| Yamanaka, H | 1 |
| Yajima, H | 1 |
| Koya, J | 1 |
| Elechi, CA | 1 |
| Ghodhbane, T | 1 |
| Robins, AH | 1 |
| Joseph, JK | 1 |
| Thomas, K | 1 |
| Spivak, B | 1 |
| Weizman, A | 2 |
| Wolovick, L | 1 |
| Hermesh, H | 2 |
| Tyano, S | 1 |
| Munitz, H | 1 |
| Srinivasan, AV | 1 |
| Murugappan, M | 1 |
| Krishnamurthy, SG | 1 |
| Sayeed, ZA | 1 |
| Burrell, MF | 1 |
| Fewster, C | 1 |
| Szabadi, E | 1 |
| Cashman, M | 1 |
| Usandizaga, I | 1 |
| Pérez de Mendiola, MM | 1 |
| Buades, J | 1 |
| Martínez, J | 1 |
| Montgomery, JN | 1 |
| Ironside, JW | 1 |
| Haisma, HJ | 1 |
| Constantinou, E | 1 |
| Chinyanga, HM | 1 |
| Thacker, AK | 1 |
| Radhakrishnan, K | 1 |
| Maloo, JC | 1 |
| Bohlaga, NH | 1 |
| Mahmood, T | 1 |
| Warren, JP | 1 |
| Adnet, PJ | 1 |
| Krivosic-Horber, RM | 1 |
| Adamantidis, MM | 1 |
| Haudecoeur, G | 1 |
| Adnet-Bonte, CA | 1 |
| Saulnier, F | 1 |
| Dupuis, BA | 1 |
| Green, BH | 1 |
| Lo, TC | 1 |
| Unwin, MR | 1 |
| Dymock, IW | 1 |
| Price, DK | 1 |
| Turnbull, GJ | 1 |
| Gregory, RP | 1 |
| Stevens, DG | 1 |
| Jones, EM | 1 |
| Dawson, A | 1 |
| Lavie, CJ | 1 |
| Ventura, HO | 1 |
| Walker, G | 1 |
| Gelenberg, AJ | 1 |
| Bellinghausen, B | 1 |
| Wojcik, JD | 1 |
| Falk, WE | 1 |
| Sachs, GS | 1 |
| Aizenberg, D | 1 |
| Schibuk, M | 1 |
| Schachter, D | 1 |
| Klein, SK | 1 |
| Levinsohn, MW | 1 |
| Blumer, JL | 1 |
2 reviews available for chlorpromazine and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Drug treatment of schizophrenia.
Topics: Antidepressive Agents, Tricyclic; Antiparkinson Agents; Antipsychotic Agents; Chemical Phenomena; Ch | 1984 |
Neuroleptic malignant syndrome in the intensive therapy unit.
Topics: Adult; Biopsy; Chlorpromazine; Critical Care; Humans; Male; Muscles; Neuroleptic Malignant Syndrome | 1990 |
44 other studies available for chlorpromazine and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Neuroleptic malignant syndrome with thyroid disorder: An unusual case report.
Topics: Aged; Antipsychotic Agents; Aripiprazole; Chlorpromazine; Creatine Kinase; Diagnosis, Differential; | 2017 |
[A neuroleptic malignant syndrome complicated by subarachnoid hemorrhage and revealing cerebral vasculitis].
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Female; Humans; Neuroleptic Malignant Syndrome; Schizop | 2014 |
Probable case of neuroleptic malignant syndrome following administration of antituberculotic drugs in a chlorpromazine-treated patient.
Topics: Adult; Antitubercular Agents; Chlorpromazine; Creatine Kinase; Drug Interactions; Enzyme Induction; | 2008 |
Neuroleptic malignant syndrome developing after acute overdose with olanzapine and chlorpromazine.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Bromocriptine; Chlorpromazine; Citalopram; Combined Mo | 2009 |
Genetic analysis of ryanodine receptor 1 gene and carnitine palmitoyltransferase II gene: an autopsy case of neuroleptic malignant syndrome related to vegetamin.
Topics: Adult; Amino Acid Substitution; Antipsychotic Agents; Brain; Brain Edema; Carnitine O-Palmitoyltrans | 2009 |
In response to Morris et al.'s "Neuroleptic malignant syndrome developing after acute overdose with olanzapine and chlorpromazine".
Topics: Antipsychotic Agents; Benzodiazepines; Bromocriptine; Chlorpromazine; Disease Progression; Dopamine | 2009 |
[Comatose patient with neuroleptic malignant syndrome brought by ambulance].
Topics: Adult; Ambulances; Basal Ganglia Diseases; Chlorpromazine; Coma; Dantrolene; Drug Overdose; Female; | 2012 |
Effects of chlorpromazine on excitation-contraction coupling events in fast-twitch skeletal muscle fibres of the rat.
Topics: Algorithms; Animals; Antipsychotic Agents; Calcium Channel Blockers; Chlorpromazine; Dose-Response R | 2004 |
Atypical neuroleptic malignant syndrome in an adolescent.
Topics: Administration, Oral; Adolescent; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Diagnosis, | 2008 |
Neuroleptic malignant syndrome and catatonia in a patient with dementia.
Topics: Aged; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Catatonia; Chlorpromazine; Choline | 2008 |
Recurrent sinus arrest in association with neuroleptic malignant syndrome.
Topics: Adult; Antipsychotic Agents; Cardiac Pacing, Artificial; Catatonia; Chlorpromazine; Clopenthixol; Dr | 1994 |
[Malignant neuroleptic syndrome under metoclopramide and neuroleptics in anuria].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Anuria; Chlorpromazine; Female; Humans; Kidney | 1993 |
Catatonia and not neuroleptic malignant syndrome.
Topics: Adult; Catatonia; Chlorpromazine; Diagnosis, Differential; Dose-Response Relationship, Drug; Female; | 1993 |
Further study of neuroleptic malignant syndrome.
Topics: Adult; Chlorpromazine; Fever; Humans; Male; Muscle Rigidity; Neuroleptic Malignant Syndrome; Psychia | 1995 |
Catatonic syndrome following recovery from neuroleptic malignant syndrome.
Topics: Anti-Anxiety Agents; Antipsychotic Agents; Catatonia; Chlorpromazine; Diazepam; Dose-Response Relati | 1995 |
Bilateral forearm compartment syndromes resulting from neuroleptic malignant syndrome.
Topics: Angioplasty, Balloon, Coronary; Antipsychotic Agents; Chlorpromazine; Compartment Syndromes; Coronar | 1996 |
[Neuroleptic malignant syndrome: case report with recurrence associated with the use of olanzapine].
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Haloperidol; Humans; Male; Neuroleptic | 1998 |
A veteran with acute mental changes years after combat.
Topics: Antipsychotic Agents; Chlorpromazine; Diagnosis, Differential; Humans; Lithium; Male; Middle Aged; M | 1999 |
Failed challenge with quetiapine after neuroleptic malignant syndrome with conventional antipsychotics.
Topics: Alzheimer Disease; Antipsychotic Agents; Chlorpromazine; Dibenzothiazepines; Haloperidol; Humans; Hy | 2001 |
Neuroleptic malignant syndrome: a case report.
Topics: Adolescent; Antipsychotic Agents; Chlorpromazine; Drug Therapy, Combination; Haloperidol; Humans; Ma | 1999 |
Catatonia and the neuroleptic malignant syndrome--a single entity?
Topics: Adult; Catatonia; Chlorpromazine; Diazepam; Female; Follow-Up Studies; Humans; Neuroleptic Malignant | 1992 |
Neuroleptic malignant syndrome and diabetic keto-acidosis.
Topics: Adult; Chlorpromazine; Clopenthixol; Diabetic Ketoacidosis; Drug Therapy, Combination; Humans; Male; | 1992 |
[A case of neuroleptic malignant syndrome with acute renal failure].
Topics: Acute Kidney Injury; Chlorpromazine; Drug Combinations; Female; Humans; Middle Aged; Neuroleptic Mal | 1992 |
Neuroleptic malignant syndrome complicating tetanus treated with chlorpromazine.
Topics: Adult; Chlorpromazine; Humans; Male; Neuroleptic Malignant Syndrome; Tetanus | 1992 |
[A feverish psychotic].
Topics: Adult; Chlorpromazine; Haloperidol; Humans; Male; Neuroleptic Malignant Syndrome; Schizophrenia | 1992 |
Catatonia: harbinger of the neuroleptic malignant syndrome.
Topics: Adult; Catatonia; Chlorpromazine; Diagnosis, Differential; Dibenzothiazepines; Female; Humans; Male; | 1991 |
Lithium toxicity--a risk factor for neuroleptic malignant syndrome.
Topics: Chlorpromazine; Drug Interactions; Humans; Lithium; Male; Middle Aged; Neuroleptic Malignant Syndrom | 1991 |
Neuroleptic malignant syndrome during abrupt reduction of neuroleptic treatment.
Topics: Adolescent; Antipsychotic Agents; Chlorpromazine; Dose-Response Relationship, Drug; Drug Therapy, Co | 1990 |
Neuroleptic malignant syndrome.
Topics: Adult; Affective Disorders, Psychotic; Antipsychotic Agents; Butyrophenones; Chlorpromazine; Drug Th | 1990 |
Clozapine-treated NMS.
Topics: Adult; Chlorpromazine; Clopenthixol; Clozapine; Drug Therapy, Combination; Humans; Male; Neuroleptic | 1991 |
[Neuroleptic malignant syndrome].
Topics: Adult; Biperiden; Chlormethiazole; Chlorpromazine; Dantrolene; Diazepam; Female; Haloperidol; Humans | 1990 |
Neuroleptic malignant syndrome.
Topics: Adult; Bromocriptine; Chlorpromazine; Dantrolene; Female; Haloperidol; Humans; Lithium; Neuroleptic | 1990 |
Neuroleptic malignant syndrome in a girl without psychosis.
Topics: Adolescent; Chlorpromazine; Diagnosis, Differential; Female; Humans; Neurocognitive Disorders; Neuro | 1990 |
Neuroleptic malignant syndrome from chlorpromazine: case report.
Topics: Chlorpromazine; Female; Humans; Middle Aged; Neuroleptic Malignant Syndrome | 1989 |
The association between the neuroleptic malignant syndrome and malignant hyperthermia.
Topics: Adult; Caffeine; Chlorpromazine; Contracture; Disease Susceptibility; Female; Halothane; Humans; Mal | 1989 |
The neuroleptic malignant syndrome and pneumomediastinum.
Topics: Adult; Chlorpromazine; Haloperidol; Humans; Male; Mediastinal Emphysema; Neuroleptic Malignant Syndr | 1989 |
Neuroleptic malignant syndrome: another medical cause of acute abdomen.
Topics: Abdomen, Acute; Adult; Chlorpromazine; Diagnostic Errors; Female; Flupenthixol; Humans; Intestinal P | 1989 |
Neuroleptic malignant syndrome in a case of post-partum psychosis.
Topics: Adult; Chlorpromazine; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Therapy, Comb | 1989 |
Neuroleptic malignant syndrome: a case report with post-mortem brain and muscle pathology.
Topics: Aged; Brain; Brain Ischemia; Chlorpromazine; Depressive Disorder; Drug Therapy, Combination; Female; | 1989 |
Neuroleptic malignant syndrome: three episodes with different drugs.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Female; Haloperidol; Humans; Neuroleptic Malignant Synd | 1986 |
A prospective survey of neuroleptic malignant syndrome in a short-term psychiatric hospital.
Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Chlorpromazine; Hospitals, Psychiatric; Humans; Lengt | 1988 |
A successful electroconvulsive treatment of neuroleptic malignant syndrome.
Topics: Adult; Chlorpromazine; Electroconvulsive Therapy; Humans; Male; Neuroleptic Malignant Syndrome; Schi | 1987 |
A role for catecholamines in the pathogenesis of neuroleptic malignant syndrome.
Topics: Akathisia, Drug-Induced; Brain Chemistry; Catecholamines; Chlorpromazine; Haloperidol; Humans; Imipr | 1986 |
Accidental chlorpromazine ingestion as a cause of neuroleptic malignant syndrome in children.
Topics: Child, Preschool; Chlorpromazine; Female; Humans; Infant; Male; Neuroleptic Malignant Syndrome | 1985 |