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chlorpromazine and Nerve Degeneration

chlorpromazine has been researched along with Nerve Degeneration in 8 studies

Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.

Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19905 (62.50)18.7374
1990's2 (25.00)18.2507
2000's1 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Delcroix, JD1
Valletta, J1
Wu, C1
Howe, CL1
Lai, CF1
Cooper, JD1
Belichenko, PV1
Salehi, A1
Mobley, WC1
de Medinaceli, L1
Church, AC1
Sanz, NR1
Stefano, FJ1
Perec, CJ1
Nyback, H1
Sedvall, G1
Ben-Shachar, D1
Pinhassi, B1
Youdim, MB1
Schmitt, N1
Lucas-Héron, B1
Ollivier, B1
Mussini, JM1
Steg, G1
Treister, G1
Bárány, EH1

Reviews

2 reviews available for chlorpromazine and Nerve Degeneration

ArticleYear
Effects of neuroleptics on striatal dopamine synthesized from 14C-tyrosine.
    Pharmacology & therapeutics. Part B: General & systematic pharmacology, 1976, Volume: 2, Issue:1

    Topics: Animals; Brain; Catecholamines; Chlorpromazine; Corpus Striatum; Dopamine; Electric Stimulation; In

1976
Pathological aspects on Parkinson's syndrome.
    Acta neurologica Scandinavica. Supplementum, 1972, Volume: 51

    Topics: Animals; Basal Ganglia; Basal Ganglia Diseases; Central Nervous System; Chlorpromazine; Corpus Stria

1972

Other Studies

6 other studies available for chlorpromazine and Nerve Degeneration

ArticleYear
Trafficking the NGF signal: implications for normal and degenerating neurons.
    Progress in brain research, 2004, Volume: 146

    Topics: Adaptor Protein Complex 2; Animals; Blotting, Western; Brain; Cadaverine; Calcium-Binding Proteins;

2004
Peripheral nerve reconnection: inhibition of early degenerative processes through the use of a novel fluid medium.
    Experimental neurology, 1984, Volume: 84, Issue:2

    Topics: Animals; Axonal Transport; Calcium; Chlorpromazine; Culture Media; Drug Combinations; Nerve Degenera

1984
Delay by drugs of adrenergic nerve degeneration after proximal or distal sympathectomy of the submaxillary gland.
    General pharmacology, 1982, Volume: 13, Issue:3

    Topics: Acid Phosphatase; Animals; Body Temperature; Bretylium Compounds; Chlorpromazine; Colchicine; Denerv

1982
Prevention of neuroleptic-induced dopamine D2 receptor supersensitivity by chronic iron salt treatment.
    European journal of pharmacology, 1991, Sep-17, Volume: 202, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Apomorphine; Brain Chemistry; Chlorpr

1991
Degeneration and subsequent regeneration of mouse skeletal muscle after a single injection of chlorpromazine: changes in mitochondrial calmitine and calcium content.
    Journal of the neurological sciences, 1991, Volume: 105, Issue:1

    Topics: Animals; Calcium; Calcium-Binding Proteins; Calsequestrin; Chlorpromazine; Fura-2; Kinetics; Mice; M

1991
Degeneration mydriasis and hyperemia of the iris after superior cervical ganglionectomy in the rabbit. Evidence for release of more than norepinephrine during degeneration of adrenergic terminals.
    Investigative ophthalmology, 1970, Volume: 9, Issue:11

    Topics: Accommodation, Ocular; Adrenergic alpha-Antagonists; Animals; Atropine; Bretylium Compounds; Chlorpr

1970