chlorpromazine has been researched along with Muscle Rigidity in 21 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Muscle Rigidity: Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results suggest that RF decerebrate rigidity can be used instead of intercollicular transection rigidity in the pharmacological and physiological studies." | 1.27 | Rigidity in rats due to radio frequency decerebration and effects of chlorpromazine and mephenesin. ( Fukuda, H; Ito, H; Nakamura, T; Oka, J; Ono, H, 1987) |
| "Presumably, the syndrome is secondary to biochemical dysfunction of the basal ganglia and possible of the hypothalmus." | 1.26 | Neuroleptic malignant syndrome. ( McCormick, WF; Morris, HH; Reinarz, JA, 1980) |
| "Chlorpromazine that depresses decerebrate rigidity in a dose-related fashion requires 1." | 1.26 | Suppression of decerebrate rigidity by phenytoin and chlorpromazine. ( Anderson, RJ; Raines, A, 1976) |
| "It is likely that these drugs reduce decerebrate rigidity by inhibiting fusimotor activity." | 1.25 | A comparison of the actions of some drugs on decerebrate rigidity, muscle spindle activity and alpha-adrenoceptors. ( Maxwell, DR; Sumpter, EA, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (80.95) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MARTIN, FI | 1 |
| DI PERRI, R | 1 |
| GIAQUINTO, S | 1 |
| Singh, D | 1 |
| Forlano, R | 1 |
| Athey, R | 1 |
| Morris, HH | 1 |
| McCormick, WF | 1 |
| Reinarz, JA | 1 |
| Baker, RW | 1 |
| Chengappa, KN | 1 |
| Hemsley, KM | 1 |
| Crocker, AD | 1 |
| Leber, K | 1 |
| Malek, A | 1 |
| D'Agostino, A | 1 |
| Adelman, HM | 1 |
| Anderson, RJ | 1 |
| Raines, A | 1 |
| Jurna, I | 1 |
| Hall, GM | 1 |
| Lucke, JN | 1 |
| Lister, D | 1 |
| Beasley, BA | 1 |
| Ford, DH | 1 |
| Share, NN | 1 |
| McFarlane, CS | 1 |
| Ono, H | 1 |
| Nakamura, T | 1 |
| Ito, H | 1 |
| Oka, J | 1 |
| Fukuda, H | 2 |
| Maxwell, DR | 3 |
| Read, MA | 2 |
| Sumpter, EA | 2 |
| Steg, G | 1 |
| Petersen, EA | 1 |
| Haase, J | 1 |
| Ito, T | 1 |
| Hashimoto, S | 1 |
| Kudo, Y | 1 |
| McClelland, HA | 1 |
| Blessed, G | 1 |
| Bhate, S | 1 |
| Ali, N | 1 |
| Clarke, PA | 1 |
| Schulterbrandt, JG | 1 |
| Raskin, A | 1 |
| Reatig, N | 1 |
4 reviews available for chlorpromazine and Muscle Rigidity
| Article | Year |
|---|---|
Striatal monoamines and reserpine and chlorpromazine rigidity.
Topics: Animals; Biogenic Amines; Cats; Chlorpromazine; Corpus Striatum; Dopamine; Humans; Mice; Motor Neuro | 1976 |
Treatment of porcine malignant hyperthermia. A review based on experimental studies.
Topics: Animals; Blood Glucose; Body Temperature; Carbon Dioxide; Catecholamines; Chlorpromazine; Dantrolene | 1975 |
Aging and the extrapyramidal system.
Topics: Aged; Aging; Basal Ganglia Diseases; Chlorpromazine; Chorea; Dopamine; Frontal Lobe; Gait; Haloperid | 1976 |
Pathological aspects on Parkinson's syndrome.
Topics: Animals; Basal Ganglia; Basal Ganglia Diseases; Central Nervous System; Chlorpromazine; Corpus Stria | 1972 |
2 trials available for chlorpromazine and Muscle Rigidity
| Article | Year |
|---|---|
The abrupt withdrawal of antiparkinsonian drugs in schizophrenic patients.
Topics: Adult; Aged; Antiparkinson Agents; Basal Ganglia Diseases; Behavior; Chlorpromazine; Clinical Trials | 1974 |
True and apparent side effects in a controlled trial of chlorpromazine and imipramine in depression.
Topics: Adult; Agranulocytosis; Chlorpromazine; Clinical Trials as Topic; Depression; Dermatitis; Edema; Eva | 1974 |
15 other studies available for chlorpromazine and Muscle Rigidity
| Article | Year |
|---|---|
The use of chlorpromazine to control spasm and rigidity in tetanus: report of a case.
Topics: Chlorpromazine; Muscle Rigidity; Spasm; Tetanus | 1957 |
[Chlorpromazine, Jendrassi's maneuver and parkinsonian rigor].
Topics: Chlorpromazine; Electroencephalography; Electromyography; Muscle Rigidity; Nervous System Physiologi | 1962 |
Neuroleptic malignant syndrome and catatonia in a patient with dementia.
Topics: Aged; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Catatonia; Chlorpromazine; Choline | 2008 |
Neuroleptic malignant syndrome.
Topics: Adult; Basal Ganglia; Chlorpromazine; Fever; Humans; Hypothalamus; Male; Muscle Rigidity; Syndrome | 1980 |
Further study of neuroleptic malignant syndrome.
Topics: Adult; Chlorpromazine; Fever; Humans; Male; Muscle Rigidity; Neuroleptic Malignant Syndrome; Psychia | 1995 |
Raclopride and chlorpromazine, but not clozapine, increase muscle rigidity in the rat: relationship with D2 dopamine receptor occupancy.
Topics: Animals; Antipsychotic Agents; Autoradiography; Brain Chemistry; Chlorpromazine; Clozapine; Dose-Res | 1999 |
A veteran with acute mental changes years after combat.
Topics: Antipsychotic Agents; Chlorpromazine; Diagnosis, Differential; Humans; Lithium; Male; Middle Aged; M | 1999 |
Suppression of decerebrate rigidity by phenytoin and chlorpromazine.
Topics: Animals; Cats; Chlorpromazine; Decerebrate State; Disease Models, Animal; Dose-Response Relationship | 1976 |
Cyclobenzaprine: novel centrally acting skeletal muscle relaxant.
Topics: Amitriptyline; Animals; Anticonvulsants; Ataxia; Cats; Chlorpromazine; Decerebrate State; Diazepam; | 1975 |
Rigidity in rats due to radio frequency decerebration and effects of chlorpromazine and mephenesin.
Topics: Animals; Chlorpromazine; Decerebrate State; Male; Mephenesin; Muscle Rigidity; Radio Waves; Rats; Ra | 1987 |
Pharmacology of M & B 18,706, a drug which selectively reduces decerebrate rigidity.
Topics: Adrenergic alpha-Antagonists; Animals; Apomorphine; Cats; Cerebellar Ataxia; Cerebellum; Chlorpromaz | 1974 |
A comparison of the actions of some drugs on decerebrate rigidity, muscle spindle activity and alpha-adrenoceptors.
Topics: Animals; Blood Pressure; Cats; Chlorpromazine; Decerebrate State; Desipramine; Dimethylamines; Dose- | 1974 |
Unstable fractures in children with acute, severe brain injury.
Topics: Accidents, Traffic; Arm Injuries; Brain Injuries; Chlorpromazine; Female; Femoral Fractures; Fractur | 1974 |
Rigidity in rats due to anemic decerebration and the effect of chlorpromazine.
Topics: Anemia; Animals; Basilar Artery; Carotid Arteries; Cerebrovascular Circulation; Chlorpromazine; Dece | 1974 |
The effects of some drugs on the rigidity of the cat due to ischaemic or intercollicular decerebration.
Topics: Acepromazine; Animals; Carisoprodol; Cats; Cerebrovascular Circulation; Chlorpromazine; Decerebrate | 1972 |