chlorpromazine has been researched along with Migraine Disorders in 34 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorpromazine, given intravenously, is a useful agent in the treatment of acute migraine headaches." | 7.68 | Response of non-migrainous headaches to chlorpromazine. ( Barclay, CL; Montoya, D; Seland, TP; Shuaib, A; Thomas, HG, 1990) |
| " Compared to other active drugs, it only showed a lower significant effect compared with granisetron regarding headache change while it showed significantly higher effects only with placebo in both rescue medication needs and headache-free symptoms and valproate in only rescue medication need." | 5.41 | The efficacy and safety of metoclopramide in relieving acute migraine attacks compared with other anti-migraine drugs: a systematic review and network meta-analysis of randomized controlled trials. ( Abd-ElGawad, M; Abdelhay, HM; Abdelmonem, H; Abdelwadoud, GT; Ahmed, AE; Al-Dardery, NM; Alhosini, ANM; Kamel, MA; Mohamed, SW, 2023) |
| "Chlorpromazine, given intravenously, is a useful agent in the treatment of acute migraine headaches." | 3.68 | Response of non-migrainous headaches to chlorpromazine. ( Barclay, CL; Montoya, D; Seland, TP; Shuaib, A; Thomas, HG, 1990) |
| "Migraine is a common, incapacitating neurological condition." | 3.01 | A prospective, randomized, double-blind trial of intravenous chlorpromazine versus intravenous prochlorperazine for the treatment of acute migraine in adults presenting to the emergency department. ( Bourke, EM; Greene, SL; Harding, AM; Hodgson, SE; Taylor, DM, 2021) |
| "Sixty patients with migraine with aura and 68 patients with migraine without aura were assigned at random to receive IV 0." | 2.70 | Intravenous chlorpromazine in the emergency department treatment of migraines: a randomized controlled trial. ( Bigal, ME; Bordini, CA; Speciali, JG, 2002) |
| "The chlorpromazine was repeated every 15 minutes as needed up to a total of three doses." | 2.66 | Comparative efficacy of chlorpromazine and meperidine with dimenhydrinate in migraine headache. ( Baggoley, CJ; Lane, PL; McLellan, BA, 1989) |
| "Eighteen patients experienced orthostatic hypotension following injection." | 2.65 | Parenteral chlorpromazine treatment of migraine. ( Iserson, KV, 1983) |
| "Recent advances in migraine therapy include the recognition of analgesic or ergotamine abuse as a cause of chronic daily migraine, the introduction of effective non-narcotic drugs such as chlorpromazine, dihydroergotamine and corticosteroids for the treatment of intractable migraine attacks, the increased number of beta-blockers now recognized as effective prophylactic agents and the introduction of calcium-channel blockers for prophylaxis." | 2.37 | Migraine. ( Edmeads, JG, 1988) |
| "In paediatric migraine, ibuprofen, acetaminophen and triptans are safe, effective therapies but there is scant paediatric data informing second-line emergency treatment." | 1.72 | Intravenous chlorpromazine for acute paediatric migraine. ( Babl, FE; Hill, A; Löllgen, RM; Mackay, MT; Palmer, GM, 2022) |
| "Intravenous migraine therapy reduces PTH pain scores for children presenting within 14 days after mTBI." | 1.42 | Intravenous migraine therapy in children with posttraumatic headache in the ED. ( Byczkowski, T; Chan, S; Kurowski, B; Timm, N, 2015) |
| "Chlorpromazine was included as an option for treatment at our institution during this shortage, although limited data exist on the effectiveness in children." | 1.40 | Chlorpromazine for the treatment of migraine in a pediatric emergency department. ( Kanis, JM; Timm, NL, 2014) |
| "Consecutive 21 patients with status migrainosus were received intra-venous chlorpromazine (maximum 25mg) with fluid treatment and their results were documented." | 1.40 | Intra-venous chlorpromazine with fluid treatment in status migrainosus. ( Benli, EM; Dinc, A; Gokce, M; Tuncel, D; Utku, U, 2014) |
| "In 1996, 1254 patients were treated for headache and 64 of them required hospitalization." | 1.30 | [Headache treatment in an emergency unit of the city of Ribeirão Preto, Brazil]. ( Bigal, ME; Bordini, CA; Speciali, JG, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (50.00) | 18.7374 |
| 1990's | 7 (20.59) | 18.2507 |
| 2000's | 3 (8.82) | 29.6817 |
| 2010's | 4 (11.76) | 24.3611 |
| 2020's | 3 (8.82) | 2.80 |
| Authors | Studies |
|---|---|
| Löllgen, RM | 1 |
| Babl, FE | 1 |
| Mackay, MT | 1 |
| Hill, A | 1 |
| Palmer, GM | 1 |
| Abdelmonem, H | 1 |
| Abdelhay, HM | 1 |
| Abdelwadoud, GT | 1 |
| Alhosini, ANM | 1 |
| Ahmed, AE | 1 |
| Mohamed, SW | 1 |
| Al-Dardery, NM | 1 |
| Abd-ElGawad, M | 1 |
| Kamel, MA | 1 |
| Hodgson, SE | 1 |
| Harding, AM | 1 |
| Bourke, EM | 1 |
| Taylor, DM | 1 |
| Greene, SL | 1 |
| Khazaei, M | 1 |
| Hosseini Nejad Mir, N | 1 |
| Yadranji Aghdam, F | 1 |
| Taheri, M | 1 |
| Ghafouri-Fard, S | 1 |
| Kanis, JM | 1 |
| Timm, NL | 1 |
| Utku, U | 1 |
| Gokce, M | 1 |
| Benli, EM | 1 |
| Dinc, A | 1 |
| Tuncel, D | 1 |
| Chan, S | 1 |
| Kurowski, B | 1 |
| Byczkowski, T | 1 |
| Timm, N | 1 |
| Bigal, ME | 2 |
| Bordini, CA | 2 |
| Speciali, JG | 2 |
| FEJER, A | 2 |
| Herman, LY | 1 |
| Logan, P | 1 |
| Loga, P | 1 |
| Lewis, D | 1 |
| Iserson, KV | 1 |
| Fozard, JR | 1 |
| Cameron, JD | 1 |
| Lane, PL | 3 |
| Speechley, M | 1 |
| Kelly, AM | 1 |
| Ardagh, M | 1 |
| Curry, C | 1 |
| D'Antonio, J | 1 |
| Zebic, S | 1 |
| Fisher, H | 1 |
| Bell, R | 1 |
| Montoya, D | 2 |
| Shuaib, A | 2 |
| Lee, MA | 1 |
| Raskin, NH | 1 |
| Barclay, CL | 1 |
| Seland, TP | 1 |
| Thomas, HG | 1 |
| McLellan, BA | 1 |
| Baggoley, CJ | 1 |
| Edmeads, JG | 1 |
| Mariani, PJ | 1 |
| McEwen, JI | 1 |
| O'Connor, HM | 1 |
| Dinsdale, HB | 1 |
| Ross, R | 1 |
| Nader, S | 1 |
| Tulloch, B | 1 |
| Blair, C | 1 |
| Vydelingum, N | 1 |
| Fraser, TR | 1 |
| Horrobin, DF | 2 |
| Cahen, RL | 1 |
| Hertrich, O | 1 |
| Wieck, HH | 1 |
| Hilton, BP | 1 |
5 reviews available for chlorpromazine and Migraine Disorders
| Article | Year |
|---|---|
The efficacy and safety of metoclopramide in relieving acute migraine attacks compared with other anti-migraine drugs: a systematic review and network meta-analysis of randomized controlled trials.
Topics: Chlorpromazine; Granisetron; Headache; Humans; Ketorolac; Metoclopramide; Migraine Disorders; Nausea | 2023 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Chlorpromazine in migraine.
Topics: Chlorpromazine; Dopamine Antagonists; Emergency Medicine; Evidence-Based Medicine; Humans; Migraine | 2007 |
Basic mechanisms of antimigraine drugs.
Topics: Amitriptyline; Animals; Chlorpromazine; Humans; Methysergide; Metoclopramide; Migraine Disorders; Pr | 1982 |
Modern pharmacotherapy of migraine.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Chlorpromazine; Dihydroergotamine; Ergotamine; | 1990 |
Migraine.
Topics: Acute Disease; Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Analgesics; Calcium Channel Blo | 1988 |
10 trials available for chlorpromazine and Migraine Disorders
| Article | Year |
|---|---|
A prospective, randomized, double-blind trial of intravenous chlorpromazine versus intravenous prochlorperazine for the treatment of acute migraine in adults presenting to the emergency department.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Australia; Chlorpromazine; Dopamine Antagonist | 2021 |
Effectiveness of intravenous dexamethasone, metoclopramide, ketorolac, and chlorpromazine for pain relief and prevention of recurrence in the migraine headache: a prospective double-blind randomized clinical trial.
Topics: Administration, Intravenous; Adult; Analgesics; Chlorpromazine; Dexamethasone; Double-Blind Method; | 2019 |
Intravenous chlorpromazine in the emergency department treatment of migraines: a randomized controlled trial.
Topics: Chlorpromazine; Dopamine Antagonists; Double-Blind Method; Emergency Service, Hospital; Humans; Inje | 2002 |
Parenteral chlorpromazine treatment of migraine.
Topics: Adolescent; Adult; Chlorpromazine; Clinical Trials as Topic; Female; Humans; Hypotension, Orthostati | 1983 |
Intravenous chlorpromazine vs intravenous metoclopramide in acute migraine headache.
Topics: Acute Disease; Adolescent; Adult; Aged; Chlorpromazine; Dopamine Antagonists; Double-Blind Method; E | 1995 |
Intravenous chlorpromazine versus intramuscular sumatriptan for acute migraine.
Topics: Adolescent; Adult; Aged; Australia; Chlorpromazine; Cross-Over Studies; Dopamine Antagonists; Emerge | 1997 |
A comparative trial of three agents in the treatment of acute migraine headache.
Topics: Adult; Chlorpromazine; Dihydroergotamine; Emergencies; Follow-Up Studies; Humans; Infusions, Intrave | 1990 |
Comparative efficacy of chlorpromazine and meperidine with dimenhydrinate in migraine headache.
Topics: Adult; Chlorpromazine; Dimenhydrinate; Double-Blind Method; Drug Therapy, Combination; Female; Human | 1989 |
Treatment of migraine with intramuscular chlorpromazine.
Topics: Adult; Chlorpromazine; Double-Blind Method; Drug Evaluation; Female; Humans; Injections, Intramuscul | 1987 |
Is prolactin involved in precipitating migraine?
Topics: Administration, Oral; Blood Glucose; Chlorpromazine; Drug Interactions; Ergot Alkaloids; Ethanol; Fa | 1974 |
19 other studies available for chlorpromazine and Migraine Disorders
| Article | Year |
|---|---|
Intravenous chlorpromazine for acute paediatric migraine.
Topics: Acetaminophen; Child; Chlorpromazine; Emergency Service, Hospital; Humans; Ibuprofen; Migraine Disor | 2022 |
Chlorpromazine for the treatment of migraine in a pediatric emergency department.
Topics: Adolescent; Child; Chlorpromazine; Cohort Studies; Dopamine Antagonists; Emergency Service, Hospital | 2014 |
Intra-venous chlorpromazine with fluid treatment in status migrainosus.
Topics: Administration, Intravenous; Adult; Antiemetics; Chlorpromazine; Cohort Studies; Female; Fluid Thera | 2014 |
Intravenous migraine therapy in children with posttraumatic headache in the ED.
Topics: Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Brain Injuries; | 2015 |
[The treatment of vascular headache with Hirepin].
Topics: Chlorpromazine; Histamine; Migraine Disorders; Promethazine; Reserpine; Vascular Headaches | 1962 |
HIREPIN TREATMENT OF VASCULAR HEADACHE.
Topics: Chlorpromazine; Migraine Disorders; Promethazine; Reserpine; Vascular Headaches | 1963 |
The efficacy of a safe, effective non-narcotic treatment of migraine headache.
Topics: Chlorpromazine; Dopamine Antagonists; Humans; Migraine Disorders | 2003 |
Parenteral chlorpromazine for migraine.
Topics: Chlorpromazine; Humans; Injections, Intravenous; Migraine Disorders | 1984 |
Migraine research methods.
Topics: Analgesics, Opioid; Butorphanol; Chlorpromazine; Dopamine Antagonists; Humans; Migraine Disorders; R | 1997 |
[Headache treatment in an emergency unit of the city of Ribeirão Preto, Brazil].
Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroida | 1999 |
Response of non-migrainous headaches to chlorpromazine.
Topics: Adult; Cerebral Hemorrhage; Chlorpromazine; Diagnosis, Differential; Headache; Humans; Male; Middle | 1990 |
Adverse reactions to chlorpromazine in the treatment of migraine.
Topics: Adult; Akathisia, Drug-Induced; Chlorpromazine; Female; Humans; Migraine Disorders | 1988 |
Intravenous chlorpromazine--preliminary results in acute migraine.
Topics: Acute Disease; Adult; Aged; Chlorpromazine; Drug Evaluation; Humans; Injections, Intravenous; Middle | 1985 |
Letter: Prolactin and migraine.
Topics: Bromine; Chlorpromazine; Drug Therapy, Combination; Ergot Alkaloids; Female; Half-Life; Humans; Inje | 1974 |
Letter: Prolactin and migraine.
Topics: Chlorpromazine; Ethanol; Female; Humans; Migraine Disorders; Prolactin | 1974 |
Emetic effect of biogenic amines.
Topics: 5-Hydroxytryptophan; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Brain; Catecholamines; | 1970 |
[Neuroleptics, thymoleptics and tranquilizers in neurological therapy].
Topics: Basal Ganglia Diseases; Chlordiazepoxide; Chlorpromazine; Diazepam; Epilepsy; Extrapyramidal Tracts; | 1969 |
[Headache. Diagnosis and therapy in general practice].
Topics: Carbamazepine; Chlorpromazine; Depression; Ergotamine; Giant Cell Arteritis; Headache; Humans; Migra | 1974 |
Effects of reserpine and chlorpromazine on 5-hydroxytryptamine uptake of platelets from migrainous and control subjects.
Topics: Blood Platelets; Carbon Radioisotopes; Cell Membrane; Chlorpromazine; Humans; Migraine Disorders; Pl | 1974 |