chlorpromazine has been researched along with Melanoma in 27 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "One hundred and fifty-seven evaluable patients with advanced metastatic malignant melanoma were randomly assigned to receive either methyl-CCNU (MeCCNU) (200 mg/m2 orally every 6 weeks) (82 patients) or a combination of MeCCNU, chlorpromazine (50 mg/m2 im), and caffeine (600 mg/m2 sc) in the periumbilical area (75 patients)." | 9.05 | Randomized trial of chlorpromazine, caffeine, and methyl-CCNU in disseminated melanoma. ( Cohen, MH; Schoenfeld, D; Wolter, J, 1980) |
| "Chlorpromazine (CPZ) distribution was measured in tissues of Syrian golden hamsters bearing Greene melanoma and in BALB/c mice bearing Harding-Passey melanoma." | 7.66 | Chlorpromazine distribution in hamsters and mice bearing transplantable melanoma. ( Atkins, HL; Brill, AB; Fairchild, RG; Fand, I; Greenberg, D; Hannon, SJ; McNally, WP; Packer, S; Som, P; Watts, KP, 1982) |
| "One hundred twenty-one patients with disseminated malignant melanoma were treated with BCNU, vincristine, DTIC, and chlorpromazine (BVD)." | 7.65 | Bis chloroethyl nitrosourea, vincristine, dimethyl triazeno imidazole carboxamide and chlorpromazine combination chemotherapy in disseminated malignant melanoma. ( Bodey, GP; Lane, M; Luce, JK; McKelvey, EM; Moon, TE; Talley, RW; Vaitkevicius, VK, 1977) |
| "One hundred and fifty-seven evaluable patients with advanced metastatic malignant melanoma were randomly assigned to receive either methyl-CCNU (MeCCNU) (200 mg/m2 orally every 6 weeks) (82 patients) or a combination of MeCCNU, chlorpromazine (50 mg/m2 im), and caffeine (600 mg/m2 sc) in the periumbilical area (75 patients)." | 5.05 | Randomized trial of chlorpromazine, caffeine, and methyl-CCNU in disseminated melanoma. ( Cohen, MH; Schoenfeld, D; Wolter, J, 1980) |
| "Chlorpromazine (CPZ) distribution was measured in tissues of Syrian golden hamsters bearing Greene melanoma and in BALB/c mice bearing Harding-Passey melanoma." | 3.66 | Chlorpromazine distribution in hamsters and mice bearing transplantable melanoma. ( Atkins, HL; Brill, AB; Fairchild, RG; Fand, I; Greenberg, D; Hannon, SJ; McNally, WP; Packer, S; Som, P; Watts, KP, 1982) |
| "The therapeutic usefulness of chlorpromazine (CPZ) and caffeine (CAF) in combination with selected nitrosoureas was investigated in mice bearing L1210 leukemia, Lewis lung carcinoma, and B16 melanoma." | 3.66 | Therapeutic potentiation of nitrosoureas using chlorpromazine and caffeine in the treatment of murine tumors. ( Dykes, DJ; Laster, WR; Rose, WC; Schabel, FM; Trader, MW, 1978) |
| "One hundred twenty-one patients with disseminated malignant melanoma were treated with BCNU, vincristine, DTIC, and chlorpromazine (BVD)." | 3.65 | Bis chloroethyl nitrosourea, vincristine, dimethyl triazeno imidazole carboxamide and chlorpromazine combination chemotherapy in disseminated malignant melanoma. ( Bodey, GP; Lane, M; Luce, JK; McKelvey, EM; Moon, TE; Talley, RW; Vaitkevicius, VK, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (96.30) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Woods, JA | 1 |
| Ferguson, JS | 1 |
| Kalra, S | 1 |
| Degabriele, A | 1 |
| Gardner, J | 1 |
| Logan, P | 1 |
| Ferguson, J | 1 |
| POTTS, AM | 1 |
| Bolt, AG | 1 |
| Forrest, IS | 1 |
| Aubert, C | 2 |
| Rouge, F | 2 |
| Mischel, M | 1 |
| Lamprecht, I | 1 |
| Prota, G | 1 |
| Nakanishi, T | 1 |
| Ichihashi, M | 1 |
| Mishima, Y | 2 |
| Matsuzawa, T | 1 |
| Fukuda, H | 1 |
| Cohen, MH | 1 |
| Schoenfeld, D | 1 |
| Wolter, J | 1 |
| Fairchild, RG | 1 |
| Greenberg, D | 1 |
| Watts, KP | 1 |
| Packer, S | 1 |
| Atkins, HL | 1 |
| Som, P | 1 |
| Hannon, SJ | 1 |
| Brill, AB | 1 |
| Fand, I | 1 |
| McNally, WP | 1 |
| Rose, WC | 1 |
| Trader, MW | 1 |
| Dykes, DJ | 1 |
| Laster, WR | 1 |
| Schabel, FM | 1 |
| Costanzi, JJ | 1 |
| McKelvey, EM | 1 |
| Luce, JK | 1 |
| Vaitkevicius, VK | 1 |
| Talley, RW | 1 |
| Bodey, GP | 1 |
| Lane, M | 1 |
| Moon, TE | 1 |
| Nakagawa, T | 1 |
| Aono, K | 1 |
| Osieka, R | 2 |
| Glatte, P | 2 |
| Schmidt, CG | 2 |
| Parsons, PG | 1 |
| Allen, BJ | 1 |
| Turner, JH | 1 |
| Maziere, M | 1 |
| Comar, D | 1 |
| Kitagawa, T | 1 |
| Amano, F | 1 |
| Akamatsu, Y | 1 |
| Pannenbäcker, R | 1 |
| Lindquist, NG | 1 |
| Zbytniewski, Z | 1 |
| Drewa, G | 1 |
| Sviatukhin, MV | 1 |
| Kovaleva, VL | 1 |
| Van Woert, MH | 3 |
| Palmer, SH | 1 |
| Saunders, RN | 1 |
| Miya, TS | 1 |
| Bousquet, WF | 1 |
| Burnett, JB | 1 |
| Korb, F | 1 |
| Prasad, KN | 1 |
| Cooper, M | 1 |
| Blois, MS | 1 |
2 trials available for chlorpromazine and Melanoma
| Article | Year |
|---|---|
Randomized trial of chlorpromazine, caffeine, and methyl-CCNU in disseminated melanoma.
Topics: Caffeine; Chlorpromazine; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Melanoma; Nit | 1980 |
DTIC (NSC-45388) studies in the southwest oncology group.
Topics: Carmustine; Chlorpromazine; Clinical Trials as Topic; Dacarbazine; Drug Evaluation; Drug Therapy, Co | 1976 |
25 other studies available for chlorpromazine and Melanoma
| Article | Year |
|---|---|
The phototoxicity of vemurafenib: An investigation of clinical monochromator phototesting and in vitro phototoxicity testing.
Topics: Cell Line; Chlorpromazine; Chromatography, High Pressure Liquid; Dermatitis, Phototoxic; Dexamethaso | 2015 |
TRACER STUDIES ON A TRANSPLANTABLE HAMSTER MELANOMA.
Topics: Animals; Chlorpromazine; Cricetinae; Eye Neoplasms; Fluoresceins; Idoxuridine; Iodine Isotopes; Mela | 1964 |
Interaction between human melanoprotein and chlorpromazine derivatives. II. Spectrophotometric studies.
Topics: Chlorpromazine; Hair; Humans; Melanoma; Pigmentation Disorders; Proteins; Spectrophotometry | 1967 |
DTIC and CPZ cytotoxicities on established human melanocyte cell lines.
Topics: Cell Division; Cell Line; Chlorpromazine; Dacarbazine; Drug Resistance; Humans; Melanocytes; Melanom | 1984 |
Dielectrophoresis of malignant human melanocytes.
Topics: Cell Line; Chlorpromazine; Electric Conductivity; Electrophoresis; Humans; Melanocytes; Melanoma; Sk | 1983 |
Thermal neutron capture therapy of malignant melanoma: in vitro radiobiological analysis.
Topics: Alpha Particles; Animals; Boron; Cell Line; Cell Survival; Chlorpromazine; Dose-Response Relationshi | 1980 |
Chlorpromazine distribution in hamsters and mice bearing transplantable melanoma.
Topics: Animals; Autoradiography; Chlorpromazine; Cricetinae; Drug Administration Schedule; Injections, Intr | 1982 |
Therapeutic potentiation of nitrosoureas using chlorpromazine and caffeine in the treatment of murine tumors.
Topics: Animals; Caffeine; Carmustine; Chlorpromazine; Drug Synergism; Drug Therapy, Combination; Female; Le | 1978 |
Bis chloroethyl nitrosourea, vincristine, dimethyl triazeno imidazole carboxamide and chlorpromazine combination chemotherapy in disseminated malignant melanoma.
Topics: Carmustine; Chlorpromazine; Dacarbazine; Drug Therapy, Combination; Eosinophils; Female; Humans; Leu | 1977 |
Syntheses of chlorpromazine undecahydrododecaborate and nonahydrodecaborate--promising agents for neutron capture therapy of malignant melanoma.
Topics: Borates; Chlorpromazine; Melanoma | 1976 |
Chemosensitization by chlorpromazine (CPZ) and caffeine (C) in human melanoma xenografts sensitive or resistant to methyl-CCNU (semustine).
Topics: Animals; Caffeine; Chlorpromazine; Drug Resistance; Humans; Melanoma; Mice; Mice, Nude; Neoplasm Tra | 1989 |
Accumulation of chlorpromazine and thiouracil by human melanoma cells in culture.
Topics: Cell Line; Chlorpromazine; Humans; Melanins; Melanoma; Monophenol Monooxygenase; Phenylthiourea; Thi | 1986 |
Localization of 11C-radiopharmaceuticals in the Greene melanoma of hamsters.
Topics: Animals; Benzodiazepinones; Carbon Radioisotopes; Chlorpromazine; Cricetinae; Flumazenil; Flunitraze | 1985 |
External ATP-induced passive permeability change and cell lysis of cultured transformed cells: action in serum-containing growth media.
Topics: Adenosine Triphosphate; Animals; Blood; Calcium; Calmodulin; Cell Membrane Permeability; Cell Surviv | 1988 |
Enhancement of semustine-induced cytotoxicity by chlorpromazine and caffeine in a human melanoma xenograft.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Caffeine; Chlorpromazine; DNA | 1986 |
Accumulation of drugs on melanin.
Topics: Animals; Autoradiography; Carbon Isotopes; Catechol Oxidase; Catecholamines; Cattle; Chloroquine; Ch | 1973 |
Inhibition of growth of transplantable melanotic melanoma in golden hamsters (Mesocricetus auratus, Waterhouse) by chlorpromazine.
Topics: Acid Phosphatase; Animals; Catechol Oxidase; Cathepsins; Chlorpromazine; Cricetinae; Liver; Male; Me | 1973 |
[Effect of aminazin on the growth of transplantable melanomas and on the effect of their x-ray irradiation].
Topics: Animals; Chlorpromazine; Injections, Intraperitoneal; Melanoma; Mice; Neoplasm Transplantation; Neop | 1973 |
Inhibition of the growth of mouse melanoma by chlorpromazine.
Topics: Animals; Antineoplastic Agents; Body Weight; Catechol Oxidase; Chlorpromazine; Melanoma; Mice; Neopl | 1969 |
Stimulation of DOPA14C incorporation into melanoma tissue by chlorpromazine and reserpine.
Topics: Animals; Carbon Isotopes; Catechol Oxidase; Chlorpromazine; Dihydroxyphenylalanine; In Vitro Techniq | 1970 |
Effect of phenothiazines on melanoma tyrosinase activity.
Topics: Adrenal Glands; Animals; Basidiomycota; Carbon Isotopes; Catechol Oxidase; Cell Membrane Permeabilit | 1970 |
The tyrosinases of mouse melanoma. Isolation and molecular properties.
Topics: Acrylates; Alcohols; Amino Acids; Animals; Catechol Oxidase; Chemical Phenomena; Chemistry; Chlorpro | 1971 |
Regulation of tyrosinase activity in mouse melanoma and skin by changes in melanosomal membrane permeability.
Topics: Animals; Bile Acids and Salts; Catechol Oxidase; Cell Membrane Permeability; Chloroquine; Chlorproma | 1971 |
Increased in vitro radio-sensitivity of malignant melanoma induced by the in vivo administration of chlorpromazine.
Topics: Animals; Chlorpromazine; Cricetinae; Free Radicals; Melanins; Melanoma; Neoplasm Transplantation; Ne | 1972 |
On chlorpromazine binding in vivo.
Topics: Animals; Chlorpromazine; Melanins; Melanoma; Mice; Pigmentation; Radioisotopes | 1965 |