chlorpromazine has been researched along with Malignant Melanoma in 27 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| "One hundred and fifty-seven evaluable patients with advanced metastatic malignant melanoma were randomly assigned to receive either methyl-CCNU (MeCCNU) (200 mg/m2 orally every 6 weeks) (82 patients) or a combination of MeCCNU, chlorpromazine (50 mg/m2 im), and caffeine (600 mg/m2 sc) in the periumbilical area (75 patients)." | 9.05 | Randomized trial of chlorpromazine, caffeine, and methyl-CCNU in disseminated melanoma. ( Cohen, MH; Schoenfeld, D; Wolter, J, 1980) |
| "Chlorpromazine (CPZ) distribution was measured in tissues of Syrian golden hamsters bearing Greene melanoma and in BALB/c mice bearing Harding-Passey melanoma." | 7.66 | Chlorpromazine distribution in hamsters and mice bearing transplantable melanoma. ( Atkins, HL; Brill, AB; Fairchild, RG; Fand, I; Greenberg, D; Hannon, SJ; McNally, WP; Packer, S; Som, P; Watts, KP, 1982) |
| "One hundred twenty-one patients with disseminated malignant melanoma were treated with BCNU, vincristine, DTIC, and chlorpromazine (BVD)." | 7.65 | Bis chloroethyl nitrosourea, vincristine, dimethyl triazeno imidazole carboxamide and chlorpromazine combination chemotherapy in disseminated malignant melanoma. ( Bodey, GP; Lane, M; Luce, JK; McKelvey, EM; Moon, TE; Talley, RW; Vaitkevicius, VK, 1977) |
| "One hundred and fifty-seven evaluable patients with advanced metastatic malignant melanoma were randomly assigned to receive either methyl-CCNU (MeCCNU) (200 mg/m2 orally every 6 weeks) (82 patients) or a combination of MeCCNU, chlorpromazine (50 mg/m2 im), and caffeine (600 mg/m2 sc) in the periumbilical area (75 patients)." | 5.05 | Randomized trial of chlorpromazine, caffeine, and methyl-CCNU in disseminated melanoma. ( Cohen, MH; Schoenfeld, D; Wolter, J, 1980) |
| "Chlorpromazine (CPZ) distribution was measured in tissues of Syrian golden hamsters bearing Greene melanoma and in BALB/c mice bearing Harding-Passey melanoma." | 3.66 | Chlorpromazine distribution in hamsters and mice bearing transplantable melanoma. ( Atkins, HL; Brill, AB; Fairchild, RG; Fand, I; Greenberg, D; Hannon, SJ; McNally, WP; Packer, S; Som, P; Watts, KP, 1982) |
| "The therapeutic usefulness of chlorpromazine (CPZ) and caffeine (CAF) in combination with selected nitrosoureas was investigated in mice bearing L1210 leukemia, Lewis lung carcinoma, and B16 melanoma." | 3.66 | Therapeutic potentiation of nitrosoureas using chlorpromazine and caffeine in the treatment of murine tumors. ( Dykes, DJ; Laster, WR; Rose, WC; Schabel, FM; Trader, MW, 1978) |
| "One hundred twenty-one patients with disseminated malignant melanoma were treated with BCNU, vincristine, DTIC, and chlorpromazine (BVD)." | 3.65 | Bis chloroethyl nitrosourea, vincristine, dimethyl triazeno imidazole carboxamide and chlorpromazine combination chemotherapy in disseminated malignant melanoma. ( Bodey, GP; Lane, M; Luce, JK; McKelvey, EM; Moon, TE; Talley, RW; Vaitkevicius, VK, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (96.30) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Woods, JA | 1 |
| Ferguson, JS | 1 |
| Kalra, S | 1 |
| Degabriele, A | 1 |
| Gardner, J | 1 |
| Logan, P | 1 |
| Ferguson, J | 1 |
| POTTS, AM | 1 |
| Bolt, AG | 1 |
| Forrest, IS | 1 |
| Aubert, C | 2 |
| Rouge, F | 2 |
| Mischel, M | 1 |
| Lamprecht, I | 1 |
| Prota, G | 1 |
| Nakanishi, T | 1 |
| Ichihashi, M | 1 |
| Mishima, Y | 2 |
| Matsuzawa, T | 1 |
| Fukuda, H | 1 |
| Cohen, MH | 1 |
| Schoenfeld, D | 1 |
| Wolter, J | 1 |
| Fairchild, RG | 1 |
| Greenberg, D | 1 |
| Watts, KP | 1 |
| Packer, S | 1 |
| Atkins, HL | 1 |
| Som, P | 1 |
| Hannon, SJ | 1 |
| Brill, AB | 1 |
| Fand, I | 1 |
| McNally, WP | 1 |
| Rose, WC | 1 |
| Trader, MW | 1 |
| Dykes, DJ | 1 |
| Laster, WR | 1 |
| Schabel, FM | 1 |
| Costanzi, JJ | 1 |
| McKelvey, EM | 1 |
| Luce, JK | 1 |
| Vaitkevicius, VK | 1 |
| Talley, RW | 1 |
| Bodey, GP | 1 |
| Lane, M | 1 |
| Moon, TE | 1 |
| Nakagawa, T | 1 |
| Aono, K | 1 |
| Osieka, R | 2 |
| Glatte, P | 2 |
| Schmidt, CG | 2 |
| Parsons, PG | 1 |
| Allen, BJ | 1 |
| Turner, JH | 1 |
| Maziere, M | 1 |
| Comar, D | 1 |
| Kitagawa, T | 1 |
| Amano, F | 1 |
| Akamatsu, Y | 1 |
| Pannenbäcker, R | 1 |
| Lindquist, NG | 1 |
| Zbytniewski, Z | 1 |
| Drewa, G | 1 |
| Sviatukhin, MV | 1 |
| Kovaleva, VL | 1 |
| Van Woert, MH | 3 |
| Palmer, SH | 1 |
| Saunders, RN | 1 |
| Miya, TS | 1 |
| Bousquet, WF | 1 |
| Burnett, JB | 1 |
| Korb, F | 1 |
| Prasad, KN | 1 |
| Cooper, M | 1 |
| Blois, MS | 1 |
2 trials available for chlorpromazine and Malignant Melanoma
| Article | Year |
|---|---|
Randomized trial of chlorpromazine, caffeine, and methyl-CCNU in disseminated melanoma.
Topics: Caffeine; Chlorpromazine; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Melanoma; Nit | 1980 |
DTIC (NSC-45388) studies in the southwest oncology group.
Topics: Carmustine; Chlorpromazine; Clinical Trials as Topic; Dacarbazine; Drug Evaluation; Drug Therapy, Co | 1976 |
25 other studies available for chlorpromazine and Malignant Melanoma
| Article | Year |
|---|---|
The phototoxicity of vemurafenib: An investigation of clinical monochromator phototesting and in vitro phototoxicity testing.
Topics: Cell Line; Chlorpromazine; Chromatography, High Pressure Liquid; Dermatitis, Phototoxic; Dexamethaso | 2015 |
TRACER STUDIES ON A TRANSPLANTABLE HAMSTER MELANOMA.
Topics: Animals; Chlorpromazine; Cricetinae; Eye Neoplasms; Fluoresceins; Idoxuridine; Iodine Isotopes; Mela | 1964 |
Interaction between human melanoprotein and chlorpromazine derivatives. II. Spectrophotometric studies.
Topics: Chlorpromazine; Hair; Humans; Melanoma; Pigmentation Disorders; Proteins; Spectrophotometry | 1967 |
DTIC and CPZ cytotoxicities on established human melanocyte cell lines.
Topics: Cell Division; Cell Line; Chlorpromazine; Dacarbazine; Drug Resistance; Humans; Melanocytes; Melanom | 1984 |
Dielectrophoresis of malignant human melanocytes.
Topics: Cell Line; Chlorpromazine; Electric Conductivity; Electrophoresis; Humans; Melanocytes; Melanoma; Sk | 1983 |
Thermal neutron capture therapy of malignant melanoma: in vitro radiobiological analysis.
Topics: Alpha Particles; Animals; Boron; Cell Line; Cell Survival; Chlorpromazine; Dose-Response Relationshi | 1980 |
Chlorpromazine distribution in hamsters and mice bearing transplantable melanoma.
Topics: Animals; Autoradiography; Chlorpromazine; Cricetinae; Drug Administration Schedule; Injections, Intr | 1982 |
Therapeutic potentiation of nitrosoureas using chlorpromazine and caffeine in the treatment of murine tumors.
Topics: Animals; Caffeine; Carmustine; Chlorpromazine; Drug Synergism; Drug Therapy, Combination; Female; Le | 1978 |
Bis chloroethyl nitrosourea, vincristine, dimethyl triazeno imidazole carboxamide and chlorpromazine combination chemotherapy in disseminated malignant melanoma.
Topics: Carmustine; Chlorpromazine; Dacarbazine; Drug Therapy, Combination; Eosinophils; Female; Humans; Leu | 1977 |
Syntheses of chlorpromazine undecahydrododecaborate and nonahydrodecaborate--promising agents for neutron capture therapy of malignant melanoma.
Topics: Borates; Chlorpromazine; Melanoma | 1976 |
Chemosensitization by chlorpromazine (CPZ) and caffeine (C) in human melanoma xenografts sensitive or resistant to methyl-CCNU (semustine).
Topics: Animals; Caffeine; Chlorpromazine; Drug Resistance; Humans; Melanoma; Mice; Mice, Nude; Neoplasm Tra | 1989 |
Accumulation of chlorpromazine and thiouracil by human melanoma cells in culture.
Topics: Cell Line; Chlorpromazine; Humans; Melanins; Melanoma; Monophenol Monooxygenase; Phenylthiourea; Thi | 1986 |
Localization of 11C-radiopharmaceuticals in the Greene melanoma of hamsters.
Topics: Animals; Benzodiazepinones; Carbon Radioisotopes; Chlorpromazine; Cricetinae; Flumazenil; Flunitraze | 1985 |
External ATP-induced passive permeability change and cell lysis of cultured transformed cells: action in serum-containing growth media.
Topics: Adenosine Triphosphate; Animals; Blood; Calcium; Calmodulin; Cell Membrane Permeability; Cell Surviv | 1988 |
Enhancement of semustine-induced cytotoxicity by chlorpromazine and caffeine in a human melanoma xenograft.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Caffeine; Chlorpromazine; DNA | 1986 |
Accumulation of drugs on melanin.
Topics: Animals; Autoradiography; Carbon Isotopes; Catechol Oxidase; Catecholamines; Cattle; Chloroquine; Ch | 1973 |
Inhibition of growth of transplantable melanotic melanoma in golden hamsters (Mesocricetus auratus, Waterhouse) by chlorpromazine.
Topics: Acid Phosphatase; Animals; Catechol Oxidase; Cathepsins; Chlorpromazine; Cricetinae; Liver; Male; Me | 1973 |
[Effect of aminazin on the growth of transplantable melanomas and on the effect of their x-ray irradiation].
Topics: Animals; Chlorpromazine; Injections, Intraperitoneal; Melanoma; Mice; Neoplasm Transplantation; Neop | 1973 |
Inhibition of the growth of mouse melanoma by chlorpromazine.
Topics: Animals; Antineoplastic Agents; Body Weight; Catechol Oxidase; Chlorpromazine; Melanoma; Mice; Neopl | 1969 |
Stimulation of DOPA14C incorporation into melanoma tissue by chlorpromazine and reserpine.
Topics: Animals; Carbon Isotopes; Catechol Oxidase; Chlorpromazine; Dihydroxyphenylalanine; In Vitro Techniq | 1970 |
Effect of phenothiazines on melanoma tyrosinase activity.
Topics: Adrenal Glands; Animals; Basidiomycota; Carbon Isotopes; Catechol Oxidase; Cell Membrane Permeabilit | 1970 |
The tyrosinases of mouse melanoma. Isolation and molecular properties.
Topics: Acrylates; Alcohols; Amino Acids; Animals; Catechol Oxidase; Chemical Phenomena; Chemistry; Chlorpro | 1971 |
Regulation of tyrosinase activity in mouse melanoma and skin by changes in melanosomal membrane permeability.
Topics: Animals; Bile Acids and Salts; Catechol Oxidase; Cell Membrane Permeability; Chloroquine; Chlorproma | 1971 |
Increased in vitro radio-sensitivity of malignant melanoma induced by the in vivo administration of chlorpromazine.
Topics: Animals; Chlorpromazine; Cricetinae; Free Radicals; Melanins; Melanoma; Neoplasm Transplantation; Ne | 1972 |
On chlorpromazine binding in vivo.
Topics: Animals; Chlorpromazine; Melanins; Melanoma; Mice; Pigmentation; Radioisotopes | 1965 |