chlorpromazine has been researched along with Long QT Syndrome in 6 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The atypicals cause fewer extrapyramidal symptoms and tardive dyskinesia, but there is growing concern regarding the significant long-term metabolic and cardiac adverse effects of these novel antipsychotics." | 2.42 | From chlorpromazine to clozapine--antipsychotic adverse effects and the clinician's dilemma. ( Abidi, S; Bhaskara, SM, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cavalli, A | 1 |
| Poluzzi, E | 1 |
| De Ponti, F | 1 |
| Recanatini, M | 1 |
| Correll, CU | 1 |
| Frederickson, AM | 1 |
| Figen, V | 1 |
| Ginn-Scott, EJ | 1 |
| Pantaleon Moya, RA | 1 |
| Kane, JM | 1 |
| Manu, P | 1 |
| Suzuki, Y | 1 |
| Watanabe, J | 1 |
| Ono, S | 1 |
| Fukui, N | 1 |
| Sugai, T | 1 |
| Tsuneyama, N | 1 |
| Someya, T | 1 |
| Abidi, S | 1 |
| Bhaskara, SM | 1 |
| Adetunji, B | 1 |
| Basil, B | 1 |
| Mathews, M | 1 |
| Osinowo, T | 1 |
| Warner, JP | 1 |
| Barnes, TR | 1 |
| Henry, JA | 1 |
1 review available for chlorpromazine and Long QT Syndrome
| Article | Year |
|---|---|
From chlorpromazine to clozapine--antipsychotic adverse effects and the clinician's dilemma.
Topics: Antipsychotic Agents; Chlorpromazine; Clozapine; Diabetes Mellitus; Humans; Hyperlipidemias; Long QT | 2003 |
2 trials available for chlorpromazine and Long QT Syndrome
| Article | Year |
|---|---|
The QTc interval and its dispersion in patients receiving two atypical antipsychotics.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Drug Therapy, Combination; Electrocardiography; Female; | 2009 |
Electrocardiographic changes in patients receiving neuroleptic medication.
Topics: Adult; Aged; Antipsychotic Agents; Chi-Square Distribution; Chlorpromazine; Death, Sudden, Cardiac; | 1996 |
3 other studies available for chlorpromazine and Long QT Syndrome
| Article | Year |
|---|---|
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go- | 2002 |
Increase in the risk of chlorpromazine-induced QT prolongation during nighttime: is a short-period ECG during daytime sufficient?
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Circadian Rhythm; Electrocardiography; Female; Humans; | 2010 |
Should the Physician's Desk Reference contraindicate the use of chlorpromazine-fluoxetine combination? A case report.
Topics: Adult; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Chlorpromazine; Contraindicat | 2006 |