chlorpromazine has been researched along with Liver Dysfunction in 62 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypoplastic bone marrow associated with agranulocytosis is a well-known side effect of chlorpromazine treatment." | 5.28 | Chlorpromazine-induced liver and bone marrow granulomas associated with agranulocytosis. ( Ben-Yehuda, A; Bloom, A; Flusser, D; Lijovetzky, G; Tur-Kaspa, R, 1990) |
| "Hypoplastic bone marrow associated with agranulocytosis is a well-known side effect of chlorpromazine treatment." | 1.28 | Chlorpromazine-induced liver and bone marrow granulomas associated with agranulocytosis. ( Ben-Yehuda, A; Bloom, A; Flusser, D; Lijovetzky, G; Tur-Kaspa, R, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 60 (96.77) | 18.7374 |
| 1990's | 1 (1.61) | 18.2507 |
| 2000's | 1 (1.61) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| GRYTTING, G | 1 |
| ELLIOTT, RN | 1 |
| SCHRUT, AH | 1 |
| MARRA, JJ | 1 |
| LASSENIUS, B | 1 |
| OSTERMAN, E | 1 |
| FLACH, A | 2 |
| SANDRING, H | 1 |
| LAMOTTA, RV | 1 |
| LUNDBERG, GA | 1 |
| WETSTONE, HJ | 1 |
| SCARPONI, E | 1 |
| NORBIATO, L | 1 |
| HAMMERBERG, PE | 1 |
| WAITZKIN, L | 3 |
| TOLSTRUP, N | 1 |
| CAMPBELL, JE | 1 |
| MOESCHLIN, S | 1 |
| SIEGENTHALER, P | 1 |
| ZELMAN, S | 1 |
| NORREDAM, K | 1 |
| MACMAHON, HE | 1 |
| BELL, JL | 1 |
| WILLIAMS, R | 1 |
| SCHALM, L | 1 |
| SAPHIER, E | 1 |
| SYAM, NK | 1 |
| SPELLBERG, MA | 1 |
| HOLDSWORTH, CD | 1 |
| ATKINSON, M | 1 |
| DOSSETT, JA | 1 |
| HALL, R | 1 |
| READ, AE | 2 |
| KUSCH, T | 1 |
| SUMMERSKILL, WH | 1 |
| MAIER, C | 2 |
| RUTTNER, JR | 1 |
| JESPERSEN, HG | 1 |
| RUETTNER, JR | 1 |
| RONDEZ, R | 1 |
| Sulaiman, AA | 1 |
| Al-Shawi, NN | 1 |
| Jwaied, AH | 1 |
| Mahmood, DM | 1 |
| Hussain, SA | 1 |
| Young, RC | 1 |
| Blass, JP | 1 |
| Matsui, T | 1 |
| Kitagawa, H | 1 |
| Kobayashi, Y | 1 |
| Mizoguchi, Y | 1 |
| Monna, T | 1 |
| Yamamoto, S | 1 |
| Morisawa, S | 1 |
| Roĭzin, L | 1 |
| Farber, JL | 1 |
| Chien, KR | 1 |
| Mittnacht, S | 1 |
| Holzbach, RT | 1 |
| Kinze, W | 1 |
| Pröhl, L | 1 |
| Brauer, H | 1 |
| Marzi, A | 1 |
| de Toranzo, EG | 1 |
| Castro, JA | 1 |
| Schenker, S | 1 |
| Ellis, FP | 1 |
| Weinreb, M | 1 |
| Kraus, V | 1 |
| Krausová, J | 1 |
| Hudcová, T | 1 |
| Arnman, R | 1 |
| Iwarson, S | 1 |
| Olsson, R | 1 |
| Bianchi, L | 1 |
| De Groote, J | 1 |
| Desmet, V | 1 |
| Gedigk, P | 1 |
| Korb, G | 1 |
| Popper, H | 1 |
| Poulsen, H | 1 |
| Scheuer, PJ | 1 |
| Schmid, M | 1 |
| Thaler, H | 1 |
| Wepler, W | 1 |
| Ben-Yehuda, A | 1 |
| Bloom, A | 1 |
| Lijovetzky, G | 1 |
| Flusser, D | 1 |
| Tur-Kaspa, R | 1 |
| Chen, MH | 1 |
| Olomu, AB | 1 |
| Vickers, CR | 1 |
| Waring, RH | 1 |
| Clements, D | 1 |
| Babbs, C | 1 |
| Warnes, TW | 1 |
| Elias, E | 1 |
| Kaplowitz, N | 1 |
| Aw, TY | 1 |
| Simon, FR | 1 |
| Stolz, A | 1 |
| Carney, MW | 1 |
| Tartarini, S | 2 |
| Bartoli, GM | 2 |
| Gaudiano, A | 3 |
| Montorsi, F | 2 |
| Petti, G | 3 |
| Polizzi, M | 3 |
| Eger, W | 1 |
| Schulz, E | 1 |
| Berthelot, P | 1 |
| Mansurova, ID | 1 |
| Bednár, B | 1 |
| Efrain Salvioli, J | 1 |
| Kühn, HA | 1 |
| Richter, E | 1 |
| Lambotte, L | 1 |
| Sinaĭko, GA | 1 |
| Paktoris, EA | 1 |
| Pozdniakova, SL | 1 |
| Kutchak, SN | 1 |
| Shumkina, OB | 1 |
| Nikiforov, GN | 1 |
| Broch, E | 1 |
| Netkovszky, K | 1 |
| Severini, G | 1 |
| Tarján, G | 1 |
| Czeizel, E | 1 |
| Görgényi, F | 1 |
| Székesi, J | 1 |
| Abramov, A | 1 |
| Neufeld, E | 1 |
| Chayen, R | 1 |
| Kerkhoven, P | 1 |
| Müller, WA | 1 |
| Truniger, B | 1 |
11 reviews available for chlorpromazine and Liver Dysfunction
| Article | Year |
|---|---|
Iatrogenic nutritional deficiencies.
Topics: Animals; Anticonvulsants; Antitubercular Agents; Avitaminosis; Cathartics; Chlorpromazine; Contracep | 1982 |
[Multifactorial nature of the pathogenesis of pathological reactions observed following the administration of psychotropic drugs].
Topics: Animals; Brain; Chemical and Drug Induced Liver Injury; Chlorpromazine; Female; Humans; Liver; Liver | 1980 |
Myocardial ischemia: the pathogenesis of irreversible cell injury in ischemia.
Topics: Animals; Calcium; Cell Membrane; Cell Survival; Chlorpromazine; Coronary Disease; Dogs; Liver Diseas | 1981 |
Drug-induced liver disease.
Topics: Analgesics; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Chlorpromazine; Contracep | 1981 |
Heat illness. II. Pathogenesis.
Topics: Adolescent; Adult; Aged; Animals; Aspartate Aminotransferases; Blood Coagulation Disorders; Brain Di | 1976 |
[Diagnosis and traditional Chinese medicine combined with Western medicine in the treatment of hepatic porphyria].
Topics: Chlorpromazine; Diagnostic Errors; Drugs, Chinese Herbal; Humans; Liver Diseases; Porphyrias | 1988 |
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Bile; Bile Acids and Salts; Biotransformation; Cell Survival; Chemical and Drug Induc | 1986 |
Mechanisms and prediction of drug-induced liver disease.
Topics: Adenosine Triphosphate; Age Factors; Animals; Bilirubin; Biotransformation; Carbon Isotopes; Carbon | 1973 |
[Role of liver in the metabolism of drugs (literature review)].
Topics: Barbiturates; Biotransformation; Carbon Tetrachloride Poisoning; Chlorpromazine; Cytochrome P-450 En | 1973 |
[Liver diseases induced by drugs].
Topics: Animals; Arsenicals; Chemical and Drug Induced Liver Injury; Chloroform; Chlorpromazine; Contracepti | 1967 |
[Pathophysiology and clinical aspects of intrahepatic cholestasis].
Topics: Alkaline Phosphatase; Animals; Arsphenamine; Bile Acids and Salts; Bilirubin; Chlorpromazine; Cholan | 1970 |
51 other studies available for chlorpromazine and Liver Dysfunction
| Article | Year |
|---|---|
[Toxic liver damage due to largactil (chlorpromazine)].
Topics: Adrenocorticotropic Hormone; Anti-Allergic Agents; Chlorpromazine; Histamine H1 Antagonists; Jaundic | 1954 |
Fatal acute aseptic necrosis of the liver associated with chlorpromazine.
Topics: Chlorpromazine; Humans; Liver; Liver Diseases; Schizophrenia | 1956 |
[Complications in prolonged chlorpromazine therapy; preliminary report].
Topics: Chlorpromazine; Humans; Liver Diseases; Obesity | 1956 |
[Studies on the problem of liver damage after phenothiazines].
Topics: Chlorpromazine; Humans; Liver; Liver Diseases; Phenothiazines | 1956 |
[Studies on the problem of liver damage after phenothiazines].
Topics: Chlorpromazine; Humans; Liver; Liver Diseases; Phenothiazines | 1956 |
[Studies on the problem of liver damage after phenothiazines].
Topics: Chlorpromazine; Humans; Liver; Liver Diseases; Phenothiazines | 1956 |
[Studies on the problem of liver damage after phenothiazines].
Topics: Chlorpromazine; Humans; Liver; Liver Diseases; Phenothiazines | 1956 |
[Liver disease in chlorpromazine therapy].
Topics: Chlorpromazine; Liver Diseases | 1957 |
Liver dysfunction following chlorpromazine therapy; a report of twenty cases.
Topics: Chlorpromazine; Humans; Liver Diseases | 1958 |
[Psychosomatic aspects of hepatic insufficiency; therapeutic possibilities of drugs with central action (meprobamate, benactyzine, chlorpromazine) and with central and peripheral action (glucose-1-phosphate)].
Topics: Benactyzine; Chlorpromazine; Glucosephosphates; Hepatic Insufficiency; Hexosephosphates; Humans; Liv | 1958 |
[Liver lesions due to chlorpromazine treatment].
Topics: Chlorpromazine; Humans; Liver Diseases | 1958 |
Hepatic dysfunction due to chlorpromazine hypertensitivity.
Topics: Chlorpromazine; Humans; Liver; Liver Diseases | 1958 |
[Fatal liver damage caused by chlorpromazine therapy].
Topics: Abdominal Injuries; Chlorpromazine; Liver Diseases | 1959 |
Myocardial lesions and granulocytopenia associated with chlorpromazine therapy. Liver necrosis resulting from unsuspected carbon tetrachloride poisoning.
Topics: Agranulocytosis; Carbon Tetrachloride Poisoning; Chlorpromazine; Liver; Liver Diseases; Myocardium | 1960 |
[Cholostatic hepatosis caused by gold; analogy to chlorpromazine and androgen icterus].
Topics: Androgens; Chlorpromazine; Gold; Jaundice; Liver Diseases | 1960 |
Liver cell necrosis in chlorpromazine jaundice (allergic cholangiolitis). A serial study of twenty-six needle biopsy specimens in nine patients.
Topics: Biopsy, Needle; Chlorpromazine; Humans; Jaundice; Liver; Liver Diseases | 1959 |
[The liver-damaging action of chlorpromazine].
Topics: Chlorpromazine; Humans; Liver Diseases | 1962 |
Hepatic injury found during chronic chlorpromazine therapy. Preliminary clinical study.
Topics: Chlorpromazine; Humans; Liver Diseases | 1962 |
Prolonged hepatic dysfunction after clinical recovery from chlorpromazine jaundice.
Topics: Chlorpromazine; Jaundice; Liver Diseases | 1962 |
THE VALUE OF JIRGL'S FLOCCULATION TEST IN THE DIAGNOSIS OF JAUNDICE.
Topics: Alkaline Phosphatase; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Chlorpromaz | 1964 |
[LIVER DAMAGE BY DRUGS].
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Arsphenamine; Chemical and Drug Induced Liver Injury; Chl | 1963 |
ANTIDEPRESSANT DRUGS AND LIVER DAMAGE.
Topics: Antidepressive Agents; Chemical and Drug Induced Liver Injury; Chlorpromazine; Hepatitis; Hepatitis | 1964 |
A CASE OF HYDATID CYST OF THE LIVER SUCCESSFULLY REMEDIED.
Topics: Child; Chlorpromazine; Dogs; Echinococcosis; Formaldehyde; Humans; India; Liver Diseases; Liver Dise | 1964 |
INTRAHEPATIC CHOLESTASIS VS. POSTHEPATIC JAUNDICE: METHODS OF DIAGNOSIS, WITH A NOTE ON HYPERCHOLESTEREMIC XANTHOMATOSIS IN A PATIENT WITH CHLORPROMAZINE CHOLESTASIS.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Alkaline Phosphatase; Androgens; Anti-Bacteria | 1964 |
AN ASSESSMENT OF THE DIAGNOSTIC AND PROGNOSTIC VALUE OF SERUM VITAMIN B12 LEVELS IN LIVER DISEASE.
Topics: Blood; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholangitis; Diagnosis; Hepatitis; He | 1964 |
DRUGS AND LIVER DISEASE.
Topics: Androgens; Anti-Bacterial Agents; Antihypertensive Agents; Antineoplastic Agents; Arsphenamine; Chem | 1965 |
[THE ACTIVITY OF HISTIDASE UNDER THE INFLUENCE OF EXPERIMENTAL LIVER DAMAGE AND PSYCHOPHARMACOLOGICAL AGENTS].
Topics: Bile Ducts; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorpromazine; | 1964 |
THE SYNDROME OF BENIGN RECURRENT CHOLESTASIS.
Topics: Bile Ducts; Bile Ducts, Intrahepatic; Chlorpromazine; Cholestasis; Cholestyramine Resin; Drug Therap | 1965 |
[Toxic hepatosis in the form of intrahepatic obstructive jaundice after chlorpromazine (largactil) atophan, salvarsan and methyltestosterone medication].
Topics: Arsphenamine; Chlorpromazine; Humans; Jaundice; Jaundice, Obstructive; Liver Diseases; Methyltestost | 1955 |
[Chlorpromazine icterus followed by chronic liver damage].
Topics: Abdominal Injuries; Chlorpromazine; Jaundice; Liver Diseases | 1959 |
[Chlorpromazine icterus, a form of cholostatic hepatosis. Clinical-pathological report on 14 observations].
Topics: Chlorpromazine; Jaundice; Liver Diseases | 1962 |
Protective effect of melatonin against chlorpromazine-induced liver disease in rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Chlorpromazine; Disease Models, Anima | 2006 |
[Studies on the drug-induced injury and changes of membrane structure in the isolated liver cells].
Topics: Ajmaline; Animals; Cell Membrane; Cell Separation; Chemical and Drug Induced Liver Injury; Chlorprom | 1983 |
[On the question of parenchyma damage caused by long-term therapy with psychotropics in adolescence].
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Chlorpromazine; Creatinine; Follow | 1980 |
Mechanism of chlorpromazine prevention of carbon tetrachloride-induced liver necrosis.
Topics: Animals; Body Temperature; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; C | 1980 |
Effects of liver disease and of aging on the disposition and elimination of sedatives.
Topics: Aging; Anti-Anxiety Agents; Chlordiazepoxide; Chlorpromazine; Diazepam; Half-Life; Hepatitis, Viral, | 1978 |
Negligible hepatotoxicity of chlorpromazine in long-term therapy.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Chlorpromazine; Humans; Liver; Liver Diseases; | 1978 |
The clinical significance of increased plasma levels of liver-synthesized coagulation factors in liver disease.
Topics: Acetaminophen; Acute Disease; Biliary Tract Diseases; Blood Coagulation Factors; Chemical and Drug I | 1977 |
[Rules for the histological evaluation of drug-induced liver lesions].
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Contraceptives, Oral; F | 1975 |
Chlorpromazine-induced liver and bone marrow granulomas associated with agranulocytosis.
Topics: Adult; Agranulocytosis; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Chlorpromazine | 1990 |
High incidence of poor sulfoxidation in patients with primary biliary cirrhosis.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Carbocysteine; Chlorpromazine; Cholestasis; | 1988 |
Hepatic porphyria with mental symptoms. Four missed cases.
Topics: Adult; Chlorpromazine; Diagnostic Errors; Female; Follow-Up Studies; Humans; Liver Diseases; Male; M | 1972 |
[Study of the changes of some enzyme activities in the liver of rats subjected to acute intoxication with allyl alcohol and of the effect of the preventive administration of chlorpromazine].
Topics: Alcohols; Animals; Cathepsins; Chemical and Drug Induced Liver Injury; Chlorpromazine; Electron Tran | 1968 |
[Effect of some neuroleptic drugs and antihistaminics on the changes of the enzyme pattern induced by ischemia in the rat liver].
Topics: Animals; Cathepsins; Chlorpheniramine; Chlorpromazine; Electron Transport Complex IV; Galactosidases | 1968 |
[Experimental studies of the influence of chlorpromazine on dextran edema of the liver].
Topics: Animals; Chlorpromazine; Chlorprothixene; Dextrans; Edema; Histamine H1 Antagonists; Liver Diseases; | 1965 |
[Pathomorphology of toxic liver lesions].
Topics: Adult; Aflatoxins; Aged; Animals; Biopsy; Chemical and Drug Induced Liver Injury; Child; Chlorpromaz | 1973 |
[Description of a computer surveillance system for isolated liver: application to the study of drugs protecting the liver from anoxic lesions].
Topics: Animals; Chlorpromazine; Computers; Dogs; Extracorporeal Circulation; Hypoxia; Isoproterenol; Liver; | 1970 |
[Differential diagnosis of aminazine jaundice and viral hepatitis developing during aminazine treatment].
Topics: Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Blood Sediment | 1972 |
[Differential diagnosis of aminazine-induced toxico-allergic hepatitis].
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Chlorpromazine; Diagnosis, Differential; Drug H | 1972 |
[Action of some drugs on experimental liver necrosis].
Topics: Animals; Chlorpromazine; Cysteine; Injections, Intraperitoneal; Ischemia; Liver Diseases; Necrosis; | 1971 |
[Medicamentous prevention of endotoxin-induced mortality of pregnant animals].
Topics: Aminocaproates; Animals; Aprotinin; Chlorpromazine; Female; Fetal Death; Liver Diseases; Maternal Mo | 1967 |
Study of serum urocanase in liver diseases.
Topics: Acrylates; Adolescent; Aged; Chlorpromazine; Cholestasis; Humans; Hydro-Lyases; Imidazoles; Jaundice | 1971 |
[Heat stroke. Clinical manifestations and therapeutic possibilities].
Topics: Adult; Blood Coagulation Disorders; Body Temperature; Body Temperature Regulation; Cardiovascular Di | 1968 |
Drugs and liver disease.
Topics: Biliary Tract Diseases; Bilirubin; Brain Diseases; Carbon Tetrachloride Poisoning; Chemical and Drug | 1969 |