chlorpromazine has been researched along with Liver Cirrhosis in 26 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gliotoxin treatment significantly reduced the number of activated stellate cells and mean thickness of bridging fibrotic septae in livers from rats treated with carbon tetrachloride." | 1.31 | Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats. ( Arthur, MJ; Iredale, JP; Issa, R; Mann, DA; Murray, GI; Primrose, JN; Smart, DE; Trim, N; Wright, MC, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (96.15) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.85) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MYERS, JD | 1 |
| OLSON, RE | 1 |
| LEWIS, JH | 1 |
| MORAN, TJ | 1 |
| HURT, P | 1 |
| WEGMANN, T | 1 |
| PANT, SS | 1 |
| GUPTA, NN | 1 |
| MEHROTRA, RM | 1 |
| BEATTIE, AS | 1 |
| FARRIS, JM | 1 |
| FREMPTER, GR | 1 |
| BELL, JL | 1 |
| WILLIAMS, R | 2 |
| KATZ, R | 1 |
| VELASCO, M | 1 |
| GUZMAN, C | 1 |
| ALESSANDRI, H | 1 |
| SAMBHI, MP | 1 |
| WEIL, MH | 1 |
| UDHOJI, VN | 1 |
| ROSOFF, L | 1 |
| HOLDSWORTH, CD | 1 |
| ATKINSON, M | 1 |
| DOSSETT, JA | 1 |
| HALL, R | 1 |
| ANDERSON, D | 1 |
| KOHN, NN | 1 |
| MYERSON, RM | 1 |
| Paumgartner, G | 1 |
| Paumgartner, D | 1 |
| Wright, MC | 1 |
| Issa, R | 1 |
| Smart, DE | 1 |
| Trim, N | 1 |
| Murray, GI | 1 |
| Primrose, JN | 1 |
| Arthur, MJ | 1 |
| Iredale, JP | 1 |
| Mann, DA | 1 |
| Schenker, S | 1 |
| Bach, N | 1 |
| Thung, SN | 1 |
| Schaffner, F | 1 |
| Tobias, H | 1 |
| Kaplowitz, N | 1 |
| Aw, TY | 1 |
| Simon, FR | 1 |
| Stolz, A | 1 |
| Morgan, MH | 1 |
| Bolton, CH | 1 |
| Morris, JS | 1 |
| Read, AE | 2 |
| Bliuger, AF | 1 |
| Maksimova, LA | 1 |
| Kartashova, OIa | 1 |
| Maxwell, JD | 1 |
| Carrella, M | 1 |
| Parkes, JD | 1 |
| Mould, GP | 1 |
| Curry, SH | 1 |
| Dölle, W | 1 |
| Eastwood, HD | 1 |
| Abramov, A | 1 |
| Neufeld, E | 1 |
| Chayen, R | 1 |
| Turek, S | 1 |
| Alcalá-Santaella, R | 1 |
| Pacheco, AF | 1 |
| Robles, J | 1 |
| Laidlaw, J | 1 |
| McCarthy, CF | 1 |
| Walker, CO | 1 |
| Combes, B | 1 |
| Wruble, LD | 1 |
| Kalser, MH | 1 |
| Jones, RH | 1 |
| Vloedman, D | 1 |
| Bachorik, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised, Controlled Trial of Losartan as an Anti-fibrotic Agent in Non-alcoholic Steatohepatitis[NCT01051219] | Phase 3 | 45 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for chlorpromazine and Liver Cirrhosis
| Article | Year |
|---|---|
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Bile; Bile Acids and Salts; Biotransformation; Cell Survival; Chemical and Drug Induc | 1986 |
25 other studies available for chlorpromazine and Liver Cirrhosis
| Article | Year |
|---|---|
Xanthomatous biliary cirrhosis following chlorpromazine, with observations indicating overproduction of cholesterol, hyperprothrombinemia, and the development of portal hypertension.
Topics: Chlorpromazine; Cholesterol; Humans; Hypertension; Hypertension, Portal; Lipidoses; Liver Cirrhosis; | 1957 |
[Protracted Largactil jaundice developing into primary biliary cirrhosis].
Topics: Chlorpromazine; Humans; Jaundice; Liver Cirrhosis; Liver Cirrhosis, Biliary | 1961 |
Tolerance of chlorpromazine by severely anemic and cirrhotic patients.
Topics: Anemia; Chlorpromazine; Humans; Liver Cirrhosis | 1961 |
Hepatohypercholesterolemic cirrhosis: report of a case implicating chlorpromazine as the etiologic agent.
Topics: Chlorpromazine; Cholesterol; Humans; Liver Cirrhosis | 1959 |
THE VALUE OF JIRGL'S FLOCCULATION TEST IN THE DIAGNOSIS OF JAUNDICE.
Topics: Alkaline Phosphatase; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Chlorpromaz | 1964 |
RED CELL SURVIVAL ESTIMATED BY RADIOACTIVE CHROMIUM IN HEPATOBILIARY DISEASE.
Topics: Alcoholism; Bilirubin; Blood Chemical Analysis; Cell Survival; Chlorpromazine; Chromium; Chromium Is | 1964 |
EFFECT OF PRESSOR AMINES ON CARDIAC OUTPUT IN PATIENTS WITH ACUTE HYPOTENSION.
Topics: Amines; Barbiturates; Blood Pressure; Cardiac Output; Chlorpromazine; Dehydration; Drug Therapy; Dye | 1964 |
AN ASSESSMENT OF THE DIAGNOSTIC AND PROGNOSTIC VALUE OF SERUM VITAMIN B12 LEVELS IN LIVER DISEASE.
Topics: Blood; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholangitis; Diagnosis; Hepatitis; He | 1964 |
Opium poisoning precipitated by chlorpromazine.
Topics: Alcoholism; Chlorpromazine; Humans; Liver Cirrhosis; Opium; Poisoning | 1955 |
Xanthomatous biliary cirrhosis following chlorpromazine.
Topics: Chlorpromazine; Lipidoses; Liver Cirrhosis; Liver Cirrhosis, Biliary; Splenomegaly | 1961 |
[Damage to liver and biliary tracts by long-term drug therapy (author's transl)].
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis, Intrahepatic; Dose-Response Rel | 1980 |
Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats.
Topics: Animals; Anti-Allergic Agents; Apoptosis; Calcium; Carbon Tetrachloride; Chlorpromazine; Collagen; C | 2001 |
Effects of liver disease and of aging on the disposition and elimination of sedatives.
Topics: Aging; Anti-Anxiety Agents; Chlordiazepoxide; Chlorpromazine; Diazepam; Half-Life; Hepatitis, Viral, | 1978 |
Exaggerated cholestasis and hepatic fibrosis following simultaneous administration of chlorpromazine and sodium valproate.
Topics: Chlorpromazine; Cholestasis; Drug Interactions; Hiccup; Humans; Liver Cirrhosis; Male; Middle Aged; | 1989 |
Medium chain triglycerides and hepatic encephalopathy.
Topics: Ammonia; Caproates; Chlorpromazine; Electroencephalography; Fatty Acids; Hepatic Encephalopathy; Hum | 1974 |
[Pathogenesis, pathological anatomy, clinical picture and diagnosis of different types of intrahepatic cholestasis].
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Female; Hepatitis | 1972 |
Plasma disappearance and cerebral effects of chlorpromazine in cirrhosis.
Topics: Adult; Aged; Brain; Chlorpromazine; Chromatography, Gas; Electroencephalography; Humans; Injections, | 1972 |
[Drug icterus and biliary cirrhosis].
Topics: Chlorpromazine; Humans; Jaundice; Liver Cirrhosis; Testosterone | 1971 |
Causes of jaundice in the elderly. A survey of diagnosis and investigation.
Topics: Aged; Anemia, Hemolytic; Bilirubin; Carcinoma; Chlorpromazine; Cholelithiasis; Cholestasis; Female; | 1971 |
Study of serum urocanase in liver diseases.
Topics: Acrylates; Adolescent; Aged; Chlorpromazine; Cholestasis; Humans; Hydro-Lyases; Imidazoles; Jaundice | 1971 |
Albumin turbidity reaction of blood serum.
Topics: Adolescent; Adult; Alcoholism; Arteriosclerosis; Blood Protein Disorders; Chemistry, Clinical; Chlor | 1967 |
[Apropos of primary biliary cirrhosis induced by chlorpromazine and its therapy with cholestyramine].
Topics: Aged; Chlorpromazine; Cholestyramine Resin; Female; Humans; Liver Cirrhosis; Liver Cirrhosis, Biliar | 1968 |
Effects of chlorpromazine in patients with hepatic disease.
Topics: Ammonia; Chlorpromazine; Drug Hypersensitivity; Electroencephalography; Humans; Liver Cirrhosis | 1969 |
Biliary cirrhosis induced by chlorpromazine.
Topics: Adult; Chlorpromazine; Female; Humans; Jaundice; Liver; Liver Cirrhosis; Male; Skin Manifestations; | 1966 |
Jaundice. Value of five-day steroid test in differential diagnosis.
Topics: Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Blood; Chlorpromazine; Cholestasis; Ch | 1966 |